7890B Brochure.indd

7890B Brochure.indd
Agilent 7890B Gas Chromatograph
RESOLVE
YOUR SEARCH
FOR RELIABILITY
Resolve your search for the next evolution
in gas chromatography
The NEW Agilent 7890B GC
Building the world’s most trusted GC system is an ongoing process. With every step, we increase
speed, improve functionality, and incorporate new analytical capabilities – all while never losing sight
of the most important objective: results.
Now, Agilent has achieved a new level of GC performance and GC/MSD system
integration
Agilent’s flagship 7890B GC system has everything you need to boost productivity, protect our
environment through better resource management, and generate data with confidence. In addition,
its seamless communication with the Agilent 5977A Series GC/MSD provides faster vent times and
system protections when using hydrogen carrier gas.
The Agilent 7890B GC adds
integrated “smart” functionality
and improved performance to the
industry-leading GC platform.
Leading-edge technologies
increase analytical
capabilities and
reliability
Proven reliability meets improved performance
Agilent’s 5th-generation electronic pneumatics control (EPC)
and digital electronics are now complemented by improved
detector specifications, making the 7890B Agilent’s most
dependable – and highest-performing GC – ever.
Faster, more intuitive software
New Agilent OpenLAB CDS is 40 times faster. Tools
and wizards have also been added to help you turn
results into answers, faster. Page 10
Higher sample throughput
End-to-end protection for active compounds
Fast oven cool-down, new backflush capabilities, and
advanced automation features help you get more done in less
time, at the lowest possible cost per sample. All can easily be
incorporated into your existing method.
Ultra Inert liners, gold seals, columns, and improved
inert flow path from injection to detection. Page 9
NEW integrated intelligence
Enhanced inlet and detector modules
Early maintenance feedback lets you replace parts quickly, and
address small problems before they lead to costly downtime.
Built-in calculators and method translator are also integrated
into the data system software to simplify method setup and
system operation.
Numerous module enhancements let you
customize your GC system in minutes to suit your
changing application needs. Page 8
New integrated system maintenance
and Parts Finder tools
What’s more, the improved GC MSD communication
cuts venting time by up to 40%, and protects the system
from damage by stopping the flow of carrier gas during
shutdown events.
Reduce downtime and operating costs with
simplified maintenance and status monitoring.
Find consumables and replacement parts faster
with a 3D graphical tool. Page 12
Expanded chromatographic capabilities
Enhanced Capillary Flow Technology (CFT)
A flexible EPC design enables sophisticated analyses, while
an optional 3rd detector (TCD or ECD) lets you run multiple
analyses on a single GC.
CFT modules enable leak-free, in-oven connections
while improving throughput and reliability. An easy
setup wizard gets you up and running quickly.
Page 6
Wide choice of system components
Configure and automate your system to increase
efficiency and productivity – and expand your
analytical capabilities. Page 14, 21
Reduce dependency on helium
Integrated calculators help you convert helium
methods to more available – and less expensive –
gases like hydrogen or nitrogen. Page 12
Eco-friendly operation
Sleep mode reduces power and gas
consumption during periods of inactivity,
while Wake mode readies the system
for high-throughput operation. You can
also switch to lower-cost gases while in
standby mode. Page 12
To learn more about the Agilent 7890B GC, visit www.agilent.com/chem/7890B
3
Advanced capabilities help you get the job done, faster
Agilent’s 7890B GC builds on a 45-year tradition of leadership and
innovation, providing everything you need to take your lab to the next
level of GC and GC/MS productivity, performance, and resource
management.
The heart of performance
Precise pneumatics and oven
temperature control, combined with
Agilent J&W Ultra Inert GC columns,
give you outstanding resolution and
retention time repeatability – the basis
for all chromatographic measurement.
The heart of reliability
No other manufacturer has Agilent’s
depth of experience in electronic flow
control. Our pneumatics manifold
reduces the need for parts and seals,
improving gas flow precision and
stability. Integrated electronics and
advanced mechanical design further
enhance dependability and versatility.
4
Precise Retention Time Locking
(RTL) software
RTL reproduces retention times from
one Agilent GC system to another –
regardless of inlet, detector, operator, or
location. So you can confidently transfer
methods worldwide.
6.624 (Target RT)
6.624
Response
6.641
6.619
200000
190000
180000
170000
160000
150000
Agilent’s 5th generation EPC and
digital electronics further improve RTL
precision for low-pressure applications
(to 0.001 psi actual).
140000
130000
0.967 psi
0.97 psi
0.96 psi
120000
110000
Column 1
at 1.000 psi
100000
90000
80000
Time
6.58
6.59
6.60
6.61
6.62
6.63
6.64
6.65
6.66
6.67
6.68
6.69
5989-8366EN: Low Pressure Retention Time Locking with the 7890 GC
Unsurpassed retention time
reproducibility
5th-generation electronic pneumatics
control (EPC) makes it easy to set
pressure and flow – and to keep these
setpoints consistent from run to run for
retention time repeatability.
