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Blackrock Microsystems STIM User manual
®
CereStim R96
User Manual
Blackrock Microsystems, LLC
391 Chipeta Way, Suite G
Salt Lake City, UT 84108
Tel: (866) 806-3692
www.blackrockmicro.com
Blackrock Microsystems
CereStim R96 - User Manual
© Copyright 2011 Blackrock Micosystems, LLC. All rights reserved. Copying or other reproduction of this
document is prohibited without prior written consent of Blackrock Microsystems, LLC.
Rev. 1.00
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Contraindications, Warnings and Cautions
IEC60101-0102
Danger of Electrostatic Discharge (ESD)
IEC 348
Consult instructions for use
ISO7000-0434
Attention, consult accompanying documents
IEC606417-5335
Type BF Applied Part
IEC60417-5172
Class II Equipment
EN-980
Combined Manufacturer/Manufacturing Date
EN-980
Serial Number
YEAR
Contraindications

The CereStim R96 should not be used in clinical applications. The CereStim R96 is intended for
animal research applications only.

The CereStim R96 should not be used in chronic applications. The CereStim R96 is intended for
acute (<30 days) operation only.

Electrocautery should not be performed while the CereStim R96 is in use.

The CereStim R96 should not be used if the device has been dropped. Dropping the device may
cause damage to internal components that affect system performance and safety. A dropped device
must be returned to Blackrock Microsystems for inspection and recalibration before it can be used
again (See Section 6 and 7 of the CereStim R96 User Manual).

The CereStim R96 should not be used with any computer that has not been tested to the IEC 60950
standards.
Warnings

The CereStim R96 must only be used by medically trained and highly qualified personnel. This
manual is to be used in support of device use by personnel who have received device training from
Blackrock Microsystems.

The CereStim R96 stimulation parameters should only be used within the safe operating range of the
specific electrode being used.

Use only the supplied CereStim R96 components (i.e. External Power Supply). Substitution of
components not supplied by Blackrock Microsystems may affect system performance and safety.

The CereStim R96 should be disconnected from the Stimulation System during defibrillation. The
CereStim R96 is not defibrillator proof.

Do not use the CereStim R96 in the presence of flammable anesthetic agents.

Only connect CereStim R96 components to properly tested, grounded and dedicated AC outlets to
reduce the risk of electrical shock. Do not use an adapter for ungrounded wall outlets.

Do not use damaged components (i.e. cables, external power supply). Damaged components may
compromise subject safety.

Do not connect the CereStim R96 to an outlet controlled by a wall switch.
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
Avoid strong static discharges from sources like televisions or computer monitors because it can
damage the electrical parts of the system.

Keep the CereStim R96 away from liquids. Contact with water, shower spray, or wet surfaces can
lead to the subject receiving an electrical shock.

Do not unplug the power supply to the CereStim R96 while the system is in use.

Do not connect/disconnect any cables to/from the CereStim R96 while the system is in use.

Do not leave the CereStim R96 connected to the microelectrode array(s) or Stim Switch when the
system is not in use.

Do not change CereStim R96 Output Voltage values while connected to the subject. Doing so may
result in an electric shock to the subject.

When connecting the CereStim R96 to the Stim Switch or microelectrode array(s), use caution to
minimize the likelihood of Electrostatic Discharge (ESD).

Ensure that the CereStim R96 is securely positioned on a flat surface during use.

Use caution when placing power cords, cables, and other connectors to minimize the likelihood of
tripping or accidentally pulling on cables. Damaged cables may result in failed ground connections.

Each component of the system must be plugged into a separate outlet (i.e. CereStim R96, Stim
Switch, subcomponents of the data acquisition and any other accessory equipment). Using a powerstrip may cause leakage currents to exceed acceptable limits.

Connecting equipment to and from the CereStim R96 may result in a summation of leakage currents
that can lead to the subject receiving an electric shock.

Care should be used in selecting equipment for connection to the Monitor port as it could potentially
transmit large voltage transients directly to the microelectrode array(s). Devices connected to this
port must be isolated from earth ground in compliance with IEC 60601-1.

Risk of Electrical Shock Hazard: Accessory equipment connected to the SIP/SOP port must be
certified according to the respective IEC standards, i.e., IEC 60950 for data processing equipment or
IEC 60601-1 for electromedical equipment in order to reduce the risk of electrical shock. All
combinations of equipment must be in compliance with IEC 60601-1-1 systems requirements.
Anyone connecting additional equipment to the SIP/SOP port configures a medical system, and
therefore is responsible that the system complies with the requirements of the system standard IEC
60601-1-1.

IEC 60950 approved Information Technology Equipment must be placed outside the “patient
environment.” The patient environment is defined as an area 1.5m (4.92 feet) from the patient.

The following options are recommended if there is a need to remediate system leakage current:

Redundant protective earth connection shall be made to either the medical device or the
other equipment.

The other equipment shall be powered from a medical grade (IEC 60601-1 compliant)
separating transformer.
Cautions

Federal law restricts this device to sale, by or on the order of a physician.

