ESCHWEILER Combi Blood Gas Electrolyte Analyser Service Manual

combi

n line

Blood-Gas-Electrolyte-Analyser

For In-Vitro-Diagnostic Use

!

Service Manual

Eschweiler GmbH & Co. KG

Development - Manufacturing - Sales - Technical Service

Made in Germany

Service Manual

Manual Version

Manual History

Software Copyrights

Manufacturer

The latest Manual version is: 4.01

Order No.: 60 8 90 10 Print: SMe COMBILINE 401.PDF

Copyright © 2010 by

Eschweiler GmbH & Co. KG, Holzkoppelweg 35, 24118 Kiel

No part of this Manual may be reproduced in any form without the written permission of Eschweiler GmbH & Co. KG.

Manual ANALYSER-Software

Version Version

4.01

2500

Revision

Date

April 2010

The software for the combiline Analyser is the User and Instrument Control Software for the combiline. The combiline Software is the intellectual property of Eschweiler GmbH & Co. KG hereafter Eschweiler.

Intellectual property rights shall remain with Eschweiler.

You are entitled to use the combiline Software and the printed accompanying material at your place of work only.

Any violations of property rights or copyright or trademark or conditions of use may be subject to legal action.

Eschweiler GmbH & Co. KG

Holzkoppelweg 35

24118 Kiel, Germany

Phone: -49- 431-54 65 80

FAX: -49- 431-54 94 23

Internet: http://www.eschweiler-kiel.de

E-Mail: [email protected]

!

Service Manual

Consumable solutions and spare parts from other manufacturers used in ESCHWEILER Analysers.

We point out specifically that fault-free operation of our analysers can be guaranteed only when original ESCHWEILER solutions and spare parts are used.

The name ESCHWEILER with its decades of experience in the field of blood gas analysis also stands for the quality of the spare parts and consumable solutions. ESCHWEILER sensors and solutions form a functional unit whose components are optimally adapted to each other. Measuring accuracy and long life of the sensors are the goal of this system.

Through intensive development work, the chemical compositions of our solutions have been adjusted optimally to the ESCHWEILER sensors and guarantee, besides precise measurements, the greatest possible protection of the sensitive sensor surfaces.

For example, special wetting solutions are used which have a decisive influence on the unconstrained contact between sensor and solution in the measuring capillary. At the same time suitable preservatives prevent the growth of micro-organisms in the consumable solutions and keep them from being introduced into the measuring capillaries of the ESCHWEILER analysers.

The characteristics and concentrations of both the wetting- and the preservative substances are selected according to the special requirements of our sensors.

Fault-free operation of our analysers with measuring accuracy and long sensor life are the main goals of our quality requirements. Only if

ESCHWEILER original parts and solutions are used we can meet these requirements.

Please support us in doing this!

Service Manual

Table of Contents

Safety Issues ................................................................................................................................................ 2-5

Technical Data. ................................................................................................................................................ 6

Menue Guide. .................................................................................................................................................. 7

System Description ...................................................................................................................................... 8-11

Tubing. ....................................................................................................................................................... 12-15

Specification of Valves. ....................................................................................................................................16

Blockdiagram. .................................................................................................................................................17

Power Supply ..................................................................................................................................................18

Power Supply ESW-MVTC. ........................................................................................................................ 19-24

Adjustment of the operating voltage for Rollerpumps RP1 and RP2. ................................................................21

Adjustment of Thermostate Temperature .........................................................................................................23

Analog-Board ESW-ANALOG..................................................................................................................... 25-35

Adjustment of O2 Polarization Voltage and O2 Zero Point. ..............................................................................27

Circuit diagram for Sample-light-Barrier ...........................................................................................................28

Circuit Diagram for Hb-unit ..............................................................................................................................28

Testing the Airpressure Indication. ...................................................................................................................29

Adjustment of Thermostat Temperature-Indication. ..........................................................................................30

Adjustment of the Sample Light-Barrier ...........................................................................................................31

Capillary exchange in Sample-Light-Barrier .....................................................................................................32

Hb-Measurement module ........................................................................................................................... 33-35

CPU / AD-Converter CL Z80ADC. .............................................................................................................. 36-40

Serial Interface with SD Card Reader RS232 SD INT1.4 ............................................................................. 41-47

Fill Level Control CL FÜLLSTAND. .............................................................................................................. 48-50

Keyboard. .......................................................................................................................................................51

Display / Contrast. ..........................................................................................................................................52

Thermoprinter GPT-4352-60 .............................................................................................................................54

Liquid-Valves .............................................................................................................................................. 55-56

Delay Circuit for Ventilation Valve ....................................................................................................................57

Suction-Pump ............................................................................................................................................ 58-59

Sensor Spare Parts and Lifetime Information. ............................................................................................. 60-62

Consumeables ........................................................................................................................................... 63-65

Spare Parts ................................................................................................................................................ 66-68

TÜV Certificate ................................................................................................................................................69

Declaration of Conformity ................................................................................................................................70

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Service- Manual - Version 4.01

Safety Issues

Please read the Instruction Manual in its entirety prior to operating the line

. In order to ensure a high level of performance, all warnings and references to technical safety in this Instruction Manual have to be followed.

! 1 Hazards and Precautions

The cautions and safety regulations in this Instruction Manual meet international classifications:

Warns of a risk of injury or of a risk to life (for example by electrical shock).

DANGER Warns of a risk of injury or of the analyser being severely damaged.

CAUTION

Biohazard

NOTE

Electrical safety

DANGER

Warns of a risk of biological material like blood or other human or animal specimen. Risk of infection! Potential infectious area/material!

Introduces rules to be observed.

The following safety issues have to be observed at all times:

- Check that the operating voltage is set correctly before you connect the device to the main power supply.

- To connect the analyser to the main power supply, use only sockets which are grounded to avoid the risk of an electrical shock.

- Use only grounded extension power cords. The used power cord has to correspond to the country specific regulations.

- Never intentionally disconnect the grounding contacts.

There is the risk of electrical shock if the protective conductor is interrupted within or outside the analyser, and/or the grounded contacts have been disconnected from the line.

- Never remove protective guards or secured components since you could expose electrically live parts in this way.

- Electrical connection contacts (plugs, sockets, etc.) can be electrically live.


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Safety Issues

- Even after an analyser has been switched off, components (e.g. capacitors) can be under voltage as the result of an electrical charge.

- All current carrying parts are sources of danger for an electrical shock.

- Surfaces (floors, work tables) have not to be moist when you are working with any electrical device.

- Carry out only the maintenance work and/or the replacement of parts described in these Instruction Manual.