Run
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
Average
Standard Deviation
Peak 1*
9.0839 min
9.0835
9.0841
9.0846
9.0851
9.0849
9.0845
9.0849
9.0847
9.0853
9.0852
9.0851
9.0847
9.0848
9.0853
9.0847 min
0.000527
Peak 2*
11.8492 min
11.8492
11.8494
11.8496
11.8507
11.8502
11.8504
11.8500
11.8504
11.8502
11.8502
11.8508
11.8503
11.8507
11.8506
11.8501 min
0.000535
*Heart-cut from column 1.
pA
12
10
15 overlaid heart cut
chromatograms on
Peak 2 showing
unsurpassed reproducibility
8
6
4
2
11.78
11.8
11.82
11.84
11.86
11.88
11.9
11.92
min
Achieve unsurpassed retention time reproducibility in standard applications – even with multi-dimensional
applications, such as the heart-cutting example shown here.
To learn more about the Agilent 7890B GC, visit www.agilent.com/chem/7890B
5
Add dimension to your chromatography
with Capillary Flow Technology
Agilent’s proprietary Capillary Flow Technology (CFT) solves
a problem chromatographers have been wrestling with for decades:
creating leak-free capillary connections that can withstand the
temperature extremes of a modern GC oven.
CFT devices are inert, with low mass and low dead volume to help you
make secure connections and precisely divert your gas flow
pneumatically. This opens the door to techniques that can expand analytical capabilities, improve your results, and
conserve both time and resources.
CFT backflush saves you time
with every run
Blank after backflush
Backflushing works by reversing the
column flow immediately after the last
compound of interest has eluted, thereby
sweeping material backwards through
the column and out the split vent.
This simple technique extends column
life and eliminates long bake-out times
for highly retained sample components.
It also prevents problems such as
carryover, retention time shifts, and MSD
source contamination.
Backflush @ 10 min
Original
1 mL/min CF
5.00
10.00
15.00
20.00
25.00
30.00
35.00
40.00
5989-9804EN: Capillary Flow Technology: Backflush – Reduce Run Time and Increase
Laboratory Throughput
Backflush Assistant Software
Wizard guides you to greater
productivity
The Backflush Assistant Software
Wizard first collects information about
your method and CFT device, then
provides a step-by step procedure for
configuring the backflush hardware
and column plumbing. Once the
backflush-enabled method and timing
are determined, a validation protocol
confirms that the method performs
properly and robustly.
5991-1114EN: Capillary
Flow Technology: Purged
Ultimate Union – Reduce
Downtime and Increase
Your Lab’s Productivity
Expert training:
just a phone call away
Backflush and Backflush Assistant
Software Wizard training from Agilent
Workflow Services can help you set up
your CFT Backflush method quickly and
efficiently.
6
Capillary Flow Technology Deans Switch and
flow splitters enhance chromatographic capabilities
Valve components have been used for decades to perform GC heart cutting between two columns. However, a Capillary
Flow Technology (CFT) Deans Switch, using fluidic switching, allows precise, 2-dimensional GC heart-cutting analysis of
trace compounds in complex matrices.
How a Deans Switch improves
selectivity for trace compounds in
complex matrices
Cut
Automatic
Liquid
Sampler
Restrictor to
Detector 1
Peaks of interest from one column are
“cut” onto a second column with a
different stationary phase. Compounds
that might co-elute with analyte on
the first column are separated from
analyte on the second column. In this
way, selectivity is improved for trace
compounds in complex matrices.
Pneumatic
connections
to solenoid
valve
Column 1
Column 2
FID1
FID2
Column
1
Column
2
7890B GC
Deans Switch
In this example, the Capillary Flow Deans Switch enabled unresolved trace components to be heart-cut onto a
second column with a different stationary phase.
5989-9384EN: Capillary Flow Technology: Deans Switch – Increase the Resolving Power of Your GC
Flow splitting can help you pull the
most data from your samples
Flow splitting – sending the sample
to multiple detectors – maximizes
the data collected in a single run, and
is especially valuable for analyzing
compounds in complex matrices. This
technique can also help you identify
peaks of interest more quickly, improve
peak integration, and identify unknowns
with greater confidence.
Strawberry extract highlighting unknowns
MSD TIC
μECD
FPD (P)
5
10
15
20
Restrictor 2
to Detector 2
TIP: Agilent UltiMetal Plus
Flexible Metal ferrules improve
the reliability of your GC column
connections. Learn more at
www.agilent.com/chem/flexiferrule
Unknown
peak not
found by
MS
25
30
35
40
Inlet
Aux EPC
Det 1
Det 2
Restrictor 1
Restrictor 3
to Detector 3
Restrictor 2
Restrictor 1
to Detector 1
Aux EPC or
PCM
MSD
Column
Restrictor 3
Splitter
Column
GC Oven
Agilent CFT devices provide easy-to-make, low-volume, connections for better chromatography.
