Agilent BIO-DIS Apparatus 3, Apparatus 7 Dissolution Tester Operator’s Manual

Below you will find brief information for Dissolution Tester BIO-DIS Apparatus 3, Dissolution Tester BIO-DIS Apparatus 7. The patented Apparatus 3 / 7 is ideal for extended-release products or any dosage form requiring release profiling at multiple pH levels. The Apparatus 3 / 7 transports each sample from one medium to the next, automatically, without operator intervention. Virtually any solid dosage form can be accommodated including pellets, tablets, and capsules.

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Agilent BIO-DIS

Apparatus 3 / 7

Operator’s Manual

Agilent Technologies

Notices

No part of this manual may be reproduced in any form or by any means (including electronic storage and retrieval or translation into a foreign language) without prior agreement and written consent from Agilent Technologies, Inc. as governed by

United States and international copyright laws.

Manual Part Number

70-9057

Edition

Rev C, March 2014

Agilent Technologies, Inc.

3501 Stevens Creek Blvd.

Santa Clara, CA 95052 USA

Warranty

The material contained in this document is provided “as is,” and is subject to being changed, without notice, in future editions. Further, to the maximum extent permitted by applicable law, Agilent disclaims all warranties, either express or implied, with regard to this manual and any information contained herein, including but not limited to the implied warranties of merchantability and fitness for a particular purpose. Agilent shall not be liable for errors or for incidental or consequential damages in connection with the furnishing, use, or performance of this document or of any information contained herein.

Should Agilent and the user have a separate written agreement with warranty terms covering the material in this document that conflict with these terms, the warranty terms in the separate agreement shall control.

Technology Licenses

The hardware and/or software described in this document are furnished under a license and may be used or copied only in accordance with the terms of such license.

Restricted Rights Legend

U.S. Government Restricted Rights. Software and technical data rights granted to the federal government include only those rights customarily provided to end user customers. Agilent provides this customary commercial license in Software and technical data pursuant to FAR 12.211

(Technical Data) and 12.212 (Computer

Software) and, for the Department of

Defense, DFARS 252.227-7015 (Technical Data - Commercial Items) and DFARS

227.7202-3 (Rights in Commercial Computer Software or Computer Software

Documentation).

Safety Notices

CAUTION

A CAUTION notice denotes a hazard. It calls attention to an operating procedure, practice, or the like that, if not correctly performed or adhered to, could result in damage to the product or loss of important data. Do not proceed beyond a CAUTION notice until the indicated conditions are fully understood and met.

WARNING

A WARNING notice denotes a hazard. It calls attention to an operating procedure, practice, or the like that, if not correctly performed or adhered to, could result in personal injury or death. Do not proceed beyond a

WARNING notice until the indicated conditions are fully understood and met.

Apparatus 3 / 7 Operator’s Manual

Figures

Tables

1 Safety

Electrical Hazards

Warning

Caution

Note

Information Symbols

2 Introduction

Conventions Used in this Manual

Serial Number Format

USP Suitability Test

USP Physical Parameters

3 Setting Up the Apparatus 3 / 7

Unpacking Your Equipment

Environmental Requirements for Installation

Setting up the Apparatus 3 / 7

Installing the Heater / Circulator

Filling the Water Bath

Installing Outer Media Tubes

Installing the Sample Tubes (Apparatus 3)

Installing the Sample Holders (6-row Apparatus 7)

Apparatus 3 / 7 Operator’s Manual 3

Contents

Installing the Sample Holders (12-row Apparatus 7)

Installing the Evaporation Curtains

Tightening the Evaporation Curtains

Powering Up the Apparatus 3 / 7

Hidden Key Functions

Configuring the Apparatus 3 / 7

4 Operating the Apparatus 3 / 7

Keypad Options

Main Menu

Setting Alarms

Heater / Circulator Control

Print

Start Dip / Stop Dip

Programing the Apparatus 3 / 7

Starting a Program

5 Conversion Procedures

300 mL to 100 mL Conversion

300 mL to 1L Conversion

1L to 300 mL Conversion

300 mL to Double Row Dip 1L Conversion

Alignment Procedure

Alignment Option 1

Alignment Option 2

General Conversion Procedures

Removing Bridge Assembly Panels

Replacing Bridge Assembly Panels

Installing the Evaporation Cover

Apparatus 3 / 7 Operator’s Manual

Removing the Agitator Shaft

Installing the Agitator Shaft

Cannula Removal

Cannula Installation

6 Maintenance and Troubleshooting

Preventive Maintenance

Daily Maintenance

Weekly Maintenance

Monthly Maintenance

Holder Care

Water Bath / Acrylic Care

Visual Checks

Report Center Impact Printer

Installing the Cartridge Ribbon

Replacing the Paper Roll

Toggling Your Printer Online

Printer Self Test

Printer Configuration

Fuse Replacement

Obtaining Warranty and Other Services

Index

Contents

Apparatus 3 / 7 Operator’s Manual 5

Contents

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6 Apparatus 3 / 7 Operator’s Manual

Figures

Figure 1. Standard 6-row Apparatus

Figure 2. Apparatus 7, Modified 12 x 12

Figure 3. Reciprocating Disk

Figure 4. Tubing Connection

Apparatus 3 / 7 Operator’s Manual 7

Figures

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8 Apparatus 3 / 7 Operator’s Manual

Tables

Table 1. Hidden Key Functions

Table 2. Select Row Style Options

Table 3. Keypad Options

Table 4. Main Menu Options

Table 5. Activate/Deactivate Alarms Options

Table 6. Bath Temperature Control/Report Options

Table 7. Print Selections Options

Table 8. Manual Dipping Options

Table 9. Program Variables Options

Table 10. Select Start Mode Options

Apparatus 3 / 7 Operator’s Manual 9

Tables

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10 Apparatus 3 / 7 Operator’s Manual

Agilent BIO-DIS Apparatus 3 / 7

Operator’s Manual

1 Safety

Electrical Hazards 11

The Apparatus 3 / 7 has been designed and tested so that when used properly you have an accurate, fast, flexible, and safe instrument.

If the equipment is used in a manner not specified by the manufacturer, the protection provided by the equipment may be impaired.

Operation of an Apparatus 3 / 7 involves the use of solid dosage forms and aqueous liquids. Unskilled, improper, or careless use of this instrument can create shock hazards, fire hazards, or other hazards which can cause death, serious injury to personnel, or severe damage to equipment and property.

Information on safety practices is provided with your instrument and operation manuals. Before using your instrument or accessories, you must thoroughly read these safety practices.

Observe all relevant safety practices at all times.

Electrical Hazards

The Apparatus 3 / 7 contains electrical circuits, devices, and components operating at dangerous voltages. Contact with these circuits, devices, and components can cause death, serious injury, or painful electric shock.

Panels or covers that are retained by fasteners which require the use of a tool for removal may be opened only by Agilent-trained,

Agilent-qualified, or Agilent-authorized service engineers. Consult the manuals or product labels supplied with the 8020 to determine which parts are operator-accessible.

Agilent Technologies

1 Safety

Application of the wrong supply voltage, connection of the instrument to an incorrectly wired supply outlet, or lack of proper electrical grounding can create a fire hazard or a potentially serious shock hazard and could seriously damage the instrument and any attached ancillary equipment.

Always use a three-wire outlet with ground connection which is adequately rated for the load. The installation must comply with local, state, and federal safety regulations.

Do not connect the instrument to the main power supply until you have made sure that the operating voltage is correctly set for the main power supply in the specific outlet in your laboratory to which the equipment will be connected.

12 Apparatus 3 / 7 Operator’s Manual

Safety 1

Warning

WARNING

A ‘Warning’ message appears in the manual when failure to observe instructions or precautions could result in death or injury.

Read all warnings and cautions carefully and observe them at all times.

Caution

CAUTION

A ‘Caution’ message appears in the manual when failure to observe instructions could result in damage to equipment (Agilent supplied and / or other associated equipment).

Note

NOTE

A ‘Note’ appears in the manual to give advice or information.

Apparatus 3 / 7 Operator’s Manual 13

1 Safety

Information Symbols

Switches main power on

Switches main power off

Indicates single-phase alternating current

Indicates the product complies with the requirements of one or more European Union

(EU) directives.

Indicates specific equipment meets standards of safety. These products are safe for use in the workplace for North America.

Indicates that this product must not be disposed of as unsorted municipal waste.

All Agilent products that are subject to the

WEEE directive shipped after August 13, 2005 are compliant with the WEEE marking requirements. Such products are marked with the

“crossed out wheelie bin” WEEE symbol in accordance with European Standard EN 50419.

For more information on collection, reuse, and recycling systems, please contact your local/regional waste administration, your local distributor, or Agilent.

Indicates the product complies with regulatory compliance requirements of New Zealand and

Australia.

Apparatus 3 / 7 Operator’s Manual

Agilent BIO-DIS Apparatus 3 / 7

Operator’s Manual

2 Introduction

Conventions Used in this Manual 19

Serial Number Format 19

USP Suitability Test 20

USP Physical Parameters 20

Agilent Technologies

2 Introduction

The patented Apparatus 3 / 7 is ideal for extended-release products or any dosage form requiring release profiling at multiple pH levels.

Capable of running unattended for periods of up to six days, the unit can store up to 15 programs and allows almost any aspect of a test to be programmed including dip speed, time in each row, hold dip time, and drain time. The seven test samples traverse the six rows of corresponding outer media tubes filled with different media. The

Apparatus 3 / 7 transports each sample from one medium to the next, automatically, without operator intervention. Virtually any solid dosage form can be accommodated including pellets, tablets, and capsules.

