ICP-MS Journal, May 2006, Issue 27

   ICP-MS Journal, May 2006, Issue 27
Agilent ICP-MS Journal
May 2006 – Issue 27
Inside this Issue
2/3
User article: Metal Profiling of Human Serum Using
SEC-ICP-MS
3
New Abundance Sensitivity Spec with Award Winning
Quadrupole
4/5
Optimizing Sample Throughput in ICP-MS
6
Benefits of the New ICP-MS ChemStation -Version B.03.03 Intelligent Rinse
7
Support and Service News: Scheduling Maintenance of Your
7500 Series ICP-MS
8
New Agilent-Supported ASX 520 Autosampler, Up & Coming
Events, Welcome to New ICP-MS Users, New Literature
Metal Profiling of
Human Serum Using
SEC-ICP-MS
Dominic Hare1, Philip Doble1,
Michael Dawson1, Anita R.
Skandarajah2, Robert L. Moritz2,
Richard J. Simpson2, Rod Minett3,
Rudolf Grimm4 and Val Spikmans1
1 University of Technology, Sydney, Australia
2 Joint Proteomics Laboratory, Ludwig
Institute for Cancer Research & The
Walter and Eliza Hall Institute of Medical
Research, Royal Melbourne Hospital, VIC,
Australia
3 Agilent Technologies Australia, VIC, Australia
4 Agilent Technologies Inc., Integrated
Biology Solutions Unit, Santa Clara, CA,
USA
Introduction
Metallomics is a new science at the
forefront of modern protein research.
It focuses on the analysis of the
metallome, a term encompassing
both metals bound to biomolecules
within the cell membrane and metals
either free or bound in interstitial
fluids [1]. Analysis of metal ions
bound to low abundant proteins
requires an element specific detector
of particularly high sensitivity. An
ICP-MS is capable of detecting most
elements important to biology
(including P, S, Se, Si) at sub-ppb
levels [2], making it the ideal analytical
tool for the trace detection of metals
bound to proteins. By connecting
size exclusion chromatography
(SEC) to ICP-MS, the proteins in the
sample can be separated based on
molecular size, allowing for the
detection of elements in specific
protein mass fractions. An analysis of
this type will generate an elemental
profile of the samples with information
on the size of the proteins carrying
these elements [3]. SEC-ICP-MS has
the potential to be a powerful
complementary
technique
to
traditional proteomics analysis
providing information on both
elemental and protein profiles [4].
Approximately one third of all
proteins within the human body are
thought to contain metal ions [5],
with roles in enzyme-based reactions,
metabolism, storage and transport.
SEC-ICP-MS has been used to
analyze these proteins in both
human tissues and fluids [6-8].
Specific metal binding proteins,
2
Agilent ICP-MS Journal May 2006 - Issue 27
Figure 1: Multi-element SEC-ICP-MS chromatogram of pooled, undiluted Type O serum. Injection
volume 10 µL. Flow rate 0.7 mL/min. Mobile phase 0.1 M NaCH3COO.
such as metallothionein (MT) have
been identified as possible biomarkers
for disease, such as breast cancer
[9], thyroid cancer [10] and
Alzheimer's disease [11].
Setup of an SEC-ICP-MS system is
relatively straightforward. The major
advantage of this approach is the
ability to analyze undiluted serum
rapidly with minimal sample
handling. Depending on the element
measured, protein depletion may
not always be necessary. Specially
designed interfaces for higher
resolution capillary chromatography
have also been described [12]. This
work attempts to develop a suitable
system for elemental profiling of
pooled human serum according to
the mass of proteins present.
Materials and Methods
Pooled human serum samples were
obtained from the Red Cross via the
Ludwig Institute for Cancer Research,
Melbourne. Tosoh Bioscience TSKGel®
SEC Column A porous inorganic
deactivated silica stationary phase
was used for all separations. A high
ionic strength 0.1 M NaCH3COO
mobile phase (pH 7.0) ensured limited
charge based retention of free and
bound metals. The TSKGel 3000SWXL
packing has a particle size of 5um
and pore size of 25nm.
