MSDS for Butadiene

MSDS for Butadiene
MATERIAL SAFETY DATA SHEET
Prepared to U.S. OSHA, CMA, ANSI and Canadian WHMIS Standards
1. PRODUCT IDENTIFICATION
CHEMICAL NAME; CLASS:
NON-FLAMMABLE GAS MIXTURE
Containing < 2% 1,3-Butadiene, < 23.5% Oxygen in a Nitrogen Balance Gas
SYNONYMS: Not Applicable
CHEMICAL FAMILY NAME: Not Applicable
FORMULA: Not Applicable
Document Number: 50066
Note: The Material Safety Data Sheet is for this gas mixture supplied in cylinders with 33 cubic feet (935 liters) or less gas capacity (DOT - 39
cylinders). This MSDS has been developed for various gas mixtures with the composition of components within the ranges listed in Section 2
(Composition and Information on Ingredients). Refer to the product label for information on the actual composition of the product.
PRODUCT USE:
U.S. SUPPLIER/MANUFACTURER'S NAME:
ADDRESS:
Calibration of Monitoring and Research Equipment
CALGAZ
821 Chesapeake Drive
Cambridge, MD 21613
1-410-228-6400 (8 a.m. to 5 p.m. U.S. EST)
1-713-868-0440
1-800-231-1366
BUSINESS PHONE:
General MSDS Information:
Fax on Demand:
EMERGENCY PHONE:
Chemtrec: United States/Canada/Puerto Rico:
Chemtrec International:
1-800-424-9300 [24-hours]
1-703-527-3887 [24-hours]
2. COMPOSITION and INFORMATION ON INGREDIENTS
CHEMICAL NAME
CAS #
mole %
EXPOSURE LIMITS IN AIR
ACGIH-TLV
OSHA-PEL
NIOSH
OTHER
TWA
STEL
TWA
STEL
IDLH
ppm
ppm
ppm
ppm
ppm
ppm
2
NE
1
See 29
CFR
1910.1051;
29 CFR
1910.19(1)
5
See 29
CFR
1910.1051;
29 CFR
1910.19(1)
2000
(Based
on 10%
of LEL)
NIOSH REL:
Reduce to lowest feasible
concentration (LOQ 0.19)
DFG MAK Germ Cell
Mutagen Class: 2
Carcinogen: EPA-B2,
IACR-2A, MAK-1,
NIOSH-Ca, NTP-K, TLVA2
1,2-Butadiene
590-19-2
< 2%
Oxygen
7782-44-7
< 23.5%
There are no specific exposure limits for Oxygen. Oxygen levels should be maintained above
19.5%.
Nitrogen
7727-37-9
Balance
There are no specific exposure limits for Nitrogen. Nitrogen is a simple asphyxiant (SA).
Oxygen levels should be maintained above 19.5%.
NE = Not Established.
See Section 16 for Definitions of Terms Used.
NOTE (1): ALL WHMIS required information is included in appropriate sections based on the ANSI Z400.1-1998 format. This product has been
classified in accordance with the hazard criteria of the CPR and the MSDS contains all the information required by the CPR.
3. HAZARD IDENTIFICATION
EMERGENCY OVERVIEW: This is a colorless, gas mixture, which may have a mild gasoline-like odor, due to the
presence of 1,3-Butadiene. Inhalation of this gas mixture in high concentrations may cause irritation of the
respiratory system and central nervous system effects. Contact with the skin and eyes may cause irritation,
especially if the irritation is prolonged. Additionally, releases of this product may produce oxygen-deficient
atmospheres (especially in small confined spaces or other poorly-ventilated environments); individuals in such
atmospheres may be asphyxiated. The 1,3-Butadiene component is a suspected human carcinogen. All contact
with this gas mixture should be prevented.
NON-FLAMMABLE GAS MIXTURE MSDS - 50066
EFFECTIVE DATE: FEBRUARY 16, 2011
PAGE 1 OF 7
3. HAZARD IDENTIFICATION(Continued)
SYMPTOMS OF OVEREXPOSURE BY ROUTE OF
H A ZA R D O U S M A T E R IA L ID E N T IF IC A T IO N S Y S T E M
EXPOSURE: The most significant route of overexposure for this
product is by inhalation.
HEALTH
1
(B L U E )
INHALATION: Due to the small size of an individual cylinder of
this product, no unusual health effects from overexposure to the
product are anticipated under routine circumstances of use.
(R E D )
0
F L A M M A B IL IT Y
Releases of this product may produce oxygen-deficient
atmospheres (especially in small confined spaces or other poorlyventilated environments); individuals in such atmospheres may be
(Y E L L O W )
1
R E A C T IV IT Y
asphyxiated. The 1,3-Butadiene component of this product
produces slight lung irritation at 2000-4000 ppm. At 8000 ppm,
P R O T E C T IV E E Q U IP M E N T B
with an 8-hour exposure, lung irritation has been experienced.
Coughing and symptoms of CNS depression were experienced by
volunteers exposed to 8000 ppm for 8 hours.
S ee S ectio n 8
SKIN AND EYES: This gas mixture may be irritating to the skin,
especially if contact is prolonged. The 1,3-Butadiene component
F o r R o u tin e In d u s tria l U s e a n d H a n d lin g A p p lic a tio n s
of this product has been found to be irritating to the eyes upon
exposure to a level of 10,000 ppm for an hour. Due to the presence of this compound, this gas mixture may be
irritating to the eyes.