Custom Apparatus 3 / 7 are available. Depending on the Apparatus 3 configuration, media volume of the outer media tube can vary from

100 mL, 300 mL (USP), or 1000 mL. This manual covers the operation of the standard 7-tube, 6-row systems as well as the modified 12-tube,

12-row Apparatus 7 system (see

Figure 1, “Standard 6-row Apparatus,”

and

Figure 2 , “Apparatus 7, Modified 12 x 12,” on page 17).

Figure 1

Standard 6-row Apparatus

Apparatus 3 / 7 Operator’s Manual

Introduction 2

Figure 2

Apparatus 7, Modified 12 x 12

A built-in Report Center Printer provides hard-copy documentation of testing progress and conditions. A four-line digital display provides constantly updated operation information as a test proceeds.

The temperature is maintained by the heater / circulator. All parameters are controlled via the Apparatus 3 / 7 keypad. Automated sampling can be performed using the 8000. This unit can be pre-programmed to withdraw samples at designated time points. Samples can be collected into either test tubes or pre-capped HPLC vials for direct transfer to an

HPLC system. Septa are pierced using the exclusive needle manifold, which lowers and raises at each sample time point. Sample trays are available in a variety of sizes to accommodate almost any size vial or test tube.

CAUTION

Panels or covers that are retained by fasteners which require the use of a tool for removal may be opened only by Agilent-trained,

Agilent-qualified, or Agilent-authorized service engineers.

Apparatus 3 / 7 Operator’s Manual 17

2 Introduction

There are various types of Apparatus 7 sample holders. Reciprocating disks with O-rings (see

Figure 3 , “Reciprocating Disk,” on page 18)

hold the transdermal systems in place as they move through the medium. The 12-row system uses custom sample holders. The inverted basket is a modified version of the Japanese sinker basket and can be used with many types of solid dosage forms.

NOTE

Figure 3

Reciprocating Disk

The sample holders used with the standard 6-row system cannot be used with the 12-row system.

WARNING

The apparatus contains electrical circuits, devices, and components operating at dangerous voltages. Contact with these circuits, devices, and components can cause death, serious injury, or painful electric shock.

18 Apparatus 3 / 7 Operator’s Manual

Introduction 2

Conventions Used in this Manual

• Items you are asked to press are in bold. For example, “press H on the keypad”.

• Key sequences you are asked to press appear like this: MENU > 0 >

Serial Number Format

The serial number contains 10 characters and follows this syntax:

CC 12 34 xxxx

Syntax Code Meaning

Country of origin

Description

2 alpha characters matching the required trade designation for the country of origin

Year of manufacture ‘09’ for 2009, ‘10’ for 2010, etc.

Week of manufacture ‘01’ for week 1 to ‘52’ for week 52

Apparatus 3 / 7 Operator’s Manual 19

2 Introduction

USP Suitability Test

NOTE

Before the first use of an Apparatus 3, run an apparatus suitability test with USP Chlorpheniramine Maleate extended-release calibrator tablets. Calibrator tablets are available from the USP at the following address:

USP

12601 Twinbrook Parkway

Rockville, MD 20852

(301) 881-0666 or (800) 227-8772

Complete instructions come with the calibrators. Apparatus suitability tests can be very sensitive to factors such as shaft misalignment, vessel shape, vibration of the system, age of the calibrators, reference standards, and many other factors. Contact the Dissolution Systems

Service Department if you have any questions regarding these procedures.

There is no USP apparatus suitability test for the Apparatus 7.

USP Physical Parameters

In addition to the apparatus suitability test, you must monitor several physical parameters, such as stroke distance, dip speed, and temperature. A Certificate of Compliance is included with your

Apparatus 3 / 7. Contact the Laboratory Services Department for more information on USP physical parameters.

20 Apparatus 3 / 7 Operator’s Manual

Agilent BIO-DIS Apparatus 3 / 7

Operator’s Manual

3 Setting Up the Apparatus 3 / 7

Unpacking Your Equipment 22

Setting up the Apparatus 3 / 7 23

Powering Up the Apparatus 3 / 7 31

Hidden Key Functions 32

Agilent Technologies

3 Setting Up the Apparatus 3 / 7

Unpacking Your Equipment

WARNING

Complete the following steps to safely unpack your apparatus and accessories:

1 Open each carton carefully and check the contents for any damages which may have occurred during shipping. Damage rarely occurs, but if it does, contact both the carrier who delivered the instruments and the Dissolution Systems Service Department. Though claims for damage are filed with the carrier, we can help you file a claim and get up and running as quickly as possible.

2 Carefully remove the Apparatus 3 / 7 from its shipping carton.

The Apparatus 3 / 7 is heavy and the track on the left side is sharp. Do not lift it alone. Also, do not lift the instrument by the drive unit. Lift by holding the water bath frame.

WARNING

3 Remove all cushioning material and tape.

4 Place the instrument on a clean, dry, level section of bench top with the drive unit front panel facing you.

5 Place the heater / circulator next to the unit.

The electrical connection at the back of the instrument is the primary disconnect. The instrument should be positioned to allow accessibility to the power cords for easy disconnection.

22 Apparatus 3 / 7 Operator’s Manual

Setting Up the Apparatus 3 / 7 3

Environmental Requirements for Installation

• Humidity: max relative humidity 80% for temperatures up to 31 ºC decreasing linearly to 50% relative humidity at 40ºC

• Indoor use only

• Pollution Degree: 2

• Installation Category: II

• Altitude: 2000 m

• Temperature: 5 ºC to 40ºC

• Power: 115/230 V ac, 50/60 Hz, 2 A

Main supply voltage fluctuations are not to exceed ± 10% of the nominal supply voltage

Setting up the Apparatus 3 / 7

WARNING

1 Level the Apparatus 3 / 7 by placing the circular level on the appropriate vessel carrier. Check for level in the front and rear center and the left and right sides. Turn the adjustable rubber feet on the bottom of the water bath frame until the bubble in the level is in the center circle at all four check points.

2 Ensure the power switch on the rear panel is in the OFF position.

3 Connect the power cord to the power receptacle on the Apparatus 3 /

7 rear panel.

4 Plug the power cord into an electrical outlet of the appropriate voltage.

Ensure the Apparatus 3 / 7 is configured for the voltage available in your laboratory.

Apparatus 3 / 7 Operator’s Manual 23

3 Setting Up the Apparatus 3 / 7

Installing the Heater / Circulator

The Apparatus 3 / 7 uses a single water bath connected directly to the inlet and outlet of the heater / circulator. Complete the following steps to install the heater / circulator:

1 Locate the heater / circulator tubing kit containing two lengths of

1/2-inch plastic tubing (one long, one short) and four tubing clamps.

NOTE

These instructions assume the heater / circulator is placed to the right of the Apparatus 3 / 7 when looking at the front of the equipment. If your heater / circulator is placed to the left of the Apparatus 3 / Apparatus 7, use the longer tubing when the instructions call for the shorter tubing and the shorter tubing when the instructions call for the longer tubing.

CAUTION

2 Locate the tubing clamps in the tubing kit. Place a clamp over one end of the shorter of the two lengths of tubing supplied. Carefully place this end of the tubing over the connector labeled INLET on the heater / circulator. Slide the tubing on until it meets the panel.

3 Slide the tubing clamp over the connector and tighten securely.

Do not overtighten the clamp as damage may occur.

CAUTION

4 Place a tubing clamp over the opposite end of the same piece of tubing. Attach the tubing to the open end of the Y connector coming from the barbed-angle tubing adapter on the right side of the water

bath (see Figure 4, “Tubing Connection,” below).

5 Slide the tubing clamp over the connector and tighten securely.

•

Do not overtighten the clamp as damage may occur.

24 Apparatus 3 / 7 Operator’s Manual

Apparatus 3 / 7 Operator’s Manual

Setting Up the Apparatus 3 / 7 3

Figure 4

Tubing Connection

6 Connect the water bath inlet located on the rear of the water bath to the heater / circulator rear panel connector labeled OUTLET in the same fashion using the longer piece of tubing.

7 Plug the supplied temperature probe into the BATH TEMP jack on the Apparatus 3 / 7 right side panel.

8 Place the temperature probe through the small hole in the vessel table at the rear left side of the instrument so that approximately 3/4 of the probe is below the surface of the table.

3 Setting Up the Apparatus 3 / 7

NOTE

9 Attach the four-pin DIN cable between the jack labeled INPUT

SIGNAL on the heater / circulator rear panel and the jack labeled

HEATER CIRCL. on the Apparatus 3 / 7 right side panel. The heater

/ circulator uses the temperature measured by the Apparatus 3 / 7 to control the water bath temperature.

Do not fill the water bath at this time.

10 Ensure the heater / circulator is powered off.

11 Connect the power cord to the power receptacle on the rear panel of the heater / circulator.

12 Plug the power cord into an electrical outlet of the appropriate voltage.

26 Apparatus 3 / 7 Operator’s Manual

Setting Up the Apparatus 3 / 7 3

Filling the Water Bath

1 Pour ultrapure water through one of the outer media tube holes in the vessel carrier. Fill the water bath 3/4 full to allow for displacement by the tubes.

NOTE

If possible, preheat the water to the desired water bath temperature. Use ultrapure water when possible to minimize scale and mineral buildup.

Use algaecide to inhibit mold and bacteria growth. Check the label to ensure the formulation is compatible with the plastic materials used in the water bath construction. The flow paths of the heater / circulator are primarily stainless steel and should tolerate most clear bath formulations.

NOTE

2 Turn on the heater / circulator.

3 Check all connections for leaks. Occasionally, bubbles appear from the water bath inlet as the air in the system is purged. After a few minutes flow into the water bath is smooth and steady.