A standard 1100 Series LC system
was used with a Peltier-controlled
sample cooling unit. Mobile phase
was delivered at 0.7 mL/min by a
quaternary pump. UV signal was
monitored using a post-column photo
diode array detector (240nm).
The LC system was connected to
the ICP-MS with 100um PEEK
tubing. Both systems were controlled
from a single computer operating
Agilent ChemStation ICP-MS Top
software. A 7500ce ICP-MS was used
and was fitted with a Glass
Expansion PFA OpalMist® concentric
nebulizer.
Results
Figure 1 shows SEC-ICP-MS chromatograms obtained from the analysis
of a 10uL sample of undiluted human
serum. Three distinct binding fractions
are observed, corresponding to
large globular proteins (<83 kDa),
high abundant transferrin and HSA
(83-20 kDa) and low mass peptides
(>20 kDa). All 9 isotopes analyzed
(7 single elements plus 56Fe and
57Fe) can be identified, bound to at
least one of these mass fractions.
Figure 2 shows the metallic content
of peptides under 20 kDa in Type O
serum, with all 9 isotopes analyzed
present. Three resolvable mass
fractions within this range are
identified. Possible unresolved peaks
are apparent in the ~14.7 kDa mass
fraction, specifically 60Ni and 66Zn,
though the peak capacity of the
column used was unable to resolve
them further.
www.agilent.com/chem/icpms
New Abundance
Sensitivity Spec
with Award Winning
Quadrupole
Figure 2: Elemental profile of peptides under 20 kDa in pooled Type O human serum.
Conclusions
SEC-ICP-MS has been shown to be a
suitable screening technique for
broad-scale analysis of elements
bound to metal-binding proteins in
human serum. High abundant metal
binding proteins can potentially be
identified according to metal
content. Higher resolution separation
techniques might be beneficial in
providing higher resolution separation
of low mass peptides. This study
highlights the possibilities of using
ICP-MS based detection in conjunction
with structural elucidation techniques
to obtain a more complete profile of
the protein and elemental content
of biological fluids.
References
1. Haraguchi, H. Journal of
Analytical Atomic Spectrometry
2003, 19, 5-14.
2. Wind, M.; Wolf, D. L. Journal of
Analytical Atomic Spectrometry
2004, 19, 20-25.
3. Jakubowski, N.; Lobinski, R.;
Moens, L. Journal of Analytical
Atomic Spectrometry 2004, 19, 1-4.
4. Lobinski, R.; Szpunar, J.
Analytica Chimica Acta 1999,
400, 321.
5. Dudev, T.; Lim, C. Chemical
Reviews 2003, 103, 773-787.
6. Coni, E.; Bocca, B.; Galoppi, B.;
Alimonti, A.; Caroli, S.
Microchemical Journal 2000, 67,
187.
7. Nischwitz, V.; Michalke, B.; Kettrup,
A. Journal of Analytical Atomic
Spectrometry 2003, 18, 444-451.
www.agilent.com/chem/icpms
8. Shiobara, Y.; Yoshida, T.;
Suzuki, K. T. Toxicology and
Applied Pharmacology 1998,
152, 309.
9. Gallicchio, L.; Flaws, J. A.;
Sexton, M.; Ioffe, O. B.
Toxicology Letters 2004, 152,
245.
10. Boulyga, S. F.; Loreti, V.;
Bettmer, J.; Heumann, K. G.
Analytical and Bioanalytical
Chemistry 2004, 380, 198.
11. Richarz, A.-N.; Bratter, P.
Analytical and Bioanalytical
Chemistry 2002, 372, 412.
12. Profrock, D.; Leonhard, P.;
Ruck, W.; Prange, A. Analytical
and Bioanalytical Chemistry
2005, 381, 194.
Agilent has developed a new
hyperbolic quadrupole - the Eagle
Quad - with a stringent manufacturing
tolerance of 1 micron. Agilent's
Harvey Loucks, who invented the
new quad, won the Bill Hewlett
innovation award in recognition of
his valuable contribution to improving
the performance of Agilent's quadbased instrumentation.
