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Clarus 500 Gas Chromatograph
change the way you
look at gas chromatography
sleek design and
easy touch screen
revolutionize GC interaction
2
QUICK GLANCE
• Intuitive touch screen is easy to use, no
training required
• Dual-channel, real-time signal display on the
touch screen
• Flexible configurations with integrated mass
spectrometry, headspace or thermal desorption
• Robust, proven design provides reliable
performance year after year
• Access to worldwide PerkinElmer service and
support team
The sleek ClarusTM 500 gas chromatograph (GC) from
PerkinElmer offers a whole new approach to the way
you interact with your GC instrument. An intuitive
touch-screen interface features real-time signal
display and seven-language support. It’s what makes
the Clarus 500 GC so easy to use and so hard for
competitors to beat.
This cutting edge user interface is combined with the
proven dependability of a PerkinElmer GC. In fact,
PerkinElmer was recognized in both 2001 and 2002
with the Scientific Computing and Instrumentation
Reader’s Choice Award for GC. The GC systems have the
performance needed for the demands of both research
and quality control environments. Unique features like
a fast-rotating autosampler tower, the PreVent pressure
control system and easy serviceability enable the Clarus
500 to deliver maximum GC productivity.
Available in hundreds of configurations ranging from
dedicated analyzers for petrochemical and air analysis
to powerful mass spectrometer units, the Clarus 500
is extremely flexible. For applications requiring mass
spectrometer detection, the Clarus 500 GC can be
coupled to the industry’s easiest-to-use and widest-massrange quadrupole mass spectrometer. The PerkinElmer
headspace and thermal desorption sample handling
devices can also be integrated, providing solutions for
applications such as beverage analysis, ambient air
testing, environmental work and more. For data management and reporting, PerkinElmer’s award-winning data
handling software makes managing data easier than ever.
PerkinElmer also backs all its products with factorytrained field support in more than 125 countries
worldwide. The only vendor with a complete offering
from gas chromatograph to sample handling to data
analysis and reporting, PerkinElmer offers an integrated
single vendor solution. You can rely on one company
for service and applications support.
www.perkinelmer.com
3
enhance system throughput
Temperature programmable inlets
maximize reproducibility
For more demanding applications, the Clarus 500 GC
inlet positions are programmed with a range of
temperature-programmable inlets. Options include two
enhanced capillary injectors, the Programmable Split/
Splitless (PSS) and Programmable On-Column (POC).
Clarus 500 split/splitless inlets significantly reduce
risk of sample loss, while maximizing accuracy and
reproducibility over a wide range of sample volumes.
For analyses including those where the sample is sensitive
to thermal degradation or susceptible to discrimination
due to non-representative vaporization, choose a PSS
inlet and programmable on-column injector.
The PSS system manages liquid sample vaporization,
reducing the boiling point discrimination that is caused
by injecting into a hot inlet. The integrated charcoal
trap cleans the split effluent to prevent contamination of
gas lines and regulators, while removing the possibility
of analyte discharge to the atmosphere. The trap also
provides a “pressure buffer” for vaporizing samples,
delivering the lowest available discrimination.
4
Pneumatic Pressure Controllers (PPC)
PPC offers additional capability and levels of performance
not attainable with manual pneumatic systems,
allowing analysis of a wide range of samples. PPC
gives you the capability to control and monitor all
injectors, detectors and auxiliary gases electronically,
using the Clarus 500 color touch screen.
PPC eliminates complexity by removing labor-intensive
and complex steps associated with measuring and
setting flows manually. You set all flows and pressures
of all the instrument gases on the touch screen – no
more knobs or complicated software. For instance, to
set up split ratios, you simply enter the required ratios
on the touch screen and the Clarus 500 GC automatically
calculates and adjusts the split vent to the correct flow
for the selected column flow. Additionally, automatic
control of detector gases allows quick and easy setup
of the detector combustion or makeup gases, reducing
variability in instrument setup due to operator bias or
environmental conditions. You can enter published
methods exactly as written, without the trial and
error, saving time and increasing reproducibility.
The Carrier Gas Pressure Program screen allows
instant access to the program with real time
progress display.
How does PPC work?
Using PPC, the Clarus 500 GC automatically
adjusts carrier gas flows to compensate for
variations of ambient temperature and
pressure, providing constant retention times
under widely varying conditions. This greatly
enhances system reproducibility even in
extreme environments. With flexible flow
velocity and pressure control, users can
program the carrier gas flow by velocity, by
pressure, or by mass flow for optimal column
performance. This allows consistent control
of one parameter, while adjusting all others
to maintain the desired flow.