Although the heater / circulator is designed to be self-priming, you occasionally have to help the priming process in a dry unit. Do this by holding the unit below the level of the water bath for a minute or two, with the back end up, to help bubbles clear from the unit. To prevent bubbles from getting into the heater / circulator flow path, it may be necessary to prime the drain hose attached to the Y connector.

Apparatus 3 / 7 Operator’s Manual 27

3 Setting Up the Apparatus 3 / 7

Installing Outer Media Tubes

The outer media tubes should be installed immediately prior to testing only. If the outer media tubes are placed in position without media, they float and can damage the agitator shafts and drive mechanism.

Installing the Sample Tubes (Apparatus 3)

1 At the first tube position, push up the evaporation cover to expose the stainless steel rod underneath.

2 Screw the inner sample tube into the stainless steel rod.

3 Release the evaporation cover.

4 Repeat steps 1 - 3 for each tube position.

Installing the Sample Holders (6-row Apparatus 7)

1 At the first tube position, push up the evaporation cover to expose the stainless steel rod underneath.

2 Loosen the set screw on the stainless steel rod.

3 Insert the sample holder into the bottom of the stainless steel rod.

4 Set the sample holder to the desired height.

5 Secure the sample holder by tightening the set screw.

6 Release the evaporation cover.

7 Repeat steps 1 - 6 for each tube position.

28 Apparatus 3 / 7 Operator’s Manual

Setting Up the Apparatus 3 / 7 3

Installing the Sample Holders (12-row Apparatus 7)

1 At the first tube position, push up the evaporation cover to expose the stainless steel rod underneath.

2 Insert the sample holder into the white plastic retaining ring attached to the bottom of the stainless steel rod.

3 Release the evaporation cover.

4 Set the sample holder to the desired height.

5 Repeat steps 1 - 4 for each tube position.

Installing the Evaporation Curtains

There are two evaporation curtains located in the front and rear of the

Apparatus 3 / 7 frame. Remove the tie wraps securing the curtains and carefully pull each curtain toward the drive unit. Place the left and right sides of the metal rods into the brackets located on the drive unit.

Apparatus 3 / 7 Operator’s Manual 29

3 Setting Up the Apparatus 3 / 7

Tightening the Evaporation Curtains

NOTE

1 Remove the front evaporation curtain rod ends from the brackets on the drive unit and allow it to carefully wind up.

2 Lift the flat end of the rod leaving the round end in its original position.

3 Using pliers, rotate the flat end approximately 20 - 25 times.

To keep an accurate count, do not remove the pliers while turning.

NOTE

4 Using the pliers, carefully slide the flat end of the rod back to its original position and replace it in the bracket on the drive unit.

To prevent accumulation of media residue, wipe the evaporation curtains with a damp cloth. Then, wipe dry. Failure to do so may result in binding or “sticking” of the evaporation curtains.

5 Repeat steps 1 - 4 for the back evaporation curtain.

30 Apparatus 3 / 7 Operator’s Manual

Setting Up the Apparatus 3 / 7 3

Powering Up the Apparatus 3 / 7

CAUTION

Ensure the retaining ties have been removed. Failure to do so could result in significant damage to the instrument.

WARNING

Turn on the Apparatus 3 / 7. The drive unit moves slightly forward from its home position and returns.

The electrical connection at the back of the apparatus is the primary disconnect for the instrument.

After the Apparatus 3 / 7 is powered up, the system monitor screen illuminates and displays the initial status screen briefly.

APP 3 / 7 TESTER

PROGRAM REVISION x.xx

INITIALIZING... PLEASE WAIT

TIME:04/16/12 10:08:00 ELAPSE:002:04:00

The firmware version (program revision) displays. This is the only time the firmware version level displays. Record the number below and refer to it if you need to call the Dissolution Systems Service Department.

Firmware version

After three seconds, the Ready screen displays.

READY

PGM# 1 Set DPM 15 BATH TEMP: 32.0 °C

TIME:04/16/12 10:08:00 ELAPSE:002:04:00

Apparatus 3 / 7 Operator’s Manual 31

3 Setting Up the Apparatus 3 / 7

Hidden Key Functions

Table 1

Hidden Key Functions

Key Sequence

MENU > 0 > 8

MENU > 0 > 9

MENU > 0 > A

MENU > 0 > B

MENU > 0 > C

MENU > 0 > F

Function

Use this key sequence to select the plate style. Select option 1, Module Plate. The Main

Menu displays. Press ESC to return to the Ready screen.

Note: Select option 1, Module Plate, or the instrument will not operate properly.

Use this key sequence to select the row style. See

“Configuring the Apparatus 3 / 7” on page 33.

Use this key sequence to configure the apparatus for a single universal DPM or a different DPM for each row. Select option 1, Single DPM, to run the same DPM throughout a program. Optionally, select option 2, DPM for Each Row, to run a different DPM for each row. The Main Menu displays. Press ESC to return to the

Ready screen.

See “SET SPEED” on page 36 and

“1 Dip Per Minute” on page 44.

Use this key sequence to enable or disable the peristaltic pump option. Select option 1 to enable or option 2 to disable the peristaltic pump. The Main Menu displays. Press

ESC to return to the Ready screen.

Use this key sequence to select the printer type. Select option 2, Impact. The Main

Menu displays. Press ESC to return to the Ready screen.

Note: Select option 2, Impact, or the instrument will not operate properly.

Use this key sequence to select the date display style. Select option 1, MM/DD/YY, or option 2, DD/MM/YY. The Main Menu displays. Press ESC to return to the Ready screen.

32 Apparatus 3 / 7 Operator’s Manual

Setting Up the Apparatus 3 / 7 3

Configuring the Apparatus 3 / 7

To configure the number of rows on your Apparatus 3 / 7, complete the following steps:

1 For firmware versions lower than 5.07, from the Ready screen press

MENU > 0 > 9. The Select Row Style screen displays.

For firmware versions 5.07 or higher, from the Ready screen press

MENU > 0 > 7. The Select Row Style screen displays.

***SELECT ROW STYLE***

1 ONE

5 EIGHT

2 TWO

6 TWELVE

3 THREE

7 TWELVE EXT

TIME:04/16/12 10:08:49 ELAPSE:000:01:09

Table 2

Select Row Style Options

2 Select one of the following options:

Option

1 One

2 Two

3 Three

4 Six

5 Eight

6 Twelve

7 Twelve Ext

4 SIX

Function

Select option 1, One, for the 1L double row dip configuration. The Main Menu displays.

Select option 2, Two, for the 2-row configuration. The Main Menu displays.

Select option 3, Three, for the 1L configuration or the double row dip with the standard 6-row configuration. The Main Menu displays.

Select option 4, Six, for the standard 6-row configuration. The Main Menu displays.

Select option 5, Eight, for the modified 8-row configuration. The Main Menu displays.

Select option 6, Twelve, for the modified 12-row configuration. The Main Menu displays.

Select option 7, Twelve Ext, for the modified 12-row configuration. Selecting this option moves the drive unit an additional inch in order to bring the sample holders / tubes to rest over the drip tray rather than the last row.

Press ESC to return to the Ready screen.

Apparatus 3 / 7 Operator’s Manual 33

3 Setting Up the Apparatus 3 / 7

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34 Apparatus 3 / 7 Operator’s Manual

Agilent BIO-DIS Apparatus 3 / 7

Operator’s Manual

4 Operating the Apparatus 3 / 7

Keypad Options 36

Main Menu 38

Print 41

Programing the Apparatus 3 / 7 43

Agilent Technologies

4 Operating the Apparatus 3 / 7

Keypad Options

CAUTION

Verify the proper configuration of your Apparatus 3 / 7 before operating. Improper configuration may seriously damage your instrument.

See “Configuring the Apparatus 3 / 7” on page 33

.

The keypad on the Apparatus 3 / 7 is similar to a personal computer keyboard. For example, it has a SPACE key, an ENTER key, and a

SHIFT key. These keys function exactly like their counterparts on a personal computer or typewriter keyboard. The keypad options are discussed on the following pages.

Table 3

Keypad Options

Option

SET SPEED

PROG

START PROG

START DIP

STOP DIP

GOTO ROW

CLEAR ROW

Function

See

“Main Menu” on page 38.

Press PRINT to record the batch information, print the dip and drain times, enable or disable the Report Center Printer, select a local or remote printer, set the communications port identification number, and set the baud rate. See

“Print” on page 41.

Press SET SPEED to manually enter the dips per minute. Enter the desired dips per minute and press ENTER. The Ready screen displays.

Use this option to set the program parameters. See

“Programing the Apparatus 3 /

7” on page 43.

Use this option to start a program. See “Starting a Program” on page 45.

Use this option to set the parameters for manual dipping. See “Start Dip / Stop Dip” on page 42.

Press STOP DIP to stop manual dipping. See “Start Dip / Stop Dip” on page 42.

Press GOTO ROW to move the drive unit to the entered row. Enter a row number and press ENTER. The drive unit moves to the desired row and the Ready screen displays.

Press CLEAR ROW to move the drive unit to the next row providing clearance in the initial row. If the sample tubes / sample holders are at the rear-most row, press

CLEAR ROW to move the drive unit to the home position. Press RESUME PROG to move the drive unit back to the initial row and continue the program.

Note: it is necessary to pause the program before pressing CLEAR ROW. See “PAUSE

PROG” below.

36 Apparatus 3 / 7 Operator’s Manual

Operating the Apparatus 3 / 7 4

Table 3

Keypad Options

Option

PAUSE PROG

RESUME PROG

HOME

LOCK KBRD

Function

Press PAUSE PROG to pause a running program. The Apparatus 3 / 7 drive unit lifts the inner sample tubes / sample holders out of the media.

Press RESUME PROG to resume a paused program.

