5991 1836EN

5991 1836EN
Agilent 7890B Gas Chromatograph
RESOLVE
YOUR SEARCH
FOR RELIABILITY
THE AGILENT 7890B GC
RESOLVE YOUR SEARCH FOR THE NEXT EVOLUTION
IN GAS CHROMATOGRAPHY
Building the world’s most trusted GC system is an ongoing process. With every step, we
increase speed, improve functionality, and incorporate new analytical capabilities – all while
never losing sight of the most important objective: RESULTS.
Now, Agilent has achieved a new level of GC performance
and GC/MSD system integration
Agilent’s flagship 7890B GC system has everything you need to boost productivity, protect our
environment through better resource management, and generate data with confidence. In
addition, its seamless communication with the Agilent 5977A Series GC/MSD provides faster
vent times and system protections when using hydrogen carrier gas.
The Agilent 7890B GC adds integrated “smart”
functionality and improved performance to the
industry-leading GC platform.
2
Leading-edge technologies
increase analytical
capabilities and
reliability
Proven reliability and high performance
Agilent’s 5th-generation electronic pneumatics control (EPC) and
digital electronics are now complemented by improved detector
specifications, making the 7890B Agilent’s most dependable – and
highest-performing – GC ever.
Increased sample throughput
Fast oven cool-down, new backflush capabilities, and advanced
automation features help you get more done in less time, at the
lowest possible cost per sample. All can easily be incorporated into
your existing method.
Faster, more intuitive software
New Agilent OpenLAB CDS is 40 times faster.
Added tools and wizards help turn results into
answers. Page 11
End-to-end protection for active
compounds
Agilent now applies our proprietary deactivation
technologies to our new Split/Splitless inlet
option, Ultra Inert liners, gold seals, columns,
and improved detectors. Page 4
Integrated system intelligence
Early Maintenance Feedback (EMF) allows you to replace parts
quickly, and address small problems before they lead to costly
downtime. Built-in calculators and method translator are also
integrated into the data system software to simplify method setup
and system operation.
Enhanced inlet and detector modules
Numerous module enhancements let you
customize your GC system in minutes.
Pages 8, 17, 21
What’s more, the improved GC MSD communication cuts venting
time by up to 40%, and protects the system from damage by
stopping the flow of carrier gas during shutdown events.
New integrated system maintenance
and Parts Finder tools
Reduce downtime and operating costs with
simplified maintenance and status monitoring.
Find consumables and replacement parts faster
with a 3D graphical tool. Pages 11, 13
Expanded chromatographic capabilities
Backflush, flow splitters, GCxGC, Dean’s switches, and purged unions
are all provided by Agilent Capillary Flow Technology (CFT).
Enhanced Capillary Flow Technology
Enable leak-free, in-oven connections while
improving throughput and reliability. An easy
setup wizard gets you up and running quickly.
Page 6
Wide choice of system components
Configure and automate your system to increase
efficiency and productivity – and expand your
analytical capabilities. Pages 14, 21
Use Agilent Condensed
Regular
Eco-friendly
operation
font for this text. Lorem ipsum
Sleep
mode
reduces
power and gas consumption
dolor. Sed
ed tempor
incididunt.
during periods of inactivity, while Wake mode
readies the system for high-throughput operation.
You can also switch to lower-cost gases while in
standby mode. Page 12
Reduce dependency on helium
Integrated calculators help you convert helium
methods to more available – and less expensive
– gases like hydrogen or nitrogen. Page 5
To learn more about the Agilent 7890B GC, visit agilent.com/chem/7890B
3
AGILENT INERT FLOW PATH
ENSURE RELIABLE, CONSISTENT INERTNESS
Actionable concentrations continue to decrease as new, relevant
compounds are increasingly active. By ensuring reliable, consistent
inertness from injector to detector, the Agilent Inert Flow Path
decreases analyte adsorption for lower Limits of Detection (LOD)
and better signal-to-noise response.
Sample
Septum
An integrated approach to inertness
Using an Agilent Inert Flow Path ensures the inertness of
every surface that touches your sample, so you can achieve the
parts-per-billion – or parts-per-trillion – detection levels that today’s
analyses demand.
Ultra Inert
GC liner
Inert Flow Path
Split/Splitless
inlet
Glass wool
• Agilent J&W Ultra Inert GC columns are tested with the
industry’s toughest test probe mixture to ensure consistent column
inertness and exceptionally low column bleed.
Ultra Inert gold seal
Retention gap
• Ultra Inert liners deliver a robust, reproducible, and reliable inert
flow path – with or without glass wool.
Agilent J&W Ultra Inert
GC column
UltiMetal Plus
Flexible Metal ferrule
and Ultimate Union
Stationary
phase
Inside GC column
• Gas Clean filter systems deliver the cleanest possible gas,
reducing column damage, sensitivity loss, and downtime.
Polyimide outer coating
Backflush:
UltiMetal Plus
Flexible Metal
ferrule and
Purged Union
• GC detectors allow the selectivity or sensitivity that your
application requires – and the ability to handle your data with
a unified platform.