A single PPC method stores all the temperatures, gas
flows and pressures so that it is easy to follow standard
operating procedures (SOP). Simply recall the method
to establish complete operating conditions. If a greater
level of data management is required, PerkinElmer
data handling software systems can control and store
all operating conditions with the chromatographic
data and the method.
Using PPC also greatly enhances confidence in system
performance and accuracy. By monitoring deviations
from the pneumatic set-points, the Clarus 500 GC can
automatically shut down if leaks are suspected. The
system constantly monitors the status of the combustion
gas. If the Clarus 500 detects that the flame is out, it
turns off combustion gas supplies, preventing injection
and possible loss of valuable samples.
Constant mass flow used with pressure
programming simplifies set up and shortens
analysis time while improving performance
of certain detectors, including those sensitive
to mass flow changes such as thermal
conductivity detectors and nitrogen
phosphorus detectors.
Injectors
Ch. A
Ch. B
Pkd
Cap
PSS
Obtain up-to-the-minute FID status information.
POC
Icons allow quick and easy recognition of selected
injectors and other devices.
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5
innovative
touch screen
makes operation simple
When you invest in a new instrument, you do not want
to waste time learning how to navigate a complicated
interface. Most interfaces require drilling down multiple
layers to locate fragments of information. By the time
you reach the function you were looking for, it is difficult
to remember how you got there, or how to get back. Many
interfaces even require you to continually reference the
manual in order to operate the system effectively.
GC analysis at your fingertips
The Clarus 500 is the first GC to replace the cumbersome
and confusing keypad user interface with a large, fullcolor touch screen. The signal screen displays a real-time
chromatogram, allowing you to monitor the current state
of the system at a glance. You can get a complete picture
of what is happening with your analysis just from
Real-time chromatogram is displayed continuously,
allowing you to monitor your runs.
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walking by. The signal monitors both channels simultaneously. To view the channels on the touch screen,
simply press a button to alternate the view, providing
immediate access to key information. You do not need
to wait for the run to complete to view results.
While easy accessibility is a critical measure of usability,
smooth navigation is equally important. A clear and
concise visual language guides users through the
system. With single-touch access to the functions you
need, the Clarus 500 GC touch screen eliminates
drilldown, simplifying instrument control for novices
and experienced users alike. The status screen presents
a comprehensive overview of the system. Icon buttons
define the type and status of each heated zone and
each injector and detector is identified by a unique
icon, which is color coded by channel.
The status screen displays the type and status
of each zone.
The injection countdown ensures high precision
manual sample injections.
Setup enables user-preferences for Startup
and Sleep modes as well as other options.
The touch screen is like having a complete GC software
program on the instrument. When you want to make
a manual injection, the countdown feature helps you
time the injection precisely every time, giving repeatable sample injections. And the functions you need are
exactly where you would expect to find them. If you
need to light the FID, just press the ignite button. If
you want to access the oven temperature program, the
oven button gets you there in one touch and the graph
shows you exactly where you are in the run.
Easy setup/methods development
Even if you don’t use the system frequently, the touch
screen interface makes method development easy.
The screen provides immediate access to all method
parameters (including detectors, columns, injectors,
temperature controlled devices, pressure controllers,
relays and valves) in any order, eliminating the need
for linear entry of analytical conditions. The system
can save up to five methods with unique names so
experiments can be quickly and accurately replicated.
Our exclusive integrated flow calculator allows optimized
adjustment of carrier gas conditions without a separate
software program. Simply pick the variable level you
want to achieve and the system will automatically
determine the correct conditions for your analysis.
The exclusive PerkinElmer built-in flow calculator
determines flow rate at a given column length
and diameter.
Multiple language support
Simplify maintenance
The Clarus 500 GC comes with multiple language
capability, including error messages, so you can work
in the language of your choice – and you can easily
switch to different languages. This ensures your entire
staff is at ease when working with the system. So
whether you speak English, Spanish, French, Russian,
Japanese, German or Italian, the Clarus 500 GC makes
perfect sense.
The touch-screen interface keeps track of the number
of injections so you know when to replace septa and
perform routine maintenance on the system, eliminating
the need to track this important information on paper.
It tracks total number of injections and elapsed time;
both can be reset. It gives proactive warning and user
error messages, using real words instead of cryptic
codes. The messages provide a detailed description of
the problem and how to resolve it. The Clarus 500 GC
also offers the ability to turn off the FID and other
instrument parameters overnight or over the weekend.