OTHER HEALTH EFFECTS: Harmful effects on the blood and blood-forming system, kidneys, liver and lungs
have been observed in animal studies of the 1,3-Butadiene component of this product.
HEALTH EFFECTS OR RISKS FROM EXPOSURE: An Explanation in Lay Terms. Overexposure to this gas
mixture may cause the following health effects:
ACUTE: Due to the small size of the individual cylinder of this product, no unusual health effects from exposure to
the product are anticipated under routine circumstances of use. Depending on the concentration and duration of
exposure, inhalation of this gas mixture may cause irritation, central nervous system effects and an oxygen-deficient
atmosphere. Skin and eye contact may be irritating, especially if the contact is prolonged.
CHRONIC: The 1,3-Butadiene component of this product is a suspect human carcinogen. See Section 11
(Toxicological Information) for further information.
TARGET ORGANS: ACUTE: Respiratory system, skin, eyes, central nervous system.
CHRONIC: The 1,3Butadiene component is a suspect human carcinogen and possible reproductive toxin. Based on animal data,
adverse effects on the blood-forming system, kidneys, and liver may occur after prolonged exposure to this gas
mixture, due to the presence of 1,3-Butadiene. See Section 11 (Toxicological Information).
EYES
RE S P IRA TO RY
H A ND S
B OD Y
4. FIRST-AID MEASURES
RESCUERS SHOULD NOT ATTEMPT TO RETRIEVE VICTIMS OF EXPOSURE TO THIS PRODUCT
WITHOUT ADEQUATE PERSONAL PROTECTIVE EQUIPMENT. At a minimum, Self-Contained
Breathing Apparatus must be worn. Victim(s) who experience any adverse effect after overexposure to this
product must be taken for medical attention. Rescuers should be taken for medical attention if necessary. Take a
copy of the label and the MSDS to physician or other health professional with victim(s).
No unusual health effects are anticipated after exposure to this product, due to the small cylinder size. If any
adverse symptom develops after overexposure to this product, remove victim(s) to fresh air as quickly as possible.
Only trained personnel should administer supplemental oxygen and/or cardio-pulmonary resuscitation if necessary.
MEDICAL CONDITIONS AGGRAVATED BY EXPOSURE: Pre-existing respiratory conditions and other disorders
may be aggravated by overexposure to this product.
RECOMMENDATIONS TO PHYSICIANS: Treat symptoms and eliminate overexposure. Some jurisdictions have
specific regulations for 1,3-Butadiene. These regulations may include requirements for medical surveillance
programs, including pre-employment and pre-placement examinations, periodic medical examinations, clinical tests,
health education and record keeping. Obtain detailed information from the appropriate government agency in
relevant jurisdictions.
5. FIRE-FIGHTING MEASURES
FLASH POINT: Not applicable.
NFPA RATING
AUTOIGNITION TEMPERATURE: Not applicable.
FLAMMABILITY
FLAMMABLE LIMITS (in air by volume, %):
Lower (LEL): Not applicable.
Upper (UEL): Not applicable.
0
FIRE EXTINGUISHING MATERIALS: Non-flammable gas mixture.
1
1
Use extinguishing media appropriate for surrounding fire.
HEALTH
REACTIVITY
UNUSUAL FIRE AND EXPLOSION HAZARDS: This gas mixture is
not flammable; however, containers, when involved in fire, may
rupture or burst in the heat of the fire.
Explosion Sensitivity to Mechanical Impact: Not Sensitive.
OTHER
Explosion Sensitivity to Static Discharge: Not Sensitive.
SPECIAL FIRE-FIGHTING PROCEDURES: The 1,3-Butadiene component is considered to be is very toxic and a
suspected human carcinogen. Do not enter fire area without wearing specialized protective/equipment suitable for
the situation. Firefighter's normal protective clothing (Bunker Gear) will not provide adequate protection. A full-body
encapsulating chemical resistant suit with positive pressure Self-Contained Breathing Apparatus (NIOSH-approved
or equivalent) may be necessary.
6. ACCIDENTAL RELEASE MEASURES
LEAK RESPONSE: Due to the small size and content of the cylinder, an accidental release of this product presents
significantly less risk of an oxygen-deficient environment and other safety hazards than a similar release from a
larger cylinder. However, as with any chemical release, extreme caution must be used during emergency response
procedures. In the event of a release in which the atmosphere is unknown, and in which other chemicals are
potentially involved, evacuate immediate area. Such releases should be responded to by trained personnel using
pre-planned procedures. Proper protective equipment should be used. In case of a leak, clear the affected area and
protect people. For emergency disposal, secure the cylinder and slowly discharge the gas to the atmosphere in a
NON-FLAMMABLE GAS MIXTURE MSDS - 50066
EFFECTIVE DATE: FEBRUARY 16, 2011
PAGE 2 OF 7
6. ACCIDENTAL RELEASE MEASURES(Continued)
well-ventilated area or outdoors. Allow the gas mixture to dissipate. If necessary, monitor the surrounding area (and
the original area of the release) for oxygen and the level of 1,3-Butadiene. Oxygen levels must be above 19.5% and
the level of 1,3-Butadiene must be below the TLV before non-emergency personnel are allowed to re-enter area. If
leaking incidentally from the cylinder or its valve, contact your supplier.
