University of Groningen Amylodextrin and poly(DL

University of Groningen Amylodextrin and poly(DL
University of Groningen
Amylodextrin and poly(DL-lactide) oral controlled release matrix tablets. Concepts for
understanding their release mechanisms
Steendam, Rob
IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to
cite from it. Please check the document version below.
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Publisher's PDF, also known as Version of record
Publication date:
2005
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Steendam, R. (2005). Amylodextrin and poly(DL-lactide) oral controlled release matrix tablets. Concepts for
understanding their release mechanisms s.n.
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Download date: 18-09-2017
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0.224
0.168
0.112
0.070
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0.16
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-60
-40
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0
20
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60
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160
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75
50
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350
300
Pressure [MPa]
250
200
150
100
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0
0.4
0.5
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0.7
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distance [cm]
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@
@
A2 B! :
@
ε
!2
@ A
@
@
A
7!5 B!
0.4
0.4
0.3
0.3
porosity [-]
porosity [-]
@B
0.2
0.2
0.1
0.1
0
0
0
100
200
300
0
100
compaction pressure [MPa]
B!
300
compaction pressure [MPa]
14( 2
. @:
200
@
5
(!%%7
- (!(6(
-0.010
@
?
C A
(!%)(
$
B
5((
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C A
0.12
/2.9,3= =" 9 W <=82G : 3
8
-0.020
6
4
-0.025
2
0
0.1
0.08
0.06
0.04
0.02
-0.030
0
0.05
0.1
0.15
0.2
0
0.25
0
0.05
moisture fraction [-]
. @:
14- 2
@
?
5
@
:
C
A$
0.15
@
+
+
5((
0.1
0.2
0.25
moisture fraction [-]
@ A2
9 :3=
=
)(
-0.015
ε c,min [-]
ER [%]
10
minumum tablet porosity [-]''
12
B! <
?
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C A
$
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@
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5
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2
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[204]E
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25
25
20
20
tensile strength [MPa]''
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!
15
10
5
0
15
10
5
0
0
100
200
300
0
141 :
200
@
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300
compaction force [kN]
compaction force [kN]
. @:
100
7
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:
@
A+ Q (!(6 4 (!%%B! :
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9 :3=
)'
tensile strength [MPa]
/2.9,3= =" 9 W <=82G : 3
25
20
15
10
5
0
0
0.1
0.2
0.3
0.4
- (!(6(
/
porosity [-]
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142 :
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[186,206]!
$
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48
[207]-
ln
σT
= −k ⋅ ε
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0
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[211]-
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!
$
50
1
40
0.8
30
0.6
20
0.4
10
0.2
0
probability (P)
24' : 4
A Q (!7(B!
mean cluster size (S)''
. @:
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0
0
0.2
0.4
0.6
0.8
1
A444B
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Aε Q (!')B! 9
porosity [-]
. @: 24( :
$
*
[213]!
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9
[212]
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2<29*2
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[214]! "
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0
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[221]-
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24-
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1
intruded fraction [-] ''
0.8
0.6
0.4
0.2
0
0
5
10
15
20
pressure [MPa]
. @:
241 :
@
$
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- (!'6
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3
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accessible fraction [-]
0.8
0.6
0.4
0.2
0
0
0.1
0.2
0.3
porosity [-]
. @:
242 9
$
$
@
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3
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0.4
water uptake [g/g] ''
0.3
0.2
0.1
0
0
50
100
150
0.5
square root of time [s ]
. @: 243
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water uptake [g/g] ''
0.3
0.2
0.1
0
0
50
100
150
200
250
time [min]
. @:
246 2?
(!(56
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0.020
0.012
2<29*2
0.008
0.004
8
Bcap [s-0.5]
0.016
0.000
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0
0.1
0.15
0.2
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247 :
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release [%]
80
60
40
20
0
0
4
8
12
16
time [hrs]
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248
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