After monitoring the quad's abundance
sensitivity (AS) performance for some
time, the ICP-MS manufacturing group
have issued new AS specifications
at both high mass and low mass for
the 7500 Series as shown in Table 1.
The 7500 Series now has the best
AS specification of any ICP-MS ever
produced.
New 7500
AS Spec
Old 7500
AS Spec
Low
5x10-7 (Cs)
1x10-6 (Cs)
High
1x10-7
5x10-7 (Cs)
(Cs)
Table 1. Latest 7500 Series ICP-MS Abundance
Sensitivity Specifications for high and low mass
All 7500 Series instruments now
ship with a new Performance
Certificate with the new AS specs.
Supporting Literature
• Agilent 7500 Series ICP-MS
Specifications, 5989-2991EN
Agilent ICP-MS Journal May 2006 - Issue 27
3
Optimizing Sample
Throughput in ICP-MS
Steven Wilbur,
Agilent Technologies Inc., USA
Technological advances in ICP-MS
hardware and software have
resulted in unprecedented levels of
performance and reliability. Sensitivity
is routinely discussed at sub-ppt
levels, interferences are all but
eliminated, and the instruments are
simple and reliable enough for routine
use in high throughput commercial
laboratories.
However,
these
laboratories, under intense competitive
pressure, also demand the highest
possible
throughput,
while
maintaining performance, simplicity
and reliability. A number of factors
contribute to overall throughput,
including instrument uptime, time
spent tuning and calibrating, etc.
However, the most obvious factors
are those that influence the actual
analysis time, which will be discussed
here.
Analysis time, or more accurately,
average run-to-run time, is really a
function of two components:
1. Sample wash-in and wash-out
2. Data acquisition
Both can be optimized, depending
on sample types and analytical
requirements.
Optimizing Sample Wash-in and
Wash-out
Without resorting to discrete sampling
systems, sample uptake and rinse
out can be improved significantly
using simple enhancements to the
conventional peristaltic pumped
sample
introduction
system,
appropriate rinse solutions and
intelligent software functions.
Software functions are discussed
on page 6.
the narrowest and shortest lengths
of tubing (including peripump
tubing) that are consistent with the
necessary flows. The standard 1.02
mm internal diameter (ID), 3-stop
peristaltic pump tubing contributes
unnecessary volume and surface
area. Additionally Tygon, while being
clean and mechanically suitable, is
prone to interacting with certain
elements under some conditions
resulting in carryover. Therefore the
length and diameter should be
minimized. At a minimum, the excess
tubing and third stop should be
removed, leaving only about 1 cm
tails beyond the 2 remaining stops.
Reducing the diameter can reduce
both the volume and surface area
significantly, resulting in faster
uptake and rinse out. If smaller
diameter tubing is used, pump
speed during acquisition must be
adjusted to maintain the correct
nebulizer flow (Table 1). Switching
from 1.02 mm to 0.64 mm tubing
can reduce the sample uptake and
rinse out time by more than 50%.
Peripump tubing
ID / mm
0.89
0.76
0.64
Correction factor
1.3
1.8
2.55
Table 1. Correction factors for various internal
diameter (ID) peristaltic pump tubes used to
maintain correct nebulizer flow. To use, multiply
pump speed used for 1.02 mm tubing by the
appropriate factor.
The following conditions have been
shown to significantly reduce uptake
and rinse out time.
Sample tubing ID
0.3 mm
Peripump tube ID
0.64
Pump Speed (analysis)
0.26 rps
Pump Speed (uptake)
0.5 rps
Chemistry
Optimizing wash-in wash-out involves
minimizing the volume and internal
surface area of the sample
introduction components including
the autosampler probe, peristaltic
pump tubing, and sample transfer
line. Also important is minimizing
chemical interactions between analytes
and the sample introduction system
components. Reducing volume and
surface area are as simple as using
Dilute nitric acid has been the
traditional diluent and rinse solution
used in ICP-MS. This has been
mainly because most metals are
soluble in nitric acid, and it does
not introduce additional matrix
components such as Cl, S, C etc. that
may cause polyatomic interferences.