5989-9667EN: Capillary Flow Technology: Splitters – Get More Information in Less Time
To learn more about the Agilent 7890B GC, visit www.agilent.com/chem/7890B
7
Keep your lab running at peak performance –
now, and in the future
The modular Agilent 7890B GC system lets you choose from the industry’s widest selection of inlets, detectors, columns,
and automated sample introduction techniques. Entire injector and detector modules can be changed in minutes, while
injector and detector components can be swapped independently of pneumatics and electronics – saving your
lab money.
Versatile Multimode Inlet (MMI)
Low Thermal Mass (LTM) technology
for faster cycle times
Agilent’s MMI combines spit/splitless operation (cold, hot,
and pulsed), temperature programming, and large-volume
injection with a solvent vent mode. Benefits include higher
system sensitivity, robust handling of dirty samples, and the
ability to analyze thermally labile compounds.
LTM technology for GC and GC/MS promotes direct, rapid
heating and cooling for faster GC analyses and higher sample
throughput. With its independent temperature control of
up to four column modules, LTM technology also enables
multidimensional GC and integration with Capillary Flow
Technology for reduced column maintenance.
Syringe Needle
Note, too, that LTM systems consume far less power than a
conventional GC platform. To simplify method transfer, most
Agilent J&W GC columns are available for LTM modules.
Baffled Liner
Carrier
Vent
GC Column
Sensor
Sample
Analyte
Solvent
Insulated
Heating Wire
Insulation
Column
The key to LTM technology: weaving direct heating and temperature-sensing
components around a standard fused-silica capillary column (up to 30 meters)
for rapid heating and cooling.
5990-3954EN: Agilent Multimode Inlet for Gas Chromatography
400
Full dynamic range FID
350
Our state-of-the-art digital electrometer delivers a linear
dynamic range of 107, seamlessly integrated into a single run.
2 m LTM
LTM Cooldown Times
(Standard Size)
300
Temp (ºC)
250
Sensitive and selective element detection
5 m LTM
10 m LTM
7890 GC
200
150
100
Agilent offers several element-selective detectors, including
our new Flame Photometric Detector (FPD) with improved
sensitivity and a temperature range up to 400 °C. For
demanding applications, Sulfur Chemiluminescence Detectors
(SCD) and Nitrogen Chemiluminescence Detectors (NCD)
provide the highest sensitivity and selectivity.
50
0
0
50
100
150
200
Time (sec)
Typical cooling times for standard (5-inch) LTM column modules are
significantly faster than a conventional GC oven.
5990-7688EN: Agilent Low Thermal Mass (LTM) Series II System for
Gas Chromatography
5990-3237EN: Dual Channel Simulated Distillation of Carbon and Sulfur with
the Agilent 7890A GC and 355 Sulfur Chemiluminescence Detector
8
250
Ensuring an inert flow path has never
been more critical
As samples become smaller, increasingly active, and more complex, you simply cannot
afford losses caused by flow path activity.
For starters, having to repeat or verify suspect analyses wastes valuable resources, hinders
productivity, and hurts your bottom line. And with trace amounts of active analytes, you might
not even get a second chance, because there may be no more sample left to analyze.
Agilent’s Inert Flow Path Split/Splitless inlet option ensures the inertness of flow path surfaces, allowing analytes to safely
pass from injector to detector.
Agilent J&W Ultra Inert GC column
Septum
-Si-O-H
-Si-O-H
-Si-O-H
-Si-O-H
-Si-O-H
-Si-O-H
Deactivation
-Si-O-H
-Si-O-H
-Si-O-H
-Si-O-H
-Si-O-H
Inert Flow Path
Split/Splitless
inlet
-Si-O-H
Ultra Inert
GC liner
Data
Stationary
phase
Fused silica
surface
-Si-O-H
Sample
Ion
source
Inside GC column
Glass wool
Polyimide outer coating
GC/MSD (or other detector)
Retention gap
Ultra Inert gold seal
UltiMetal Plus Flexible
Metal ferrule and Ultimate Union
Backflush: UltiMetal Plus
Flexible Metal ferrule and Purged Union
An integrated approach to inertness: The Agilent advantage
• Ultra Inert gold seals feature deactivation chemistry applied
on top of their gold plating for the most inert surface and
highest-quality seal.
As the GC industry’s premier measurement company, Agilent
is uniquely positioned to help ensure the inertness of every
surface that touches your sample, so you can achieve the
parts-per-billion – or parts-per trillion – detection levels that
today’s analyses demand.
• UltiMetal Plus Flexible Metal ferrules are compatible with
Capillary Flow Technology fittings, promoting a leak-free seal
that requires less torque – and reduces the risk of column
breakage.
• Agilent J&W Ultra Inert GC columns are tested with the
industry’s toughest test probe mixture to ensure consistent
column inertness and exceptionally low column bleed.
• Gas Clean filter systems deliver the cleanest possible gas,
reducing column damage, sensitivity loss, and downtime.