7. HANDLING and USE
WORK PRACTICES AND HYGIENE PRACTICES: Due to the potential carcinogenic effect of the 1,3Butadiene component of this product, requirements under OSHA 29 CFR 1910.1051; 29 CFR 1910.19(1) must
be followed. Be aware of any signs of dizziness or fatigue; exposures to fatal concentrations of this product could
occur without any significant warning symptoms, due to oxygen deficiency. Do not attempt to repair, adjust, or in any
other way modify the cylinders of this product. If there is a malfunction or another type of operational problem,
contact nearest distributor immediately.
STORAGE AND HANDLING PRACTICES: Cylinders should be firmly secured to prevent falling or being knockedover. Cylinders must be protected from the environment, and preferably kept at room temperature (approximately
21°C, 70°F). Cylinders should be stored in dry, well-ventilated areas, away from sources of heat, ignition, and direct
sunlight. Protect cylinders against physical damage. Full and empty cylinders should be segregated. Use a first-in,
first-out inventory system to prevent full containers from being stored for long periods of time. These cylinders are
not refillable. WARNING! Do not refill DOT 39 cylinders. To do so may cause personal injury or property
damage.
SPECIAL PRECAUTIONS FOR HANDLING GAS CYLINDERS: WARNING! Compressed gases can present
significant safety hazards. During cylinder use, use equipment designed for these specific cylinders. Ensure all lines
and equipment are rated for proper service pressure.
PROTECTIVE PRACTICES DURING MAINTENANCE OF CONTAMINATED EQUIPMENT: Follow practices
indicated in Section 6 (Accidental Release Measures). Make certain that application equipment is locked and
tagged-out safely. Always use product in areas where adequate ventilation is provided.
8. EXPOSURE CONTROLS - PERSONAL PROTECTION
VENTILATION AND ENGINEERING CONTROLS: Due to the presence of the 1,3-Butadiene component in this gas
mixture, refer to OSHA 29 CFR 1910.1051; 29 CFR 1910.19(1) for specific ventilation requirements. As with all
chemicals, use this product in well-ventilated areas. If this product is used in a poorly-ventilated area, install
automatic monitoring equipment to detect the levels of Isobutane and oxygen.
RESPIRATORY PROTECTION: No special respiratory protection is required under normal circumstances of use.
Use supplied air respiratory protection if the levels of Isobutane exceeds exposure limits presented in Section 2
(Composition and Information of Ingredients) and Oxygen levels are below 19.5%, or unknown, during emergency
response to a release of this product. If respiratory protection is needed, use only protection authorized in the U.S.
Federal OSHA Standard (29 CFR 1910.134), applicable U.S. State regulations, or the Canadian CSA Standard
Z94.4-93 and applicable standards of Canadian Provinces. Oxygen levels below 19.16.33% are considered IDLH
by OSHA. In such atmospheres, use of a full-facepiece pressure/demand SCBA or a full facepiece, supplied air
respirator with auxiliary self-contained air supply is required under OSHA’s Respiratory Protection Standard
(1910.134-1998). The following are NIOSH respiratory protection guidelines for 1,3-Butadiene:
1,3-BUTADIENE
CONCENTRATION
RESPIRATORY PROTECTION
At Concentrations Above the NIOSH REL, or Where There is no REL, at Any Detectable Concentration: Any SelfContained Breathing Apparatus (SCBA) that has a full facepiece and is operated in a
pressure-demand or other positive-pressure mode, or any Supplied-Air Respirator(SAR)
that has a full facepiece and is operated in a pressure-demand or other positive-pressure
mode in combination with an auxiliary SCBA operated in pressure-demand or other
positive-pressure mode.
Escape:
Any Air-Purifying, Full-Facepiece Respirator (gas mask) with a chin-style, front- or backmounted canister providing protection against the compound of concern, or any
appropriate escape-type, SCBA.
EYE PROTECTION: Safety glasses. If necessary, refer to U.S. OSHA 29 CFR 1910.133 or appropriate Canadian
Standards.
HAND PROTECTION: Due to the presence of 1,-3-Butadiene, it is recommended that gloves, such as Viton™,
Saranex™, Barricade™, Responder™, or Teflon™. If necessary, refer to U.S. OSHA 29 CFR 1910.138 or
appropriate Standards of Canada.
BODY PROTECTION: No special protection is needed under normal circumstances of use. If a hazard of injury to
the feet exists due to falling objects, rolling objects, where objects may pierce the soles of the feet or where
employee’s feet may be exposed to electrical hazards, use foot protection, as described in U.S. OSHA 29 CFR
1910.136.
9. PHYSICAL and CHEMICAL PROPERTIES
Unless otherwise specified, the following information is for Nitrogen, the main component of this gas
mixture.
GAS DENSITY @ 0°C (32°F) and 1 atm: .072 lb./ ft3 (1.153 kg/m3)
BOILING POINT: -320.4°F (-195.8°C)
FREEZING/MELTING POINT @ 10 psig -210°C (-345.8°F)
pH: Not applicable.