- Unauthorized work on the analyser can lead to the guarantee obligation becoming null and void with necessary expensive service work to correct it.

- All work, which requires the analyser to be opened, have to be carried

out by an authorised technician who is familiar with the risks related thereto.

- Use only replacement fuses of the stated type and with the stated nominal current. Never use fuses, which have been “repaired”.

- There is a Lithium battery on MAIN BOARD that have to be replaced

by the authorised technical service every 5 years! In case of a battery fault, all memorised parameter might be lost.

Mechanical Safety (Analyser is operating)

- Never open or unscrew analyser's casing parts while it is switched ON.

There is a risk of injury due to moving parts as fans, pumps, stepper-motors or any other mechanical movements.

CAUTION

Biological Material - Risk of Infection

- Wear gloves in all cases if there is a risk of infection.

Biohazard

- Avoid any direct contact with samples that are potentially infectious or which may generate other risks to the human body (Aids, Hepatitis etc).

In case of direct body contact go and wash the contaminated area immediately. Use a suitable skin disinfection solution. Ask your doctor for aid.

- If sample material (blood) or reagent is spilled onto the analyser, wipe it off immediately and refer to the chapter ! 2 Maintenance and Hygiene.

- Do not open a waste bottle as long as the analyser is in process.

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Safety Issues

Reagents and Controls

CAUTION

- Observe the suggestions in the package inserts for an exact use of the reagents and quality controls. Note that reagents and quality control material can be biological material!

- Don't use Reagents, Controls and other Liquids after expiration date!

- Avoid any liquid penetration into the analyser.

Restrictions for Samples, Reagents and Controls

- For consumables no guarantee can be provided for any resistance against organic solvents. For this reason, do not use any organic solvents unless such solvents are expressly indicated.

CAUTION

- Do not use any other rinsing or cleaning solutions as recommended by the manufacturer or representative.

- Waste liquid has to be disposed in compliance with the legislation.

Accuracy and Precision of the

Measured Results

CAUTION

- In order to ensure a flawless operation of the analyser measure control samples and watch the function of the analyser closely.

- Faulty measurement results may result in an incorrect diagnosis or range danger for patient.

Fire and Explosion Hazards

- Do not place any flammable or hazardous explosive material in the proximity of the device. Electrical sparks could cause fire or explosions.

CAUTION

Operator Qualification

- The analyser should only be operated by trained personnel. Improper operation of the analyser might cause inaccurate measuring results!

! 2 Maintenance and Hygiene

- No organic acid based cleaning substances should be applied. Instead use cleaner designed for cleaning and disinfecting laboratory analysers.

Only use a dampened cloth to clean the analyser.

CAUTION

- Never spray or pour cleaning solution directly onto the analyser, that may negatively impact the analyser’s functions significantly.

- Keep the analyser clean and do not spill liquids onto it.

- In case liquids were spilled onto the analyser, immediately absorb liquid with a suitable cloth.

- Contact your distributor if your control measurements do not produce the expected results.


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Safety Issues

Recommended Disinfectant

Solutions.

A suitable disinfectant is available by BODE Chemie, Hamburg:

Bacillol ® , is recommended for areas at risk of infection, where rapid contact times and drying times are necessary.

BODE Chemie GmbH & Co

Melachtonstr. 27 - 22525 Hamburg, Germany

Phone: +49- (0)40-54 00 60 - Internet: www. bode-chemie.de

Another suitable disinfectant is available by S&M Schülke & Mayr:

TERRALIN ® Liquid

Schülke & Mayr GmbH

Robert-Koch-Str. 2 - 22851 Norderstedt, Germany

Phone: + 49- (0)40-521 00-0 - Internet: www.schuelke-mayr.com

See the website for your nearest representation. Ask for an EC Material

Safety Data Sheet according to EC 91/155.

! 3 First-Aid Measures

If a person swallowed any chemical solution may be while servicing, wash out mouth with water.

If provided person is unconscious, than call a physician.

If inhaled, remove to fresh air. If breathing becomes difficult, than call a phy-

sician.

In case of contact, immediately wash skin with soap and copious amount of water.

In case of contact with eyes, flush with copious amounts of water for at least

15 minutes.

Assure adequate flushing by separating the eyelids with fingers, than call a physician.

! 4 Repairs

CAUTION

- Repairs to the analyser may only be carried out by trained personnel, and replacement parts have to comply with the analyser specifications.

- In case of analyser problems contact your representative.

Useful hint

NOTE

In this Manual a bullet "•" draws your attention to an instruction.

Example:

• Press enter-key to confirm ...

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Technical Data


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Menue-Guide

POWER UP COMBILINE

Rev. 2.500

WARM UP PHASE

OF 1 HOUR press 1 x

OPERATION key to select Menu

ECONOMY

PROGRAM

AUTO-CALIBRATION

OF SENSORS

STAND BY

DIALOGUE

DISPLAY

MEASURED

PRINT

MEASURING DIALOGUES

Sample introduction by selection of:

MEASURE

(SYRINGE or CAPILLARY) specify:

- BGA and meta values only

- ISE and meta values only

QC specify:

- LEVEL 1

- LEVEL 2

- LEVEL 3

- LEVEL 4

ASPIRATION GAS

Attention!

Sofware functions marked with * are not accessible during Warming Up!

Software functions marked with ** are not available in BGA types!

Software functions marked with *** are not available in ISE types!

OPERATION

1 = RINSE

2 = CALIBRATION *

3 = CALIBRATION BGA * **

4 = CALIBRATION ISE * **

5 = ACTIVATION HB *

6 = SENSOR PARAMETER *

7= ECONOMY MODE *

8 = DISPLAY MEASURED press 2 x


SERVICE - TEST

1 = BGA 1 / 3 ***

2 = BGA 2 / 4 ***

3 = CAL 3 **

4 = CAL 4 **

5 = GAS ***

6 = AIR / TEMP

7 = LIGHT BARRIER

8 = PROTEIN *

9 = REAGENT TEST press 3 x


STANDARD DATA

1 = CALIBRATION DATA ***

2 = DATE / TIME

3 = CORRELATION

4 = SETTINGS

5 = SENSOR SELECTION

6 = AB-PARAMETER ***

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System Description

Opened front cover

1 - LCD-Display

2 - Function keys

3 - Numerical keys

Order no.

F100.4.2

50 8 20 70 (keyboard compl.)

50 8 20 70 (keyboard compl.)