GC/MSD
(or other detector)
Ion source
Data
For more information about creating an inert GC flow path, visit agilent.com/chem/inert
4
-Si-O-H
-Si-O-H
-Si-O-H
-Si-O-H
-Si-O-H
Deactivation
-Si-O-H
-Si-O-H
-Si-O-H
-Si-O-H
-Si-O-H
• UltiMetal Plus Flexible Metal ferrules are compatible with
Capillary Flow Technology fittings, promoting a leak-free seal that
requires less torque – and reduces the risk of column breakage.
-Si-O-H
Fused silica
surface
-Si-O-H
• Ultra Inert gold seals feature deactivation chemistry applied
on top of their gold plating for the most inert surface and highestquality seal.
-Si-O-H
• Inert Flow Path Split/Splitless inlet option provides an extra
measure of inertness to the sample pathway.
CARRIER GAS OPTIONS
USE RESOURCES EFFICIENTLY
Alternate carrier gases
minimize the impact of
the helium shortage
In response to the global shortage of
analytical-grade helium, many labs are
switching to alternate carrier gases – such
as nitrogen and hydrogen.
Nitrogen is a good choice when there
is sufficient chromatographic resolution.
Hydrogen has excellent chromatographic
qualities and can increase throughput.
The Agilent Hydrogen Sensor can detect
potential leaks early to bring your system
to a safe stand-by if necessary.
Helium conservation
for validated methods
Agilent’s helium conservation module,
helium switch, and other tools allow you
to use helium for your GC runs, and switch
to an alternate gas (such as nitrogen)
when your GC is idle. That means you
can dramatically decrease helium usage
without changing your validated methods.
Precise Retention Time Locking
(RTL) software
RTL reproduces retention times from one
Agilent GC system to another, regardless
of inlet, detector, operator, or location for
confident methods transfer worldwide.
Agilent’s 5th generation EPC and digital
electronics further improve RTL precision
for low-pressure applications.
Agilent
Hydrogen Sensor
Run
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
Average
Standard Deviation
Peak 1*
9.0839 min
9.0835
9.0841
9.0846
9.0851
9.0849
9.0845
9.0849
9.0847
9.0853
9.0852
9.0851
9.0847
9.0848
9.0853
9.0847 min
0.000527
Peak 2*
11.8492 min
11.8492
11.8494
11.8496
11.8507
11.8502
11.8504
11.8500
11.8504
11.8502
11.8502
11.8508
11.8503
11.8507
11.8506
11.8501 min
0.000535
*Heart-cut from column 1. Demonstrating retention time reproducibility.
pA
12
10
15 overlaid heart cut
chromatograms on
Peak 2 showing
unsurpassed reproducibility
8
6
4
2
11.78
11.8
11.82
11.84
11.86
11.88
11.9
11.92
min
Achieve unsurpassed retention time reproducibility in standard applications – even with multi-dimensional
applications, such as the heart-cutting example shown here.
To learn more about the Agilent 7890B GC, visit agilent.com/chem/7890B
5
CAPILLARY FLOW TECHNOLOGY
INCREASE FLEXIBILITY AND THROUGHPUT
Agilent’s proprietary Capillary Flow Technology (CFT) solves a problem
chromatographers have been wrestling with for decades: creating
leak-free capillary connections that can withstand the temperature
extremes of a modern GC oven.
Blank after backflush
CFT devices are inert, with low mass and low dead volume to help
you make secure connections and precisely divert your gas flow
pneumatically. This opens the door to techniques that can expand
analytical capabilities, improve your results, and conserve both time
and resources.
Backflush @ 10 min
CFT backflush saves you time with every run
Original
1 mL/min CF
Backflushing works by reversing the column flow immediately after
the last compound of interest has eluted, thereby sweeping material
backwards through the column and out the split vent.
5.00
10.00
15.00
20.00
25.00
30.00
35.00
40.00
5989-9804EN: Capillary Flow Technology: Backflush – Reduce Run Time and Increase
Laboratory Throughput
This simple technique extends column life and eliminates long bakeout times for highly retained sample components. It also prevents
problems such as carryover, retention time shifts, and MSD source
contamination.
Backflush Assistant Software Wizard simplifies
method set-up
The Backflush Assistant Software Wizard first collects information
about your method and CFT device, then provides a step-by-step
procedure for configuring the backflush hardware and column
plumbing. Once the backflush-enabled method and timing are
determined, a validation protocol confirms that the method performs
properly and robustly.
Expert training: just a phone call away
Backflush and Backflush Assistant Software Wizard training from
Agilent Workflow Services can help you set up your CFT Backflush
method quickly and efficiently.
Backflush Wizard simplifies method development and set-up.
6
DEANS SWITCH AND FLOW SPLITTERS
ENHANCE CHROMATOGRAPHIC CAPABILITIES
A Capillary Flow Technology (CFT) Deans
Switch, using fluidic switching, allows precise,
2-dimensional GC heart-cutting analysis of
trace compounds in complex matrices.
Deans Switch improves selectivity
for trace compounds in complex
matrices
Peaks of interest from one column are
“cut” onto a second column with a different
stationary phase. Compounds that might
co-elute with analyte on the first column
are separated from analyte on the second
column.
Flow splitting delivers more
information per injection
Flow splitting – sending the sample to
multiple detectors – maximizes the data
collected in a single run, and is useful for
analyzing compounds in complex matrices.
This technique can also help you identify
peaks of interest quickly, improve peak
integration, and identify unknowns.