SPECIFIC GRAVITY (air = 1) @ 21.1°C (70°F): 0.906
SPECIFIC VOLUME (ft3/lb): 13.8
SOLUBILITY IN WATER vol/vol @ 0°C (32°F) and 1 atm: 0.023
MOLECULAR WEIGHT: 28.01
EVAPORATION RATE (nBuAc = 1): Not applicable.
EXPANSION RATIO: Not applicable.
VAPOR PRESSURE @ 70°F (21.1°C) psig: Not applicable.
COEFFICIENT WATER/OIL DISTRIBUTION: Not applicable.
The following information is for this gas mixture.
ODOR THRESHOLD (values for 1,3-Butadiene): Detection: 4.50x10-1 ppm, purity not specified; 0.35 mg/m3
(odor low) 2.86 mg/ m3 (odor high).
APPEARANCE, ODOR AND COLOR: This product is a colorless, odorless gas mixture.
HOW TO DETECT THIS SUBSTANCE (warning properties): There are no unusual warning properties
associated with a release of this product.
NON-FLAMMABLE GAS MIXTURE MSDS - 50066
EFFECTIVE DATE: FEBRUARY 16, 2011
PAGE 3 OF 7
10. STABILITY and REACTIVITY
STABILITY: Normally stable in gaseous state, under conditions of normal pressure and temperature. The 1,3Butadiene component of this mixture can polymerize if exposed to high temperatures.
DECOMPOSITION PRODUCTS: Acetaldehyde and acrolein have been identified as products of photo-oxidation.
MATERIALS WITH WHICH SUBSTANCE IS INCOMPATIBLE: The 1,3-Butadiene component is incompatible with
strong oxidizers (e.g. chlorine, chlorine dioxide, nitrogen oxides, nitrates, perchlorates, peroxides), copper,
copper alloys or Monel, Aluminum Tetrahydroborate, buten-3-yne (vinylacetylene), crotonaldehyhde, boron trifluoride
and phenol.
HAZARDOUS POLYMERIZATION: The 1,3-Butadiene component of this product may polymerize explosively
when exposed to elevated temperatures, air, sunlight, rust, and in the presence of incompatible materials, such as
peroxides. Cylinders and closed containers may rupture violently if heated. The 1,3-Butadiene component may
form explosive peroxides in the presence of air or oxygen. Can decomposes explosively at high temperatures and
pressure. 1.3-Butadiene vapor in contact with cobalt metal will initiate "popcorn" polymerization of the diene.
CONDITIONS TO AVOID: Contact with incompatible materials. Cylinders exposed to high temperatures or direct
flame can rupture or burst.
11. TOXICOLOGICAL INFORMATION
TOXICITY DATA: The following toxicology data are available for the components of this product:
1,3-BUTADIENE:
TCLo (Inhalation-Human) 2000 ppm/7 hours:
Sense Organs and Special Senses (Eye):
effect, not otherwise specified; Behavioral:
hallucinations, distorted perceptions
TCLo (Inhalation-Human) 8000 ppm: Sense
Organs and Special Senses (Eye): visual
field changes, conjunctive irritation; Lungs,
Thorax, or Respiration: cough
LD50 (Oral-Rat) 5480 mg/kg
LD50 (Oral-Mouse) 3210 mg/kg
3
LC50 (Inhalation-Rat) 285 gm/m /4 hours:
Behavioral: general anesthetic; Lungs,
Thorax,
or
Respiration:
respiratory
depression
3
LC50 (Inhalation-Mouse) 270 gm/m /2 hours
LCLo (Inhalation-Rabbit) 25 pph/23 minutes:
Sense Organs and Special Senses (Eye):
mydriasis (pupillary dilation); Behavioral:
tremor, muscle weakness
TCLo (Inhalation-Rat) 1000 ppm/6 hours/13
weeks-intermittent: Liver: changes in liver
weight; Kidney, Ureter, Bladder: changes in
bladder weight
TCLo (Inhalation-Rat) 1000 ppm/6 hours/1
years-intermittent: Liver: changes in liver
weight; Related to Chronic Data: death
3
TCLo (Inhalation-Rat) 2200 mg/m /4 hours/17
weeks-intermittent:
Blood:
leukopenia;
Biochemical: Metabolism (Intermediary):
lipids including transport, other proteins
TCLo (Inhalation-Rat): 625 ppm/6 hours/61
weeks: Tumorigenic: Carcinogenic by
RTECS criteria; Cardiac: tumors; Lungs,
Thorax, or Respiration: tumors
TCLo (Inhalation-Rat) 1000 ppm/6 hours/2
years-intermittent:
Tumorigenic:
Carcinogenic by RTECS criteria; Skin and
Appendages: tumors
TCLo (Inhalation-Rat) 8000 ppm/6 hours/2
years-intermittent: Tumorigenic: neoplastic
by RTECS criteria; Gastrointestinal: tumors;
Endocrine: thyroid tumors
TCLo (Inhalation-Mouse) 1250 ppm/6
hours/14 weeks-intermittent: Related to
Chronic Data: death
TCLo (Inhalation-Mouse) 1250 ppm/6 hours/6
weeks-intermittent:
Blood:
normocytic
anemia, changes in bone marrow (not
otherwise specified), changes in erythrocyte
(RBC) count