4 - Screw joint of Reagentwall

5 - Display-Contrast

6 - Peristaltic Pump meta 50 7 40 00

7 - Peristaltic Pump

8 - WASH-Valve

50 7 40 00

F200.25

9 - Sampleport-Insert 1-8.106

10- Liquid-Valves for Cal.Solutions 50 8 30 20

11- Suction-Valve

12- Sampleport-Valve

13- Input-Valve

14- Sample Light-Barrier

Order no.

F200.25

F200.28

F200.25

40 7 10 20

15- Thermostat with Sensors

16- Hb-Sensor type II

17- Sensorcatch

50 2 10 01

50 7 20 10

18- Panel for therm. illumination 50 7 20 21

19- Metabolite valve

20-Metabolite unit

F200.25


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Opened Front

1 - Switching power supply

2 - Thermoprinter GPT-4352-60

3 - Intermediate Vessel for suction

4 - Dampness Absorber

5 - Interface RS232 with SD-Card Reader

6 - Pinch Valve VE1 and VE2

7 - Filling Level Control board CL-FÜLLSTAND

8 - Suction Pump

Order no.

60 8 10 90

60 8 20 90

40 7 10 50

40 7 10 50

60 8 20 40

F200.25

40 8 20 00

F10.19

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Opened Rear Wall

11 - Switching Power Supply

12 - Intermediate Vessel

13 - Thermoprinter GPT-4352-60

14 - Analogboard ESW-ANALOG

Order no.

60 8 10 90

40 7 10 50

60 8 20 90

60 8 10 xx / 60 8 11 xx

15 - Filling Level Control board CL-FÜLLSTAND 40 8 20 00

16 - Rollerpump Motor with gear

17 - Suction Pump

50 7 40 10

F10.19


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Opened Rearwall, inside

CPU Board Z80ADC 1.2 and Power Supply ESW_MVTC

ESW_MVTC 2.0

60 8 10 80

1 - Potentiometer Rollerpump 2

2 - Potentiometer Rollerpump 1

3 - Buzzer

4 - Voltage input from Switching Power Supply

CPU CL Z80ADC 1.2

60 8 10 70

5 - L4 Connector for Analogboard ESW ANALOG

6 - Connector for DC-Supply (+5V)

7 - Driver ICs for Valve and Motor Control

8 - Printer Interface 9600 Baud

9 - Connector for RS232 Interface, 9600 Baud

10- Lithium Battery 3V Type BR2325

11- L11 LCD-Display

12- L10 Keyboard

13- Eprom with Analyser Software

14- L12 Filling Level board CL FÜLLSTAND

15 -RAM

16 - SD-Card Reader with RS232 Interface

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Reagent-Transport

combiline BGA

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o s o ma om nor str r rbe r bso A tef ess ch pn

Feu

Dam el ess

äß e-V gef

8 .2

R20 ed hen erm

Zw

Int

1 0.2

10 Rm


combiline


combiline ISE

n n pe ffe

o s o ally rm om no str r rbe bso ter s A efil cht nes mp

Feu

Da el ess

äß

-V gef

8 0.2

ate hen

R2 edi erm

Zw

Int

1 0.2

10 Rm

1 0.2

10 Rm

1 0.2

10 Rm

combiline



combiline BGA+E

n n pe ffe

o s o ally rm om no str er rb r bso te

A efil ess cht pn

Feu

Dam el

ß ess fä

-V

.28

ate nge he

R20 edi erm

Zw

Int

1 0.3

10 Rm

1 0.3

10 Rm

0 0.3

10 Rm


combiline


combiline meta

n n pe ffe

o s o ma om nor str r rbe er bso filt

A te ess uch pn

Fe

Dam se

ß

Ves fä

8 ge

.2

tehen

R20 ed erm

Zw

Int

1 0.3

10 Rm

1 0.3

10 Rm

0 0.3

10 Rm

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Valves

Determination of Valves

EV

BGA1

BGA2

Input-valve, module holder (one stage pinch valve, normally open)

Liquid-valve for calibration solution BGA 1 (normally closed) 1

Liquid-valve for calibration solution BGA 2 (normally closed) 1

LV

ABS

META

VE1

VE2

PV

BGA 3 Liquid-valve for calibration solution BGA 3 (normally closed) 2

BGA 4 Liquid-valve for calibration solution BGA 4 (normally closed) 2

CAL 3 Liquid-valve for calibration solution CAL 3 (normally closed) 2

CAL 4 Liquid-valve for calibration solution CAL 4 (normally closed) 2

Liquid-valve for ventilation (normally closed)

Suction-valve (one stage pinch valve, normally open)

Valve for triggering of the metabolite sensors 3

Ventilation-valve, intermediate vessel (one stage pinch valve, norm. open)

Ventilation-valve, suction pump (one stage pinch valve, normally open)

Sample port valve (one stage pinch valve, normally open)

SP Rinsing solution valve (one stage pinch valve, normally closed)

1

2

3 not available in combiline with electrolytes or metabolites not available in combiline BGA available in combiline meta only


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Blockdiagram rs er ve ib dri

Tre

D LC T IN PR Z80 OL CO R IE LT PE

OG AL AN

combiline ly pp su erow il

A te

5-2 g p etz

0-4 hin altn

11 itc sw

Sch

PM


Switching Power-Supply

Type: PM110-45-2A

+5V

±12V

+24V

Supply for Logic (with Protection Diode1N5630A): Z80 ADC, Level Control board CL Füllstand,

LCD Converter

Analogboard ESW- ANALOG, CL Z80 ADC Multiplexer

Printer, Valves, Suction-Pump, Thermostat-Heating

Power Supply für Pumps, Valves and Heating

Type: ESW-MVTC

Rollerpump 1

+6,2V

+11,5V

(E slow) Rollerpump 1 - slow speed (Testpoint MOTOR)

(E fast) Rollerpump 1 - fast speed (Testpoint MOTOR)

Rollerpump 2 (available in meta version only)

+6,0V (E slow) Rollerpump 2 - slow speed (Testpoint MOTOR_META)

+8,0V (E fast) Rollerpump 2 - fast speed (Testpoint MOTOR_META)


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Power-Supply ESW-MVTC

Voltage Supply for Pumps and Valves

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Voltage Supply for Pumps and Valves


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Adjustment of the operating voltage for Roller pump RP

Preparations:

1. Switch off the analyser.

2. Open the rear wall.

3. Have a voltmeter ready

4. The board ESW-MVTC is located at the inner side of the rear wall

Adjustment of the roller pump 1:

1. Switch the equipment on again.

2. Press Program key and Select menu SERVICE-TEST.

3. Activate the program 9 REAGENT TEST.

4. Connect the voltmeter to the test-points MOTOR (+) and GND1 (ground).

5. Press key „3“ (calibration solution) to run the roller pump 1 with slow speed.

6. Set the voltage at test-point MOTOR to 6.2V using potentiometer TR_SLOW.

7. Press key „2“ (WASH solution) to run the roller pump 1 with high speed.

8. Set the voltage at test-point MOTOR to 11.5V using potentiometer TR_FAST.

Continue with point 14 if second roller-pump is not available.