The CereStim R96 is ONLY recommended for use with low impedance (<100 kΩ) electrodes such as
the NeuroPort SIROF array provided by Blackrock Microsystems.
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Electromagnetic Compatibility
The following tables document compliance levels and guidance from the IEC 60601-1-2 2007 Standard, for
the electromagnetic environment in which the CereStim R96 should be used. Medical Electrical Equipment
requires special precautions regarding EMC and should be installed and put into service according to the
guidelines provided in the tables below.
Guidance and Manufacturer’s Declaration – Electromagnetic Emissions
The CereStim R96 is intended for use in the electromagnetic environment specified below. The
customer or the user of the CereStim R96 should assure that it is used in such an environment
Emissions Test
Compliance
Electromagnetic Environment - Guidance
The CereStim R96 uses RF energy only for its internal
RF Emissions
function. Therefore, its RF emissions are very low and
Group 1
CISPR 11
are not likely to cause any interference in nearby
electronic equipment.
RF Emissions
The CereStim R96 is suitable for use in all
Class A
CISRP 11
establishments other than domestic establishments
and those directly connected to the public low-voltage
Harmonic Emissions
Not Applicable
power supply network that supplies buildings used for
IEC 61000-3-2
domestic purposes.
Voltage Fluctuations/
Flicker Emissions
Not Applicable
IEC 61000-3-3
Guidance and Manufacturer’s Declaration – Electromagnetic Immunity
The CereStim R96 is intended for use in the electromagnetic environment specified below. The
customer or the user of the CereStim R96 should assure that it is used in such an environment
Electromagnetic Environment Immunity Test
IEC 60601 Test Level
Compliance Level
Guidance
Floors should be wood,
Electrostatic
concrete or ceramic tile. If
Discharge (ESD)
±6kV Contact
Not Applicable
floors are covered with
±8kV Air
synthetic material, the relative
IEC 61000-4-2
humidity should be at least
30%.
Electrical Fast
Transient/Burst
IEC 61000-4-4
Surge
± 2kV for power
supply lines
±2 kV for input/output
Lines
±1kV line(s) to line(s)
±2kV line(s) to earth
± 2kV for power
supply lines
±2 kV for
input/output
Lines
Not Applicable
IEC 61000-4-5
Voltage dips, short
interruptions and
voltage variations on
power supply input
lines
IEC 61000-4-11
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<5% UT
(>95% dip in UT)
for 0.5 cycle
40% UT
(60% dip in UT)
for 5 cycles
70% UT
(30% dip in UT)
Not Applicable
Mains power quality should be
that of a typical commercial or
hospital environment.
Mains power quality should be
that of a typical commercial or
hospital environment.
Mains power quality should be
that of a typical commercial or
hospital environment. If the
user of the CereStim R96
requires continued operation
during power mains
interruptions, it is
recommended that the
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Guidance and Manufacturer’s Declaration – Electromagnetic Immunity
for 25 cycles
CereStim R96 be powered from
<5% UT
an uninterruptible power
(>95% dip in UT) for 5
supply or a battery.
sec
It may be necessary to position
the CereStim R96 further from
Power Frequency
sources of power frequency
(50/60 Hz) magnetic
magnetic fields or to install
3 A/m
field
Not Applicable
magnetic shielding. The power
frequency magnetic field
IEC 61000-4-8
should be measured in the
intended installation location to
assure that it is sufficiently low.
Guidance and Manufacturer’s Declaration – Electromagnetic Immunity
The CereStim R96 is intended for use in the electromagnetic environment specified below. The
customer or the user of the CereStim R96 should assure that it is used in such an environment
Electromagnetic Environment Immunity Test
IEC 60601 Test Level
Compliance Level
Guidance
Portable and mobile RF
communications equipment
should be used no closer to any
part of the CereStim R96
including cables, than the
recommended separation
distance calculated from the
equation applicable to the
frequency of the transmitter.
Recommended Separation
Distance
Conducted RF
IEC 61000-4-6
Radiated RF
IEC 61000-4-3
3V
150kHz – 80MHz
80%am**
3V/m
80-2500 MHz
80%am**
3V
d = 1,2√P
150kHz to 80MHz
3V/m
d = 1,2√P
80MHz to 800MHz
d = 2,3√P
800MHz to 2.5GHz
Where P is the maximum
output power rating of the
transmitter in watts (W)
according to the transmitter
manufacturer and d is the
recommended separation
distance in meters (m).
Field strengths from fixed RF
transmitters, as determined by
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Guidance and Manufacturer’s Declaration – Electromagnetic Immunity
an electromagnetic site survey
a
, should be less than the
compliance level in each
frequency range. b
Interference may occur in the
vicinity of equipment marked
with the following symbol:
** Modulation scheme can be 2 Hz or 1 kHz.
NOTE 1 At 80 MHz and 800 MHz, the higher frequency range applies
NOTE 2 These guidelines may not apply in all situations. Electromagnetic propagation is affected by
absorption and reflection from structures, objects and people.
a
Field strengths from fixed transmitters, such as base stations for radio (cellular/cordless) telephones
and land mobile radios, amateur radio, AM and FM radio broadcast and TV broadcast cannot be
predicted theoretically with accuracy. To assess the electromagnetic environment due to fixed RF
transmitters, an electromagnetic site survey should be considered. If the measured field strength in
the location in which the CereStim R96 is used exceeds the applicable RF compliance level above, the
CereStim R96 should be observed to verify normal operation. If abnormal performance is observed,
additional measures may be necessary, such as re-orienting or relocating the CereStim R96.
b
Over the frequency range 150 kHz to 80 MHz, field strength should be less than 3 V/m
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System Specifications
Model Name
CereStim R96
Number of Output
Channels
96
Number of Current
Modules
16
Type of Protection
Class II
Degree of Protection
Type BF Applied Part
Output Current
1-215 µA, adjustable in 1 µA increments
Maximum Output Voltage ±4.7V to ±9.5V, adjustable in 0.6V increments
Train Duration
194µs-66,845,700µs (0.000194 – 66.8 seconds)
1-255 pulses/train
Pulse Duration
141µs – 196,605µs (0.000141 – 0.196605 seconds)
Anodic Pulse Duration: 44-65,535µs/phase
Cathodic Pulse Duration: 44-65,535µs/phase
Adjustable in 1µs increments
Recommended Electrode
Impedance
<100 kΩ
PC Hardware Interface
USB A-B cable
Stim Manager PC Software Windows XP (32-bit), Windows 7 (32-bit or 64-bit)
Compatibility
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Analog Resolution
12 bits
Slew Rate
550 V/µs
External Power Supply
PMP15M-13 Protek Power Supply
AC Input: 100-240Vac, 0.5-0.3A, 50-60Hz (The system
was only evaluated to 120V, 60Hz)
DC Output: 15V, 1A MAX
Emergency Off Switch
¼” Mono Phone Plug
Normally Closed Switch with < 10Ω on resistance
recommended.
CereStim R96 Cable
Connectors
40 pin shrouded header; 2.54mm pitch
Manufacturer: Assman Electronics/AWH40G-0222-T-R
Monitor Connector
10 pin dual row header; 2.56mm pitch
Manufacturer: Samtec/SSQ-110-01-G-D
IPX Rating
Ordinary Equipment, Not Fluid Resistant, IP20
Operating Environment
10˚C to 40˚C, 10 to 85% R.H. (non-condensing)
Storage/Transportation
Environment
-15˚C to 60˚C, 10 to 85% R.H. (non-condensing), 500 to
1060 hPA
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Table of Contents
