KDIGO Controversies Conference - Kidney Disease: Improving

KDIGO Controversies Conference
Cardiovascular Disease in CKD: What is it and
what can we do about it?
October 29-31, 2010
Radisson Blu Portman Hotel
London, United Kingdom
CONFERENCE OVERVIEW
Kidney Disease Improving Global Outcomes (KDIGO) is an international organization
whose mission is to improve the care and outcomes of kidney disease patients
worldwide by promoting coordination, collaboration, and integration of initiatives to
develop and implement clinical practice guidelines. Periodically, KDIGO sponsors
conferences on topics of importance to patients with kidney disease. These conferences
are designed to review the state of the art on a focused subject, and to ask conference
participants to determine what needs to be done in this area to improve patient care and
outcomes. Sometimes the recommendations from these conferences lead to KDIGO
guideline efforts, but other times they highlight needed areas for additional research to
produce evidence that might lead to guidelines in the future.
A growing amount of evidence suggests that chronic kidney disease (CKD) at all stages
is an important, independent risk factor for cardiovascular disease (CVD). As a
consequence many patients with CKD die prematurely before they reach dialysis or die
on dialysis, despite the technical achievements in organ replacement
therapy. However, the reasons for these adverse associations are not well understood
and are therefore controversial. In particular, whether CVD and CVD events are
different in CKD patients compared to patients without CKD is poorly defined.
Similarly, whether there are important differences in CVD in patients with CKD that
suggest preventative or therapeutic strategies that are unique to this population is
unclear.
Therefore, KDIGO is sponsoring “Cardiovascular Disease in CKD: What is it and what
can we do about it?” The conference will be held on 29-31 October 2010 in London,
England. Drs. Eberhard Ritz and Charles Herzog will co-chair this conference, which
will attempt to define the current state of our knowledge of CVD in patients with CKD
Stages 1-5. Topics will include epidemiology, pathophysiology, diagnosis, prevention
and treatment, with the focus on four areas of utmost clinical relevance: 1) Coronary
artery disease and myocardial infarction, 2) Congestive heart failure, 3) Sudden cardiac
death and 4) Cerebrovascular disease and stroke.
Invited participants and speakers will include the leading worldwide experts in these
topic areas, including nephrologists, cardiologists and representatives of other
disciplines to give the broadest views possible on the subject. Their task will be to
summarize the existing knowledge, develop recommendations on what can be done to
optimize the prognosis of CKD patients based on this knowledge, and to formulate and
prioritize research questions. The conference output will include publication of a
position statement that will help guide KDIGO and others on additional research and
ultimately clinical practice guidelines.
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CONFERENCE AGENDA
Thursday, 28 October
20:00 – 22:00 hrs
LOCATION
20:00 – 22:00 hrs
Welcome Reception
Lobby Fireplace
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Day 1 – Friday, 29 October
08:00 – 18:15 hr
07:30 – 08:00 hrs
Continental Breakfast
Ballroom 3 & 4
Introduction: Meeting Overview
08:00 – 08:10 hrs
Welcome and Introductions
Ballroom 1 & 2
Presenters: Kai-Uwe Eckardt & Bertram Kasiske, KDIGO Co-Chairs
08:10 - 08:40 hrs
World Health Organization Perspective
Presenter: Ala Alwan
08:40 - 08:55 hrs
Conference Overview and Objectives
Presenters: Charles Herzog & Eberhard Ritz, Conference Co-Chairs
Plenary Sessions: Epidemiology of CVD in CKD
Session Moderators: Charles Herzog and Eberhard Ritz
08:55 – 09:25 hrs
CVD in CKD Stages 1-4: KDIGO Prognosis Consortium
Invited Presenter: Josef Coresh
09:25 – 09:55 hrs
CVD in CKD Stage 5
Presenter: Kitty Jager
09:55 – 10:25 hrs
CVD in CKD: Asian Experience
Presenter: Kunitoshi Iseki
10:25 – 10:45 hrs
Break
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Plenary Sessions: CVD Pathophysiology in CKD
Session Moderators: Charles Herzog and Eberhard Ritz
10:45 – 11:10 hrs
Pathology of Cardiovascular Disease in CKD
Presenter: Kerstin Amann
11:10 – 11.35 hrs
Uraemic Vascular Damage and Calcification in
Children on Dialysis
Presenter: Rukshana Shroff
11:35 – 12:00 hrs
Pathophysiology of Vascular Function in CKD
Presenter: Gérard London
12:00– 12:30 hrs
Biochemical Abnormalities: Pathophysiology &
Conventional Risk Factors
Presenter: Peter Stenvinkel
12:30 – 13:00 hrs