Press HOME to return the drive unit to the home position.

Press LOCK KBRD to lock the keypad. Press LOCK KBRD again to unlock the keypad.

Apparatus 3 / 7 Operator’s Manual 37

4 Operating the Apparatus 3 / 7

Main Menu

From the Ready screen, press MENU. The Main Menu displays.

***MAIN MENU***

1 SET CLOCK

3 BATH TEMPERATURE

5 MANUAL HOLD DIP

2 SET ALARMS

4 DELAY START TIME

Following is a description of the Main Menu screen options:

Table 4

Main Menu Options

Option

1 Set Clock

2 Set Alarms

3 Bath Temperature

4 Delay Start Time

5 Manual Hold Dip

Function

Select option 1, Set Clock. Enter the current date in the appropriate format and press ENTER. Enter the current time in 24-hour format and press ENTER. The

Main Menu displays.

See

“Setting Alarms” on page 39.

See

“Heater / Circulator Control” on page 40.

Select option 4, Delay Start Time. Enter the desired start time in 24-hour time format and press ENTER. Enter the start date in the appropriate format and press ENTER. The Main Menu displays.

Note: this information is stored for use in all programs under Program Start. See

“Starting a Program” on page 45.

Use this option to stop the inner sample tubes / sample holders at the bottom of the stroke for the length of time entered. For the Apparatus 3, this allows for adequate filling of the inner sample tube with dissolution medium before the dipping cycle begins.

Select option 5, Manual Hold Dip. Enter the desired duration and press ENTER.

The Main Menu displays.

38 Apparatus 3 / 7 Operator’s Manual

Operating the Apparatus 3 / 7 4

Setting Alarms

From the Main Menu, select option 2, Set Alarms. The

Activate/Deactivate Alarms screen displays.

***ACTIVATE/DEACTIVATE ALARMS***

1 ELAPSED TIMER

3 PRG COMPLETION

2 ROW DIP COMPLETION

TIME:04/16/12 10:08:49 ELAPSE:000:01:09

Following is a description of the Activate/Deactivate Alarms screen options:

Table 5

Activate/Deactivate Alarms Options

Option Function

1 Elapsed Timer The elapsed time alarm sounds when the entered time span has passed. For example, use it as a reminder when the entire test has been completed or when a certain phase of the test is finished.

Select option 1, Elapsed Timer. To activate the elapsed timer, enter the desired duration and press

ENTER. To deactivate the elapsed timer, enter 00:00 and press ENTER. The Activate/Deactivate

Alarms screen displays. Press ESC to return to the Main Menu. Press ESC again to return to the

Ready screen.

Note: press ENTER to silence the alarm.

2 Row Dip

Completion

3 Prg

Completion

The row dip completion alarm sounds when a row dip is finished.

Select option 2, Row Dip Completion. The Row Dipping Completion Alarm screen displays. Select option 1, Enable, to enable the alarm. Optionally, select option 2, Disable, to disable the alarm. The

Activate/Deactivate Alarms screen displays. Press ESC to return to the Main Menu. Press ESC again to return to the Ready screen.

Note: press ENTER to silence the alarm.

The program completion alarm sounds when a program is finished.

Select option 3, Prg Completion. The Program Completion Alarm screen displays. Select option 1,

Enable, to enable the alarm. Optionally, select option 2, Disable, to disable the alarm. The

Activate/Deactivate Alarms screen displays. Press ESC to return to the Main Menu. Press ESC again to return to the Ready screen.

Note: press ENTER to silence the alarm.

Apparatus 3 / 7 Operator’s Manual 39

4 Operating the Apparatus 3 / 7

Heater / Circulator Control

From the Main Menu, select option 3, Bath Temperature, to control the heater / circulator. The Bath Temperature Control/Report screen displays.

***BATH TEMPERATURE CONTROL/REPORT***

1 SET BATH TEMP

3 CALIBRATION

2 DELAY HEATING

4 DISABLE (ENABLE) REPORT

TIME:04/16/12 10:08:49 ELAPSE:000:01:09

Following is a description of the Bath Temperature Control/Report screen options:

Table 6

Bath Temperature Control/Report Options

Option

1 Set Bath Temp

2 Delay Heating

3 Calibration

4 Disable / Enable

Report

Function

Select option 1, Set Bath Temp. Enter the desired water bath temperature in xx.x format and press ENTER. The Main Menu displays. Press ESC to return to the Ready screen.

Select option 2, Delay Heating. Enter the desired start time in 24-hour format and press

ENTER. Enter the start date in the appropriate format and press ENTER. The top line of the screen continues to flash until the function is canceled or until the set date and time are reached.

To cancel the delayed heating function, press ESC. The Ready screen displays.

Note: any time and day of the week is acceptable. Pumping functions are not affected by the delay. This feature inhibits the growth of organisms and evaporation by allowing the water bath to be heated only when necessary rather than continuously.

Select option 3, Calibration, to calibrate the temperature to 1/100 of a degree.

Press ESC to return to the Ready screen.

Use this option to control whether or not the water bath temperature displays on the screen.

Select option 4 to toggle between

ENABLE REPORT

and

DISABLE REPORT

. Press ESC twice to return to the Ready screen.

Note: the Bath Temperature Control/Report screen displays the opposite of the current status. If the temperature control / report is enabled,

DISABLE REPORT

displays. If the temperature control / report is disabled,

ENABLE REPORT

displays. If the temperature control / report is disabled, the temperature does not display on the screen.

40 Apparatus 3 / 7 Operator’s Manual

Operating the Apparatus 3 / 7 4

Print

From the Ready screen, press PRINT. Enter a program number and press ENTER. The Print Selections screen displays.

***PRINT SELECTIONS***

1 BATCH INFORMATION

3 TURN OFF (ON) REP CENTER

5 SET COM PORT ID

2 DIP/DRAIN TIMES

4 CHANGE TO REMOTE (LOCAL)

6 SET BAUD RATE

Following is a description of the Print Selections screen options:

Table 7

Print Selections Options

Option

1 Batch Information

2 Dip/Drain Times

3 Turn Off / On Rep Center

4 Change to Remote / Local

5 Set Com Port ID

6 Set Baud Rate

Function

Select option 1, Batch Information, to print the program number, operator, product and batch information.

Select option 2, Dip/Drain Times, to print the dip and drain times.

Select option 3 to toggle between

TURN OFF REP CENTER

and

TURN ON REP

CENTER

Note: this option displays the opposite of the current status. If the printer is enabled,

TURN OFF REP CENTER

displays. If the printer is disabled,

TURN ON REP

CENTER

displays.

Select option 4 to toggle between

CHANGE TO REMOTE

and

CHANGE TO LOCAL

Note: this option displays the opposite of the current status. If using the local printer on the Apparatus 3 / 7,

CHANGE TO REMOTE

displays. If using a remote or external printer,

CHANGE TO LOCAL

displays.

Select option 5, Set Com Port ID, to set the communications port identification number. Enter 01 and press ENTER. The Print Selections screen displays.

Select option 6, Set Baud Rate, to set the baud rate on the Apparatus 3 / 7. Select option 4, 9600 Baud. The Print Selections screen displays.

Apparatus 3 / 7 Operator’s Manual 41

4 Operating the Apparatus 3 / 7

Start Dip / Stop Dip

From the Ready screen, press START DIP. The Manual Dipping screen displays.

***MANUAL DIPPING***

1 START

3 GOTO ROW

2 SET SPEED (DPM)

4 SET HOLD DIP TIME

ROW # Set DPM xx Hold DIP TIME xx:xx

Following is a description of the Manual Dipping screen options:

Table 8

Manual Dipping Options

Option

1 Start

2 Set Speed (DPM)

3 Goto Row

4 Set Hold Dip Time

Function

Select option 1, Start, to begin manual dipping. To start dipping manually, the drive unit must be at a row position. If it is at home position, the start option is blocked.

Note: select this option last.

Select option 2, Set Speed (DPM). Enter the desired DPM and press ENTER. The

Manual Dipping screen displays.

This option functions just like the SET SPEED function key. See “SET SPEED” on page 36

Select option 3, Goto Row. Enter the desired row number and press ENTER. The

Apparatus 3 / 7 drive unit moves to the entered row. The Manual Dipping screen displays.

This option functions just like the GOTO ROW function key. See “GOTO ROW” on page 36.

Select option 4, Set Hold Dip Time. Enter the desired interval and press ENTER.

The Manual Dipping screen displays.

This option functions just like Main Menu option 5, Manual Hold Dip. See “5

Manual Hold Dip” on page 38.

42 Apparatus 3 / 7 Operator’s Manual

Operating the Apparatus 3 / 7 4

NOTE

Press STOP DIP to manually stop dipping. The inner sample tubes / sample holders are lifted out of the outer media tubes and the instrument stops.

Options 2 and 4 are also options on other screens. You can adjust these parameters from different points in the manual operation.

Programing the Apparatus 3 / 7

NOTE

Programs are not write-protected. Check with other users before proceeding.

NOTE

From the Ready screen, press PROG. Enter a program number and press ENTER. The Program Variables screen displays.

The Apparatus 3 / 7 can accept and store up to 15 different program sequences.

All programming begins at the Ready screen.

***PROGRAM VARIABLES***

1 DIP PER MINUTE

3 DRAIN TIME

5 BATCH INFORMATION

2 DIP TIME INTERVAL

4 HOLD DIP TIME

6 PRINT FREQUENCY

Apparatus 3 / 7 Operator’s Manual 43

4 Operating the Apparatus 3 / 7

Table 9

Program Variables Options

Following is a description of the Program Variables screen options:

Option

1 Dip Per Minute

2 Dip Time Interval

3 Drain Time

4 Hold Dip Time

5 Batch Information

6 Print Frequency

Function

Select option 1, Dip Per Minute. Enter the desired dips per minute and press

ENTER. The Program Variables screen displays.