Warnings ....................................................................................................................................... i
1
System Overview ........................................................................................................................... 1
1.1 Packing List ........................................................................................................................................... 1
1.2 Accessories (Not Included) ................................................................................................................... 1
2
Hardware....................................................................................................................................... 2
2.1 CereStim R96 Front Panel..................................................................................................................... 2
2.2 CereStim R96 Back Panel ...................................................................................................................... 3
2.3 Computer Setup ................................................................................................................................... 4
2.4 Hardware Setup .................................................................................................................................... 4
2.4.1 CereStim R96 Connection to the Stim Switch.............................................................................. 4
2.4.2 CereStim R96 Connection to Electrodes ...................................................................................... 5
3
Stim Manager Software.................................................................................................................. 6
3.1 Stim Manager Configuration Tab ......................................................................................................... 6
3.2 Stim Manager Report Tab .................................................................................................................. 11
3.3 Stim Manager Administration Tab ..................................................................................................... 12
3.4 Saving and Exporting Information ...................................................................................................... 13
3.5 Application Programming Interface (API)........................................................................................... 13
4
Device Care and Storage ............................................................................................................... 13
5
Troubleshooting........................................................................................................................... 13
6
Warranty ..................................................................................................................................... 14
7
Return Merchandise Authorization ............................................................................................... 14
Appendix A: ......................................................................................................................................... 15
List of Figures
Figure 1-1: Application Overview ............................................................................................................ 1
Figure 2-2: CereStim R96 Front Panel ...................................................................................................... 2
Figure 2-3: CereStim R96 Back Panel ....................................................................................................... 3
Figure 2-4: CereStim R96 Cable Connector Layout ................................................................................... 3
Figure 2-5: Monitor Pinout ..................................................................................................................... 4
Figure 2-6: CereStim R96 Computer Setup............................................................................................... 4
Figure 3-7: Stim Manager Main Window ................................................................................................. 6
Figure 3-8: Test Pulse ............................................................................................................................. 7
Figure 3-9: Cathodic and Anodic Pulse Figures ......................................................................................... 8
Figure 3-10: Stimulation Script Window .................................................................................................. 9
Figure 3-11: Stim Manager Report Tab .................................................................................................. 11
Figure 3-12: Stim Manager Administration Tab ..................................................................................... 12
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CereStim R96 - User Manual
System Overview
The CereStim R96 is a fully programmable neurostimulator with 96 output channels and the capability of
producing up to 16 simultaneous stimuli. The biphasic current pulses generated by the CereStim R96 are
intended to stimulate neurons in proximity to a set of implanted electrodes. By interfacing the CereStim
R96 with a switching system for stimulation and recording, the CereStim R96 becomes a very flexible and
powerful tool for analyzing neural signals. The figure below shows an application overview of how the
CereStim R96 fits into a switching system for stimulation and data acquisition applications.
Figure 1-1: Application Overview
1.1
Packing List
1
CereStim R96
1
External Power Supply
1
USB A-B Cable
1
Stim Manager Software CD-ROM
1
CereStim R96 User Manual
1
CereStim R96 API
1.2
Accessories (Not Included)
1
Stim Switch System
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Hardware
The CereStim R96 hardware is composed of one main board and at least one current generator
module. Currently, the system can hold up to 16 current modules. Each current module is
connected to each output channel (96), so that the number of channels is independent of the
number of modules. Systems containing multiple modules (2 or more) are capable of generating
simultaneous stimuli, where N modules allow N stimuli at the same precise time. This allows the
CereStim R96 to produce up to 16 simultaneous stimuli.
2.1
CereStim R96 Front Panel
The CereStim R96 Front Panel interfaces the PC with the CereStim R96 main board and its attached
current modules. CereStim R96 configuration is accomplished using the Stim Manager program
described in Section 3.
2
6
7
8
4
1
3
5
Figure 2-2: CereStim R96 Front Panel
Power Supply Connector (1): The CereStim R96 is capable of being powered through an external,
medical grade power supply that is included as part of the CereStim R96 packaging. The green LED
labelled ‘Power’ will light up when the external power supply is connected to the unit. The power
cord is to be used for mains disconnection.
On/Off Switch (2): Use the on/off switch to turn on the CereStim R96. The green LED labelled ‘On’
will illuminate when the unit is turned on.
LED Indicators (3): The green LEDs labelled ‘On’ and ‘Power’ illuminate when the CereStim R96 unit
is turned on and powered through the external power supply. The ‘Low’ and ‘Charged’ LEDs are
non-functional in the current version of the CereStim R96. The ‘Status’ LED illuminates during
activity on the USB port to indicate communication between the CereStim R96 and PC.
