Veterinary Automatic Insulin Delivery Pen VetPenTM is only for use with 2.7 ml Caninsulin® cartridges Instructions for Use 1–16 units 0.5–8 units Components Pen Needles VetPen is available in two versions: VetPen 8, which delivers 0.5 to 8 units per injection, and VetPen 16, which delivers 1 to 16 units per injection. The insulin pen comes with specially lubricated Unifine® Pentips® 29G/12 mm pen needles. Sterility is guaranteed for 5 years from the date of sterilization if the package seal is undamaged. The insulin pen should be used solely with 29G/12 mm pen needles. TM 1 9 2 3 6 10 11 4 7 5 1. Dose selector 2. Pen body 3. Release button 4. Internal plunger 5. Cartridge holder 6. Pen cap 8 12 7. Dose selector adapter 8. Release button extension 9. Pen needle & protective caps 10. Cartridge plunger 11. Cartridge 12. Needle remover How to Use VetPenTM PLEASE FOLLOW THESE STEP-BY-STEP INSTRUCTIONS CAREFULLY BEFORE USING VETPEN. 4 Load the insulin cartridge into the cartridge holder by inserting the metal cap in first. Failure to follow these instructions may result in an inaccurate dose. Insulin cartridges from any supplier other than Intervet/Schering-Plough Animal Health should not be used with either VetPen. Loading a cartridge 1 Prior to loading, turn the insulin cartridge 5 Screw the cartridge holder and pen body firmly together. up and down at least 10 times until the insulin appears uniformly milky. Do not use if there are agglomerates in the insulin after mixing thoroughly. 2 Pull off the pen cap and unscrew the pen body from the cartridge holder. Priming the insulin pen Steps 6 through 8 must be followed before each injection. 6 Peel the protective film from a new pen needle. Screw the pen needle straight onto the cartridge holder. Remove the outer protective needle cap from the pen needle. 3 Check to ensure that the internal plunger is fully retracted. If the internal plunger is extended, please refer to step 13 to see how to wind it back in. Priming the insulin pen (cont.) Replace the pen cap onto the insulin pen. Turn the pen up and down at least 10 times. Repeat steps 7 and 8 until a drop of insulin appears at the needle tip. The insulin pen is now ready for use. If the start line (—) on the dose selector does not return to the arrow (u) on the pen body, please refer to the Priming Advice information at the end of these instructions. Injecting the dose into your pet 9 Make sure the arrow (u) on the pen body points to the start line (—) on the dose selector. 7 It is important to prime the pen before use to avoid injection of air and ensure proper dosing. Dial one unit on the dose selector. Remove the pen cap. Dial up the number of units required per your veterinarian’s direction. (The dose shown in this photograph is an example only. Your veterinarian will tell you the recommended dose for your dog or cat.) 8 Hold the pen with the needle pointing up. Tap the cartridge gently with your finger a few times to push any air bubbles to the top of the cartridge. Push and hold the release button towards the needle until the arrow (u) on the pen body points to the starting line (—) on the dose selector. Never attempt to forcefully dial back the dose selector, as doing so may damage the insulin pen and result in inaccurate dosing. Injecting the dose into your pet (cont.) If at any time you overdial the dose, we recommend that the incorrect dose is fully expelled into a safe place and the required dose is redialed. Make sure before injecting that the arrow (u) points towards the correct number of units on the dose selector. Removing the needle 11 Remove the needle by inserting it in the removal device and unscrewing it. Press the blue tip on the device to release the needle. Always check that your pen needle has been removed. 10 The injection should be performed subcutane- ously, 2 to 5 cm (3/4 to 2 in) from the dorsal midline, varying from behind the scapulae to the mid-lumbar region and alternating sides. Insert the needle using the injection technique recommended by your veterinarian then push the release button towards the pen needle and hold it in place until the start line on the dose selector returns to the arrow on the pen body (u —). Count to 5 before removing the needle from the skin. If the dose selector stops before the start line (—) returns to the arrow (u), this indicates that your pet has not received a full dose. If only a partial dose was administered, do not attempt to re-dose. Wait and give your pet its usual dose at the next injection. If your pet dislodges the needle before the count of 5, do not attempt to re-dose. Wait and give your pet its usual dose at the next injection. Replace the pen cap onto the insulin pen. Dispose of used pen needles carefully in accordance with the advice given by your veterinarian or local regulations. Changing the cartridge 12 Before changing the cartridge, always make sure that the pen needle has been removed to prevent accidental injury. Then unscrew the cartridge holder from the pen body and remove the cartridge. Safety Precautions •V etPen should be used only after consultation with your veterinarian. • P lease refer to the Caninsulin® cartridge package insert for relevant storage conditions for the insulin prior to and during use. • Always ensure that VetPen has been primed in accordance with the instructions detailed in steps 7 and 8. Failure to follow the exact priming procedures could result in an inaccurate dose being delivered. 13 Rewind the internal plunger by holding the gray lower part of the pen body between the thumb and finger. Turn the pen body until the internal plunger is fully retracted. Then return to step 1 to load the next cartridge. • To avoid potential damage to the VetPen, never dial a dose and push the release button without a cartridge in the cartridge holder. • A new needle should be used for each injection. •T he needle should be removed with the needle remover and safely disposed of immediately after each injection. If the needle is left on it may become blocked and affect the dose delivered. •C onsult your veterinarian should you encounter difficulty in injecting your pet or should your pet display any changes in behavior or clinical condition. Storage and Cleaning VetPen should always be stored or carried with the needle removed, and the pen cap on. To clean VetPen, wipe with a damp cloth. Do not immerse in water. Note: If the internal plunger is rewound incorrectly it can damage the VetPenTM. Priming Advice If the dose selector does not return to the start line, and no insulin has been expelled, this may indicate one of two possibilities. 1 The pen needle that you are using may be blocked. Remove the pen needle currently attached to the pen and replace it with a new one. Then return to steps 7 and 8. 2 The cartridge plunger may require releasing. If so: A. Replace the outer protective cap onto the needle. B. Unscrew the cartridge holder. C. Slide the release button towards the internal plunger and hold in place until the start line on the dose selector returns to the arrow on the body. D. Dial up 2 units on the dose selector without screwing the internal plunger back together and simply push and hold down the release button towards the internal plunger until the start line on the dose selector returns to the arrow on the body. E. Without rewinding the internal plunger, screw the cartridge holder and body firmly together. This will release the cartridge plunger and expel some of the insulin. However, the device will not be primed. F. R epeat steps 7–8, thus priming the device fully.