Select option 2, Dip Time Interval. Enter the duration of dipping time for each row and press ENTER to advance to each remaining row. To skip a row of outer media tubes, enter a dip time of 0 for that row and press ENTER. After the last row dip time interval has been entered, the Program Variables screen displays.

Select option 3, Drain Time. Enter the duration the inner sample tubes / sample holders drain over the outer media tubes after being lifted from the media and press

ENTER to advance to each remaining row. After the last drain time has been entered, the Program Variables screen displays.

Select option 4, Hold Dip Time. Enter the duration the inner sample tubes / sample holders are stopped at the bottom of the stroke before dipping begins and press

ENTER to advance to each remaining row. After the last hold dip time interval has been entered, the Program Variables screen displays.

Select option 5, Batch Information. The Batch # Selections screen displays. For each option, enter the desired information and press ENTER. Press ESC to return to the

Program Variables screen.

Note: the Batch # Selections screen displays options for the report header information. The print field accepts ten characters. Characters can be letters, numbers, special characters or spaces. The information entered for each selection prints in the header of each printout. The entries made from this menu are attached to the active program. Since there are 15 programs, there can be a different set of entries for each. All are stored in the battery-protected memory and remain until changed via this menu.

Select option 6, Print Frequency, to enter how often the Apparatus 3 / 7 status prints during a dip time interval. Enter a time interval in minutes (for example, enter 005 for 5 minutes) and press ENTER. If no status printout is desired, enter 000 for the time interval.

Note: do not use this option to disable the Report Center Printer. If no printout is desired, turn off the printer via the Print Selections screen option 3. See “3 Turn Off

/ On Rep Center” on page 41.

44 Apparatus 3 / 7 Operator’s Manual

Operating the Apparatus 3 / 7 4

NOTE

After entering the desired parameters, press ESC to return to the Ready screen. Press PRINT, enter the program number and press ENTER to print and review the program before beginning the test.

Starting a Program

From the Ready screen, press START PROG. Enter a program number and press ENTER. The Select Start Mode screen displays.

***SELECT START MODE***

1 START NOW

3 REMOTE START

PRG# 29 SetDPM 8

2 DELAYED START

4 MODIFY PROGRAM

Apparatus 3 / 7 Operator’s Manual 45

4 Operating the Apparatus 3 / 7

Following is a description of the Select Start Mode screen options:

Table 10 Select Start Mode Options

Option

1 Start Now

2 Delayed Start

3 Remote Start

4 Modify Program

Function

Select option 1, Start Now, to begin the test according to the programmed variables.

Select option 2, Delayed Start, to begin the test at the delayed start time. The values entered under Main Menu option 4 display, if applicable. See “4 Delay Start

Time” on page 38. To change the start time and date, enter the desired start time in

24-hour format and press ENTER. Enter the desired date in the appropriate format and press ENTER.

Note: entering new values under Select Start Mode option 2 changes the values under Main Menu option 4 as well.

Select option 3, Remote Start, to start the program from a remote unit. The Ready screen displays. Contact the Dissolution Systems Service Department to discuss the use of this option.

Select option 4, Modify Program, to modify or review the program parameters.

The Program Variables screen displays. See “Programing the Apparatus 3 / 7” on page 43 for information about the program variables and how to set them. Once all

the variables have been changed or verified, press ESC. The Select Start Mode screen displays. Select a mode to start the program or press ESC to return to the

Ready screen.

46 Apparatus 3 / 7 Operator’s Manual

Agilent BIO-DIS Apparatus 3 / 7

Operator’s Manual

5 Conversion Procedures

300 mL to 100 mL Conversion 48

300 mL to 1L Conversion 50

1L to 300 mL Conversion 52

300 mL to Double Row Dip 1L Conversion 54

Alignment Procedure 58

General Conversion Procedures 59

CAUTION

The following information guides you step-by-step through the conversion procedures for

• 300 mL to 100 mL conversions

• 300 mL to 1L conversions

• 1L to 300 mL conversions

• 300 mL to Double Row Dip 1L conversions

• General conversions

Ensure proper row configuration is set on the Apparatus 3 / 7 program. Serious damage could occur if rows are not properly

configured. See “Configuring the Apparatus 3 / 7” on page 33.

Agilent Technologies

5 Conversion Procedures

300 mL to 100 mL Conversion

Following is a list of items included with the 100 mL conversion kit:

Quantity

Item

Front vessel carrier, 100 mL

Mid / back vessel carriers, 100 mL

Evaporation covers, 100 mL

Upper caps for inner sample tubes, 100 mL

Lower caps for inner sample tubes, 100 mL

Inner sample tubes, 100 mL

Outer media tubes, 100 mL

Handles, vessel carrier

Part Number

1050-0288

1050-0289

1400-0067

27-1010

27-1030

27-5010

27-5110

4040-0195

NOTE

Complete the following steps to convert your instrument from 300 mL to 100 mL:

1 Turn off the instrument and remove the power cord from the power entry module.

2 Remove all 300 mL outer media tubes from the vessel carriers.

3 Remove the front, middle, and back 300 mL vessel carriers from the water bath frame by grasping the handles and lifting up and out.

4 Remove all 300 mL inner sample tubes / sample holders from the agitator shafts.

If your instrument is equipped with autosampling, refer to

“Cannula

Removal” on page 61 and

“Cannula Installation” on page 62 for

instructions.

5 Remove all 300 mL evaporation covers from the agitator shafts. See

“Removing the Evaporation Cover” on page 60.

6 Install 100 mL evaporation covers in positions 1 - 7. See

“Installing the Evaporation Cover” on page 61.

48 Apparatus 3 / 7 Operator’s Manual

Conversion Procedures 5

7 Install 100 mL inner sample tubes / sample holders in positions 1 - 7.

8 Install the handles onto the back, middle, and front 100 mL vessel carriers. Ensure the right-angle catches point inward.

9 Install the back, middle, and front 100 mL vessel carriers onto the water bath frame. Ensure the notches in the back and middle carriers are oriented toward the rear of the instrument. Also, ensure the studs of the vessel carriers are seated in the frame holes to provide proper alignment for the outer media tubes.

10 Install 100 mL outer media tubes in the vessel carriers.

11 Attach the power cord between the rear panel and an outlet of the appropriate voltage.

12 Turn on the instrument.

Apparatus 3 / 7 Operator’s Manual 49

5 Conversion Procedures

300 mL to 1L Conversion

NOTE

Firmware version 3.0 or higher is required to perform this procedure.

Following is a list of items included with the 1L conversion kit:

Quantity Item

1 Front vessel carrier, 1000 mL

Mid / back vessel carriers, 1000 mL

Adapters, agitator shaft, 1000 mL, short

Agitator shafts, 1000 mL, long

Evaporation covers, 1000 mL

Outer media tubes, 1000 mL

Handles, vessel carrier

Part Number

1050-0254

1050-0255

1200-0430

1200-0431

1400-0027

27-5120

4040-0195

NOTE

Complete the following steps to convert your instrument from 300 mL to 1L:

1 Move the Apparatus 3 drive unit to a convenient row to provide easy access to the rear panel.

2 Turn off the instrument and remove the power cord from the power entry module.

3 Remove the four panels from the bridge assembly. See “Removing

Bridge Assembly Panels” on page 60.

4 Remove the inner sample tubes / sample holders from the agitator shafts at positions 1, 3, 5, and 7.

If your instrument is equipped with autosampling, refer to

“Cannula

Removal” on page 61 and

“Cannula Installation” on page 62 for

instructions.

50 Apparatus 3 / 7 Operator’s Manual

Apparatus 3 / 7 Operator’s Manual

Conversion Procedures 5

5 Remove the 300 mL evaporation covers from the agitator shafts at positions 1, 3, 5, and 7. See “Removing the Evaporation Cover” on page 60.

6 Remove the agitator shafts from positions 1, 3, 5, and 7. See

“Removing the Agitator Shaft” on page 61.

7 Install adapter agitator shafts (4 3/4 inch) into positions 1, 3, 5, and 7.

See the item list on page 50 . Note this step is calling for the short

adapter agitator shaft, P/N 1200-0430. See “Installing the Agitator

Shaft” on page 61.

8 Remove all 300 mL outer media tubes from the vessel carriers.

9 Remove the front, middle, and back 300 mL vessel carriers from the water bath frame by grasping the handles and lifting up and out.

10 Install the handles onto the back, middle, and 1000 mL front vessel carriers. Ensure the right-angle catches point inward.

11 Install the back, middle, and front 1000 mL vessel carriers onto the water bath frame. Ensure the notches on the back and middle carriers are oriented toward the rear of the instrument. Also, ensure the studs of the vessel carriers are seated in the frame holes to provide proper alignment for the outer media tubes.

12 Install 1000 mL outer media tubes in the vessel carriers.

13 Install evaporation covers onto the 1000 mL outer media tubes.

14 Replace the four panels to the bridge assembly. See

“Replacing

Bridge Assembly Panels” on page 60.

15 Attach the power cord between the rear panel and an outlet of the appropriate voltage.

16 Turn on the instrument.

17 Set up the instrument for a three-row configuration. From the Ready screen, press MENU > 0 > 9. The following screen displays:

***SELECT ROW STYLE***

1 ONE 2 TWO 3 THREE 4 SIX

5 EIGHT 6 TWELVE 7 TWELVE EXT

TIME:04/16/12 10:08:49 ELAPSE:000:01:09

5 Conversion Procedures

CAUTION

18 Select option 3 for three rows. The Main Menu displays.

Failure to set the instrument to the correct row configuration may

cause serious damage. See “Configuring the Apparatus 3 / 7” on page 33.