USB Port (4): The CereStim R96 is programmed through commands sent via a USB A-B cable
connected between the USB port on the CereStim R96 and a USB port on the PC. The ‘Status’ LED
illuminates during activity on the USB port.
RS-232 Isolated Port (5): This feature has not been implemented in the current version of the
CereStim R96. The RS-232 isolated port is intended to provide hardware-hardware communication
in future firmware updates of the device.
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TTL 5V Output (6): The TTL 5V output signal is intended to be used as a method for synchronizing
external data acquisition systems. The TTL goes high 60 µs before stimulating, and goes low once the
stimulation sequence is complete.
If you have a Stim Switch System, the TTL 5V output can be connected to an Enable In port on the
front panel of the Stim Switch Control Module and used to enable/disable single or multiple banks of
the stimulation connections simultaneously.
TTL Trigger (7): This feature has not been implemented in the current version of the CereStim R96.
The TTL Trigger is intended to provide the user with a method for using external devices to trigger
when the CereStim R96 sends a stimulation pulse. This feature will be implemented in future
firmware updates of the device.
Emergency Off (8): The emergency stop jack is used to attach an emergency stop switch (not
included) if emergency stop capabilities are required for your application. When activated, the
emergency stop controller will shut off all power to the CereStim R96 unit. The CereStim R96 is
designed for use with Normally Closed (NC) Emergency Stop Switches.
2.2
CereStim R96 Back Panel
The CereStim R96 Back Panel interfaces the CereStim R96 either directly to electrodes or to a
Blackrock Stim Switch system. The user is responsible for supplying any cables necessary for direct
connection to the electrodes.
9
11
10
Figure 2-3: CereStim R96 Back Panel
CereStim R96 Cable Connectors (9): Connectors A-C provide a connection between the CereStim
R96 and the Stim Switch/Electrodes. Connector A corresponds with electrode output channels 1-32,
connector B with channels 33-64 and connector C with channels 65-96. Instructions for connecting
the CereStim R96 to a Switching System are provided in Section 4 below. The layout of the CereStim
R96 Cable Connector is shown in Figure 2-4 below.
Figure 2-4: CereStim R96 Cable Connector Layout
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Monitor (10): Connection to the monitor allows users to observe the
operation of the CereStim R96 Current Modules using an oscilloscope or
other monitoring device. The pinout for this connector is shown in Figure 2-5
to the right. Numbers 1-16 refer to the monitor line of the corresponding
current module (i.e. number 1 corresponds to module 1).
Care should be used in selecting equipment for connection to the Monitor
port as it could potentially transmit large voltage transients directly to the
patient electrodes. Devices connected to this port must be isolated from
earth ground in compliance with IEC 60601-1.
Patient Ground (11): The patient ground should be connected to the
Patient Ground connector. The CereStim R96 System provides a
minimum isolation of 2.5 kV between the patient and the mains
power supply.
2.3
Figure 2-5:
Monitor Pinout
(NC = Not Connected)
Computer Setup
The CereStim R96 uses a USB connection to
communicate with the PC. It uses a standard
Human Interface Device (HID) USB
communication, so no specific drivers are
needed. The Stim Manager Software runs
on Windows XP and Windows 7.
WARNING: The Stim Switch (if required
for your application) should only be used
with an IEC 60950 Computer. The
computer must be placed outside of the
patient environment which is defined as
an area 1.5m (4.92 feet) from the patient
2.4
Figure 2-6: CereStim R96 Computer Setup
Hardware Setup
The CereStim R96 and its subcomponents (i.e. USB A-B Cable and external power supply) are all
suitable for use within the “patient environment.” However, any IEC 60950 approved information
technology equipment that is intended for use with the CereStim R96 System (i.e. computer) must be
placed outside of the “patient environment.” The patient environment is defined as an area 1.5m
(4.92 feet) from the patient.
2.4.1
CereStim R96 Connection to the Stim Switch
2.4.1.1 Unpack all components of the CereStim R96 packaging.
2.4.1.2 Turn on your IEC 60950 PC and load the Stim Manager Software (included in
packaging).
WARNING: When connecting to a Stim Switch, the IEC 60950 PC must be plugged
into the medical grade isolation transformer included in the Stim Switch
packaging. For further instructions, please refer to the Stim Switch User Manual
2.4.1.3 Confirm that the CereStim R96 is turned off.
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WARNING: Always make sure that the CereStim R96 is turned off before
connecting/disconnecting any cables
2.4.1.4 Connect the external power supply to the CereStim R96 and plug it into a wall
outlet.
2.4.1.5 Connect the USB port on the Front Panel of the CereStim R96 to a USB port on the
computer with the USB A-B cable (included in packaging).
2.4.1.6 Connect the appropriate end of the CereStim R96 Interconnection Cables to the
CereStim R96 cable connectors labelled A-C on the back panel of the CereStim R96.
These connections are keyed and lock the cables in place when connected
appropriately.
2.4.1.7 Connect the opposite end of the cables to the ‘STIM IN’ Connectors on the front
panel of the Stim Switch Control Module. Secure each connector in place using two
thumbscrews (provided in Stim Switch packaging). Please refer to the Stim Switch
User Manual for further instructions regarding the use of this system.
2.4.1.8 Open the Stim Manager Software on your PC and turn on the CereStim R96. The
status bar in the lower right-hand corner of the Stim Manager window should
change from green to orange, indicating that the CereStim R96 is connected. Refer
to Section 3 below for further instructions regarding the use of the Stim Manager
Software.
WARNING: The CereStim R96 must be turned off when not in use.
2.4.2
CereStim R96 Connection to Electrodes
For customer supplied connections, connection to the CereStim R96 is as follows:
2.4.2.1 Unpack all components of the CereStim R96 packaging.
2.4.2.2 Turn on your IEC 60950 PC and load the Stim Manager Software (included in
packaging).
2.4.2.3 Confirm that the CereStim R96 is turned off.
WARNING: Always make sure that the CereStim R96 is turned off before
connecting/disconnecting any cables
2.4.2.4 Connect the external power supply to the CereStim R96 and plug it into a wall
outlet
2.4.2.5 Connect the USB port on the Front Panel of the CereStim R96 to a USB port on the
computer with the USB A-B cable (included in packaging).
2.4.2.6 Connect one end of the customer supplied cables to the CereStim R96 Cable
Connectors on the Back Panel of the CereStim R96. Connect the other end of the
cables directly to the connectors on the patient electrodes. Refer to Figure 2-4 for
a pinout of the locking connector on the CereStim R96.
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CAUTION: The CereStim R96 is ONLY recommended for use with low
impedance (<100 kΩ) electrodes such as the NeuroPort™ SIROF array
provided by Blackrock Microsystems
2.4.2.7 Open the Stim Manager Software on your PC and turn on the CereStim R96. The
status bar in the lower right-hand corner of the Stim Manager window should