However, now that collision/reaction
cells can eliminate polyatomic
interferences, the analyst is free to
Agilent ICP-MS Journal May 2006 - Issue 27
This solution can be made up as
follows and may improve washout in
many circumstances. When using an
alkaline rinse solution to rinse out
samples prepared in acid solutions,
it is advisable separate the acid
samples and alkaline rinse by
introducing a short rinse of DI
water before and after the alkaline
rinse.
Stock Solution: 2.5g EDTA (as the
acid not Na salt); 0.2g Triton X-100;
15g NH4OH; 20g H2O2 & make up to
250 mL with water. Dilute 1:10 in
DI water for the final rinse solution.
Data Acquisition
Hardware
4
use more appropriate chemistry for
sample preparation and rinse
solutions. At the very minimum, the
addition of 0.5% HCl to the normal
1-2% HNO3 will stabilize Ag and
significantly improve the performance
(linearity, washout) for Hg and the
platinum group elements. Some
elements (including Hg, Mo, Sb and Tl)
exhibit better washout characteristics
under alkaline conditions. An alkaline
rinse solution composed of ammonium
hydroxide, EDTA, Triton x-100 and
hydrogen peroxide has long been
used in the semiconductor industry
for cleaning critical components.
Data acquisition time can be reduced
in a number of ways, depending on
the analytical requirements. The main
contributors to excessive data
acquisition time are:
1. Unnecessary isotopes acquired
2. Unnecessarily long integration
time
3. Excessive stabilization time at
acquisition start and at ORS
mode switching
4. More replicate acquisitions than
necessary
In many cases, data quality or
regulatory requirements may mandate
specific acquisition parameters
including the isotopes acquired and
the number of replicates. When not
restricted by specific regulations,
the use of collision/reaction cell
ICP-MS such as the Agilent 7500
ORS, can reduce the number of
necessary isotopes by eliminating
the need for backup isotopes and
interference correction masses.
Other parameters can generally be
optimized for faster analysis as well.
While there may be some element of
compromise between acquisition time
and data quality, it is almost always
www.agilent.com/chem/icpms
possible to improve analysis time
while still meeting data quality
objectives. The data in Table 2
shows the effects of various changes
in the parameters listed above on
the acquisition time for a typical
environmental method for the
analysis of 26 analytes in water
samples.
Discussion
For many applications, depending
on the sample type and analytical
requirements, significant reduction
in run-to-run time can be achieved
by reducing acquisition time without
adverse effects on performance.
This is possible due to the high
sensitivity and precision of the
7500 Series instruments. In most
cases, detection limits are more
limited by blank contamination
than by instrument signal to noise.
Reduction in integration time from
0.3 seconds per isotope (typical) to
0.1 seconds per isotope had no
significant effect on calculated
detection limits under typical
environmental analysis conditions,
but reduced the total acquisition
time by 0.5 - 1 minute. In addition
to reducing integration time, other
techniques can also reduce the
acquisition time. For example, while
the use of the ORS to remove
interferences will result in superior
data for complex samples, in clean
samples, the advantage may not
justify the extra time required.
Some tricks to improve throughput
have no down side. For example,
the ChemStation can be instructed
to automatically return to the first
ORS mode at the end of acquisition,
thereby eliminating the need for
additional gas stabilization before
the next sample. This can save 1015 seconds per run. Finally, though
many regulations require multiple
replicates, acceptable data can be
had with a single replicate (as is the
case for all time-resolved data).
Reducing the number of replicates
reduces the acquisition time
proportionately, though at some
cost in precision. Depending on the
conditions, acquisition times for 26
elements can vary from as much as
166 seconds or more, to as little as 12.6
seconds, depending on requirements
- see Table 3.