19 Press ESC to return to the Ready screen.

1L to 300 mL Conversion

1 Turn off the instrument and remove the power cord from the power entry module.

2 Remove the two side panels from the bridge assembly. See

“Removing Bridge Assembly Panels” on page 60.

3 Install 1000 mL agitator shafts (8 5/8 inch) into positions 1, 3, 5, and

7. See the item list on page 50 . Note this step is calling for the long agitator shaft (P/N 1200-0431).

•

Guide the agitator shaft through the bridge assembly.

•

Looking through either side opening, screw the agitator shaft onto the adapter agitator shaft that is attached to the crosshead assembly.

4 Install 300 mL evaporation covers at positions 1, 3, 5, and 7. See

“Installing the Evaporation Cover” on page 61.

5 Remove the evaporation covers from the 1000 mL outer media tubes.

6 Remove the 1000 mL outer media tubes from the vessel carriers.

7 Remove the front, middle, and back 1000 mL vessel carriers from the water bath frame by grasping the handles and lifting up and out.

8 Install the handles onto the back, middle, and front 300 mL vessel carriers. Ensure the right-angle catches point inward.

9 Install the back, middle, and front 300 mL vessel carriers onto the water bath frame. Ensure the notches on the back and middle carriers are oriented toward the rear of the instrument. Also, ensure the studs of the vessel carriers are seated in the frame holes to provide proper alignment for the outer media tubes.

10 Install 300 mL outer media tubes in the vessel carriers.

52 Apparatus 3 / 7 Operator’s Manual

Conversion Procedures 5

11 Replace the two side panels from the bridge assembly. See

“Replacing Bridge Assembly Panels” on page 60.

12 Attach the power cord between the rear panel and an outlet of the appropriate voltage.

13 Turn on the instrument.

14 Set up the instrument for a six-row configuration. From the Ready screen, press MENU > 0 > 9. The following screen displays:

CAUTION

***SELECT ROW STYLE***

1 ONE 2 TWO 3 THREE 4 SIX

5 EIGHT 6 TWELVE 7 TWELVE EXT

TIME:04/16/12 10:08:49 ELAPSE:000:01:09

15 Select option 4 for six rows. The Main Menu displays.

Failure to set the instrument to the correct row configuration may

cause serious damage. See “Configuring the Apparatus 3 / 7” on page 33.

16 Press ESC to return to the Ready screen.

Apparatus 3 / 7 Operator’s Manual 53

5 Conversion Procedures

300 mL to Double Row Dip 1L Conversion

NOTE

Firmware version 4.2 or higher is required to perform this procedure.

Following is a list of items included with the Double Row Dip 1L conversion kit:

Quantity

Item

Front vessel carrier, 1000 mL

Mid / back vessel carriers, 1000 mL

Back vessel cover, Double Row Dip 1L

Plate adapter, Double Row Dip 1L

Covers, legs, Double Row Dip 1L

Right side leg, Double Row Dip 1L

Left side leg, Double Row Dip 1L

11-inch agitator shaft extensions, 3-row

5 9/16-inch agitator shafts, 3-row

Plate adapters, 1L to 300 mL

Evaporation covers, 1L

Belt, 1/5P 165T, Double Row Dip 1L

Part Number

1050-0254

1050-0255

1050-0362

1050-0365

1100-0275

1100-0276

1100-0277

1200-0311

1200-0313

1200-0607

1400-0027

3020-0028

Complete the following steps to convert your instrument from 300 mL to Double Row Dip 1L:

1 Move the drive unit to a convenient row to provide easy access to the rear panel.

2 Turn off the instrument and remove the power cord from the power entry module.

3 Remove the four panels from the bridge assembly. See “Removing

Bridge Assembly Panels” on page 60.

54 Apparatus 3 / 7 Operator’s Manual

Conversion Procedures 5

NOTE

4 Remove all 300 mL inner sample tubes / sample holders from the agitator shafts.

5 Remove all 300 mL evaporation covers from the agitator shafts. See

“Removing the Evaporation Cover” on page 60.

6 Remove the agitator shafts from positions 1 - 7. See “Removing the

Agitator Shaft” on page 61.

7 Remove the side covers on the left and right leg assembly.

•

Remove the three white caps and three Phillips-head screws on each leg.

8 On the water bath frame, loosen the 8/32-inch hex screw securing the guide rod to the guide rod bracket on all four brackets.

9 Slide the guide rod forward to free the upright assembly.

Have another person hold the upright assembly firmly when performing this step.

CAUTION

10 Using two people, lift the upright assembly off the frame and lay it flat on its back side.

11 Remove the four 8/32-inch hex screws from both the left and right leg assemblies. These screws attach the leg assembly to the bridge assembly. This step frees the legs from the bridge.

12 Remove all internal components from the left and right legs and transfer them to the longer conversion left and right legs.

13 Attach the conversion left and right legs to the bridge assembly with the four 8/32-inch hex screws.

Excess tightening of hex screws could shear or snap them.

14 Using two people, lift the upright assembly onto the frame.

Apparatus 3 / 7 Operator’s Manual 55

5 Conversion Procedures

NOTE

15 Push the guide rods forward through the conversion legs and the rear guide rod brackets.

Wipers must be installed to maintain guide rod lubrication and cleanliness.

CAUTION

•

As the rod enters the left and right leg assembly, slide a wiper onto each guide rod between the leg frame and the front bearing block.

•

As the guide rods pass through the rear bearing block, slide another wiper onto each guide rod so that it is positioned between the rear bearing block and the leg frame.

16 Tighten the 8/32-inch hex screws on the four guide rod brackets.

Excess tightening of hex screws could shear or snap them.

17 Install the conversion kit drive belt.

18 Adjust the belt tension so that the belt deflection falls between 1/4 and 1/2 inch.

•

Loosen the 6/32-inch hex screws securing the idler.

•

Adjust the idler so that belt tension falls within parameters.

•

Tighten the 6/32-inch hex screws and verify the deflection.

19 Install 11-inch agitator shaft extensions to positions 2, 4, and 6. See

“Installing the Agitator Shaft” on page 61.

20 Attach the plate adapter to the agitator shaft extensions with 3 mm hex screws with both locking and flat washers. Use the holes of the center row positions 2, 4, and 6.

21 Install six agitator shafts (5 9/16 inch) to the plate adapter with 3 mm hex screws with both locking and flat washers. Attach the six conversion kit shafts to the six outside notches on the plate adapter.

22 Install front, middle, and back 1000 mL vessel carriers onto the water bath frame. Ensure the notches on the back and middle carriers are oriented toward the rear of the instrument. Ensure the studs of the

Apparatus 3 / 7 Operator’s Manual

Conversion Procedures 5

vessel carriers are seated in the frame holes to provide proper alignment for the outer media tubes.

23 Install 1000 mL outer media tubes in the vessel carriers.

24 Install evaporation covers onto the 1000 mL outer media tubes.

25 Replace the four panels on the bridge assembly. See

“Replacing

Bridge Assembly Panels” on page 60.

26 Attach the power cord between the rear panel and an outlet of the appropriate voltage.

27 Turn on the instrument.

28 Set up the instrument for a single-row configuration. From the Ready screen, press MENU > 0 > 9. The following screen displays:

CAUTION

***SELECT ROW STYLE***

1 ONE 2 TWO 3 THREE 4 SIX

5 EIGHT 6 TWELVE 7 TWELVE EXT

TIME:04/16/12 10:08:49 ELAPSE:000:01:09

29 Select option 1 for one row. The Main Menu displays.

Failure to set the instrument to the correct row configuration may

cause serious damage. See “Configuring the Apparatus 3 / 7” on page 33.

30 Press ESC to return to the Ready screen.

31 Perform a bridge assembly alignment so that the agitator shafts,

evaporation covers and outer media tubes line up. See “Alignment

Procedure” on page 58.

•

Complete steps 1 through 7 in “Cannula Removal” on page 61.

32 Once alignment is achieved, install the left and right leg covers.

Apparatus 3 / 7 Operator’s Manual 57

5 Conversion Procedures

Alignment Procedure

Operating the instrument without proper alignment could cause damage.

It may be necessary to perform both types of alignment.

To properly adjust the bridge assembly so the evaporation covers and outer media tubes align, complete the steps on the following page.

Alignment Option 1

1 Move the drive unit to a convenient row.

2 Loosen the three hex screws on the bottom panel of the bridge assembly.

3 Move the evaporation covers until they are centered over the outer media tubes.

4 Tighten the three hex screws.

5 Press HOME.

Alignment Option 2

1 Move the drive unit to a convenient row to provide easy access to the leg and bridge assemblies.

2 Remove the side panel of the left leg assembly.

3 Loosen the four 8/32-inch hex screws on the left leg assembly that attaches the leg assembly to the bridge assembly.

4 Pivot the bridge assembly left or right to center the evaporation covers over the outer media tubes.

5 Tighten the four 8/32-inch hex screws.

6 Replace the left and right leg assembly side panels.

7 Press HOME.

58 Apparatus 3 / 7 Operator’s Manual

Conversion Procedures 5

General Conversion Procedures

WARNING

To convert a standard 300 mL Apparatus 3 / 7 to a 100 mL, 1000 mL, or

Double Row Dip Apparatus 3 / 7, use the commonly performed procedures on the following pages.

Before performing any conversion procedure, turn off the instrument and remove the power cord.

Apparatus 3 / 7 Operator’s Manual 59

5 Conversion Procedures

Panel

Left Side

Back

Front

Removing Bridge Assembly Panels

Right Side with Printer

Directions

Remove the four white caps.