Adjustment of the roller pump 2:

9. Connect the voltmeter to the test-points MOTOR_META (+) and GND1 (ground).

10. Press key „8“ (Meta) to run the roller pump 2 with slow speed.

11. Set the voltage at test-point MOTOR_META to 6.2V ±0.3V using potentiometer TRM_SLOW.

12. Press key „7“ (Gas) to run the roller pump 2 with high speed.

13. Set the voltage at test-point MOTOR_META to 8.0V ±0.3V using potentiometer TRM_FAST.

14. Switch off the instrument, disconnect Voltmeter

15. Close the rear wall

16. Switch analyser on again

Remark:

The operating voltage for the roller pump has to be checked and adjusted only when an intact, good-as-new roller pump tube is used.

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Circuit Diagram Temperature-Regulation


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Temperature-Regulation

Description:

The Thermostate-Temperature Regulation is located on the power supply board ESW-MVTC

Via the plug connection V1 the low voltage 24 V~/4.5A is supplied. Furthermore the external elements for heavy-duty heating resistors as well as the temperature sensor (both in thermostats) are connected.

Exchange of Temperature regulation board (ESW-MVTC) or the NTC

After exchange of one of these components, the temperature, indicated on the display, is adjusted to 37°C with potentiometer T-CAL. The PIC IC must not be exchanged. Otherwise a re-adjustment of the circuit is required. For this adjustment special equipment is required.

Thermostat temperature correction on-site:

There should be made no adjustments without the required auxiliaries. Adjustments should not be done without contacting Eschweiler Service department!

LED for Temperature control indication:

A yellow LED for Temperature indication is located at the analyser’s front, below the reagent-wall. This LED is an indicator for temperature regulation status.

The more the actual thermostat temperature reaches to the nominal value (37°C), the longer the LED is

“ON”.

The LED is permanently “ON” when the temperature is in a range of ±0.5°C from 37°C.

The LED is blinking when the temperature deviation from 37°C is more than ±0.5°C.

The higher the blinking frequency, the higher is the temperature difference (e.g. Warm-up Phase).

In case of defective NTC-sensor or released temperature safety switch, the LED just blinks very short.

The LED is permanently on when the heating system is functioning.

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Metabolite Temperature Regulation, Circuit Diagram


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Analog-Board ESW ANALOG 1_01

Layout

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Circuit-Diagram for Sensor Amplifiers


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Adjustment of polarization voltage

Preparations:

1. Switch off the equipment

2. Open the rear cover of the instrument

3. The board ESW ANALOG is located at the rear-side of the reagent wall

Adjustment of polarization voltage:

1. Switch the equipment on again

2. Connect a voltmeter to the testpoint UPOL ant pos.B and Ground

3. Adjust the indicated voltage to 0.700V with the potentiometer POL at pos. A

4. Switch the equipment off

5. Close the analogue box, the reagent-wall and the frot cover again

Remark:

The polarization voltage is connected to the platinum cathode of the pO2 sensor. It is set to 0.700V at the factory

Adjustment of O

2

zero point

1. Activate Testprogram 5, GAS, in the SERVICE menue and remove the plug from the pO

2

-sensor

2. Adjust the voltage, indicated on the screen, to -1.700V with potentimeter ZERO at pos. C

3. Connect sensor cable to pO2 sensor, stop the Testprogram and start a calibration

4. Repeat this adjustment after approx. 30 min. operation time!

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Circuit-Diagram for BP, TEMP, Sample-Light-Barrier, Hb


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Adjustment and Testing of the Barometric Pressure indication

1. Find out the actual atmospheric pressure (Barometric Pressure)

2.

Press PROGRAM key and select the menu SERVICE-TEST

3. Select Program 6 AIR / TEMP

4. The atmospheric pressure measured by the internal air-pressure sensor is indicated as follows:

AIRPRESSURE 760 MMHG (example!)

5. Adjust the indicated value to the actual Barometric Pressure with the potentiometer T PS at pos. D

Remark:

A testpoint for measurement of the output voltage of the Barometric Pressure sensor is located at pos. E

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Adjustment of thermostate-temperature indication-circuit

Preparation:

1. Switch OFF the analyser

2. Open the front cover of the instrument

3. The board ESW ANALOG is located at the rear side of the reagentwall

The adjustment can be made with a suitable PT100-Transmitter or alternatively with 2 calibrated resistors. The adjustment is made for the value +20°C with a resistance of 107.80 Ohm and for +40ºC with a resistance of

115.54 Ohm. At the transmitter and the resistors the same lengths of cable must be used as on the built-in temperature sensor.

Adjustment procedure:

1. Switch the analyser ON again

2. Press PROGRAM key, and Select menu SERVICE-TEST.

3. Then activate the program 6 - AIR / TEMP

4. Disconnect the temperature sensor at plug PT100 at pos. H

5. Set +20ºC at the PT100-Transmitter and connect it at pin1 and pin3 of plug M2. Alternatively, connect a precision resistance* of 107.8 Ohm.

6. Set the temperature value in the display to 20.0°C with potentiometer T_ZERO at pos. G

7. Set +40ºC at the transmitter or connect a precision resistance* of 115.54 Ohm.

8. Set the temperature value in the display to 40.0ºC with Potentiometer T_GAIN at pos F

* Corresponding resistors with suitable plugs are available at ESCHWEILER

It may be necessary to repeat this procedure several times until both values are reached.


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Adjustment of the Sample Light-Barrier

The Sample Light Barrier can be adjusted at potentiometer TR_LB at pos. K on the analog board ESW

ANALOG

For Adjustment:

1. Open the Reagentwall and move it to the front

2. Press OPERATION key, and select menue SERVICE-TEST

3. Then activate the program 7, LIGHTBARRIER

4. Adjust the voltage, indicated for air, with potentiometer TR_LB at pos. K to a value between 2,000 V -

2.300V

4. Press key TEST (WASH solution is filled into the measuring cell). The indicated voltage must be between

0.300V and 0.500V!

Should it not be posssible to reach the a.m. voltage values, an exchange of the Sample Light Barrier or its capillary might be required. For instructions for LB-exchange please note next page.