ORS Mode - optimized to remove all interferences using 3 modes (36 isotopes*)
Conditions
15 sec stabilization
Reduce first
Reduce integration pattern
time after all mode
stabilization time to
to 1 point/peak, 0.1 sec
switches, 3 pts/pk, 3 reps
5 sec
per mass*
Reduce to 1 replicate
Total acquisition
time (sec)
166
156
89
53
Vial to vial run
time including
uptake and rinse
(min)#
5.3
5.1
4.0
3.4
* 26 elements + 6 internal standards + correction masses for Li, In and Pb
# Using the standard rinse program allows for a reduction of 4 orders of magnitude after a running a 100 ppb standard
Table 2. Comparison of total acquisition times using ORS mode depending on acquisition parameters
No-gas Mode or no ORS - using correction equations to remove interferences (46 isotopes*)
Conditions
3 pts/pk, total 0.3 sec
Reduce integration pattern
integration time per mass
to 1 point/peak, 0.1 sec
per mass *
Reduce to 1 replicate
Total acquisition
time (sec)
71
38
12.6
Vial to vial run
time including
uptake and rinse
(min)#
3.7
3.1
2.7
* 26 elements (multiple isotopes for several) + 6 internal standards + multiple correction masses
# Using the standard rinse program allows for a reduction of 4 orders of magnitude after a running a 100 ppb standard
Table 3. Comparison of total acquisition times using non-ORS mode depending on acquisition parameters.
*Typical acquisition parameters include 3 points per peak at 0.1 second per point for most elements. By reducing
the number of points to 1 pt per peak, the total integration time is effectively reduced by a factor of three.
www.agilent.com/chem/icpms
Agilent ICP-MS Journal May 2006 - Issue 27
5
Benefits of the New
ICP-MS ChemStation
– Version B.03.03
Intelligent Rinse
Steven Wilbur, Agilent Technologies
Inc., USA
The newest version of the ICP-MS
ChemStation includes more than 30
new features and enhancements
designed to improve ease of use and
productivity, including:
• Easier to use Tuning Window
• Pre-Run Monitor
• Batch View - data file viewer
• Offline Acquisition Editor
• New, more powerful Autotune for
easier operation
•Higher sample throughput
- Pre-emptive rinse and
Intelligent Rinse
- More flexible control of 2nd peri
pump option
Of these, Intelligent Rinse is likely
to be among the most useful for
laboratories needing to analyze
large numbers of highly variable
samples in the shortest time possible.
Figure 1. 7500 ICP-MS ChemStation screenshot of the Peristaltic Pump Control Panel set-up page
where Intelligent Rinse is configured
Because of the high sensitivity and
wide dynamic range of ICP-MS,
rinsing back to blank levels after
high samples is much more challenging
than for less sensitive techniques
like ICP-OES. The traditional approach
has been to extend the program
rinse times to insure that even after
very high samples adequate rinsing
is accomplished. However, in the case
of very clean samples, or samples
very similar to one another, this
results in unnecessary time spent
rinsing, which can add minutes to
the total run time. A more efficient
approach is to actively monitor the
background while rinsing between
samples and rinse only as long as
necessary. This is exactly what
Intelligent Rinse does.
The ChemStation supports 4
independent autosampler positions
to be used in any combination for
rinsing as needed. Any of these 4
positions can be set as an
Intelligent Rinse position. Figure 1
shows the Peristaltic Pump Control
Panel where Intelligent Rinse is
configured.
Intelligent Rinse allows the user to
specify up to 10 critical elements to
monitor during rinsing. These can be
monitored as raw Counts Per Second
(CPS), internal standard corrected
CPS (effectively concentration), or
any other ratio desired. Then when
the user defined thresholds have
been achieved, rinsing stops and
the next sample is introduced.
6
Agilent ICP-MS Journal May 2006 - Issue 27
Rinsing is always complete, but
never any longer than necessary.