Remove the four Phillips-head screws.

Remove the left panel.

Remove the four white caps.

Remove the four Phillips-head screws.

Pull the panel out slightly and disconnect the two connectors on the printer.

Remove the right panel with the printer.

Remove the seven white caps.

Remove the seven Phillips-head screws.

Pull the panel out slightly and disconnect the wiring.

Note: before disconnecting the wiring, draw a diagram to indicate how the wires are to be reconnected. Connecting wires in the wrong position may damage the instrument.

Remove the rear panel.

Loosen the four 5/16-inch nuts that secure the front panel. Note that it is not necessary to remove the nuts.

Disconnect the display and keypad connectors from the main PCB.

Lift the front panel up and out.

Replacing Bridge Assembly Panels

To replace the bridge assembly panels, follow the appropriate steps

under “Removing Bridge Assembly Panels” on page 60 in the reverse

order.

Removing the Evaporation Cover

1 Slide the evaporation cover upward to expose the black O-ring.

2 Roll the O-ring down and off the agitator shaft.

3 Slide the evaporation cover down and remove.

60 Apparatus 3 / 7 Operator’s Manual

Conversion Procedures 5

Installing the Evaporation Cover

1 Slide the evaporation cover up and onto the agitator shaft.

2 Roll the black O-ring onto the agitator shaft until it sits in the groove.

3 Slide the evaporation cover down until it rests on the O-ring. Ensure the cap is secured on the agitator shaft.

Removing the Agitator Shaft

1 Using a 1/16-inch hex key, loosen the hex screw while holding the agitator shaft.

2 Once the shaft is free, pull it down through the bottom of the bridge assembly.

Installing the Agitator Shaft

1 Guide the agitator shaft up through the bridge assembly and then through the bottom of the crosshead assembly until the shaft is flush with the top of the crosshead assembly.

2 Tighten the 1/16-inch hex screw with the hex key.

Cannula Removal

1 Turn on the instrument.

2 Press GOTO ROW.

3 Enter 1 and press ENTER.

4 Press START DIP and select option 2, Set Speed (DPM).

5 Enter 5 DPM and press ENTER.

6 Select option 1, Start, to start dipping.

7 Allow the evaporation covers to move downward to the lowest position.

8 Turn off the instrument before dipping begins.

Apparatus 3 / 7 Operator’s Manual 61

5 Conversion Procedures

9 Grasp the sampling cannula at the top of the first evaporation cover and pull upward until the cannula is free. Repeat this action for the return cannula and all remaining sampling / return cannulas. Note the sampling cannula is the longer cannula in front. The return cannula is shorter and to the rear. Remove the evaporation cover if a conversion is being performed. See “Removing the Evaporation Cover” on page 60.

10 Turn on the instrument. The drive unit returns to the home position.

Cannula Installation

1 Turn on the instrument.

2 Press GOTO ROW.

3 Enter 1 and press ENTER.

4 Taking care not to bend the sampling cannula, guide it through the top of the position 1 evaporation cover.

5 Push the cannula through until stopped by the clear tubing that connects the cannula to the colored sample tubing.

6 Repeat the above procedure with the return cannula on position 1 as well as the remaining positions 2 - 7. Note the sampling cannula is the longer cannula in front. The return cannula is shorter and to the rear.

7 If a conversion is being performed, install the evaporation covers onto the agitator shafts in the appropriate order. See

“Installing the

Evaporation Cover” on page 61.

8 Press HOME.

62 Apparatus 3 / 7 Operator’s Manual

Agilent BIO-DIS Apparatus 3 / 7

Operator’s Manual

6 Maintenance and Troubleshooting

Preventive Maintenance 64

Report Center Impact Printer 69

Fuse Replacement 74

Agilent Technologies

6 Maintenance and Troubleshooting

Preventive Maintenance

WARNING

The apparatus contains electrical circuits, devices, and components operating at dangerous voltages. Contact with these circuits, devices, and components can cause death, serious injury, or painful electric shock.

Preventive maintenance intervals may vary depending on frequency of instrument usage.

Daily Maintenance

See

“Holder Care”

on page 65 and “Water Bath / Acrylic Care” on page 66 as applicable for additional information on proper maintenance

of your equipment.

• All parts exposed to the dissolution media should be cleaned after each use. Parts made from stainless steel are particularly susceptible to surface corrosion if not cleaned thoroughly after use. If any stainless steel parts show signs of surface discoloration, lightly wipe the surface with a soft cloth or nonabrasive pad to remove it.

• Carefully wipe the holders after each use.

• Carefully wash the media tubes after each use.

Weekly Maintenance

See

“Water Bath / Acrylic Care” on page 66 as applicable for additional

information on proper maintenance of your equipment.

• Inspect the water bath and heater / circulator tubing for algae or other materials. If algae is present, change the bath water and add an algaecide.

• If you use a water bath algaecide or clear bath product, ensure it is compatible with PETG and acrylic.

Apparatus 3 / 7 Operator’s Manual

Maintenance and Troubleshooting 6

Monthly Maintenance

See

“Water Bath / Acrylic Care” on page 66 as applicable for additional

information on proper maintenance of your equipment.

• Drain the water from the water bath and clean the bath thoroughly. Refill the water bath and add an algaecide.

• It is recommended that the water bath temperature probe jack is checked for surface corrosion and wiped clean with a soft cloth or nonabrasive pad every one to three months.

NOTE

Depending on the frequency of use, it may be necessary to complete this maintenance procedure more often.

• Clean the agitator shafts. Inspect the agitator shaft evaporation cover O-rings for excessive wear. Replace the O-rings as necessary.

• Clean and lubricate the horizontal guide rods with a silicone-based lubricant.

• Clean the entire external surface of the instrument.

Holder Care

• When using with corrosive materials such as hydrochloric acid or media containing salts, be sure to rinse them thoroughly with deionized water immediately after each use, and dry thoroughly with a soft towel or cloth.

• Do not clean with abrasive cleansers or cloths. Use deionized water whenever possible. If you must use a cleanser or solvent, be sure that it is as mild as possible, non-abrasive, and fully compatible with fluorocarbons and stainless steel before use. If in doubt, call the service department for advice before proceeding.

• We recommend that you do not use a laboratory dishwasher.

Clean holders only by hand.

• Be sure to handle with care.

Apparatus 3 / 7 Operator’s Manual 65

6 Maintenance and Troubleshooting

• Use care when removing outer media tubes from the apparatus while the holders are installed so that you do not bump them.

• Store holders properly between uses.

Water Bath / Acrylic Care

CAUTION

Do not use cleaning compounds containing ammonia or abrasive cleaners on your water bath.

The water bath supplied with the Apparatus 3 / 7 should be maintenance free except for an occasional cleaning. If you use a water bath algaecide or clear bath product, ensure it is compatible with PETG and acrylic.

The flow paths in the heater / circulator are primarily stainless steel and should tolerate most clear bath formulations. Check with the product manufacturer to be sure the product is safe for your water bath.

•

All of our water baths are fabricated entirely of commercial grade acrylic. When using them with corrosive materials such as hydrochloric acid or media containing salts, be sure to rinse them thoroughly with deionized water immediately after each use, and dry thoroughly with a soft towel or cloth.

•

Do not clean with abrasive cleansers or cloths. Use deionized water whenever possible. If you must use a cleanser or solvent, be sure that it is as mild as possible, non-abrasive, and fully compatible with PETG and acrylic before use. If in doubt, call the service department for advice before proceeding.

•

Do not use ammonia, window-cleaning sprays, kitchen scouring compounds, or solvents such as acetone, gasoline, benzene, alcohol, carbon tetrachloride, or lacquer thinner. These can scratch the material’s surface and / or weaken it causing small surface cracks called “crazing”.

•

Our recommendations include but are not limited to the following:

•

Hot water:< 150 °F

•

Vinegar (5% Glacial Acetic Acid)

•

Ethyl alcohol: maximum 10%

Apparatus 3 / 7 Operator’s Manual

Maintenance and Troubleshooting 6

•

Isopropyl alcohol: maximum 25%

Repairing Leaking Fittings

Complete these steps if any of your water bath fittings are leaking:

1 Turn off the heater / circulator and drain the water bath completely.

2 Remove the leaky bulkhead fitting.

3 Remove the elbow fitting from the bulkhead fitting.

4 Inspect the bulkhead fitting gaskets for damage and replace them as necessary.

5 Remove the old PTFE tape from all male fittings. Inspect the threads for damage and replace the fitting as necessary.

6 Apply new PTFE tape to the male fitting threads.

7 Reinstall and tighten the bulkhead fitting on the water bath.

8 Reinstall and tighten the elbow fitting to the bulkhead fitting.

9 Fill the water bath and turn on the heater / circulator.

10 Inspect the fitting for leaks. If the fitting still leaks, contact the

Dissolution Systems Service Department.

6 Maintenance and Troubleshooting

Visual Checks

CAUTION

Panels or covers that are retained by fasteners which require the use of a tool for removal may be opened only by Agilent-trained,

Agilent-qualified, or Agilent-authorized service engineers.

1 Turn off power to the instrument and remove the power cord.

2 Remove the four screws from the top left panel and remove the panel.

3 Remove the four screws from the left side panel and remove the panel.

4 Inspect the drive belt for unusual wear, fraying, and tension.

5 Replace the left side cover and secure by reattaching the four Phillips screws.

6 Replace the top left cover and secure by reattaching the four Phillips screws.

7 Reconnect the power cord and turn on the instrument.

68 Apparatus 3 / 7 Operator’s Manual

Maintenance and Troubleshooting 6

Report Center Impact Printer

The following is helpful information for using your impact printer.