• Ultra Inert liners deliver a robust, reproducible and reliable
inert flow path – with or without glass wool.
• GC detectors allow the selectivity or sensitivity that your
application requires – and the ability to handle your data
with a unified platform.
• Inert Flow Path Split/Splitless inlet option provides an
extra measure of inertness to the sample pathway.
For more information about creating an inert GC flow path, visit www.agilent.com/chem/inert
9
Intuitive software tools simplify operations
and boost productivity for every user
Integrated method development tools and calculators take the guesswork out of tasks such as changing carrier
gas, selecting the right liner, or changing to a column of different dimensions.
Interactive graphical consumables and parts identification tool quickly locates key parts on the GC system, and
provides part numbers and descriptions for easy ordering.
Consumables database simplifies method development by minimizing tracking errors and automatically populating
analytical methods with key configuration information.
Resource conservation tools, such as automatic sleep and wake modes, reduce gas and power consumption, while
making sure the system is ready to run when you need it.
GC/MS MassHunter with MSD ChemStation
Data Analysis: Agilent’s newest platform designed
to resolve your search for data
Quickly and confidently find the answers
you seek for routine quantitation and more
challenging discovery applications.
Choose either MassHunter or MSD ChemStation Data
Analysis – the traditional choice for GC/MS analysis.
Common instrument control for Agilent GC/MS systems simplify
your laboratory operation.
Agilent’s Barcode Printing Bundle
(G9201AA) has everything you
ou need
to print labels for the 7693 ALS and
7697A Headspace Samplers..
10
OpenLAB
CAPTURE • ANALYZE • SHARE
OpenLAB CDS resolves
your search for speed with
updated data analysis and
reporting
OpenLAB CDS is available in
ChemStation and EZChrom Editions.
Both retain their familiar look and feel,
but with significant improvements
that will make your work routine more
efficient. These include:
• Easy, intuitive custom reporting
with new OpenLAB Intelligent
Reporting – featuring graphical
“drag and drop” capability
• Powerful data analysis speeds up
results review and enables you to
process large data sets faster
• Optimized control, data acquisition,
and data processing for your
Agilent 7890B GC
• Better management of user privileges
and password protection
Centralized data storage is also available
through Agilent OpenLAB Data Store
and OpenLAB ECM software.
Flexible
architecture
expands from a
single instrument
to lab-wide
implementation.
Advanced data analysis
and reporting drives greater
throughput and productivity.
A trusted upgrade
path preserves
your investment in
workflows, data,
and methods.
Networked OpenLAB
CDS allows you to
get your work done
from anywhere in the
lab – and simplifies
the administration of
methods, user roles,
and permissions.
To learn more about the Agilent 7890B GC, visit www.agilent.com/chem/7890B
11
Resolve your search for integration
Smart features take supportability,
performance, and safety to new heights
Integrated GC MSD communication
and safety controls
Direct communication between the 7890B GC and 5977A
Series GC/MSD enhances and protects your investment:
► If the MSD vents… the system increases the flow of
carrier gas, shortening vent times by up to 40%
► If the pump fails… the system shuts off the carrier gas,
saving expensive helium or avoiding hydrogen build-up
► If communications are lost… the system shuts down the
GC thermal zones
Can also be used with hydrogen or
nitrogen carrier gas to reduce
operating costs
Sleep/wake modes reduce gas and
energy consumption
12
Parts information
at your fingertips
► Easily locate part numbers for
consumables and supplies with Parts
Finder, an interactive 3D graphical
tool
► Instantly see parts and consumables
specific to your instrument
configuration. You can then print or
email purchase orders, or import
directly into your Agilent.com cart
► Keep track of columns and supplies
with an optional barcode reader, and
auto-import accurate configuration
information into your GC and
analytical method
► Parts ID tool quickly identifies parts
and part numbers for easy
re-ordering
Optimize productivity
► Early-maintenance feedback allows you to plan
routine maintenance tasks and reduce unnecessary
downtime
► Agilent Data Systems easily develop and optimize
methods through:
– Integrated GC Calculators, including method
translator and vapor volume calculator
– Auto transfer of calculated values to the
method editor
– Setup and status of maintenance tracking
counters
To learn more about the Agilent 7890B GC, visit www.agilent.com/chem/7890B
13
Agilent autosamplers:
the perfect partners for your 7890B GC
With its 16-vial capacity and dual simultaneous injection, the Agilent 7693
Series Automatic Liquid Sampler (ALS) delivers the fastest injection times of
any GC autosampler. For large-capacity labs, the 7693A platform offers a
16- or 150-vial capacity. Enhanced capabilities – such as automated dilution,
internal standard addition, heating, mixing, and solvent addition – help
eliminate variability and rework.
If your lab processes fewer than 50 samples per day, the Agilent 7650A ALS
is a robust, lower-cost option for optimizing workflows and maximizing
sample throughput.