Cut
Automatic
Liquid
Sampler
Restrictor to
Detector 1
Pneumatic
connections
to solenoid valve
Column 1
Column 2
FID1
FID2
Column
1
Column
2
7890B GC
Deans Switch
In this example, the Capillary Flow Deans Switch enabled unresolved trace components to be heart-cut onto a
second column with a different stationary phase.
5989-9384EN: Capillary Flow Technology: Deans Switch – Increase the Resolving Power of Your GC
Restrictor 2 to Detector 2
Inlet
Aux EPC
Det 1
Restrictor 1
Restrictor 3 to Detector 3
Restrictor 2
Restrictor 1 to Detector 1
Aux EPC or PCM
Column
Column
Splitter
Restrictor 3
GC Oven
Agilent CFT devices provide easy-to-make, reliable connections for better chromatography.
5989-9667EN: Capillary Flow Technology: Splitters – Get More Information in Less Time
Strawberry extract highlighting unknowns
MSD TIC
TIP: Agilent UltiMetal Plus
Flexible Metal ferrules improve the
reliability of your GC column connections.
Learn more at
agilent.com/chem/flexiferrule
Det 2
µECD
Unknown peaknot
found by MS
FPD (P)
5
10
15
20
25
30
35
40
To learn more about the Agilent 7890B GC, visit agilent.com/chem/7890B
7
MSD
INLETS, DETECTORS, AND LTM TECHNOLOGY
KEEP YOUR LAB RUNNING AT PEAK PERFORMANCE –
NOW, AND IN THE FUTURE
The modular Agilent 7890B GC system lets you choose from
the industry’s widest selection of inlets, detectors, columns, and
automated sample introduction techniques. Entire injector and
detector modules can be changed in minutes, while injector and
detector components can be swapped independently of pneumatics
and electronics – saving your lab time and money.
Low Thermal Mass (LTM) technology
for more injections per hour
LTM technology promotes rapid heating and cooling for faster GC
analyses, higher throughput, and less power consumption. With its
independent temperature control of up to four column modules, LTM
technology also enables multidimensional GC and integration with
Capillary Flow Technology for reduced column maintenance. To simplify
method transfer, most Agilent J&W GC columns are available for LTM
modules.
Multimode Inlet (MMI) for flexibility and sensitivity
Agilent’s MMI combines spit/splitless operation, temperature
programming, and large-volume injection with a solvent vent mode.
Benefits include higher sensitivity, robust handling of dirty samples,
and the ability to analyze thermally labile compounds.
GC Column
Sensor
Syringe Needle
Insulated
Heating Wire
Insulation
Baffled Liner
Carrier
The key to LTM technology: weaving direct heating and temperature-sensing
components around a standard fused-silica capillary column.
Vent
5990-7688EN: Agilent Low Thermal Mass (LTM) Series II System for
Gas Chromatography
400
Sample
Analyte
Solvent
350
Column
Temp (ºC)
250
5990-3954EN: Agilent Multimode Inlet for Gas Chromatography
2 m LTM
5 m LTM
LTM Cooldown Times
(Standard Size)
300
10 m LTM
7890 GC
200
150
100
Full dynamic range FID
50
0
Our state-of-the-art digital electrometer delivers a linear dynamic
range of 107, seamlessly integrated into a single run.
0
50
100
150
200
250
Time (sec)
Typical cooling times for standard (5-inch) LTM column modules are significantly faster
than a conventional GC oven.
Sensitive and selective element detection
5990-3237EN: Dual Channel Simulated Distillation of Carbon and Sulfur with the
Agilent 7890A GC and 355 Sulfur Chemiluminescence Detector
Agilent’s Flame Photometric Detector (FPD) is highly sensitive, with
a temperature range of up to 400 °C. For demanding applications,
Sulfur Chemiluminescence Detectors (SCD) and Nitrogen
Chemiluminescence Detectors (NCD) provide the highest sensitivity
and selectivity.
8
EXTERNAL VALVE OVEN
CONFIGURATIONS EXPAND YOUR GAS SAMPLING OPTIONS
The Agilent Large Valve Oven (LVO) for GC is a versatile, high
capacity external oven, which can be configured to support
complex, multi-valve GC applications. The LVO supports several
standard Agilent multi-valve analyzers such as RGA and NGA, but
is also available as a highly customizable option on the 7890B GC.
Precisely engineered for thermal isolation from the GC oven, the
LVO provides a homogeneous isothermal environment for up to six
valves and convenient open-access for maintenance, adjustment or
customization. Accessibility, capacity, and thermal uniformity make the
Agilent LVO a premium GC valving option, especially suited to support
the rising trend of combining multiple complex analyses on a single
GC platform.
Other advantages include:
• Open configuration, which allows easy maintenance and servicing
– while maintaining the standard 7890B GC system footprint.
• The ability to configure analyzers, such as RGA, that require
multiple thermal zones.
• Six valve positions, with a maximum 14-port valve, so you can
configure the system to meet your application requirement.
• Use only one heated GC zone with optional valve configurations to
meet your current and future testing needs.
1
2
4
3
5
17
9
6 7
8
10 11 12 13
16
14 15
22
18 19 20 21
1.
2.
3.
4.
5.
6.
7.
8.
9.
10.
11.
12.
13.
14.
15.
16.
17.
18.
19.
20.
21.
22.