Intelligent Rinse even anticipates
the case where it is not possible to
achieve the specified rinse targets
by utilizing a user-set maximum
rinse time and action on failure. If,
by the maximum time, the targets
have not been achieved, rinsing will
terminate and the specified action
will be taken. This allows the user
to either continue the sequence, as
would be the case without
Intelligent Rinse, or abort it. In the
example above, Intelligent Rinse
time after highly contaminated
samples would be as long as 1 minute
(the max specified), but rinse time
after clean samples would be only a
few seconds (the time required to
determine that thresholds had been
met). The net effect is that when
running a sequence of highly varied
samples, ranging for example from
clean waters to highly contaminated soils, overall run-to run time
can be reduced by as much as 30%.
Version B.03.03 Availability
Version B.03.02 is currently shipping
with new instruments. The version
described in this article (B.03.03) will
start shipping with new instruments
from mid July. Any user with
B.03.xx software can download a
free upgrade to B.03.03 from the
Agilent website when available.
Free upgrades for version B.03.xx
users will be available for download
on the Agilent website from July.
http://www.chem.agilent.com/
Scripts/cag_checkreg.asp?anch=ICP
The software is also upgradeable
from earlier versions – see web site
for more details.
http://www.chem.agilent.com/
Scripts/cag_checkreg.asp?anch=ICP
www.agilent.com/chem/icpms
Revised Maintenance
Schedule for 7500
Series
Frequency
Component
Task/Action
Daily
Argon gas
Check argon gas pressure and volume
Daily
Drain vessel
Check, empty if required
Hidenori Koide, Agilent Technologies,
Daily
Peristaltic pump tubing
Check for wear
Tokyo, Japan
Weekly
Torch, spray chamber,
connector
Clean, replace when necessary
Weekly
Sampling cone, Skimmer
connector
Check orifice and clean if required.
Replace when necessary.
Monthly
Rotary pump
Check oil level and color.
Check mist filter for presence of oil
Monthly
Nebulizer
Run "Neb test" and take
appropriate action as indicated
Monthly
RF return strips and
shield bar
Clean
Monthly
Cooling water
Check water level
Semi-Annually
Rotary pump
Change oil
Annually
Rotary pump oil mist filter
Replace mist filter
Annually
Penning gauge
Clean
Annually
Water strainer
Check and clean
Biannually
Argon gas filter
Replace
It is important to maintain your
Agilent 7500 regularly to extend the
useful life of its components and
optimize its analytical capabilities.
Defining an appropriate maintenance
schedule for your instrument depends
on the number of samples/day, sample
matrix type and the environment of
the instrument. The 7500 Series
user manuals are very conservative
when stating typical recommended
maintenance frequency, representing
a worst-case sample load scenario.
However, over the past two years since
the 7500ce was introduced, Agilent
has been carefully monitoring the
performance of the 7500ce when
used in very tough conditions in
routine labs. Users report that the
7500ce is exceptionally rugged and
can handle a high workload of high
matrix samples with minimal
maintenance. As a result, the
recommended maintenance interval
for the ion lenses and ORS has been
significantly extended on the 7500ce.
The guidelines given in the table below
apply to a typical environmental lab
running a mix of sample matrices
for 8 hours/day, 5 days/week. Under
the new recommended maintenance
schedule, 7500ce users typically will
only need to break the vacuum
system every 6 months to clean the
cell lenses, and annually to clean or
replace the octopole. The octopole can
be cleaned if it becomes contaminated,
but some users may prefer to simply
install a new one to save a little time.
Refer
to
the
7500
Series
Maintenance DVD (Agilent part #
G3270-65100 – see Journal issue
#26) for instructional videos on
how to perform all maintenance
tasks. It is easier to schedule
maintenance if you keep a log of the
instrument readings for each analysis.