Boost your lab’s output with advanced sample
preparation capabilities
Automatically introduce volatile compounds from
virtually any sample matrix
The Agilent PAL Autosampler is ideal for liquid injection,
headspace, and solid-phase microextraction (SPME)
applications. Although this versatile platform can be
configured solely for liquid injection, it also offers many
capabilities – including large-volume injection (LVI), multiple
vial sizes, and extended sample vial capacity.
Agilent’s 7697A Headspace Sampler ensures an inert sample
pathway for superior GC system performance without analyte
degradation or loss. Electronic Pneumatics Control (EPC), a
111-vial capacity, and three exchangeable 36-vial racks make
the 7697A an ideal choice for high-throughput labs. In addition,
the Agilent 7697A Headspace Sampler is the industry’s only
dedicated headspace unit that supports the use of hydrogen
as a carrier gas.
Protect your instrument – and the integrity of your samples – with Agilent’s industry-leading
vials, caps, and syringes
` Optimize your productivity
` Extend the life of your system
` Maximize your uptime
View the Agilent Sample Introduction brochure at www.agilent.com/chem/library and search for 5991-1287EN.
14
Pharmaceutical applications
Confidently detect impurities at very low levels
Gas chromatography, coupled with static headspace sampling, is an easy-to-use, high-throughput tool for
determining residual solvent impurities in pharmaceutical products. Sample preparation is relatively simple, and the
method is easily validated. In addition, headspace sampling allows you to avoid large-water injections that can cause
column degradation and coelution.
Residual solvent analysis using
an Agilent 7890B GC system with
an Agilent 7697A Headspace
Sampler
Excellent chromatographic performance
was achieved for residual solvents at
USP <467> specified limits, as shown
in this example for Procedure A - Class
1 Solvents.
Agilent 7890A GC methods and equivalent results will transfer directly to the 7890B GC.
5991-1834EN: “Analysis of USP <467> Residual Solvents using the 7697A Headspace
Sampler with the 7890B Gas Chromatograph”
Save energy and conserve valuable resources. Sleep/wake
mode lets you put your system to sleep when not in use, and
have it awaken exactly when you need it.
Early maintenance feedback (EMF) keeps track of injections and consumable usage, so you
can establish maintenance SOPs.
To learn more about the Agilent 7890B GC, visit www.agilent.com/chem/7890B
15
Energy and chemical applications
Take your lab to a higher level of reliability
and productivity
If your lab still uses an “old workhorse” GC just because it gives you “acceptable results,” perhaps it’s time to consider
the transformative advantages of Agilent’s 7890B GC. It goes beyond “acceptable results” to give you increased
productivity, safety, cost effectiveness, and environmental friendliness – all with greater precision and reliability than
instruments past their prime.
Technology innovations expand
your range of analyses:
Fast Simulated Distillation using Low Thermal Mass Module (LTM)
ASTM D2887 Reference Oil
Calibration sample C5-C40
• LTM technology that reduces cycle
time for Simulated Distillation.
• An isothermal oven that enables rapid
RGA with H2S and O2 separation.
• Pre-configured hardware and methodspecific separation tools that let you
focus on calibration and validation per
your lab’s SOPs.
The simulated distillation results for ASTM D2887 RGO agree with the RGO specification of
ASTM D2887, with RSDs of 0.12 to 0.47 percent across the reported percent off range.
5990-3174EN: Fast Hydrocarbon and Sulfur Simulated Distillation Using the Agilent Low
Thermal Mass (LTM) System on the 7890 GC and 355 Sulfur Chemiluminescence Detector
600
500
400
300
200
100
t-2-Butene
1-Butene
i-Butene
c-2-Butene
i-Pentane
n-pentane
1,3-Butadiene
Propyne
t-2-Pentene
2-Methyl-2-butene
1-Pentene
c-2-Pentene
Propylene
i-Butane
n-Butane
Propadiene
Acetylene
700
Propane
Methane
Ethane
Ethylene
pA
800
n-Hexane
FID Channel
0
1
2
3
4
5
6
7
min
800
CO2
700
Methane
N2
Ethane
600
500
2nd TCD Channel
Ethylene
400
300
200
CO
100
H2S
Our extensive portfolio of pre-tested,
pre-configured GC and GC/MS
analyzers let you focus on calibration
and validation per your lab’s SOPs.They
are designed specifically for energy and
chemical applications such as refinery
gas, natural gas, TOGA, standard, and
alternative fuels.
Fast RGA Analysis
O2
Factory-configured analyzers let
you start your analysis immediately
after installation
0
1
2
3
4
5
6
7
min
Oxygenates in finished gasoline per ASTM D4815
1.
2.
3.
4.
5.
6.
7.
8.
9.
10.
11.
12.
13.
14.
Methanol
Ethanol
Isopropanol
tert-Butanol
n-Propanol
MTBE
sec-Butanol
DIPE
Isobutanol
tert-Pentanol
DME
n-Butanol
TAME
Heavier
hydrocarbon
13
14
3
5
11
1
7 9
8
2 4 6
10
12
5991-1561EN: Analyzer Solution Guide for Energy & Chemicals Industry
16
Conform to industry requirements
for sulfur levels
Sulfur distribution in feedstocks is
critical to the refining industry as it
adjusts to meet clean fuel requirements.