change from green to orange, indicating that the CereStim R96 is connected. Refer
to Section 3 below for further instructions regarding the use of the Stim Manager
Software.
3
Stim Manager Software
The parameters of the biphasic current pulses output by the stimulator can be altered in the Stim Manager
Software and updated to the CereStim R96 via a USB A-B cable. The Stim Manager main window is shown
in Figure 3-6 below.
3.1
Stim Manager Configuration Tab
5
9
2
3
6
4
7
8
10
1
Figure 3-7: Stim Manager Main Window
Status Bar (1): The status bar can be in one of the three following states:
CereStim R96 is not connected
CereStim R96 is connected
Stimulating…
If the CereStim R96 unit is on and the USB cable is connected, the status bar should change from green to
orange. The CereStim R96 must be powered on in order for the software to recognize the connection.
Modules Array Panel (2): Once the CereStim R96 has been connected and recognized by the Stim Manager
Software, the available current modules are highlighted green in the Modules Array Panel. All unavailable
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modules are grey. Active current modules can be disabled by clicking on one of the active arrays.
Deactivated modules change from green to red.
Enabled
Disabled
Unavailable
Mode Panel (3): Stim Manager has two working modes: automatic and manual. The mode is changed by
clicking the ‘Switch’ button in the Mode Panel.
Auto Mode: This is the default mode. Stim Manager must be in Auto Mode in order to create a
new pulse configuration or make any changes to existing pulse configurations. Auto mode allows
the user to create complex stimulation scripts as well as repetitive cycles.
Manual Mode: This mode is intended for single stimulation applications. In this mode, the user
selects an electrode channel from the Electrode Array Panel and a Pulse Configuration from the
Configuration ID Panel. Click ‘Start’ to send the selected pulse to the selected electrode channel.
Stimulation scripts are not available in this mode.
Electrode Array Panel (4): In Auto Mode, selecting an electrode channel from this panel will disable that
channel, turning the channel from green to red. The channel can be re-enabled by clicking on that channel
a second time. In Manual Mode, clicking on an electrode channel will select it for stimulation, turning the
channel from green to yellow. If the electrode channel is unavailable, the channel appears grey.
Test Modules: The CereStim R96 has an auto-check function called Test Modules. When the Test
Modules button is selected, the system sends a pulse (Config 0)
to an internal 100KΩ resistor and measures the output voltage
at five different points of the test pulse (Figure 3-9).
If the output voltages are in line with the parameters of the
current pulse, then the module is “OK.” If not, Stim manager
provides the following message: “ERROR. Possible voltage
limitation. Please check it.”
Figure 3-8: Test Pulse
Test Electrodes: Clicking the Test Electrodes button sends a stimulus (config 0) to each of the
enabled electrodes and measures the output voltages (V) at five different points of the pulse (same
as Test Modules). These values, along with an estimation of the impedance values (KΩ) for each
electrode channel, are provided in the Log Window of the Report Tab. The impedance
measurements offer the user a tool for detecting broken electrodes or gradual degradation.
During this test, the system also checks the second voltage point of the pulse to determine if it’s
close to the Output Vmax. If so, the message “HIGH IMPEDANCE. Possible voltage limitation”
appears, and the user should adjust the Output Vmax value or re-evaluate the stimulation
parameters.
In addition to the log window, the results are saved in a file named:
“/Measurements/CereStim R96_ddmmyy_hhmmss.txt”. These files are tabulated for easy
importation into a database
Pulse Figure: This feature identifies each parameter of the stimulation pulse with a red circle as the
user moves the mouse over the corresponding parameter boxes in the Stimulus Panel. The pulse
figure also identifies whether the first phase of the selected stimulus from the Configuration ID
Panel is anodic or cathodic.
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Anodic First
Cathodic First
Figure 3-9: Cathodic and Anodic Pulse Figures
Pulses Panel (5): This panel allows the user to define up to 16 different stimulation patterns. The available
features are as follows:
Config Id: This drop down box allows the user to select an identification number for up to 16
different pulse configurations. Config 0 is used in the Test Modules and Test Electrodes functions
and should not be changed.
Wave Form: The user can set the stimulator to generate either the Anodic or Cathodic phase of the
biphasic pulse first. The pulse figure in the lower left-hand corner of the Stim Manager Window
indicates whether a selected pulse configuration is ‘anodic first’ or ‘cathodic first.’
Number of Pulses: 1-255 biphasic pulses are available for each Configuration ID.
Range of Interpulse Delay: 53-65,535 µs
Range of Interphase Delay: 53-65,535 µs
Range of Amplitudes (Phase I & Phase II): 1-215 µA
Phase Width (Phase I & Phase II): 44-65,535 µs
Fast Discharge: The nature of the CereStim R96 implies that there may be some undesirable
effects in the output waveform. The Fast Discharge parameter enables a 100 Ω resistor at the
generator output that removes any undesirable effects and cleans up the waveform. NOTE: The
user should analyze the possible consequences of enabling this option in experiments.
Add: After defining the parameters of the pulse, click ‘Add’ to add the new pulse configuration to
the Configuration ID Panel (4). All new pulse configurations created by the user must be added to
the Configuration ID Panel before the user can begin stimulating.
NOTE: Stim Manager enforces balanced charge in the biphasic pulse configurations created by the
user. In the event that the user creates a pulse with an unbalanced charge, the software will
produce an error message notifying the user that the parameters of the biphasic pulse must be
modified to balance the charge.
Remove: In order to remove a pulse configuration from the Configuration ID Panel (4), click on the
Configuration ID number that is to be deleted and click the ‘Remove’ button.
Remove All: This feature allows the user to delete all pulse configurations in the Configuration ID
Panel at the same time.
Hz: This box reports the frequency (Hz) of the pulse configuration based on the user inputs for the
interpulse delay, interphase delay, width of phase I and width of phase II.
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Configuration ID Panel: This panel stores the pulse configurations created by the user in the Pulses
Panel. The test pulse parameters are saved as Config 0 and should not be changed.
Stimulation Panels (6): Stimulation scripts are defined by a series of single stimulations, groups and wait
instructions.
Stimulus Panel: This feature is available when Stim Manager is set to Auto Mode. It allows the
user to select an electrode channel (1-96) and assign it to an electrode configuration from the
Configuration ID Panel. By clicking ‘Add,’ the electrode channel and electrode configuration pairs
are added to the Stimulation Script.
Group Definition Panel: Groups allow the user to generate stimuli from different current modules
at the same time. There are four basic rules for groups:




A group must have both begin and end instructions
A group can’t have more stimuli than enabled current modules
An electrode can’t be used more than once in the same group
Wait instructions cannot be used within a group
By clicking ‘Add,’ the command to begin or end a group is added to the Stimulation Script.
Wait Instruction Panel: Wait instructions allow the user to introduce delays in milliseconds to the
stimulation script. Delays can be added before or after any single stimulus or group. This command
is recommended for long delays. Short delays can be implemented using
the Interpulse delay defined in the pulse configuration. By clicking
‘Add,’ the wait instruction is added to the Stimulation Script.
Stimulation Script Window (7): This window allows the user to view the stored
sequence of stimulation events added from the Stimulus, Group Definition and
Wait Instruction Panels. Stimulation is sequential for single stimuli and
simultaneous for stimuli within a group. The maximum number of commands in
a sequence is 128.
Stimulation Script Commands (8): These command buttons begin, end, pause
and make adjustments to the Stimulation Script.
Remove: By clicking this button, the user is able to remove any single
line in the Stimulation Script.
Remove All: By clicking this button, the user is able to clear the
Stimulation Script.
Pre-Process: Once a Stimulation Script has been created, the PreFigure 3-10: Stimulation
Process button must be selected prior to stimulation in order to:
Script
 Send the pulse configurations to the available current
modules within the CereStim R96 unit.
 Check for correct syntax of the groups in the Stimulation Script.
 Assign a current module to each stimulus.
 Send the Stimulation Script to the CereStim R96 motherboard.
 Calculate the total elapsed time for the Stimulation Script (recorded in the Log
Window). Timing measurements depend on the pulse configurations and internal
hardware delays. The internal hardware delays are as follows:
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68 µs delay between single stimulations
76 µs delay between the end of a stimulus and the beginning of a group
68 µs delay between the end of a group and the beginning of another stimulus
116 µs delay between the end of a group and the beginning of another group.
Repetition Panel: This feature allows the user to repeat the Stimulation Script a specified number
of times, or to run it as a continuous loop. Without a defined number of repetitions, the CereStim
R96 defaults to a single pass of the Stimulation Script. In a continuous loop, the CereStim R96
requires a manual stop in order to end stimulation.
Start: Once Pre-Process has been completed, the system is ready to stimulate. Stimulation is
initiated by clicking the Start button.
Pause: Clicking this button immediately pauses the Stimulation Script. To resume stimulation from
the same point in the Script, click the Start button.
Stop: Clicking this button manually stops the stimulation. It is not possible to modify any
parameter during stimulation. The user must stop the stimulation sequence prior to making any
changes to the Stimulation Script or Pulse configurations. After making changes, the Pre-Process
button must be pressed again in order to update the changes to the CereStim R96.
Output Vmax Panel (9): This feature allows the user to select the maximum analog output voltage as a
safety measure for stimulation. Users should be cautious when making changes to the Output Vmax. A low
Vmax may provide more safety, but it may also distort higher voltage output signals, either because the
current is too high or the impedance is too high.
Drop-down Menu: The user can select maximum output voltages ranging from ±4.7V to ±9.5V
(0.6V) from the drop-down menu.
Update: Clicking the Update button updates any changes to the Output Vmax in the hardware.
Read: Clicking the Read button will return the measured analog voltage active in the system.
WARNING: Do not change CereStim R96 Output Vmax values while connected to the patient.
Doing so may result in an electric shock to the patient.
Log Window (10): The Log Window echoes commands sent from the Stim Manager Software to the
CereStim R96, provides updates on the connection status between the CereStim R96 and the PC, and
indicates any discrepancies in the Pulse Configurations or Stimulation Script. It also provides the user with
results from the Test Modules and Test Electrodes functions.
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Stim Manager Report Tab
1
2
4
3
Figure 3-11: Stim Manager Report Tab
Researcher Panel (1): This feature allows the user to record and save the name of the researcher
conducting the test/procedure.
Patient Panel (2): This panel allows the user to record and save identifying information for the patient,
including the patient’s name and pathology as well as the date and time of the test/procedure.
Comments Panel (3): This panel allows the user to record and save comments or observations noted
during the test/procedure.
Log Window (4): This panel provides an extended view of the Log Window. The Log Window echoes
commands sent from the software to the CereStim R96, provides updates on the connection status of the
CereStim R96 and indicates any discrepancies in the Pulse configurations or Stimulation Scripts defined by
the user. It also provides the user with results from the Test Modules and Test Electrodes functions.
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Stim Manager Administration Tab
1
2
3
Figure 3-12: Stim Manager Administration Tab
Unlock Administrator Rights Panel (1): Unlocking the Administrator Rights allows users to restrict the
Output Vmax, Amplitude, Phase Width, Interphase Delay, Interpulse Delay and Charge per Phase to a set of
maximum values. Upon initial start-up, the administrator password is set to ‘Stim100.’ After unlocking the
administrator rights, the user can change this password in the ‘Change Password’ panel.
Unlock: After entering the appropriate password, click the ‘Unlock’ button to gain Administrative
Rights.
Lock: After any settings are changed, click the ‘Lock’ button to store the changes and prevent other
users from making adjustments to the settings.
Max Values Panel (2): Only users with Administrative Rights are able to make adjustments to the
maximum allowable values for the Output Vmax, Amplitude, Phase Width, Interphase Delay, Interpulse
Delay and Charge per Phase. When making changes to the Max Values, administrative users must specify
all max values in order for Stim Manager to accept the update. Upon initial start-up, the default Max
Values are as follows:






Max Output Voltage: 6.5V
Max Amplitude: 100µA
Max Width: 300µs
Max Interphase: 300µs
Max Interpulse: 300µs
Max Charge per Phase: 30,000pC
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Update: New max values are stored by clicking the ‘Update’ button. This button is only available to
users with administrative rights.
Read: All users are able to read the existing Max Value settings by clicking the ‘Read’ button regardless
of administrative rights.
Change Password Panel (3): After unlocking Administrator Rights, users can change an existing password
to a new password by entering the old password into the ‘Enter Old Password’ box, entering the new
password in the ‘Enter New Password’ box and retyping the new password in the ‘Confirm New Password’
box. New passwords must not be more than 32 characters.
Change Password: Click the ‘Change Password’ button to apply changes to the password.
3.4
Saving and Exporting Information
Stim Manager is able to save any changes the user makes in the software environment, including:
activated and deactivated current modules, test electrodes results, pulse configurations, stimulation
scripts, and reports.
Stim Manager is then able to export any of that information as a text file. The default roots are:
Environment files:
Test electrodes result:
System advanced configurations:
3.5
[application folder]/Documents/
[application folder]/Measurements/
[application folder]/SystemFiles/
Application Programming Interface (API)
For customers who want to control the CereStim R96 via proprietary software, a complete API is
made available. Please refer to the CereStim R96 API User Manual included in the CereStim R96
packaging for further information.
4
Device Care and Storage