Methane
Ethane
Ethylene
Propane
Propylene
i-Butane
n-Butane
Propadiene
Acetylene
t-2-Butene
1-Butene
i-Butene
c-2-Butene
i-Pentane
n-Pentane
1,3-Butadiene
Propyne
t-2-Pentene
2-Methyl-2-Butene
1-Pentene
c-2-Pentene
C6+
4
1. Carbon Dioxide
2. Ethane
3. Oxygen
4. Nitrogen
5. Methane
6. Carbon Monoxide
1
2
3
5
6
Results of the fast analysis time possible with the RGA method. In this example, the new Large Valve Oven is setup and running as the RGA analyzer, which is preconfigured and
provides guaranteed chromatographic performance.
To learn more about the Agilent 7890B GC, visit agilent.com/chem/7890B
9
MASSHUNTER AND OPENLAB SOFTWARE
SIMLIFY OPERATIONS AND BOOST PRODUCTIVITY
Integrated method development tools and calculators take the guesswork out of tasks
such as changing carrier gas, selecting the right liner, or changing to a column of different
dimensions.
Interactive graphical consumables and Parts Finder tool quickly locates key parts on
the GC system, and provides part numbers and descriptions for easy ordering.
Consumables database simplifies method development by minimizing tracking errors and
automatically populating analytical methods with key configuration information.
Resource conservation tools, such as automatic sleep and wake modes, reduce gas and
power consumption, while making sure the system is ready to run when you need it.
GC/MS MassHunter with MSD ChemStation
Data Analysis: Agilent’s newest platform designed
to resolve your search for data
Quickly and confidently find the answers
you seek for routine quantitation and more
challenging discovery applications.
Choose either MassHunter or
MSD ChemStation Data Analysis –
the traditional choice for GC/MS analysis.
Common instrument control for Agilent GC/MS
systems simplify your laboratory operation.
Agilent’s Barcode Printing Bundle
(G9201AA) has everything you need to
print labels for the 7693 ALS and 7697A
Headspace Samplers.
10
OpenLAB
Scalable
architecture
expands from a
single instrument
to lab-wide
implementation.
CAPTURE • ANALYZE • SHARE
Make your lab more productive
with OpenLAB CDS
Advanced data analysis
and reporting drives greater
throughput and productivity.
OpenLAB CDS software makes your lab more efficient by reducing the
time spent on data processing, review, and reporting. With OpenLAB
CDS you can:
• Create reports using powerful and intuitive “drag-and-drop”
capabilities.
• Process large data sets up to 40 times faster and review results
quickly with powerful data analysis tools.
• Completely control your Agilent 7890B GC – including Parts Finder,
Sleep/Wake, and Retention Time Locking.
• Accelerate and preserve your workflows – whether they are
interactive or automated.
• Streamline the management of user privileges and password
protection.
• Scale from a single instrument to a lab-wide network that
centralizes system administration while allowing you to work from
anywhere.
A trusted
upgrade path
preserves your
investment in
workflows, data,
and methods.
Secure centralized data storage is available through Agilent OpenLAB
Data Store and OpenLAB ECM software, both of which integrate
seamlessly with OpenLAB CDS.
To learn more about the Agilent 7890B GC, visit agilent.com/chem/7890B
11
Networked OpenLAB
CDS allows you to
get your work done
from anywhere in the
lab – and simplifies
the administration of
methods, user roles,
and permissions.
RESOLVE YOUR SEARCH FOR INTEGRATION
SMART FEATURES TAKE SUPPORTABILITY,
PERFORMANCE, AND SAFETY TO NEW HEIGHTS
INTEGRATED GC MSD COMMUNICATION
AND SAFETY CONTROLS
Direct communication between the 7890B GC and 5977A Series
GC/MSD enhances and protects your investment:
• If the MSD vents… the system increases the flow of carrier gas,
shortening vent times by up to 40%. • If the pump fails… the system shuts off the carrier gas, saving
expensive helium or avoiding hydrogen build-up.
• If communications are lost… the system shuts down
the GC thermal zones.
ECO-FRIENDLY
Use
Agilent Condensed Regular
font for this text. Lorem ipsum
• Can also be used with hydrogen or nitrogen carrier gas to
dolor. Sed ed tempor incididunt.
reduce operating costs
• Sleep/wake modes reduce gas and energy consumption.
• Helium Conservation Switch to move from helium when
the system is not in use
PARTS INFORMATION
AT YOUR FINGERTIPS
• Easily locate part numbers for consumables and
supplies with Parts Finder, an interactive 3D
graphical tool.
• Instantly see parts and consumables specific to your
instrument configuration. You can then print or email
purchase orders, or import directly into your
agilent.com cart.
• Keep track of columns and supplies with an
optional barcode reader, and auto-import accurate
configuration information into your GC and
analytical method.
OPTIMIZE PRODUCTIVITY
• Early-maintenance feedback allows you to plan routine
maintenance tasks and reduce unnecessary downtime.
• Parts ID tool quickly identifies parts and part
numbers for easy re-ordering.
• Agilent Data Systems easily develop and optimize
methods through:
– Integrated GC Calculators, including method translator
and vapor volume calculator.
– Auto transfer of calculated values to the method editor.
– Setup and status of maintenance tracking counters.