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Sample-Light-Barrier LB

Capillary exchange in Sample Light-Barrier LB

By the time, the sensitivity of the sample-light-barrier can decrease. That means samples as well as calibration solutions are not recognized by the system. This leads to filling level indication for calibration solutions or even to permanent wash-cycles. Samples can be washed out without beeing measured.

The loss of sensitivity is mainly caused by deposits on the inner surface of the light-barrier-capillary. If an adjustment as described on previous page is not possible, the capillary needs to be replaced. For replacement proceed as follows:

- Activate Reagenttransport Program in menu SERVICE

- Remove sensors on left side (figure 1).

- Remove tube from LB-capillary (a)

- Put the exchange tool on the LB-capillary as shown in figure 2.

- Push the capillary out of the light-barrier as shown in figure 3.

- Take a new LB-capillary, place it on the tip of the exchange tool and push it left into the light-barrier as shown in figure 4.

- Reinstall sensors, connect tube to new LB-capillary and Quit Reagenttransport Program.

After replacement, check and adjust light-barrier voltage as described on previous page.


a figure 1 figure 2 figure 3 figure 4

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Analog-Board ESW ANALOG 1_01 Hb

Measure method

The Hb-sensor is based on the combination of reflexion (scattered) and Transmission measurement of infrared light.

The data processing of Hb-values in the range of 6 - 30g/dl is done by the Reflexion-measurement method.

The data processing of Hb-values in the range of 3 - 6g/dl is done by the Transmission-measurement method.

The Hb-measure unit is located on the analog amplifier board ESW-ANALOG 1_01.

The following has to be noticed:

- The use of Hb-calibration is not required, only the input of two parameters forrefexion and Transmission

(HB-R and HB-T) is necessary.

- After setting the Combiline into operation, sensor related parameters have to be entered by keyboard. After that the Hb-sensor is active for measurement. These parameters (HB-R and HB-T) are printed on a white flag at the Hb-sensor cable.

- The sample volume required for a fully equipped Combiline BGA+E+HB is min. 210 - 240µl. The sample volume required for a combiline BGA+HB is approx. 160µl. So it is of particular relevance to use capillaries with adequate volume.

- Please note that this measure method is suitable for measurement of whole-blood only! Quality controls are not usable!

- The measure range of the Hb-sensor is 3 - 30g/dl

- Hb will be measured if the sample light-barrier detects a whole-blood sample. Otherwise the programmed standard Hb-value is displayed (e.g. 15g/dl) and used for the calculation of the acid-base parameters.

- In case of too less sample volume, a “Transmission-voltage” of -4.000V is detected. The displayed Hbvalue will be 0.0g/dl then. This can be observed on a sensor-parameter printout which can be made after a sample measurement (see attached example of printout)

combiline


Analog-Board ESW ANALOG 1_01 Hb

Activation of Hb-Sensor type II

Carry out of an Hb-Sensor activation in STAND-BY mode

In order to maintain the measuring accuracy for determination of Hb and to activate the Hb-sensor, an input of two factors HB-R and HB-T has to be carried out in STAND-BY mode

In case the COMBILINE was switched off for less than 24 hours the Hb-factors are retained in the memory and the sensor remains ACTIVE.

In case the COMBILINE was switched off for more than 24 hours the Hb-factors have to be entered as described below, the Hb-sensor is marked with OFF.

The mentioned Hb-factors are printed on a white flag at the Hb-sensor cable (see attached photo)

Carry out Hb-factor input to activate the Hb-sensor:

• Press the 5-key in OPERATION MENU to perform the Hb-activation process, the following dialogue appears:

HB-SENSOR

HB R : 0.000

HB T :

• Enter the HB-R value given on the white ensign at the Hb-sensor by keypad e.g. 0.970 and press the

Enter-key to confirm.

The following dialogue appears:

HB-SENSOR

HB R : 0.970

HB T : 0.000

• Enter the HB-T value given on the white ensign at the Hb-sensor by keypad e.g. 0.517 and press the

Enter-key to confirm.

• The input range for HB-R and HB-T is 0.300 to 1.800

For quality control of the Hb-Sensor, whole blood specimens whose Hb-concentration have already been determined with the help of suitable measuring methods might be used (e.g. oximeter).


combiline


HB - SENSOR

HBR / HBT 0.970 0.517

MESS. [mV] -1182 -320 printout of Hb-sensor parameter

HB/R = Reflexion factor

HB/T = Transmission factor

MESS = Hb-sensor voltages for Reflexion and Transmission measurement of the last sample measurement (in millivolt)

Hb

Hb-factors HB-R and HB-T

Hb-sensor type II

Hb-sensor type II installed in combiline (optional)

combiline


CPU Board CL Z80 ADC12

Layout


combiline


Circuitdiagram 1/3

a a

F

F

T

0n

0n uF

F

F

F

T

F

F

F

0n

0n

0n uF

0n

0n

0n

F 0n

10

10

10

10

10

10

10

10

10

10

10

1 C1

C9

C8

3

0

4

C1

C1

C1

C7

C6

C5

C4

C3

combiline

E AC RF TE IN HB ste ce nitt rfa ch te

S se se ria rie r r nte cke pri

Dru





combiline



22

20

18

16

26

24

14

12

10

8

23

21

25

19

17

13

11

15

4

6

2

5

3

1

9

7

7

6

5

4

9

8

3

2

1

IN

IN

IN

IN

IN

IN

IN

IN

IN

10

IN

IN

IN

IN

IN

IN

IN

16

15

14

13

12

11

8

9

7

10

11

26

25

5

6

4

23

22

24

21

20

19

combiline



Specification

AD-conversion: (2 x 8 Bit parallel) 12 Bit AD-converter, ICL7109 int., range -4.096V to +4.096V, resolution

1mV. 16 channel multiplexer, HI506

Driver Output (24 pieces) 3 x 8 Bit outputs, with D-Latch (74HC273), Optocoupler (galvanic insulation) and driver circuits for loads up to 1A (ULN2803)

Display:

Level control:

Graphic-display NLC240x128BTGLE at L11 via ECODISP

(1 x 8 Bit) 8 Input-Ports for checking the filling levels of reagents via L12 CL FÜLLSTAND

Serial interface: 1. External interface RS-232 SD INT at L2

2. Thermo printer at L3

EPROM: 64KB Program (27C512)

RAM: 8KB (8K x 8)

Keyboard: Two parallel Ports at L10

Reset-component: battery operation, automatic reset generation, switch over to battery operation

4 Timer and counter channels: Baudrate generation (2 channels) Timer (multitasking software modul)

Remark:

An automatic reset is generated if the operation voltage of the CPU board becomes lower than 4.75V or higher than 5.25V.


combiline

Serial Interface RS-232 SD INT 1.4

Serial interface with SD-Card Reader RS-232 SD INT 1.4

Technical Data:

Baudrate: 9600 bit/sec

Databit: 8

Parity:

Startbit: no

1 (STX = 02HEX))

Stopbit: 1 (ETX = 03HEX) no handshake (unidirectional) connector: terminal RS232 at the rear panel of the instrument

Description:

All data which is sent to the printer after completition of a sample measurement, will also be transmitted to the RS232 interface at the same time together with CR (carriage return) and LF (line feed) at the end of the line. The transmission is unidirectional, there is no dialog between COMBILINE and PC. The data has to be received in a polling mode after starting a measurement. The data is given out in standard ASCII code.