Agilent’s new Flame Photometric
Detector, with its high temperature
capability and improved sensitivity, is
an ideal tool for determining sulfur in
blending stocks, such as light cycle oil
(LCO). Profiling dibenzothiophenes is
particularly important for achieving the
lowest sulfur levels in the final products.
For optimal results, the FPD must be
operated at temperatures above 300 ºC.
Analysis of substituted dibenzothiophenes in light cycle oil (LCO) using a CFT Deans
Switch system with an Agilent 7890B FPD. This enhanced separation reduces the
possibility for quenching caused by co-elution with hydrocarbons.
5991-1752EN: An Improved Flame Photometric Detector For the Analysis of
Alkyldibenzothiophenes in Light Cycle Oil, and Gas Oil Feedstocks using the 7890B
Reliable trace sulfur analysis. Excellent
reproducibility was achieved by coupling
the Agilent 7890B GC with our sensitive,
high-temperature FPD.
Comprehensive GC flow modulation
The Agilent 7890B GC uses Capillary
Flow Technology to enable flow
modulation without the need for
complicated – and costly – cryo-focusing
techniques. This analysis of diesel
fuel shows the normal boiling point
distribution in the first dimension, and
functional group clusters in the second
dimension.
Zoom: C16 and C18
methyl esters
GC x GC of a B20 Biodiesel showing separation of the C16 and C18 methyl esters. Column 1: 20 m x 0.18 mm x
0.18 µm DB1, Column 2: 4 m x 0.24 mm x 0.25 µm HP-INNOWax. Modulation period: 2.800 seconds.
5989-9889EN: Capillary Flow Technology: GC x GC Flow Modulator: Get a Second Dimension of Information on
Complex Mixtures
To learn more about the Agilent 7890B GC, visit www.agilent.com/chem/7890B
17
Environmental applications
Simplify and accelerate complex screening methods
US EPA Method 8270 is widely used to determine the concentration of semi-volatile organic compounds in
environmental matrices – many of which contain a mix of acids, bases, and neutrals. This method can be challenging,
due to interactions between analytes and flow path surfaces.
Semi-volatiles analysis
Here, a 5 ppm EPA 8270 standard run
was spiked into 5000 ppm of heavy oil
to simulate interference from hazardous
waste.
During the first run, peaks of interest
eluted in less than 16 minutes, but
a 24-minute bake-out at 320 °C was
required to elute heavy components.
The sample was rerun with a 4-minute
backflush, which cut the cycle time by
20 minutes per run – a 50% total cycle
time savings. ALS overlap and faster
cool down saved an additional 4 minutes
per cycle.
5989-6026EN: Significant
Cycle Time Reduction
Using the Agilent
7890/5975 GC/MSD for
EPA Method 8270
Analysis of TPH (Mineral Oil)
This technique meets regulated method
requirements for analyzing the C10-C40
hydrocarbon fraction in soil and water
extracts using splitless injection. The
total analytical cycle time was less than
five minutes.
4000000
3500000
Motor oil
3000000
Response
Fast oven temperature programming
using a low-thermal-mass system
reduces cycle time and increases
sensitivity for GC-FID analysis of mineral
oil in environmental samples.
Diesel
4500000
2500000
2000000
1500000
1000000
500000
0
0.00 0.20 0.40 0.60 0.80 1.00 1.20 1.40 1.60 1.80 2.00 2.20 2.40 2.60 2.80
Time (min)
Method Calculator makes it easy
to set up a method that shortens
analysis time or facilitates the
changing of carrier gas.
18
5990-9104EN: High
Throughput Mineral Oil
Analysis (Hydrocarbon Oil
Index) by GC-FID using the
Agilent Low Thermal Mass
(LTM II) System
Food applications
Confidently execute your most specialized analyses
In addition, an integrated Solvent
Elimination Calculator provides a
complete set of initial conditions for easy
LVI method development.
Hexazinone
Leptophos
Dieldrin
p,p'-DDE
Chlorpyrifos
Cypermethrin I
Chlorothalonil
Fenvalerate I
Propargite
Methyl parathion
Chlorpyrifos Methyl
Heptachlor
25-µL Solvent Vent (35 ºC)
Bromacil
Malathion
Prometon
b-BHC
Atrazine
Lindane
Ethalfluralin
Trifluralin
Vernolate
Dichlorvos
Agilent’s MMI has the same form factor
and uses the same consumables (such
as liners, O-rings, and septa) as our
split/splitless inlet, so you can replicate
your existing hot splitless methods. Its
temperature programmability also lets
you perform both cold splitless and
large-volume injection (LVI) methods for
improved detection limits.