To learn more about the Agilent 7890B GC, visit
agilent.com/chem/7890B
13
AGILENT AUTOSAMPLERS
THE PERFECT FIT FOR YOUR 7890B GC
The Agilent 7693 Series Automatic Liquid Sampler (ALS) delivers the fastest injection times
of any GC autosampler. In addition, our 7693A platform offers a 16- or 150-vial capacity for
reproducibility with small sample loads and high sample throughput, if needed. Enhanced
capabilities – such as automated dilution, internal standard addition, heating, mixing, and
solvent addition – help eliminate variability and rework.
If your lab processes fewer than 50 samples per day, the Agilent 7650A ALS is a robust,
lower-cost option for optimizing workflows and maximizing sample throughput.
Boost your lab’s output with advanced sample preparation capabilities
Agilent 7693 Series ALS
The Agilent PAL Autosampler is ideal for liquid injection, headspace, and solid-phase
microextraction (SPME) applications. Although this versatile platform can be configured solely
for liquid injection, it also offers many capabilities – including large-volume injection (LVI),
multiple vial sizes, and extended sample vial capacity.
Automatically introduce volatile compounds from virtually
any sample matrix
Agilent’s 7697A Headspace Sampler ensures an inert sample pathway for superior GC system
performance without analyte degradation or loss. Electronic Pneumatics Control (EPC), a
111-vial capacity, and three exchangeable 36-vial racks make the 7697A an ideal choice for
high-throughput labs. In addition, the Agilent 7697A Headspace Sampler is the industry’s only
dedicated headspace unit that supports the use of hydrogen as a carrier gas.
Agilent PAL Autosampler
Protect your instrument – and the
integrity of your samples – with
Agilent’s industry-leading vials,
caps, and syringes
7697A Headspace Sampler
` Optimize your productivity
` Extend the life of your system
` Maximize your uptime
View the Agilent Sample Introduction brochure at agilent.com/chem/library and search for 5991-1287EN.
14
PHARMACEUTICAL APPLICATIONS
CONFIDENTLY DETECT IMPURITIES AT VERY LOW LEVELS
Gas chromatography, coupled with static
headspace sampling, is an easy-to-use,
high-throughput tool for determining
residual solvent impurities in pharmaceutical
products. Sample preparation is simple, and
the method is easily validated. In addition,
headspace sampling allows you to avoid
matrix injections that can cause column
degradation and coelution.
Residual solvent analysis using
an Agilent 7890B GC system with
an Agilent 7697A Headspace
Sampler
Excellent chromatographic performance was
achieved for residual solvents at USP <467>
specified limits, as shown in this example for
Procedure A - Class 1 Solvents.
Excellent chromatographic performance is achieved on the Agilent 7890 Series GC. Equivalent data will be
produced on a 7890A and 7890B system.
5991-1834EN: Analysis of USP <467> Residual Solvents using the 7697A Headspace Sampler with the 7890B
Gas Chromatograph
This instrument configuration is available as
an analyzer with guaranteed chromatographic
performance.
Save energy, simplify maintenance, and conserve resources
Sleep/wake mode lets you put your system to sleep
when not in use, and have it awaken exactly when you
need it.
Early maintenance feedback (EMF) keeps track of injections and consumable
usage, so you can establish maintenance SOPs.
To learn more about the Agilent 7890B GC, visit agilent.com/chem/7890B
15
ENERGY AND CHEMICAL APPLICATIONS
TAKE YOUR LAB TO A HIGHER LEVEL OF RELIABILITY
AND PRODUCTIVITY
500
400
300
200
100
All preconfigured analyzers provide the ability
to install the new system and begin validation.
There is no need to waste time developing
methods, the method is factory proven. As a
result, the time from installation to running
samples is greatly reduced.
t-2-Butene
1-Butene
i-Butene
c-2-Butene
i-Pentane
n-pentane
1,3-Butadiene
Propyne
t-2-Pentene
2-Methyl-2-butene
1-Pentene
c-2-Pentene
600
FID Channel
0
1
2
3
4
5
6
7
700
Methane
800
Ethane
600
500
400
min
2nd TCD Channel
300
CO
O2
200
100
H2S
Factory-configured analyzers
let you start your analysis
immediately after installation
Propylene
700
Propane
pA
800
i-Butane
n-Butane
Propadiene
Acetylene
Fast RGA analysis
Ethylene
• Pre-configured hardware and methodspecific separation tools let you focus on
calibration and validation per your lab’s
SOPs.
5990-3174EN: Fast Hydrocarbon and Sulfur Simulated Distillation Using the Agilent Low Thermal
Mass (LTM) System on the 7890 GC and 355 Sulfur Chemiluminescence Detector
CO2
• External Valve Oven enables rapid RGA with
H2S and O2 separation.
Calibration sample C5-C40
The simulated distillation results for ASTM D2887 RGO agree with the RGO specification of ASTM
D2887, with RSDs of 0.12 to 0.47 percent across the reported range.
Methane
Ethane
Ethylene
• LTM technology reduces cycle time for
Simulated Distillation.
ASTM D2887 Reference Oil
N2
Technology innovations expand
your range of analyses
Fast simulated distillation using Low Thermal Mass module (LTM)
n-Hexane
If your lab still uses an “old workhorse”
GC just because it gives you “acceptable
results,” perhaps it’s time to consider the
transformative advantages of Agilent’s 7890B
GC. It goes beyond “acceptable results” to
give you increased productivity, safety, cost
effectiveness, and environmental friendliness
– all with greater precision and reliability
than instruments past their prime. Applicated
analyzers are also available, which provide
methods and guaranteed chromatographic
performance.