Data recalled from the memory (SD-Card) will not be sent via RS232 !

The data transmission is unidirectional only.

Remark:

The data given by the interface can be detected by any terminal program for example TERMINAL.

combiline



Printout:

Example of print out of measurering results with corresponding data output

* see next page for description

Data output

27,-24.20

28,-17.1

29,4.4

30,171.1

31,22.81

32,1.8

33,0.25

34,7.373

35,0.00

36,0.00

37,760

38,101.3

65

0

11,45.0

12,42.4

13,1.36

14,126

15,37.0

16,20.9

17,0.85

18,1.0

19,13.3

20,-19.0

21,-21.5

22,1.1

23,29.0

24,99.4

25,20.5

26,27.67

(position no.,Value)

STX

80,CL3000

81,0945250808

82,09:45,25.08.08

0,171.1

1,1.8

2,7.373

3,5.9

4,104

5,1.38

6,141

7,0.92

8,0.0

9,0.0

10,15.0

255

ETX


Meaning

(Parameter

Start of Text

Type of analyser

Sample number

Time and Date pO

2 pCO

2 pH

K +

Na

Ca

Cl

Li +

GLU

LAC

Hb

-

+

++

(QC) unit)

(02HEX) mmHg or kPa mmHg or kPa mmol/l mmol/l mmol/l mmol/l mmol/l mmol/l mmol/l g/dl

HCT

H +

% nmol/l

Ca ++ 7.4

mmol/l

Cl - (Blood / Serum) mmol/l

Temperature

FIO

2

RQ

°C

%

HCO3A

HCO3S

BE

SBE mmol/l mmol/l mmol/l mmol/l

TCO

2

BB

O

2

O

2

SAT

-CT

P50 mmol/l mmol/l

%

%

AADO

A-GAP

2

SHUNT mmHg mmHg mmol/l

% pO

2 pO

2

, temp. correct. mmHg

, temp. correct. kPa pCO

2 pCO

2

, temp. correct. mmHg

, temp. correct. kPa pH, temp corrected

GLU

LAC mg/dl mg/dl

Barometric Pressure mmHg

Barometric Pressure kPa

Sample type

Timeouts

(MESART)*

(ADCMSK)*

Active Sensors (MESMSK)*

End of Text (03HEX)

combiline


Meaning of the last three Values of a data output:

1. Value - MESART= kind of measurement

2. Value - ADCMSK = sensors which exceeded the permissible time for measurement (measure-value with ?)

3. Value - MESMSK = sensors which were ACTIVE during measurement

All values are available in ASCII-Format as hexadecimal value. The value range is from 0 to 32768.

Explanation:

Bit Valence

00 1

01 2

02 4

03 8

04 16

05 32

06 64

07 128

08 256

09 512

10 1024

11 2048

12 4096

13 8192

14 16384

15 32768 -

-

-

-

-

-

MESART

Syringe

Capillary

BGA only

ISE only

QC

K

NA

Respiratory Gas CA

Serum, Plasma CL

ADCMSK, MESMSK

PO2

PCO2

PH

-

-

Blood

-

LI

HB

-

-

-

-

-

-

combiline



Example for MESART:

65 64 + 1

82 64 + 16 + 2

133 128 + 4 + 1

Example for ADCMSK:

0 0

3 2 + 1

Examples for MESMSK:

255 128+64+32+16+8+4+2+1

7 4 + 2 + 1

Serum, Plasma ; Syringe

Serum, Plasma ; QC ; Capillary

Blood ; BGA only ; Syringe

All Sensors comply with permissible measure times pO

2

+ pCO

2

did not comply with permissible measure times pO

2

, pCO

2

, pH, K + , Na + , Ca ++ , Cl , Li + were ACTIVE during measurement pO

2

+ pCO

2

+ PH were ACTIVE during measurement


combiline


Layout

RS 232 Interface with SD Card-Reader

combiline



Circuit Diagram


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Interface Cable

combiline


Fill Level Control CL FÜLLSTAND

Description:

Via L2 the waste bottle sensor is connected. The control of the Calibrants is made by the Sample Light

Barrier in the Sensorholder (Thermostat).

Via L1 the voltage supply (+5V / GND digital) and the outputs of the comparators are connected. The switch thresholds of the light barrier LS1 for WASH is adjusted with potentiometer TR1.

The light barriers must fulfil the following conditions:

1. Rinsing solution/calibration solution in tube Umax = 0.300 V

2. Air in tube Umin = 1.000 V

The outputs of the comparators supply the following signals: empty full rinsing solution T8 0 V +5 V

Push bar BGA 1/3 T4

Push bar BGA 2/4 T3 waste bottle T5

0 V

0 V

+5

+5 V (released / pressed)

+5 V (released / pressed)

0 V

Check of the waste bottle control

1. Reference voltage at

2. Sensors of waste bottle: in air, in tap water,

T6 = 2.500 V

T7 approx. 3.500 V

T7 approx. 2.000 V in distilled water T7 approx. 2.400 V

For testpoints (T...) see circuit diagram CL FÜLLSTAND

Transport of calibration solutions CAL3, CAL4, BGA1, BGA2, BGA3 and BGA4 is controled by the Sample

Light Barrier during calibration procedure!


combiline


Layout

Filling-Level Control Board CL-FÜLLSTAND

combiline



Circuit Diagram


combiline

Keyboard

Specification

The keyboard is operated directly at a parallel 8-bit port. Debouncing of the contacts takes place by by a progranmable Controller (PIC)

The PIC scans the keyboard-matrix permanently. If a key is pressed, the corresponding value is sent to the port. By an interrupt the information is interpreted by the analyser software. The corresponding action will be performed then.