TCLo (Inhalation-Mouse) 8000 ppm/6
hours/15 days-intermittent: Nutritional and
Gross Metabolic: weight loss or decreased
weight gain
1,3-BUTADIENE (continued):
TCLo (Inhalation-Mouse) 1250 ppm/6
hours/24
weeks-intermittent:
Blood:
pigmented or nucleated red blood cells,
changes in erythrocyte (RBC) count,
changes in leukocyte (WBC) count
3
TCLo (Inhalation-Rabbit) 100 mg/m /4
hours/17 weeks-intermittent: Immunological
Including Allergic: decrease in cellular
immune response; Biochemical: Enzyme
inhibition, induction, or change in blood or
tissue levels: true cholinesterase
TCLo (Inhalation-Mouse) 625 ppm/6 hours/13
weeks-intermittent:
Tumorigenic:
Carcinogenic by RTECS criteria; Sense
Organs and Special Senses (Olfaction):
tumors; Cardiac: tumors
TC (Inhalation-Rat) 8000 ppm/6 hours/15
weeks-intermittent:
Tumorigenic:
Carcinogenic by RTECS criteria; Endocrine:
tumors
TC (Inhalation-Rat) 8000 ppm/6 hours/2
years-intermittent:
Tumorigenic:
Carcinogenic by RTECS criteria; Endocrine:
thyroid tumors; Skin and Appendages:
tumors
TC (Inhalation-Mouse) 200 ppm/40 weeksintermittent:
Tumorigenic:
equivocal
tumorigenic agent by RTECS criteria;
Gastrointestinal: tumors
TC (Inhalation-Mouse) 625 ppm/6 hours/65
weeks-intermittent: Tumorigenic: equivocal
tumorigenic agent by RTECS criteria;
Sense Organs and Special Senses (Eye):
tumors; Cardiac: tumors
TC (Inhalation-Mouse) 63 ppm/6 hours/2
years-intermittent:
Tumorigenic:
Carcinogenic by RTECS criteria; Vascular:
tumors; Liver: tumors
TCLo (Inhalation-Rat) 8000 ppm/6 hours:
female 6-15 day(s) after conception:
Reproductive:
Specific
Developmental
Abnormalities: musculoskeletal system
TCLo (Inhalation-Mouse) 500 ppm/6 hours:
male 5 day(s) pre-mating: Reproductive:
Paternal Effects: testes, epididymis, sperm
duct; Effects on Embryo or Fetus:
cytological changes (including somatic cell
genetic material)
TCLo (Inhalation-Mouse) 1000 ppm/6 hours
female 6-15 day(s) after conception:
Reproductive: Maternal Effects: uterus,
cervix, vagina
1,3-BUTADIENE (continued):
TCLo (Inhalation-Mouse) 1000 ppm/6 hours:
female 6-15 day(s) after conception:
Reproductive: Fertility: post-implantation
mortality (e.g. dead and/or resorbed
implants per total number of implants);
Effects on Embryo or Fetus: extraembryonic structures (e.g., placenta,
umbilical cord), fetotoxicity (except death,
e.g., stunted fetus)
Mutation in Microorganisms (BacteriaSalmonella typhimurium) 20 pph/2 hourscontinuous
Mutation in Microorganisms (BacteriaSalmonella typhimurium) 2 pph
Sister
Chromatid
Exchange
(HumanLymphocyte) 500 µmol/L
Micronucleus Test (Inhalation-Mouse) 6250
ppb/6 hours/13 weeks-intermittent
Specific Locus Test (Inhalation-Mouse) 500
ppm/6 hours/5 days-continuous
DNA Damage (Inhalation-Mouse) 125 ppm/6
hours-continuous
DNA Adduct (Inhalation-Mouse) 200 ppm/5
days/6 hours-continuous
Cytogenetic Analysis (Inhalation-Mouse) 625
ppm/6 hours/10 days-intermittent
Sister Chromatid Exchange (InhalationMouse) 6250 ppb/6 hours/10 daysintermittent
Dominant Lethal Test (Inhalation-Mouse)
1250 ppm/6 hours/10 weeks-intermittent
Mutation in Mammalian Somatic Cells
(Mouse-Lymphocyte) 20 pph
Mutation in Mammalian Somatic Cells
(Inhalation-Mouse) 625 ppm/6 hours/2
weeks-intermittent
Sperm Morphology (Inhalation-Mouse) 130
ppm/5 days/6 hours-continuous
Heritable Translocation Test (InhalationMouse) 500 ppm/6 hours/5 days-continuous
Sister Chromatid Exchange (Hamster-Ovary)
25 µmol/L
NITROGEN:
There are no specific toxicology data for
Nitrogen. Nitrogen is a simple asphyxiant.
OXYGEN:
There are toxicity data for oxygen, but are
only related to exposure to oxygen in an
elevated pressure environment, such as a
hyperbaric chamber.
OTHER TOXICOLOGICAL DATA: Blood system effects (changes in bone marrow stem cell development,
reduction in white and red blood cells and an increase in the volume of circulating red blood cells) were observed in
several studies involving male mice exposed to 1250 ppm of the 1,3-Butadiene component of this gas mixture for 631 weeks. Effects on red blood cell enzymes, grooming activity and salivation were observed in rats exposed to
1000-8000 ppm for 13 weeks.