0
1
2
3
4
5
6
7
min
Oxygenates in finished gasoline per ASTM D4815
1.
2.
3.
4.
5.
6.
7.
8.
9.
10.
11.
12.
13.
14.
Methanol
Ethanol
Isopropanol
tert-Butanol
n-Propanol
MTBE
sec-Butanol
DIPE
Isobutanol
tert-Pentanol
DME
n-Butanol
TAME
Heavier
hydrocarbon
13
3
14
5
11
1
2 4 6
7 9
8
10
12
5991-1561EN: Analyzer Solution Guide for Energy & Chemicals Industry
16
Conform to industry requirements
for sulfur levels
Sulfur distribution in feedstocks is critical
to the refining industry as it adjusts to
meet clean fuel requirements. Agilent’s
new Flame Photometric Detector, with its
high temperature capability and improved
sensitivity, is an ideal tool for determining
sulfur in blending stocks, such as light cycle
oil (LCO). Profiling dibenzothiophenes is
particularly important for achieving the lowest
sulfur levels in the final products.
Analysis of substituted dibenzothiophenes in light cycle oil (LCO) using a CFT Deans Switch
system with an Agilent 7890B FPD. This enhanced separation reduces the possibility for
quenching caused by co-elution with hydrocarbons.
5991-1752EN: An Improved Flame Photometric Detector For the Analysis of
Alkyldibenzothiophenes in Light Cycle Oil, and Gas Oil Feedstocks using the 7890B
Reliable trace sulfur analysis. Excellent
reproducibility was achieved by coupling
the Agilent 7890B GC with our sensitive,
high-temperature FPD.
Flow modulation for
comprehensive GC (GCxGC)
Zoom: C16 and C18
methyl esters
The Agilent 7890B GC uses Capillary Flow
Technology to enable flow modulation
without the need for complicated – and
costly – cryo-focusing techniques. This
analysis of diesel fuel shows the normal
boiling point distribution in the first dimension,
and functional group clusters in the second
dimension.
GCxGC of a B20 biodiesel showing separation of C16 and C18 methyl esters. Modulation period: 2800 seconds.
Column 1: 20 m x 0.18 mm, 0.18 µm DB1, Column 2: 4 m x 0.24 mm, 0.25 µm HP-INNOWax.
5989-9889EN: Capillary Flow Technology: GCxGC Flow Modulator: Get a Second Dimension of Information on
Complex Mixtures
To learn more about the Agilent 7890B GC, visit agilent.com/chem/7890B
17
ENVIRONMENTAL APPLICATIONS
ACCELERATE SCREENING METHODS
US EPA Method 8270 is widely used to
determine the concentration of semi-volatile
organic compounds in environmental matrices
– many of which contain a mix of acids,
bases, and neutrals. This method can be
challenging without an Agilent Inert Flow Path
due to interactions between analytes and flow
path surfaces.
5000 ppm oil
4 min.
backflush of spike
Scale 20x more
sensitive than
above
Backflush improves cycle time for
semi-volatiles analysis
5.00
10.00
Solvent blank after backflush,
inlet and column clean
15.00
Here, a 5 ppm EPA 8270 standard run was
spiked into 5000 ppm of heavy oil to simulate
interference from hazardous waste.
20.00
25.00
30.00
5989-6026EN: Significant Cycle
Time Reduction Using the Agilent
7890/5975 GC/MSD for EPA
Method 8270
35.00
Diesel
4500000
4000000
3500000
Motor oil
3000000
Response
During the first run, peaks of interest eluted
in less than 16 minutes, but an additional
24-minute bake-out at 320 °C was required
to elute components with high boiling points.
The sample was rerun with a 4-minute
backflush, which cut the cycle time by 20
minutes per run – a 50% total cycle time
savings. Autosampler overlap functionality
and faster cool down saved an additional 4
minutes per cycle – that’s an additional 15
samples that can be run every 12 hours.
20 min. time savings
2500000
2000000
1500000
1000000
500000
0
0.00 0.20 0.40 0.60 0.80 1.00 1.20 1.40 1.60 1.80 2.00 2.20 2.40 2.60 2.80
5990-9104EN: High Throughput
Mineral Oil Analysis (Hydrocarbon
Oil Index) by GC-FID using the
Agilent Low Thermal Mass (LTM II)
System
Time (min)
LTM technology accelerates
analysis of TPH (Mineral Oil)
Fast oven temperature programming using a
low-thermal-mass system reduces cycle time
and increases sensitivity for GC-FID analysis
of mineral oil in environmental samples.
This technique meets regulated method
requirements for analyzing the C10-C40
hydrocarbon fraction in soil and water
extracts using splitless injection. The total
analytical cycle time was less than five
minutes.
Method Calculator makes it easy
to set up a method that shortens
analysis time or facilitates the
changing of carrier gas.
