Linear Control of Neuronal Spike Timing Using Phase Response

Linear Control of Neuronal Spike Timing Using Phase Response
Linear Control of Neuronal Spike Timing Using Phase
Response Curves
Tyler Stigen
University of Minnesota
P. Danzl and J Moehlis
University of California–Santa Barbara
T. I. Netoff
Univeristy of Minnesota
We propose a simple, robust, and linear method to control the
spike timing of a periodically firing neuron. The control scheme
uses the neuron’s phase response curve to identify an area of
A Manual Insertion Mechanism for Percutaneous
Cochlear Implantation
Daniel Schurzig, Zachariah W. Smith, D. Caleb Rucker, Robert F.
Labadie, and Robert J. Webster III
Vanderbilt University
Percutaneous cochlear implantation 共PCI兲 is a recently developed minimally invasive technique that utilizes image guidance
and a custom-made microstereotactic frame to guide a drill directly to the cochlea. It enables cochlear access through a single
drill port, reducing invasiveness in comparison to mastoidectomy.
Journal of Medical Devices
optimal sensitivity for the chosen stimulation parameters. The
spike advance as a function of current pulse amplitude is characterized at the optimal phase, and a linear least-squares regression
is fit to the data. The inverted regression is used as the control
function for this method. The efficacy of this method is demonstrated through numerical simulations of a Hodgkin–Huxley style
neuron model as well as in real neurons from rat hippocampal
slice preparations. The study shows a proof of concept for the
application of a linear control scheme to control neuron spike
timing in vitro. This study was done on an individual cell level,
but translation to a tissue or network level is possible. Control
schemes of this type could be implemented in a closed loop implantable device to treat neuromotor disorders involving pathologically neuronal activity such as epilepsy or Parkinson’s disease.
With the reduction in invasiveness, PCI enables a corresponding
reduction in visualization and space in which to work at the
cochlear entry point. This precludes standard cochlear implant deployment techniques and necessitates a new insertion tool that can
deploy a cochlear implant into the cochlea while working down a
deep, narrow channel. In this paper, we describe a manual insertion tool that we have developed for this purpose. The tool is
capable of inserting an electrode array into the cochlea using the
advance off-stylet technique, using simple manual controls on its
Copyright © 2010 by ASME
JUNE 2010, Vol. 4 / 027533-1
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