View and modify instrument parameters using
the Active Method screen.
Available in seven languages, the Clarus 500
speaks everyone’s language (Italian shown above).
www.perkinelmer. com
8
exclusive
PreVent technique
improves
performance
The Clarus 500 GC features the
PerkinElmer-exclusive PreVent
operating modes. This powerful
mode uses the combined features of
the temperature programmable PSS
injector and the PPC, to increase analytical throughput,
manage difficult samples, protect the column and
chromatograph and lower detection limits.
Time Saver mode
The PreVent Time Saver mode selectively prevents
unwanted components such as high boiling point
analytes or residues from going through the chromatographic separation system and detector. This reduces
analysis time, while improving system stability and
overall uptime.
Enhanced Solvent Purge mode
The PreVent Enhanced Solvent Purge mode can
reduce effects of high solvent levels in the column
and detector more completely than PSS alone. This
mode eliminates solvent flooding of the column and
allows use of methylene chloride as a solvent with an
ECD. Enhanced Solvent Purge mode also enhances the
performance of large volume injections by removing
the influence of excess solvent from the system. Large
volume injections can be made into a cold injector and
the solvent vented before the analytes are transferred
to the column, providing online solvent evaporation
and higher productivity.
Time Saver reduces analysis time.
Enhanced Solvent Purge enables large-volume injections.
Isolation mode
The PreVent Isolation mode minimizes downtime by
allowing a septum change without interruption of
carrier flow to the column, making it possible to perform
routine maintenance on the inlet without impacting
system stability. Following maintenance, the system is
available immediately for analysis. There is no need to
equilibrate the column or purge the mass spectrometer.
Enhanced Solvent Purge allows the use of chlorinated
solvents with an electron capture detector.
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9
New septa can even be conditioned for high sensitivity
analysis without compromising the established performance of the column and detector. Isolation mode can be
used while chromatography is taking place. Isolation
mode even works with the Clarus 500 GC autosampler
which positions the tower and syringe away from the
GC inlets except during injection. This facilitates easy
access to the injectors during analysis without interrupting or interfering with the autosampler sequence.
High pressure pulse injection
The high pressure pulse injection optimizes reproducibility of sample transfer onto the column for splitless
injectors when you use a timed high pressure pulse at
injection. This enhances peak shape, consequently
Split Vent
PSS
Injector
F
Restrictor
Detector
Midpoint
Capillary Column
P
P
improves detection limits and minimizes mass
discrimination when using low injector pressures for
Mass Spectrometer detectors.
Large volume injection
Large volume injection (LVI) and solvent purge
capabilities of the Clarus 500 GC and PSS injector
make the system extremely flexible. LVI allows injection
of a large amount of sample without degradation in
chromatographic performance. It reduces sample
preparation time by eliminating the need for sample
concentration through evaporation. LVI uses standard
hardware and is totally compatible with the Clarus 500
autosampler for samples up to 50 µL. Sample volumes
greater than 50 µL can be injected manually. The only
limit to sample size is the capacity of the PSS liner to
contain the liquid sample during injection.
LVI can also enhance system sensitivity without sacrificing performance. The solvent purge mode vents the
solvent from a sample injection into a cold PSS before
analytes are transferred to the column. Compared to a
conventional injection of 1 to 5 µL, a 50 µL LVI results
in a 10 to 50 percent increase in sensitivity.
Pressure
Control
Diagram of PreVent with injector restrictor installed.
By eliminating the final stage of sample evaporation, LVI can
double sample throughput. Note: Total analysis time =
GC run time + sample preparation time.
10
Three successive injections of diesel oil run in Isolation
mode. Septum changed and injector liner inspected
during run B.
one company,
one solution
Combine the Clarus 500 GC with the Clarus 500
mass spectrometer (MS), market-leading PerkinElmer
sample handling accessories, flexible user-friendly
software and world-class service and support for an
integrated, complete analytical solution. Whatever your
application — environmental, chemical, flavor and
fragrance, food, beverage, forensic or pharmaceutical —
PerkinElmer delivers the accuracy and precision you need.
Integrated autosampler
The totally integrated Clarus
autosampler provides flexibility
and automation capability for
the gas chromatograph. The autosampler accommodates three
autosampler syringe sizes (0.5,
5.0 and 50 µL) and three injection
speeds (slow, normal and fast) for
complete applications flexibility. Unobstructed access
to either injection port with one autosampler permits
any combination of analyses for the most efficient
utilization of the gas chromatograph.