18
FOOD APPLICATIONS
Propargite
Cypermethrin I
Fenvalerate I
Hexazinone
Leptophos
Dieldrin
p,p'-DDE
Chlorpyrifos
Methyl parathion
Chlorpyrifos Methyl
Heptachlor
25-µL Solvent Vent (35 ºC)
Chlorothalonil
Bromacil
Malathion
Prometon
b-BHC
Atrazine
Lindane
Ethalfluralin
Trifluralin
Mevinphos
Dichlorvos
Agilent’s MMI has the same form factor
and uses the same consumables as our
split/splitless inlet, so you can replicate your
existing hot splitless methods. Its temperature
programmability also lets you perform both
cold splitless and large-volume injection (LVI)
methods for improved detection limits. An
integrated Solvent Elimination Calculator also
provides a complete set of initial conditions
for easy LVI method development.
MMI inlet
Vernolate
Lower detection limits with the
Agilent Multimode Inlet (MMI)
Mirex
CONFIDENTLY EXECUTE YOUR MOST SPECIALIZED ANALYSES
split/splitless inlet
10-µL Cold Splitless (30 ºC)
2-µL Hot Splitless (280 ºC)
4.00
Pesticides in milk extract:
Flow splitting enables multiple
detectors – increasing productivity
6.00
8.00
10.00
12.00
14.00
16.00
18.00
20.00
Total ion chromatogram comparing
a 25-μL solvent vent injection with a
2-μL hot splitless injection for 40-ppb
pesticides. Note the significant
signal-to-noise improvement (lower
detection limits).
5990-4169EN: Achieving Lower
Detection Limits Easily with the
Agilent Multimode Inlet (MMI)
Full scan TIC
Agilent’s flow splitting device proportionally
splits column effluent to multiple detectors.
Full-scan TIC from the MSD provides
quantitation and confirmation, while elementspecific GC signals highlight trace-level
compounds for MSD identification.
SIM
It took additional 33 min
and column heating to 320 ºC
to remove these high boilers.
µECD
DFPD(P)
5.00
10.00
15.00
20.00
25.00
30.00
35.00
40.00
The splitter also provides backflush
capabilities to shorten cycle time and
increase column life. Backflushing reduces
ion source contamination by preventing
column bleed and stopping heavy residues
from being introduced into the MSD. It also
eliminates carryover from any sample that
accumulates at the column head, improving
data integrity.
Run stopped at 42 min and
backflushed at 280 ºC for 7 min
Blank run after backflush
showing the column was clean
5
10
15
20
25
30
35
40
45
50
55
60
Four chromatograms collected simultaneously from a single injection of milk extract.
5989-6018EN: Improving Productivity and Extending Column Life with Backflush
To learn more about the Agilent 7890B GC, visit agilent.com/chem/7890B
19
65
70
min
FORENSIC/TOXICOLOGY APPLICATIONS
SCREEN AND QUANTITATE TARGET COMPOUNDS
IN COMPLEX MATRICES
Rapid drug screening: Obtain more
information in less time
Scan TIC
An Agilent Capillary Flow device splits column
eluent, allowing the simultaneous acquisition
of NPD and MSD data – and eliminating the
need for multiple runs on different GCs. CFT
Backflush further reduces cycle time and
stabilizes retention times.
1
2
Toxicology screen on real blood extract.
3
4
5
U
6
7
35
30
20
15
10
1.203 - ETHANOL
25
1.752- ACETONE
1.465 - ISOPROPANOL
40
1.971 - N-PROPANOL
FID1 A, Front Signal (2012-11-01\CHECK0000001.D
pA
5
0
0.5
0.75
1
1.25
1.5
1.75
2
2.25
2.5
min
1.75
2
2.25
2.5
min
40
1.342 - ETHANOL
35
30
25
20
15
1.587 - ISOPROPANOL
pA
1.494 - ACETONE
FID2 B, Front Signal (2012-11-01\CHECK0000001.D
1.057 - METHANOL
This system collects Scan, SIM, and NPD
data simultaneously. Scan is used to screen
for 725 toxic compounds. SIM is used for
selecting low-level targets. NPD is used for
confirmation aid and highlighting suspicious
non-targets.
NPD
0.955 - METHANOL
GC/NPD/MSD with simultaneous
SIM/Scan offers advantages such as broadrange screening for unlimited targets,
full-spectrum identity confirmation, and nontarget identification through Deconvolution
Reporting Software (DRS) library searches.
SIM TIC
10
5
0
0.5
0.75
1
1.25
1.5
Ethanol and mixed volatile calibrator at 0.01% per component. N-propanol ISTD. The compounds elute at different retention
times due to different column selectivities; therefore, two-channel analysis provides additional confirmation of accuracy.