Mevinphos
Mirex
Lower your pesticide detection limits
with the Agilent Multimode Inlet
(MMI)
10-µL Cold Splitless (30 ºC)
2-µL Hot Splitless (280 ºC)
4.00
6.00
8.00
10.00
12.00
14.00
16.00
18.00
20.00
Total ion chromatogram comparing a 25-μL solvent vent injection with a 2-μL hot splitless injection
for 40-ppb pesticides. Note the significant signal-to-noise improvement (lower detection limits).
5990-4169EN: Achieving Lower Detection Limits Easily with the Agilent Multimode Inlet (MMI)
Pesticides in milk extract:
Flow splitting enables multiple
detectors – increasing productivity
Full scan TIC
Agilent’s flow splitting device
proportionally splits column effluent
to multiple detectors: MSD, DFPD and
μECD. Full-scan TIC from the MSD
provides quantitation and confirmation,
while element-specific GC signals
highlight trace-level compounds to be
identified by the MSD.
The splitter also provides backflush
capabilities to shorten cycle time and
increase column life. Backflushing
reduces ion source contamination
by preventing column bleed and
stopping heavy residues from being
introduced into the MSD. It also
eliminates carryover from any sample
that accumulates at the column head,
improving data integrity.
SIM
It took additional 33 min
and column to 320 ºC to
remove these high boilers.
µECD
DFPD(P)
5.00
10.00
15.00
20.00
25.00
30.00
35.00
40.00
Run stopped at 42 min and
backflushed at 280 ºC for 7 min
Blank run after backflush
showing the column was clean
5
10
15
20
25
30
35
40
45
50
55
60
Four chromatograms collected simultaneously from a single injection of milk extract.
5989-6018EN: Improving Productivity and Extending Column Life with Backflush
To learn more about the Agilent 7890B GC, visit www.agilent.com/chem/7890B
19
65
70
min
Forensic/toxicology applications
Screen and quantitate target compounds
in complex matrices
Rapid drug screening: Obtain more
information in less time
GC/NPD/MSD with simultaneous SIM/
Scan offers advantages such as broadrange screening for unlimited targets,
full-spectrum identity confirmation,
and non-target identification through
Deconvolution Reporting Software (DRS)
library searches.
Scan TIC
This system collects Scan, SIM, and
NPD data simultaneously. Scan is used
to screen for 725 tox compounds. SIM
is used for select low-level targets.
NPD is used for confirmation aid and
highlighting suspicious non-targets.
NPD
SIM TIC
U
1
2
3
4
5
6
7
Toxicology screen on real blood extract.
An Agilent Capillary Flow device
splits column eluent, allowing the
simultaneous acquisition of NPD and
MSD data – and eliminating the need
for multiple runs on different GCs. CFT
Backflush further reduces cycle time and
stabilizes retention times.
Liquid
injector
XEPC
Solvent
Vent
NPD
MSD
Column
The GC/NPD/MSD
configuration allows:
(1) Splitting column
effluent to NPD and
MSD
(2) Solvent venting
(3) Backflushing
(4) No-vent column
changing
(Note: The MSD shown
here is for illustration only.
The MSD is actually on
the left side of the GC).
Chromatographic Peak
SIM data points
Scan data points
Scan
SIM
Scan
SIM
Scan
SIM
Scan
SIM
!"#$%&'(%
SIM
Scan
MSD SIM and Scan data
points are alternately
collected, with two separate
data signals constructed
at the end of the run. Each
data signal can be processed
like a SIM or Scan signal
collected separately.
5989-8582EN: Improved Toxicology Screening Using a GC/MS/NPD System with a 725-Compound DRS Database
20
Inlets, detectors, and accessories
expand the possibilities of system configuration
A wide inlet selection lets you optimize your system
for your analysis
High-sensitivity detectors accommodate
every sample type
•
•
•
•
•
•
•
•
•
•
•
•
•
•
•
•
•
•
•
•
•
•
•
•
•
•
•
•
•
•
Split/splitless (SSL) capillary
Inert flow path split/splitless (ISSL) capillary
Multimode inlet (MMI)
Purged packed injection port (PPIP)
Cool on-column (COC)
Cool on-column with solvent vapor exit (COC-SVE)
Programmable temperature vaporizing (PTV)
Volatiles interface (VI)
High-pressure gas sample injection
Gas sampling valve (GSV)
Liquid sampling valve (LSV)
The Agilent 7890B GC
provides a versatile
platform for all system
configurations.
Mass selective detector (MSD)
Triple Quadrupole MS
Q-TOF MS
Ion Trap MS
ICP-MS
Flame ionization (FID)
Thermal conductivity (TCD)
Micro-electron capture (Micro ECD)
Flame photometric, single- or dual-wavelength (FPD)
Nitrogen-phosphorus (NPD)
Sulfur chemiluminescence (SCD)
Nitrogen chemiluminescence (NCD)
Atomic emission (AED)*
Pulsed flame photometric (PFPD)*
Photoionization (PID)*
Electrolytic conductivity (ELCD)*
Halogen Specific Detector (XSD)*
Oxygenate Flame Ionization Detector (O-FID)*
Pulsed Discharge Helium Ionization Detector (PDHID)*
* Available through Agilent Channel Partners. Contact Agilent for other custom
configurations, and additional solutions available through Agilent Channel Partners
GC and GC/MS Analyzers let you focus on system validation and data
generation… not method development
Agilent GC and GC/MS Analyzers are factory configured and chemically tested to meet method
requirements, and get you on the “Fast Track” to producing quality data and processing sample
backlogs.
