Mini Gamma Ray Camera (MGRC)
NuViews: combined optical
and gamma camera system
John Lees and Alan Perkins
20 May 2014
The Challenge
Major cancers
Breast cancer
Pancreatic
worldwide incidence
1,383,000
277,000
deaths worldwide
300,000 – 400,000
266,000
• Interventional imaging techniques
• New technologies to meet this challenge
• Better diagnosis and treatment outcomes for patients
• Reduce the mortality rate of cancer
• Improve patient management
• Reduce cost of treatment
Sentinel Node Detection
RCS New Start Programme 2007-2008:
Sentinel Lymph Node Biopsy Training Programme
Regionally run programme aimed at all members of the breast care team.
Clinical Applications & Evaluation
Nasal
clearance
(drug delivery
studies)
thyroid
morphology
Sentinel node
detection
(breast)
Joint
imaging
lacrimal
drainage
(eye)
Sentinel node
detection
skin (melanoma)
General surgical
exploration
in bone (osteoid
osteoma) tumour
detection, (colon, ovary).
Gamma Cameras and Probes
A dual head gamma camera
A nuclear probe detector
UoL Space Research Centre
Technologies and Expertise
Optical, UV, X-rays, gamma rays
Charge Coupled Devices: CCD
XMM-Newton: EPIC
Design evolution - MGRC
Compact Gamma Camera
Mini Gamma Ray Camera (MGRC)
•
•
•
•
•
•
•
Scintillator coated CCD
Complementary to “standard” Gamma Camera
High spatial resolution (<1mm)
Energy range 30-160 keV.
International Patents
Hand held potential
Point of care testing
15 mm
15 mm
NuViews and CLASP Funding
 Standard research funding difficult
 CLASP enabled development of Nuviews
 Bridging the gap to commercial funding
 Options
Licence
Spinout
Joint Ventures
 Long development time off putting for
Investors
Gamma Technologies Limited
 Design commercial prototype
 CE marking
 Ethics approval in place
 Clinical imaging trials at QMC
 Clinicial Trials in a number of key centres
 Further Investment
NuViews Schematic
Imaging display
Readout electronics
Gamma camera
Optical camera
Radioisotope
Patient
NuViews – in practice
Detector
Collimator
Mirror
Camera
Source
Hybrid Clinical Simulation
Hybrid gamma-optical
First Hybrid Clinical Use
• Lymphatic drainage study
• 10MBq 99mTc-nanocoll intradermal
injection site (1 hour after
injection)
• 9.8MBq 99mTc syringe
• 250mm distance
• 100s acquisition time
Lacrimal drainage study
NuViews
Benefits
 Combined optical and gamma imaging
 Point-of-care imaging
 High spatial resolution
 Reduction of the cost of diagnosis and
treatment
 Affordable technology
 Complementary to existing γ cameras
Development Goals
• Optimisation of the current HGC
• Testing of the HGC in the clinical environment
• Evaluation of results and design modification.
• CE marking of the HGC
• Pilot trials with clinicians and surgeons
• Next stage – commercial prototype
More Information
John Lees
john.lees@le.ac.uk
http://www.le.ac.uk/physics/bioimaging/
Papers
• Bugby, S.L., J.E. Lees, B.S. Bhatia, and A.C. Perkins,
Characterisation of a high resolution small field of view portable gamma
camera. Physica Medica, 30 (2014) 331-339.
• J E Lees, DJ Bassford, OE Blake, PE Blackshaw, AC Perkins,
A Hybrid Camera for simultaneous imaging of gamma and optical
photons, J. Inst. 7 (2012) P06009
• J E Lees, DJ Bassford, OE Blake, PE Blackshaw, AC Perkins,
A high resolution Small Field Of View (SFOV) gamma camera: a columnar
scintillator coated CCD imager for medical applications,
J. Inst. 6 (2011) C12033
Preliminary Evaluation
CGC
Typical LFOV camera
40 x 40
210 Ø
FWHM (mm)
0.63
2.7
FWTM (mm)
1.06
7.6
FWHM (mm)
1.28
7.8
FWTM (mm)
2.35
X
Absolute (mm)
0.12
0.5
Differential (mm)
0.09
0.2
Integral Uniformity (%)
8.5
2.5
Spread of Differential Uniformity (%)
0.60
1.7
20% Expected Value (kBq)
>1.2
180
Maximum Counts (kBq)
>1.2
250
Intrinsic (cps/MBq)
2860
X
Extrinsic (cps/MBq)
214
150
FWHM at 141keV (%)
58
9.4
Performance Characteristic
Field of View
Intrinsic Spatial Resolution
System Spatial Resolution
Spatial Linearity
Spatial Uniformity
Count-Rate Capability
Sensitivity
Energy Resolution
Nominal (mm)
CLASP – Healthcare
Time
Item
10.00 – 10.30 Registration and Coffee
10.30 – 10.45 Welcome and Introduction
10.45 – 11.05 STFC Capabilities in Healthcare
Speaker
Dewi Lewis - CLASP Panel
and former GE Healthcare and
Barbara Camanzi – STFC
Futures
James Ballinger - NHS
11.05 – 11.30 Healthcare Challenges for CLASP Radioisotopes
11.30 – 11.55 Healthcare Challenges for CLASP –
Peter Jarritt - NHS
Imaging Technology
11.55 – 12.20 Healthcare Challenges for CLASP – Early Linda Mahon-Daly – HNS
Diagnosis
12.20 – 13.20 Lunch
13.20 – 13.40 Case Study – Gamma Technologies Ltd
13.40 – 13.50 CLASP Funding Details
13.50 – 16.00 Networking and collaboration building
John Lees - University of
Leicester
Phillip Tait
STFC External Innovations
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