The autosampler is fully controllable from the
Clarus 500 GC touch screen, featuring run status
and automation logs that tell whether there was any
deviation from the preprogrammed method conditions.
The autosampler provides a mechanically robust,
dependable system. Performance is assured by optical
sensors that consistently monitor the system to make
certain all is proceeding as planned.
Clarus 500 Mass Spectrometer
The Clarus 500 MS features a wealth of innovative
technology to provide the most complete characterization
of samples. PerkinElmer Selected Ion and Full Ion (SIFITM)
scanning technology and high scan speeds increase
system accuracy. The mass spectrometer boasts a fast
scanning speed with the widest mass range available for
GC/MS, providing capability to analyze a greater scope
of applications. The Clarus 500 MS also includes proven
gold technology for enhanced performance.
Headspace sample handling
PerkinElmer TurboMatrixTM Headspace Samplers
eliminate tedious and error-producing steps required in
other GC sample preparation techniques, enabling you
to extract more information from your samples in less
time. The intuitive touch-screen graphical user interface provides easy control of the sampler. Models with
built-in analyte trapping capability maximize the
extraction and transfer of headspace vapor into the GC
column, thereby lowering the detection limits by up to
100 times. Building on more than 40 years of experience in GC sample handling and introduction,
PerkinElmer headspace samplers incorporate proven
pressure-balanced sampling for better performance.
Thermal Desorption sample handling
Thermal Desorption is a clean technique that simplifies
and speeds up a wide range of GC applications, including indoor and outdoor air monitoring, analysis of
flavors and fragrances and analysis of outgassing volatile
compounds from packaging, polymers, pharmaceuticals
and semiconductor materials. An intuitive touch-screen
graphical user interface on the TurboMatrix Thermal
Desorber provides easy control of the sampler. The
system is available in manual and automatic configurations and can be upgraded to meet the challenges of
tomorrow’s analyses.
Chromatography data handling
The combination of a PerkinElmer Clarus 500 GC with
a data handling system provides a total laboratory
solution from data collection and analysis to reporting
and storage. Whatever your data handling requirements,
there is a system to fit your budget and your technical
demands. Operating in the industry-standard Windows®
operating environment, the PerkinElmer chromatography
data system can control up to eight instruments.
www.perkinelmer.com
11
turnkey solutions to
applications problems
PerkinElmer develops a broad array of custom
analyzers for a wide range of applications and multiple
industry segments. These systems combine proven gas
chromatography products and accessories with expertise,
technology, hardware and software. Because the
analyzers and systems are integrated and performance
tested before shipment, no complex set up or method
development is required during installation.
In partnership with ArnelTM, PerkinElmer has produced
more than 100 turnkey solutions that have greatly
increased your analytical options. Laboratory and
plant-based tools for environmental, QC and process
monitoring are available for indoor air monitoring, as
well as petrochemical, food, beverage, pharmaceutical
and other industries.
Petrochemical analysis
from Hydrogen to Asphalt
The analytical challenges of monitoring and controlling
petrochemical processes and products are as complex
as the chemical processes themselves. The term
“Hydrogen to Asphalt” categorically represents the
breadth and depth of raw materials and products
derived from crude oil. Each category has a set of
analytical requirements that include single or multiple
component analysis plus the determination of metals
and carbon content.
Refinery Gas Analysis includes hydrocarbon mixtures
in refinery feed stocks and products such as naphtha,
reformate, alkylate and gasoline. Natural gas analysis
includes a family of gas analyzers to address a full
range including H2, O2, N2, CO2, and C1 through C5
as well as C6 and higher hydrocarbons.
Analytical methodologies play a critical role in ensuring
that manufacturing conditions are monitored and that
product quality is consistently maintained. PerkinElmer
12
C8
C13
C17
C22
C32
Chromatogram of Reference Gas Oil standard for ASTM D2887.
analytical solutions complement these methods by
providing gas chromatography solutions from sample
handling to data handling. These systems monitor
every aspect of your application including Refinery Gas
Analysis, Natural Gas Analysis, and Trace Sulfur
Analysis. PerkinElmer analytical solutions meet or
exceed published methodologies and address your
specific analysis criteria.
Ozone Precursors analysis
In the United States, the Clean Air Act of 1970 gave the
Environmental Protection Agency (EPA) responsibility
for maintaining clean air. Six parameters are measured
routinely in ambient air: SOx, NOx, PM10, Pb, CO
and ozone. In the 1990’s, the Clean Air Act was expanded to include volatile organic compounds (VOCs) that
contribute to the formation of ground-level ozone. These
measurements are implemented through Photochemical
Assessment Monitoring Stations (PAMS). Similar
recommendations have also been made in Europe.