SUSPECTED CANCER AGENT: The components of this gas mixture are listed by agencies that track the cancer
potential of chemicals as follows:
1,3-BUTADIENE: ACGIH TLV-A2 (Suspected Human Carcinogen); EPA-B2 (Probable Human Carcinogen. Sufficient evidence from animal
studies; inadequate evidence or no data from epidemiologic studies); IARC-2A (Probably Carcinogenic to Humans); MAK-1 (Substances that
Cause Cancer in Man and Can be Assumed to Make a Significant Contribution to Cancer Risk); NIOSH-Ca (Potential Occupational
Carcinogen with No Further Categorization); NTP-K (Known to be a Human Carcinogen).
Inhalation carcinogenesis studies of 1,3-Butadiene were conducted by exposing groups of 50 male and 50 female
B6C3F1 mice 6 hours/day 5 days/week to air containing 1,3-Butadiene at concentrations of 0 (chamber controls),
625, or 1,250 ppm. These studies were planned for 103 week exposures but were terminated at weeks 60 for male
mice and weeks 61 for female mice because of the rapidly declining survival, primarily due to neoplasia. Under the
conditions of these studies, there was clear evidence of carcinogenicity for 1,3-Butadiene in male and female
B6C3F1
NON-FLAMMABLE GAS MIXTURE MSDS - 50066
EFFECTIVE DATE: FEBRUARY 16, 2011
PAGE 4 OF 7
11. TOXICOLOGICAL INFORMATION (Continued)
mice as shown by increased incidences and early induction of hemangiosarcomas of the heart, lymphomas,
alevolar/bronchiolar adenomas and carcinomas, and papillomas of the stomach in males and females; and of acinar
cell carcinomas of the mammary gland, granulosa cell tumors of the ovary, and hepatocellular adenomas and
adenomas or carcinomas (combined) in females.
The remaining components of this gas mixture are not found on the following lists: U.S. FEDERAL OSHA Z LIST,
NTP, CAL/OSHA, and IARC; therefore are not considered to be, nor suspected to be, cancer-causing agents by
these agencies.
IRRITANCY OF PRODUCT: The 1,3-Butadiene component of this gas mixture can cause some irritation to mucus
membranes.
SENSITIZATION OF PRODUCT: No component of this gas mixture is known to be a skin or respiratory sensitizer.
REPRODUCTIVE TOXICITY INFORMATION: Listed below is information concerning the effects of this gas mixture
on the human reproductive system.
Mutagenicity: This gas mixture is not expected to cause mutagenic effects in humans. Despite their limitations,
some human studies have shown mutagenic effects in the blood cells of people occupationally exposed to the 1,3Butadiene. Animal information clearly indicates that 1,3-Butadiene is mutagenic to both somatic and germ cells.
Positive and negative results have been obtained in cultured mammalian cells, including some tests with human
cells.
Embryotoxicity: This gas mixture is not expected to cause embryotoxic effects in humans. A fetotoxic effect
(reduced body weight) has been observed in mice, in the absence of harmful effects on mothers in tests involving
the 1,3-Butadiene component of this gas mixture.
Teratogenicity: This gas mixture is not expected to cause teratogenic effects in humans. Teratogenic effects were
observed in rats in tests involving the 1,3-Butadiene component, at maternally toxic concentrations.
Reproductive Toxicity: This gas mixture is not expected to cause adverse reproductive effects in humans; however,
in animal tests 1,3-Butadiene is mutagenic to sperm which has reproductive implications.
A mutagen is a chemical which causes permanent changes to genetic material (DNA) such that the changes will propagate
through generation lines. An embryotoxin is a chemical which causes damage to a developing embryo (i.e. within the first
eight weeks of pregnancy in humans), but the damage does not propagate across generational lines. A teratogen is a
chemical which causes damage to a developing fetus, but the damage does not propagate across generational lines. A
reproductive toxin is any substance which interferes in any way with the reproductive process.
ACGIH BIOLOGICAL EXPOSURE INDICES (BEIs): Currently there are no ACGIH Biological Exposure Indices
(BEIs) applicable for this gas mixture’s components.
12. ECOLOGICAL INFORMATION
ENVIRONMENTAL STABILITY: The components of this gas mixture occur naturally in the atmosphere. The gas
will be dissipated rapidly in well-ventilated areas. The following environmental data are applicable to the
components of this product.
1,3-BUTADIENE:
Terrestrial Fate: : If spilled on land, 1,3-Butadiene will predominately volatilize very rapidly due to its very low boiling point. Dissolved in
water, it may leach through soil into groundwater due to its high water solubility and low estimated soil adsorption coefficient. It will not
appreciably hydrolyze but may be subject to biodegradation based on screening tests.
Aquatic Fate: When released into water, 1,3-Butadiene will volatilize rapidly with a half-life estimated to be 5.7 hours. It will not hydrolyze
appreciably, but may be subject to biodegradation, based on screening test.
Atmospheric Fate: Reaction with hydroxyl radicals is the dominant removal mechanism, with an estimated half life 5 hours. Reaction with ozone
and nitrate radicals may also contribute to the degradation of the chemical. Polluted urban atmospheres increase the rate of degradation
somewhat during day light hours as suggested by the detection of the highest atmospheric levels of the chemical in the early morning hours.