5
Handle the CereStim R96 with care. Do not drop or strike the device. In the event that the device is
dropped, the CereStim R96 must be returned to Blackrock Microsystems for inspection and
recalibration before the device can be used again (See section 7).
Clean the outside of the CereStim R96 using a cloth dampened with water or alcohol when
necessary. Do not submerge the device in water or cleaning solutions.
Keep the device away from liquids. The CereStim R96 is not fluid resistant and can become
damaged by fluid ingress.
Store the CereStim R96 at -20˚C to 50˚C, 10 to 100% relative humidity (non-condensing).
Troubleshooting
Stim Manager does not recognize the CereStim R96. I am unable to send commands from Stim Manager
to the CereStim R96.
1. Make sure that your PC recognizes the CereStim R96 as an HID interface. Right Click on ‘My
Computer’ in the Start-up Menu and select Manage. Select Device Manager, expand the
Human Interface Devices List and confirm that your USB device is recognized. If the USB is
not recognized, the CereStim R96 may require a shorter USB cable.
2. Check to make sure that all connections are secure.
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3. If the problem persists, contact Blackrock Microsystems for additional troubleshooting or to
initiate an RMA
I am unable to make changes to the pulse configurations or the stimulation script.
1. Confirm that you are in Auto Mode. Stim Manager must be in Auto Mode in order to
make any changes to the pulse configurations or the stimulation script.
2. Click the ‘Stop’ button. If you have just finished a stimulation sequence, you must press
‘Stop’ in order to make changes to the pulse configurations or the stimulation script.
3. If the problem persists, contact Blackrock Microsystems for additional troubleshooting or
to initiate an RMA.
6
Warranty
Blackrock Microsystems, Inc. warrants that its products are free from defects in materials and
manufacturing for a period of one year from the date of shipment. Blackrock will, at its option,
repair or replace any product that does not comply with this warranty. This warranty is voided by:
1. Any modification or attempted modification to the product done by anyone other than an
authorized Blackrock employee
2. Any abuse, negligent handling or misapplication of the product.
This constitutes the sole warranty made by Blackrock, Inc. There are no other warranties,
expressed or implied, which extend beyond those described herein or to anyone other than the
original purchaser, including the implied warranties of merchantability and fitness for a particular
purpose. In no event shall Blackrock Microsystems, Inc. be liable for any incidental or
consequential damages, or for the infringement of any patent rights or third party rights due to the
use of its products.
7
Return Merchandise Authorization
In the unlikely event that your system needs to be returned to Blackrock for repair or maintenance,
do not send any equipment back without a Return Merchandise Authorization Number. An RMA
number will be issued to you by a Blackrock representative. If you need to obtain an RMA number,
you may contact a product support representative at (801) 582-5533 or toll free at (866) 806-3692.
Once an RMA number has been issued, it is important to safely pack the returned item for
shipping back to Blackrock. It is preferred that you save the original boxes and packing materials
that your system arrived in for return shipment. Please address the package as follows:
Blackrock Microsystems, Inc.
ATTN: RMA#
391 Chipeta Way, Suite G
Salt Lake City, UT 84108 USA
Tel: (801) 582-5533
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Appendix A:
Observed Current at Increasing Output Vmax
Appendix A provides indications for the amount of output current (µA) that is observed at each
output Vmax voltage for either 99 kΩ or 49.9 kΩ electrode impedances.
The figures below show the observed output current (µA) measured from the CereStim R96
electrode outputs for both the Cathodic and Anodic phases. These measurements are based on a
set of input current values (µA) that were entered into the Stim Manager software. CereStim R96
output measurements were taken at each Output Vmax using both 99 kΩ and 49.9 kΩ electrode
impedances.
99 kΩ Electrode Impedances
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49.9 kΩ Electrode Impedances
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