It is also strongly recommended to
generate a tuning report each day,
so any degradation in performance
can be tracked. Table 1 lists the
Agilent 7500 maintenance tasks by
recommended task frequency.
www.agilent.com/chem/icpms
The components listed below should be checked periodically, at least on an
annual basis, and appropriate action taken
Periodically
Electron multiplier
Evaluate; replace when necessary
Periodically
Plasma gas, auxiliary
gas tubing
Check; replace when necessary
Table 1. Maintenance schedule guidelines - general items
Ion Lenses and ORS
The frequency of maintenance
required for these parts is more
dependent on number of samples
run per day and the sample matrix
type. The guidelines given in the Table
2 apply to a typical environmental
lab running a mix of sample matrices
for 8 hours/day, 5 days/week. Labs
with lighter workloads or cleaner
sample matrices will be able to
extend periods between cleaning.
Running Intelligent Rinse and
Pre-emptive Rinse software programs
(ChemStation
version
B.03
onwards), or using ISIS will expose
the interface to less sample matrix
over time which will also extend
periods between cleaning.
Frequency
Component
Task/Action
3 to 6 Months
7500a Extraction lenses
Clean
6 Months
7500a Einzel/Omega lenses
Clean
3 to 6 Months
7500ce/cs Extraction/Omega lenses
Clean
6 Months
7500ce/cs Entrance lens, Exit lens,
Plate bias /Cell entrance, QP focus
Clean
Octopole
Clean or replace if preferred
Annually
Table 2. Maintenance schedule guidelines - ion lenses and ORS
Agilent ICP-MS Journal May 2006 - Issue 27
7
New Agilent-Supported Welcoming New Agilent ICP-MS Users
A very warm welcome to all companies and institutions that have recently
ASX Autosampler
added an Agilent ICP-MS to their analytical facilities. Remember to join
the Agilent web-based ICP-MS User Forum – the place where you can
exchange information relating to your 7500.
To access the Forum, you will simply need to log-in to the Agilent web site,
or register if you haven't already, and enter your instrument's serial number on your first visit only.
Look for the link to the ICP-MS User Forum from:
www.agilent.com/chem/icpms
Useful features include:
• e-Mail notification of any activity on the Forum
• Powerful search facility
• Agilent ICP-MS User Resource Library - a database specifically for userrelevant information
Agilent has launched a new Agilentbranded autosampler which is
manufactured by CETAC and is
based on the ASX 520. The Agilent
product number is G3286A.
The new Agilent branded autosampler
is fully supported by Agilent
engineers, which makes it much
easier for users of the new systems
to get autosampler support. A full
range of Agilent service contracts and
preventative maintenance programs
are also offered. The standard support
procedure is an exchange program:
Agilent
sends
an
exchange
autosampler and the user sends their
faulty autosampler to Agilent in the
packaging materials provided. On site
repair by Agilent engineers is also
available in cases where the existing
autosampler can not leave the lab - for
example in some nuclear facilities.
Contents of the Agilent ICP-MS User Resource Library:
• 7500ce Tuning Guide
• 7500a Tuning Guide
• 7500cs Tuning Guide
• Clinical Sample Prep Guide
• Guide to Analyzing Organic Solvents
• How to use FileView
• Technical Note: Configuration of Sample Introduction System for Rapid
Measurement of 'Sticky' Analytes by ICP-MS
• New! Laser Ablation-ICP-MS Operation Guide
Subscribe to the ICP-MS Journal Via Agilent
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Note: Agilent only supports the
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of Elements in Biological, Enviro
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and Toxicological Sciences
21-25 June 2006, Bialowieza, Poland www.agilent.com/chem/icpms and look under "Library Information"
http://www.eurocongress.com.pl/i
• Unmatched Spectral Interference Removal in ICP-MS Using the Agilent
ssebets2006
Octopole Reaction System with Helium Collision Mode, 5989-4905EN
Agilent ICP-MS UK & Ireland User • Agilent 7500 Series ICP-MS Specifications, 5989-2991EN
Meeting
Karen Morton for Agilent Technologies
27 June 2006, Kingston University,
Agilent ICP-MS Journal Editor
e-mail: editor@agilent.com
Kingston-upon-Thames.
Agilent ICP-MS Publications
This information is subject to change
without notice
© Agilent Technologies, Inc. 2006
Printed in the U.S.A. May 28, 2006
5989-5132EN
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