Acetaldehyde and acrolein have been identified as products of photo-oxidation. Rainout may contribute to removal of 1,3-Butadiene from the
atmosphere; However, evaporation from the rain may be rapid and the compound returned to the atmosphere relatively quickly unless it
leaches into the soil.
Bioconcentration: No information on the bioconcentration factor for 1,3-Butadiene could be found in the literature. However, based on its
octanol/water partition coefficient (log Kow=1.99(1)) its estimated bioconcentration factor is 9.1 and, therefore, the chemical is not expected
to appreciably bioconcentrate.
NITROGEN:
Water Solubility = 2.4 volumes Nitrogen/100 volumes water at 0°C; 1.6 volumes Nitrogen/100 volumes water at 20°C.
OXYGEN:
Water Solubility = 1 volume Oxygen/32 volumes water at 20°C. Log Kow = -0.65
EFFECT OF MATERIAL ON PLANTS or ANIMALS: No evidence is currently available on the effects of this product on
plants or animals.
EFFECT OF CHEMICAL ON AQUATIC LIFE: No evidence is currently available on the effects of this product on aquatic
life. The following are aquatic toxicity data for the 1,3-Butadiene component of this gas mixture:
1,3-BUTADIENE:
TLm (Pin perch) 71.5 mg/L/24 hours
13. DISPOSAL CONSIDERATIONS
PREPARING WASTES FOR DISPOSAL PREPARING WASTES FOR DISPOSAL: Waste disposal must be in
accordance with appropriate U.S. Federal, State, and local regulations, or the applicable standards of Canada and
its Provinces. Cylinders with undesired residual product may be safely vented outdoors with the proper regulator.
For further information, refer to Section 16 (Other Information).
14. TRANSPORTATION INFORMATION
THIS GAS MIXTURE IS HAZARDOUS AS DEFINED BY 49 CFR 172.101 BY THE U.S. DEPARTMENT OF
TRANSPORTATION.
PROPER SHIPPING NAME:
Compressed gases, n.o.s. (Oxygen, 1,3-Butadiene, Nitrogen)
HAZARD CLASS NUMBER and DESCRIPTION:
2.2 (Non-Flammable Gas)
UN IDENTIFICATION NUMBER:
UN 1956
PACKING GROUP:
Not Applicable
DOT LABEL(S) REQUIRED:
Non-Flammable Gas
NORTH AMERICAN EMERGENCY RESPONSE GUIDEBOOK NUMBER (2000): 126
MARINE POLLUTANT: The components of this gas mixture are not classified by the DOT as Marine Pollutants
(as defined by 49 CFR 172.101, Appendix B).
SPECIAL SHIPPING INFORMATION: Cylinders should be transported in a secure position, in a well-ventilated
vehicle. The transportation of compressed gas cylinders in automobiles or in closed-body vehicles can present
serious safety hazards. If transporting these cylinders in vehicles, ensure these cylinders are not exposed to
extremely high temperatures (as may occur in an enclosed vehicle on a hot day). Additionally, the vehicle
should be well-ventilated during transportation.
NON-FLAMMABLE GAS MIXTURE MSDS - 50066
EFFECTIVE DATE: FEBRUARY 16, 2011
PAGE 5 OF 7
14. TRANSPORTATION INFORMATION (Continued)
Note: DOT 39 Cylinders ship in a strong outer carton (outer package). Pertinent shipping information goes on the
outside of the outer package. DOT 39 Cylinders do not have transportation information on the cylinder itself.
TRANSPORT CANADA TRANSPORTATION OF DANGEROUS GOODS REGULATIONS: This gas mixture is
considered as dangerous goods, per regulations of Transport Canada. Use the above U.S. DOT information for
the preparation of Canadian Shipments.
15. REGULATORY INFORMATION
ADDITIONAL U.S. REGULATIONS:
U.S. SARA REPORTING REQUIREMENTS: The components of this product are subject to the reporting
requirements of Sections 302, 304, and 313 of Title III of the Superfund Amendments and Reauthorization Act, as
follows:
CHEMICAL NAME
1,3-Butadiene
SARA 302
(40 CFR 355, Appendix
A)
No
SARA 304
(40 CFR Table 302.4)
SARA 313
(40 CFR 372.65)
No
Yes
ADDITIONAL U.S. REGULATIONS (continued):
U.S. SARA THRESHOLD PLANNING QUANTITY: There are no specific Threshold Planning Quantities for this
material. The default Federal MSDS submission and inventory requirement filing threshold of 10,000 lb (4,540 kg)
may apply, per 40 CFR 370.20.
U.S. CERCLA REPORTABLE QUANTITY (RQ) : 1,3-Butadiene = 10 lb (0.45 kg)
U.S. TSCA INVENTORY STATUS: The components of this gas mixture are on the U.S. TSCA Inventory.
OTHER U.S. FEDERAL REGULATIONS:
• The 1,3-Butadiene component of this gas mixture has requirements under OSHA 29 CFR 1910.1051; 29 CFR
1910.19(1).
• The 1,3-Butadiene component of this gas mixture is subject to the reporting requirements of Section 112(r) of the
Clean Air Act. The reportable quantity (RQ) of 1,3-Butadiene under this regulation is 10,000 lb (4550 kg).
1,3-Butadiene listed as a Hazardous Air Pollutant (HAP) generally known or suspected to cause serious
health problems.