Cleaning

Use a suitable cleaning solution as described in chapter !2 Maintenance and Hygiene and pay attention to the notes.

Keyboard Adaptor CL-TASTATUR

TASTATUR

ENTER

F1

1

2

3

F2

4

5

6 .

F4

C

0

F3

7

8

9

3

2

1

5

4

L2

7

6

9

8

AR1

4*10K

Q1

4.0 MHz

+5V

C1

100nF

1

TOCKI

2

+U

6

RA0

7

RA1

8

RA2

9

RA3

IC1

28

MCLR

PIC 16C57C

10

RB0

11

RB1

12

RB2

13

14

RB3

RB4

RC0

18

19

RC1

20

RC2

21

RC3

22

RC4

23

RC5

24

RC6

25

RC7

27

OSC1

26

OSC2

GND

4

13

11

9

7

25

26

17

15

5

3

1,2

L1

L10

Z80ADC

ESCHWEILER CombiLine

Tastaturadapter CL TASTATUR Rev. 1.2

CL TASTATUR 12.tcd / 01.02.2010

Ident-No. 3031

TASTATURADAPTER CL TASTATUR Rev. 1.2

SCHALTBILD UND BESTÜCKUNGSPLAN / CIRCUIT DIAGRAM AND LAYOUT

combiline

ESCHWEILER GmbH & CO. KG KIEL GERMANY

DATUM / DATE : 01.02.2010

BEZ.: CL TASTATUR 12.TCD

IDENT Nr.: 3031

BLATT / PAGE : 1 / 1

Keyboard Adaptor, Circuit Diagram and Layout


LCD-Display

Specification

Type: NLC240x128BTGLE

15 lines LCD-Display 30 characters / line

Contrast Adjustment

The trim potentiometer for contrast adjustment is located above the roller pump, as shown in figure 42a.

• Turn the potentiometer knob until the contrast of the display is pleasant for the operator.

Contrast Potentiometer for LCD-Display

Display contrast adjustment


combiline

LCD-Converter

Circuit-Diagram and Layout

combiline


Thermoprinter GPT-4352-60

Pin configuration for Printer GPT-4352-60

Voltage supply plug:

Pin 1: GND

Pin 2:GND

Pin 3:GND

Pin 4:+24V

Pin 5:CTS (output)

Paper specifications:

Figure 44 printer board

Interface (TTL/ 4,5V Pegel ):

Pin 1:GND

Pin 2:TXD (input)

Pin 3:RXD (output)

Pin 4:RTS (input)

Pin 5:CTS (output)

Roll diameter:

Roll width: up to 60mm

57mm

Paper thickness: 0.04mm

Key-Functions

FEED / ENTER key (1)

Printer self test:

Press key 1 then switch analyser ON.

Keep key 1 pressed for at least 3 seconds.

The printer software version and the character set will be printed

Paper feed will be performed during normal operation

1 LED


combiline

Liquid-Valve SMC

Description

Liquids will be sucked in by the control of Liquid Valves. 5 of them are sampled together to an array back beside of the Sample Port inside the housing.

The Liquid Valves are controlled by the NT-Move board.

Following liquids are controlled by the Liquid Valves (depending onconfiguration)

BGA 1 for Calibration Solution BGA 1




CAL 3 for Calibration solution CAL 3

CAL 4 for Calibration solution CAL 4 (+M)

LV for Air

Sedimentation

After a longer period of use, or the COMBILINELayout has been parked for a longer time, it can be possible that a sedimentation on the seal can cause a leakage.

Error evidence:

Valve does not respond of commands: Check magnetic coil with a digital multimeter. In case of trouble, replace valve.

In case of sedimentations inside of the valve, the liquid cannot be transported properly. The valve must be cleaned inside.

Replacement of a Liquid Valve

Order no.:

40 8 20 10 Liquid-valve block SMC complete, for COMBILINE BGA+E and meta versions

40 8 20 15 Liquid-valve block SMC complete, for COMBILINE BGA

40 8 20 20 Liquid-valve block SMC complete, for COMBILINE ISE

Order no. of a single valve:

50 8 30 20 Liquid-valve SMC

• Proceed as follows:

• Power OFF COMBILINE and disconnect it from Mains.

• Unscrew the three slotted-head retaining screws at the right side of the reagent wall.

• Remove all tubes from the valves.

Each of the valves is assembled together with two screws.

• Unscrew the two two for dismantling.

• Replace the valve to be replaced.

• Plug in the cables at the new valve (don't misplace cable!)

• Assemble the valve group in reverse order.

continued next page

• Power ON COMBILINE and open REAGENT TRANSPORT in SERVICE menu

• Ventilate the replaced Valve by pressing the corresponding function-key

combiline


Liquid-Valve SMC

Cleaning of a Liquid Valve

Proceed as described as follows:

• Dismantle the Valve Group.

• Dismantle the Valve as described above

• Clean the internal parts with suitable cleaning solution.

• For assembling of the valve proceed in reverse order.

• For reassembling of the Valve Group proceed as described b

Liquid Valve - SMC Type

Liquid Valve SMC Type - Fluidics


air

CAL3

CAL4

BGA3/1

BGA4/2 outlet

combiline

Ventilation-Valve VE1

Delay-circuit, Layout and Circuit-Diagram

The delay-circuit CL ASV is mounted on the ventilation valve VE2

combiline


Suction-Pump

Replacement of the Suction Pump

The Suction Pump is mounted with an aluminium angle beside the transformer and is controlled by the Main Board M1.

For a replacement proceed as follows:

• Switch OFF COMBILINE and disconnect it from Mains.

• Unscrew the two retaining screws on the aluminium angle.

• Remove angle from pump.

• Exchange the two cables to the new motor (don't misplace cables!).

• Exchange the two tubes (don't misplace in/out).

• Assemble the new pump with aluminium angle to its place.

• Switch ON COMBILINE.

• Open the dialogue REAGENTTRANSPORT in SERVICE-TEST menu

• Press 1-key for SUCTION to check its functioning.

Cleaning of Pump's Head

The internal parts of the pump could properly be contaminated with biological material. There is a risk of infection!

• Wear gloves!

• Uninstall the Suction Pump as described in the chapter above.

• Remove lid (B) from pump head, see figure 49 on next page.Liquid-Valve

• Remove the two screws (A) and the front panel (don't loose centre ring for motor axis).

• Loosen the allen screw (D) at motor axis.

• Remove both retaining screws for motor and pull pump head from motor axis.

• Clean the corresponding internal parts with a suitable solution, see chapter

!2 Hygiene.

Attention: There is no spare part available!

• Proceed in reverse order to install the pump head.