More than just instruments, Agilent Analyzers are complete workflow solutions that incorporate
advanced technologies, such as Capillary Flow Technology and target compound databases that
allow us to optimize your system for your unique application.
Each Analyzer arrives ready to perform with pre-set chromatography and checkout samples to
verify separation capabilities. That means your team can work toward system validation as soon as
installation is complete – and significantly reduce your method development costs. And as always,
our support team is available, should any problems arise.
To learn more about the Agilent 7890B GC, visit www.agilent.com/chem/7890B
21
Sample Preparation
Reliably extract and concentrate samples
from complex matrices
Agilent Bond Elut QuEChERS Kits make sample
preparation easier and more reliable
Agilent Bond Elut SPE: A full line of sample preparation
products to support your lab
Pre-packaged Agilent QuEChERS Kits capture the time-saving
benefits of QuEChERS sample preparation.
Bond Elut SPE products deliver the quality and performance
you expect from the industry’s leading manufacturer of
chromatography instruments, columns, and supplies.
• Extraction kits with pre-weighed salts in anhydrous packets
allow you to add salts after you add organic solvent to
your sample – avoiding an exothermic reaction that can
compromise analyte recovery
• A wide selection of polymer, silica, and other sorbents in
formats ranging from multiple cartridge sizes to 96-well
plates
• Dispersive kits with sorbents and salts supplied in 2 mL or
15 mL centrifuge tubes accommodate the aliquot volumes
specified by current AOAC and EN methodologies
• Tri-functional silica bonding provides greater stability than
monomeric bonding, while increasing solvent compatibility
• Industry-leading quality control processes ensure
consistent particle size, so you get superior flow-through
and performance
• Ceramic homogenizers break up salt agglomerates,
promoting consistent sample extraction and increasing
product recovery during extraction and dispersion
• A variety of vacuum manifolds and accessories help you
meet all your SPE challenges
To learn more, visit www.agilent.com/chem/sampleprep
22
Agilent stands behind every instrument
with unmatched service and support
Compliance
Agilent Value Promise
Agile
With over 100,000 qualification
deliveries, and decades of quality testing
ng
experience, Agilent is your trusted source
urce
for the system qualification and proof
of calibration you need for regulatory
compliance.
We gguarantee you at least 10 years
of ins
instrument use from your date of
purchase, or we will credit you with the
purch
residual value of the system toward an
resid
upgraded model.
upgra
Agilent Service Guarantee
Real-time support and reporting
If your Agilent instrument requires service
while covered by an Agilent service
agreement, we guarantee the repair, or
we will replace your instrument for free.
Agilent Remote Advisor is a remote
monitoring, diagnostic, and reporting
feature now included in all Agilent
Advantage service plans. It can help you
preempt instrument problems to maximize
your uptime and productivity.
Workflow Services
Capillary Flow Technology (CFT) Backflush
and Backflush Assistant Software Wizard
training are available through Agilent
Workflow Services. Expert assistance in
setting up your CFT Backflush method is
just a phone call away.
To learn more about the Agilent 7890B GC, visit www.agilent.com/chem/7890B
23
The Agilent 7890B Series GC
Resolve your search for
integration, reliability, and
intelligence
• Powerful software tools for data acquisition, analysis, and reporting help you
get the most out of your instrument
• Integrated Parts Finder tool and database makes it easy to find and order
columns, supplies, and parts
• Agilent Inert Flow Path solutions ensure a reliably inert GC flow path for
higher sensitivity, accuracy, and reproducibility – especially at trace levels
• 5th-generation electronic pneumatics control, combined with improved
specifications, raises the bar on GC performance
• Direct GC MSD communication minimizes downtime while conserving
power and gas
• Eco-friendly features, such as sleep/wake modes, conserve electricity and
other resources
• Early maintenance feedback keeps the system performing at its best
• Fast oven cool-down, new backflush capabilities, and advanced automation
boost your productivity
For more information
360°
Interactive
View
Experience the most feature
rich and advanced 7890B GC
and 5977A Series GC/MSD at
www.agilent.com/chem/resolve
Information, descriptions, and specifications in this
publication are subject to change without notice.
© Agilent Technologies, Inc. 2013
Printed in the USA February 1, 2013
5991-1836EN
Learn more
www.agilent.com/chem/7890B
U.S. and Canada
1-800-227-9770
[email protected]
In other countries, please call your local Agilent Representative or
Agilent Authorized Distributor – visit www.agilent.com/chem/contactus
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