20
INLETS, DETECTORS, AND ACCESSORIES
EXPAND THE POSSIBILITIES OF SYSTEM CONFIGURATION
A wide inlet selection lets you optimize your system
for your analysis
High-sensitivity detectors accommodate
every sample type
• Split/splitless (SSL) capillary
• Mass selective detector (MSD)
• Inert flow path split/splitless (ISSL) capillary
• Triple Quadrupole MS
• Multimode inlet (MMI)
• Q-TOF MS
• Purged packed injection port (PPIP)
• Ion Trap MS
• Cool on-column (COC)
•ICP-MS
• Cool on-column with solvent vapor exit (COC-SVE)
• Flame ionization detector (FID)
• Programmable temperature vaporizing (PTV)
• Thermal conductivity detector (TCD)
• Volatiles interface (VI)
• Micro-electron capture detector (Micro ECD)
• High-pressure gas sample injection
• Flame photometric, single- or dual-wavelength detector (FPD)
• Gas sampling valve (GSV)
• Nitrogen-phosphorus detector (NPD)
• Liquid sampling valve (LSV)
• Sulfur chemiluminescence detector (SCD)
• Nitrogen chemiluminescence detector (NCD)
• Atomic emission detector (AED)*
• Pulsed flame photometric detector (PFPD)*
• Photoionization detector (PID)*
• Electrolytic conductivity detector (ELCD)*
• Halogen specific detector (XSD)*
*Available through Agilent Channel Partners. Contact
Agilent for other custom configurations, and additional
solutions available through Agilent Channel Partners
• Oxygenate flame ionization detector (O-FID)*
• Pulsed discharge helium ionization detector (PDHID)*
GC and GC/MS Analyzers let you focus on system validation and data generation…
not method development
Agilent GC and GC/MS Analyzers are factory configured and chemically tested to meet method requirements, and get you on the “Fast
Track” to producing quality data and processing sample backlogs. More than just instruments, Agilent Analyzers are complete workflow
solutions that incorporate advanced technologies, such as Capillary Flow Technology and target compound databases that allow us to
optimize your system for your unique application.
Each Analyzer arrives ready to perform with pre-set chromatography and checkout samples to verify separation capabilities. That
means your team can work toward system validation as soon as installation is complete – and significantly reduce your method
development costs. And as always, our support team is available, should any problems arise.
To learn more about the Agilent 7890B GC, visit agilent.com/chem/7890B
21
SAMPLE PREPARATION
RELIABLY EXTRACT AND PREPARE SAMPLES
FROM COMPLEX MATRICES
Simplify sample prep with pre-packaged
Agilent Bond Elut QuEChERS Kits
• Extraction kits with pre-weighed salts in anhydrous packets allow you to add salts after
you add organic solvent – avoiding exothermic reactions.
• Dispersive kits accommodate the aliquot volumes specified by current AOAC
and EN methodologies.
• Ceramic homogenizers break up salt agglomerates, promoting consistent sample
extraction and increasing recovery.
Produce cleaner extracts using Agilent Bond Elut SPE
• A selection of polymer, silica, and other sorbents in formats ranging from multiple
cartridge sizes to 96-well plates.
• Consistent particle size ensures superior flow-through and performances.
• Vacuum manifolds and accessories help you meet all of your SPE challenges.
Make sample prep consistent, accurate, and safe with
the Agilent 7696A Sample Prep WorkBench
Agilent’s 7696A Sample Prep WorkBench combines precise automation with an intuitive
software interface to eliminate variability in dilution, extraction, standards addition, and
other key steps. It also significantly reduces exposure to hazardous solvents for long-term
peace-of-mind.
All prepared samples are finished in 2 mL vials that are compatible with most GC and
LC autosamplers for direct analysis without transferring to other sample containers.
To learn more, visit agilent.com/chem/sampleprep
22
UNMATCHED SERVICE AND SUPPORT
AGILENT STANDS BEHIND EVERY INSTRUMENT
Compliance
Agilent Value Promise
With over 100,000 qualification deliveries, and
decades of quality testing experience, Agilent is
your trusted source for the system qualification
and proof of calibration you need for regulatory
compliance.
We guarantee you at least 10 years of
instrument use from your date of purchase, or
we will credit you with the residual value of
the system toward an upgraded model.
Agilent Service Guarantee
Real-time support and reporting
If your Agilent instrument requires service
while covered by an Agilent service
agreement, we guarantee the repair, or we
will replace your instrument for free.
Agilent Remote Advisor is a remote monitoring,
diagnostic, and reporting feature now included
in all Agilent Advantage service plans. It can
help you preempt instrument problems to
maximize your uptime and productivity.
Workflow Services
Capillary Flow Technology (CFT) Backflush and
Backflush Assistant Software Wizard training are
available through Agilent Workflow Services.
Expert assistance in setting up your CFT
backflush method is just a phone call away.
To learn more about the Agilent 7890B GC, visit agilent.com/chem/7890B
23
THE AGILENT 7890B GC SYSTEM
RESOLVE YOUR SEARCH FOR
INTEGRATION, RELIABILITY,
AND INTELLIGENCE
• Powerful software tools for data acquisition, analysis, and reporting help you get the most
out of your instrument.
• Integrated Parts Finder tool and database makes it easy to find and order columns,
supplies, and parts.
• Inert GC Flow Path ensures higher sensitivity, accuracy, and reproducibility – especially at
trace levels.
• Capillary Flow Technology (CFT) enhances chromatographic capabilities.
• Direct GC
and gas.
MSD communication minimizes downtime while conserving power
• Eco-friendly features, such as sleep/wake modes, conserve electricity, helium,
and other resources.
• Early maintenance feedback keeps the system performing at its best.
• Fast oven cool-down, new backflush capabilities, and advanced automation
boost your productivity.
For more information
Learn more
agilent.com/chem/7890B
U.S. and Canada
1-800-227-9770
[email protected]
Europe
[email protected]
Asia Pacific
[email protected]
In other countries, please call your local Agilent Representative or
Agilent Authorized Distributor – visit agilent.com/chem/contactus
This information subject to change without notice.
© Agilent Technologies, Inc. 2013
Printed in the USA December 24, 2013
5991-1836EN
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