Installing the Cartridge Ribbon

If the printer is used infrequently, the print impression sometimes becomes weak because the ribbon dries out. If the printed material is difficult to read and you suspect this is the cause of the problem, advance to a new section of the ribbon by pressing the printer toggle switch to the Paper feed position. If the printing is still faint, replace the cartridge.

To install the cartridge, complete the following steps:

1 Toggle the printer off line by pressing the printer toggle switch to the

OnLine / Off Line position. When the printer is off line, the Ready

LED does not illuminate.

2 Four small grooves are embossed on the printer cover. Gently push on these grooves to tilt the cover. When the printer cover is tilted up, you can lift it off completely.

3 Push down on the right side of the ribbon cartridge (marked PUSH) and remove the old cartridge.

4 Install the new cartridge. If there is already paper in the printer, hold the cartridge between your thumb and index finger, slide it over the paper and into the printer compartment. Ensure the paper is between the ribbon cartridge and the ink ribbon. Ensure the ink cartridge is inserted firmly to prevent weak or irregular printing. The cartridge must be properly seated and aligned for the best printing.

5 Turn the cartridge knob (marked by an arrow) clockwise to stretch the ribbon taut.

6 Replace the cover.

7 Toggle the printer online by pressing the printer toggle switch to the

OnLine / Off Line position. The Ready LED illuminates.

8 Replace the paper if necessary.

Apparatus 3 / 7 Operator’s Manual 69

6 Maintenance and Troubleshooting

If you get ribbon ink on the printer’s plastic cover, remove it immediately. Once dried, it is difficult to remove.

Replacing the Paper Roll

CAUTION

1 Toggle the printer off line by pressing the printer toggle switch to the

OnLine / Off Line position. When the printer is off line, the Ready

LED does not illuminate.

2 Grasp the paper roll cover firmly by the grooves on the side and the front edge. Pull outward to remove the cover.

3 Press the printer toggle switch to Paper feed to advance the paper approximately one inch beyond the paper cutter.

4 Using scissors, cut the paper feeding to the printer and remove the paper roll.

5 Pull the remaining paper through the printer mechanism. Pull the

paper from the front (paper cutter side). Pulling the paper out of the back of the printer will damage the print mechanism.

6 Unroll several inches of paper on the new roll.

7 If it is jagged, cut a straight edge on the paper roll to facilitate the entry of the paper into the printer.

8 Slide the paper through the slot connecting the paper compartment and the printer compartment. You can slide it in approximately 1/4 inch before it stops.

9 While holding the paper in place, press the printer toggle switch to the Paper feed position and hold until approximately one inch of paper has emerged from the top of the printer.

Ensure the roll of paper feeds squarely. If it does not, the paper can jam and possibly damage the printer mechanism.

10 Release the printer toggle switch.

11 Turn the paper roll to take up any slack in the paper feeding to the printer.

12 Place the paper roll into the paper compartment.

Apparatus 3 / 7 Operator’s Manual

Maintenance and Troubleshooting 6

13 Replace the paper roll cover. If the cover is difficult to remove or replace, the left and right edges can be trimmed or shaved with a utility knife allowing the cover to slide easier.

14 Toggle the printer online by pressing the printer toggle switch to the

OnLine / Off Line position. The Ready LED illuminates.

Toggling Your Printer Online

Complete these steps to toggle your printer online:

1 Toggle the printer online by pressing the printer toggle switch to the

OnLine / Off Line position. When the printer is off line, the Ready

LED does not illuminate.

2 Release the switch and it returns to the center position. The Ready

LED illuminates and a

READY

message prints if the

PRINT READY

command has not been turned off. See “Printer Configuration” on page 72 for instructions on turning on and off the

PRINT READY command. When you first turn on the instrument, it prints a

READY message to assure you that the built-in microprocessor is operating properly.

When you turn off the printer, wait at least three seconds before turning it on again.

Apparatus 3 / 7 Operator’s Manual 71

6 Maintenance and Troubleshooting

Printer Self Test

You can test the print head and ribbon only after inserting paper. Do not attempt to print without paper. Follow these steps to perform a printer self test:

1 Turn off the Apparatus 3 / 7.

2 Press and hold the printer toggle switch in the Paper feed position.

3 Turn on the Apparatus 3 / 7.

4 Hold the printer toggle switch until printing begins. The printer prints a list of the current configuration settings and performs a continuous print test.

5 Press the printer toggle switch to the OnLine / Off Line position to stop the printing operation.

6 The printer is ready to resume normal operation.

Printer Configuration

NOTE

The printer configuration is set by the factory. This procedure should be performed only if the printer displays erroneous characters. Contact the

Dissolution Systems Service Department for assistance, if necessary.

1 Turn off the Apparatus 3 / 7.

2 Press and hold the printer toggle switch in the OnLine / Off Line position while turning on the instrument. Hold the printer toggle switch in the OnLine / Off Line position for six seconds after the instrument is turned on, then release the switch.

3 The printer should print: ***

SETUP MENU

*** and

CONFIGURE

...

[

]. If this message does not print, repeat steps 1 through 3.

72 Apparatus 3 / 7 Operator’s Manual

Maintenance and Troubleshooting 6

NOTE

4 The printer toggle switch is used to complete the configuration.

Pressing the left side of the printer toggle switch selects

to advance to the next menu item. Pressing the right side of the printer toggle switch selects

to accept what is stated on this line of the menu item. Each time the switch is pressed, another part of the menu prints. Allow the printer to finish printing before pressing the switch again. See the table of commands below.

The printout is easier to read if the printer cover is removed.

*** SETUP MENU***

CONFIGURE [NEXT/OK]

CUSTOM [NEXT/OK]

***CUSTOM MENU***

PRINT CUSTOM SETUP [NEXT/OK]

AUTO SEQ = NO [NEXT/OK]

ZERO = Ø [NEXT/OK]

POUND SIGN = # [NEXT/OK]

_(UNDERSCORE) [NEXT/OK]

ONLINE/OFFLINE = YES [NEXT/OK]

EXT CH SET = NO [NEXT/OK]

PRINT READY = YES [NEXT/OK]

PRINT READY = NO [NEXT/OK]

READY...

Press NEXT to avoid configuration

Press OK to enter custom mode

Press NEXT

Press OK

Press NEXT

Press OK

Your printer is now configured correctly.

Apparatus 3 / 7 Operator’s Manual 73

6 Maintenance and Troubleshooting

Fuse Replacement

WARNING

The apparatus contains electrical circuits, devices, and components operating at dangerous voltages. Contact with these circuits, devices, and components can cause death, serious injury, or painful electric shock.

Panels or covers that are retained by fasteners which require the use of a tool for removal may be opened only by Agilent-trained,

Agilent-qualified, or Agilent-authorized service engineers.

WARNING

The fuse compartment is located in the power entry module on the

Apparatus 3 / 7 rear panel. To check or replace the fuse, complete the following steps:

1 Remove the power cord from the Apparatus 3 / 7.

2 Use a screw driver to release the fuse compartment holder.

3 Pull the fuse compartment holder out of the power entry module. The fuse is located in the removable holder. For 115 V and 230 V equipment, the fuse is a 2 amp metric (5 x 20 mm) standard type.

4 Replace the fuse in the holder and insert the fuse compartment holder into the power entry module. The holder is keyed and can only be inserted one way.

Never replace a fuse with one of a higher amperage rating.

Doing so may compromise the safety margin and could result in damage to the instrument or personal injury.

5 Push the fuse compartment holder into the power entry module until both sides snap.

6 Replace the power cord.

74 Apparatus 3 / 7 Operator’s Manual

Maintenance and Troubleshooting 6

Obtaining Warranty and Other Services

To place a service order (warranty or other services), please contact your local Customer Care Center. Contact information can be found at www.agilent.com under your country using the Contact Us link. Place your service request using the displayed phone number or E-mail address.

Apparatus 3 / 7 Operator’s Manual 75

6 Maintenance and Troubleshooting

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76 Apparatus 3 / 7 Operator’s Manual

Index

Numerics

750 installation,

Acrylic care,

alarm program completion,

row dip completion,

setting,

Apparatus 3 Setup,

Bath Temperature Control/Report

Screen,

Calibrating Temperature,

Cartridge Ribbon,

CLEAR ROW,

Conventions,

Date, setting,

Delay Heating,

delay start time, setting,

Dip Per Minute,

Dip Time Interval,

Drain Time,

Fuse Replacement,

Heater / Circulator Control,

Hold Dip Time,

holder Care,

Installing sample Holders,

Installing sample tubes,

installing the printer cartridge ribbon,

Leaking Fittings, repairing,

Main Menu,

Monthly Maintenance,

Physical Parameters, USP,

Preventive Maintenance,

printer configuration,

self test,

toggling online,

Program Completion Alarm,

Programmed Operation,

Repairing Leaking Fittings,

Report Center printer,

Row Dip Completion Alarm,

self test, printer,

Setting delay start time,

Setting the Bath Temperature,

Starting a Program,

Suitability Test, USP,

Temperature Control / Report,

Time, setting,

unpacking your equipment,

USP

Address,

Physical Parameters,

Suitability Test,

voltage configuration,

Water bath Care,

Weekly Maintenance,

Apparatus 3 / 7 Operator’s Manual 77

Index

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78 Apparatus 3 / 7 Operator’s Manual

Key features

Extended-release product testing
Multiple pH level testing
Automated sample transport
Unattended operation up to 6 days
Program storage for up to 15 sequences

Frequently asked questions

The Apparatus 3/7 can accommodate virtually any solid dosage form, including pellets, tablets, and capsules.

The Apparatus 3/7 can run unattended for up to six days.

The evaporation curtains help to minimize evaporation of the dissolution medium during testing.