PerkinElmer, in conjunction with the U.S. EPA, developed an analyzer and methodology for collecting and
automatically measuring C2-C20 without the use of
liquid cryogen. This system incorporates an on-line
thermal desorber and the Clarus 500 GC.
Workspace air monitoring helps you
breathe easy
Maintaining a safe work environment is a requirement
and challenge faced by many companies. Monitoring
air quality can be particularly difficult because, unlike
other workplace hazards, the problem is invisible.
PerkinElmer provides air quality analyzers that help
companies ensure safe environments for workers.
These systems utilize gas chromatography to test
for single or multiple gaseous contaminants.
The Workspace Air Monitoring System (WAMS) is
a laboratory — or control room-based tool. It provides
protection to the workforce and documents occupational
safety, thus meeting regulatory requirements. The
PerkinElmer-Arnel Series 5200 WAMS monitors
workspace air for low levels of controlled compounds.
Typical environments where the WAMS have been
successfully implemented include facilities for
ethylene oxide sterilization and those that use
industrial solvents such as benzene.
Air Toxics analysis
capability of the Clarus 500 GC/MS offers the benefits
of both full-scan and single-ion monitoring simultaneously within a single analytical run.
Food & Beverage Quality Control
Trace levels of acetaldehyde develop as an impurity
or byproduct in the manufacture of bottles from
Polyethylene Terephthalate (PET) and affect the taste of
water and carbonated beverages placed in these bottles.
The PerkinElmer-Arnel Series 5100 analyzers are
designed as a QC tool to batch sample bottles sequentially and automatically at the rate of about one bottle
per minute as well as report and store data with a
software/computer system.
The Series 4000 analyzers are designed to meet or
exceed ISBT (International Society of Beverage
Technologists) specifications for trace impurity
compounds in beverage grade CO2. These analyzers
provide a complete solution to test at each stage of
manufacture, during product delivery and in the final
use at the beverage producer, from sample handling
and instrument calibration to analyzing compounds
and data handling.
The PerkinElmer Air Toxics analyzer integrates
several analytical techniques into a single, unified
system solution, performing tube-based sampling in
accordance with established methodologies such
as U.S. EPA method TO-17. Tube-based sampling
offers greater convenience as well as some analytical
advantages over traditional canisterbased analysis. Comprised of a
PerkinElmer TurboMatrix Thermal
Desorber and Clarus 500 GC/MS, the
system provides outstanding analytical
performance as well as several unique
features to simplify and speed analysis.
A powerful purge technique allows
for analysis under extreme levels of
The PerkinElmer Air Toxics analyzer couples a Clarus GC/MS to a thermal
humidity/moisture, while a unique
desorber for convenient high performance air analysis.
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13
PerkinElmer, Inc.
PerkinElmer, Inc. is a global technology
There are over 60 years of experience
leader focused in the following busi-
built into every product we make,
nesses — Life and Analytical Sciences,
backed by an unparalleled service
Optoelectronics, and Fluid Sciences.
and support team that serves customers
Combining operational excellence and
in more than 125 countries around the
technology expertise with an intimate
world. And online consumables,
understanding of its customers’ needs,
reagents and accessories ordering
PerkinElmer creates innovative solu-
lets you get your hands on what you
tions that accelerate drug discovery,
need fast.
enhance research productivity, help
Additional information on the
meet regulatory requirements, improve
company is available through
time-to-market and increase manufac-
www.perkinelmer.com or
turing efficiencies.
1-877-PKI-NYSE.
PerkinElmer Life and
Analytical Sciences
710 Bridgeport Avenue
Shelton, CT 06484-4794 USA
Phone: (800) 762-4000 or
(+1) 203-925-4602
www.perkinelmer.com
For a complete listing of our global offices, visit www.perkinelmer.com/lasoffices
©2004 PerkinElmer, Inc. All rights reserved. The PerkinElmer logo and design are registered trademarks of PerkinElmer, Inc. Clarus, TurboMatrix and SIFI are trademarks of
PerkinElmer, Inc. or its subsidiaries, in the United States and other countries. All other trademarks not owned by PerkinElmer, Inc. or its subsidiaries that are depicted herein
are the property of their respective owners. PerkinElmer reserves the right to change this document at any time and disclaims liability for editorial, pictorial or typographical
errors.
006669B_01
AP020415
Printed in USA
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