• This gas mixture does not contain any Class I or Class II ozone depleting chemicals (40 CFR part 82).
• Nitrogen, Oxygen, and 1,2-Butadiene are not listed as Regulated Substances, per 40 CFR, Part 68, of the Risk
Management for Chemical Releases.
U.S. STATE REGULATORY INFORMATION: The components of this gas mixture are covered under the following
specific State regulations:
Alaska - Designated Toxic and Hazardous
Substances: 1,3-Butadiene.
California - Permissible Exposure Limits
for
Chemical
Contaminants:
1,3Butadiene, Nitrogen.
Florida - Substance List: 1,3-Butadiene.
Illinois - Toxic Substance List:
1,3Butadiene.
Kansas - Section 302/313 List:
1,3Butadiene.
Massachusetts - Substance List:
1,3Butadiene.
Michigan - Critical Materials Register: No.
Minnesota - List of Hazardous Substances:
1,3-Butadiene.
Missouri - Employer Information/Toxic
Substance List: 1,3-Butadiene.
New Jersey - Right to Know Hazardous
Substance List: 1,3-Butadiene, Nitrogen.
North Dakota - List of Hazardous
Chemicals, Reportable Quantities: None.
Pennsylvania - Hazardous Substance List:
1,3-Butadiene, Nitrogen.
Rhode Island - Hazardous Substance List:
1,3-Butadiene, Nitrogen.
Texas - Hazardous Substance List: 1,3Butadiene.
West Virginia - Hazardous Substance List:
1,3-Butadiene.
Wisconsin - Toxic and Hazardous
Substances: 1,3-Butadiene.
CALIFORNIA SAFE DRINKING WATER AND TOXIC ENFORCEMENT ACT (PROPOSITION 65): The 1,3Butadiene component of this gas mixture is on the California Proposition 65 lists. WARNING! This gas mixture
contains a compound that is known to the State of California to cause cancer.
ADDITIONAL CANADIAN REGULATIONS:
CANADIAN DSL/NDSL INVENTORY STATUS: The components of this product are on the Canadian DSL
Inventory.
OTHER CANADIAN REGULATIONS: Not applicable.
CANADIAN ENVIRONMENTAL PROTECTION ACT (CEPA) PRIORITIES SUBSTANCES LISTS:
components of this product are not on the CEPA Priorities Substances List.
The
CANADIAN WHMIS CLASSIFICATION: This gas mixture is categorized as a Controlled Product, Hazard Class A,
D2A, as per the Controlled Product Regulations.
NON-FLAMMABLE GAS MIXTURE MSDS - 50066
EFFECTIVE DATE: FEBRUARY 16, 2011
PAGE 6 OF 7
16. OTHER INFORMATION
INFORMATION ABOUT DOT-39 NRC (Non-Refillable Cylinder) PRODUCTS
DOT 39 cylinders ship as hazardous materials when full. Once the cylinders are relieved of pressure (empty)
they are not considered hazardous material or waste. Residual gas in this type of cylinder is not an issue
because toxic gas mixtures are prohibited. Calibration gas mixtures typically packaged in these cylinders are
Nonflammable n.o.s., UN 1956. A small percentage of calibration gases packaged in DOT 39 cylinders are
flammable or oxidizing gas mixtures.
For disposal of used DOT-39 cylinders, it is acceptable to place them in a landfill if local laws permit. Their
disposal is no different than that employed with other DOT containers such as spray paint cans, household
aerosols, or disposable cylinders of propane (for camping, torch etc.). When feasible, we recommended
recycling for scrap metal content. CALGAZ will do this for any customer that wishes to return cylinders to us
prepaid. All that is required is a phone call to make arrangements so we may anticipate arrival. Scrapping
cylinders involves some preparation before the metal dealer may accept them. We perform this operation as a
service to valued customers who want to participate.
MIXTURES: When two or more gases or liquefied gases are mixed, their hazardous properties may combine to
create additional, unexpected hazards. Obtain and evaluate the safety information for each component before
you produce the mixture. Consult an Industrial Hygienist or other trained person when you make your safety
evaluation of the end product. Remember, gases and liquids have properties which can cause serious injury or
death.
Further information about the handling of compressed gases can be found in the following pamphlets published
by: Compressed Gas Association Inc. (CGA), 1725 Jefferson Davis Highway, Suite 1004, Arlington, VA 222024102. Telephone: (703) 412-0900.
P-1
AV-1
“Safe Handling of Compressed Gases in Containers”
“Safe Handling and Storage of Compressed Gases”
“Handbook of Compressed Gases”
This Material Safety Data Sheet is offered pursuant to OSHA’s Hazard Communication Standard, 29 CFR, 1910.1200. Other government
regulations must be reviewed for applicability to this product. To the best of CALGAZ knowledge, the information contained herein is
reliable and accurate as of this date; however, accuracy, suitability or completeness are not guaranteed and no warranties of any type, either
express or implied, are provided. The information contained herein relates only to this specific product. If this product is combined with other
materials, all component properties must be considered. Data may be changed from time to time. Be sure to consult the latest edition.
NON-FLAMMABLE GAS MIXTURE MSDS - 50066
EFFECTIVE DATE: FEBRUARY 16, 2011
PAGE 7 OF 7
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