Biochemical Abnormalities: Novel Risk Predictors
Presenter: Roberto Pecoits-Filho
13:00 – 13:45 hrs
Lunch
13:45 – 14:15 hrs
Imaging 1: Echocardiography and Stress Nuclear Imaging (CAD,
LVH, Valvular Disease)
Presenter: Thomas Marwick
14:15 – 14:45 hrs
Imaging 2: Screening for Coronary Artery Disease with CT and MR
Presenter: Antonio Bellasi
14:45 – 15:15 hrs
Sudden Death
Presenter: Charles Herzog
15:15 – 15:45 hrs
Break
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15:45 – 18:15 hrs
Breakout Sessions: Epidemiology, Screening, Diagnosis, and
Evaluation
Breakout Group #1: Coronary Artery Disease/Myocardial Infarction
Discussion Leaders: Alan Berger and David Charytan
(Stay in Main Meeting Room)
Breakout Group #2: Cerebral Vascular Disease/Stroke/
Atrial-Fibrillation/Peripheral Artery Disease
Discussion Leaders: Robert Hart and Richard Asinger
(Room: Gloucester Suite)
Breakout Group #3: Congestive Heart Failure
Discussion Leaders: Javier Díez and Peter McCullough
(Room: Devonshire Suite)
Breakout Group #4: Sudden Death
Discussion Leaders: Rod Passman and Patrick Pun
(Room: Montagu Suite)
Free evening – dinner on your own
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Day Two – Saturday, 30 October
8:00 to 19:00 hrs
7:30 - 8:00 hrs Continental Breakfast
LOCATION_
Ballroom 1 & 2
Breakout Group Reports and Discussion
Ballroom 3 & 4
08:00 – 08:30 hrs
Breakout Group #1: Coronary Artery Disease/Myocardial Infarction
Presenters: Alan Berger and David Charytan
08:30 – 09:00 hrs
Breakout Group #2: Cerebral Vascular Disease/Stroke/
Atrial-Fibrillation/Peripheral Artery Disease
Presenters: Robert Hart and Richard Asinger
09:00 – 09:30 hrs
Breakout Group #3: Congestive Heart Failure
Presenters: Javier Díez and Peter McCullough
09:30 – 10:00 hrs
Breakout Group #4: Sudden Death
Presenters: Rod Passman and Patrick Pun
10:00 – 10:30 hrs
Break
Plenary Sessions: Risk Predictors of CVD in CKD
Session Moderators: Charles Herzog and Eberhard Ritz
10:30 – 11:00 hrs
Role of Sodium/Potassium ATPase Inhibitors in Hypertensive &
Cardiovascular Disorders & in Kidney Disease Progression
Presenter: Jules B. Puschett
11:00 – 11:30 hrs
Salt Intake as a CV Risk Factor
Presenter: Kirstin Bibbons-Domingo
11:30 – 12:00 hrs
Sympathetic Activity
Presenter: Peter Blankestijn
12:00 – 12:30 hrs
Blood Pressure in CKD Stage 1-4
Presenter: Johannes Mann
12:30 - 13:00 hrs
Vitamin D and Phosphorus
Presenter: Ravi Thadhani
13:00 – 13:30 hrs
Lunch
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Plenary Sessions: Dialysis-Related Risk Predictors
Session Moderators: Charles Herzog and Eberhard Ritz
13:30 – 14:00 hrs
Blood Pressure in CKD Stage 5
Presenter: Rajiv Agarwal
14:00 – 14:30 hrs
Intradialytic Stunning
Presenter: Christopher McIntyre
14:30 – 15:00 hrs
Salt and Fluid Balance in CKD Stage 5
Presenter: Charles Chazot
15:00 – 15:30 hrs
Method and Duration of Dialysis
Presenter: Ercan Ok
15:30 – 16:00 hrs
Heart Failure/Cardiomyopathy
Presenter: Javier Díez
16:00 – 16:30 hrs
Dyslipidemias/Statins
Presenter: David Wheeler
16:30 – 17:00 hrs
Break
17:00 – 19:00 hrs
Breakout Sessions: Prevention and Management
Breakout Group #1: Coronary Artery Disease/Myocardial Infarction
Discussion Leaders: Alan Berger and David Charytan
(Stay in Main Meeting Room)
Breakout Group #2: Cerebral Vascular Disease/Stroke/
Atrial-Fibrillation/Peripheral Artery Disease
Discussion Leaders: Robert Hart and Richard Asinger
(Room: Gloucester Suite)
Breakout Group #3: Congestive Heart Failure
Discussion Leaders: Javier Díez and Peter McCullough
(Room: Devonshire Suite)
Breakout Group #4: Sudden Death
Discussion Leaders: Rod Passman and Patrick Pun
(Room: Montagu Suite)
20:00 – 22:00 hrs
Group Dinner (Meet in hotel Lobby at 19:30 hrs)
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Day 3 - Sunday, 31 October
8:00 to 12:30 hrs
LOCATION
7:30 - 8:00 hrs Continental Breakfast
Ballroom 1 & 2
Breakout Group Reports and Discussion
Ballroom 3 & 4
08:00 – 08:30 hrs
Breakout Group #1: Coronary Artery Disease/Myocardial Infarction
Presenters: Alan Berger and David Charytan
08:30 – 09:00 hrs
Breakout Group #2: Cerebral Vascular Disease/Stroke/
Atrial-Fibrillation/Peripheral Artery Disease
Presenters: Robert Hart and Richard Asinger
09:00 – 09:30 hrs
Breakout Group #3: Congestive Heart Failure
Presenters: Javier Díez and Peter McCullough
09:30 – 10:00 hrs
Breakout Group #4: Sudden Death
Presenter: Rod Passman and Patrick Pun
10:00 – 10:30 hrs
Break/Check Out
10:30 – 12:15 hrs
Discussion and Consensus on Recommendations
12:15 – 12:30 hrs
Wrap up and next steps
12:30 hrs
Adjourn (Departures)
Lunch available after adjournment
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