• Check the functioning as described in the above.


combiline

Suction-Pump

C

G

D

ASF

E

A B

Figure 49 Suction Pump explored

F

combiline


ESCHWEILER

automatic analysing systems

Sensor Spare Parts and average lifetime information

Ref.

1

Haltbarkeit

(Monate) durability

(month)

12 - 36

pO

2

Haltbarkeit


(month)

pCO

2

Ersatzteil-Liste für BGA-Sensoren spare part list for BGA sensors

Haltbarkeit


(month)

pH

Haltbarkeit


(month)

1 1

2

3

4

12 - 36

2

3

4

3 - 6

12 - 48

2

3

3 - 6 4

12 - 24

1

3

2

12 - 24

5

6

12 - 48

5

6

12 - 48

Referenzsensor kompl.

reference sensor compl.

50 5 10 00

1

2

3

4

5

6

Ref. Ableitsystem ref. conduct. system

50 5 10 10

Schraubkopf screw cap

50 1 10 21

Ref.-Aufsatz ref.- extension

50 5 10 50

Hülse mit Membran membrane shell

50 5 10 30

Sensorgehäuse sensor casing

50 5 10 20

O-Ring 1.8 x 1.0

o-ring 1.8 x 1.0

50 1 10 25

1 pO

2 pO

2

Sensor kompl.

sensor compl.

50 1 10 00

2

3

4

5

6


50 1 10 21

Sensoreinheit sensor unit

50 1 10 10

O-Ring 8.0 x 1.0

o-ring 8.0 x 1.0

50 1 10 50


50 1 10 30


50 1 10 20

O-Ring 1.8 x 1.0

o-ring 1.8 x 1.0

50 1 10 25

5

6

12 - 48

1 pCO

2 pCO

2

Sensor kompl.

sensor compl.

50 1 20 00

2

3

4

5

6


50 1 10 21


50 1 20 10

O-Ring 8.0 x 1.0

o-ring 8.0 x 1.0

50 1 10 15


50 1 20 30


50 1 20 20

O-Ring 1.8 x 1.0

o-ring 1.8 x 1.0

50 1 10 25

3

4

12 - 24

1 pH Sensor kompl.

pH sensor compl.

50 1 30 00

2

3

4


50 1 10 21


50 1 30 10


50 1 30 20

O-Ring 1.8 x 1.0

o-ring 1.8 x 1.0

50 1 10 25

BGA_combiline/15012009HEU


combiline

Sensor Spare Parts

Sensor Spare Parts and average lifetime information

combiline

Na

Haltbarkeit


(month)

ISE

Haltbarkeit


(month)

1

12 - 36

1

2

12 - 36 2

K

+

3 - 6

Ca

++

Li

+

3 - 6

3 - 6

Cl- 3 - 6

Na

+

12-24

3 3

4

12 - 24

4

Na

Na

+

+

Sensor kompl.

sensor compl.

50 3 20 00

ISE Sensoren:

ISE sensors:

K

+

/ Ca

++

/ Cl- / Li

+

1

2

3

Ableitsystem conducting system

50 3 20 10

O-Ring 3.2 x 1.8

o-ring 3.2 x 1.8

50 3 20 15

Na

+

Na

+

Sensorgehäuse

sensor casing

50 3 20 20

K

+

K

+

Sensor kompl.

sensor compl.

50 3 10 00

Ca

Ca

++

++

Sensor kompl.

sensor compl.

50 3 30 00

Cl- Sensor kompl.

Cl- sensor compl.

50 3 40 00

4

Ersatzteile ISE Sensoren / spare parts ISE sensors K

+

/ Ca

++

/ Cl- / Li

+

1 Ableitsystem conducting system

K

+

50 3 10 10

Ca

++

50 3 30 10

Cl-

Li

+

50 3 40 10

50 3 50 10

3 Sensorgehäuse sensor casing

K

+

50 3 10 20

Ca

++

50 3 30 20

Cl- 50 3 40 20

Li

+

50 3 50 20

2

O-Ring 1.8 x 1.0

o-ring 1.8 x 1.0

50 1 10 25


K

+

50 3 10 30

Ca

++

50 3 30 30

Cl-

Li

+

50 3 40 30

50 3 50 30

Li

Li

+

Sensor kompl.

+

sensor compl.

50 3 50 00

4 O-Ring 1.8 x 1.0

o-ring 1.8 x 1.0

50 1 10 25


Lifetime of Sensors

Ref.

pO

2 pCO

2 pH

Lebensdauer von Sensoren / Lifetime of sensors

Referenzsensor reference sensor

50 5 10 00

Ableitsystem conducting system

12 - 36 Monate

12 - 36 months

Membran membrane

6 - 9 Monate

6 - 9 months pO

2 pO

2

Sensor

sensor

50 1 10 00 pCO

2

Sensor pCO

2

sensor

50 1 20 00 pH Sensor pH sensor

50 1 30 00

Sensor-Einheit sensor unit

12 - 48 Monate

12 - 48 months

12 - 24 Monate

12 - 24 months

12 - 24 Monate

12 - 24 months

Membran membrane

3 - 6 Monate

3 - 6 months

3 - 6 Monate

3 - 6 months

K

Cl

Li

+

Na

Ca

+

-

+

++

K+ Sensor

K+ sensor

50 3 10 00

Na+ Sensor

Na+ sensor

50 3 20 00

Ca++ Sensor

Ca++ sensor

50 3 30 00

Cl- Sensor

Cl- sensor

50 3 40 00

Li+ Sensor

Li+ sensor

50 3 50 00

Ableitsystem 1 conducting system

12 - 36 Monate

12 - 36 months

1

12 - 36 Monate

12 - 36 months

12 - 36 Monate

12 - 36 months

12 - 36 Monate

12 - 36 months

12 - 36 Monate

12 - 36 months

Membran membrane

3 - 6 Monate

3 - 6 months

12 - 24 Monate

12 - 24 months

3 - 6 Monate

3 - 6 months

3 - 6 Monate

3 - 6 months

3 - 6 Monate

3 - 6 months

GLU

LAC

GLU Sensor

GLU sensor

50 4 20 00

LAC Sensor

LAC sensor

50 4 10 00

30 Tage oder ca. 1000 Proben

30 days or approx. 1000 samples

15 Tage oder ca. 400 Proben

15 days or approx. 400 samples

1

Das Ableitsystem der ISE-Sensoren kann bei Beschädigung der Chloridschicht werksseitig regeneriert werden.

In case of damaged chlorid layer the conducting system of ISE sensors can be regenerated by manufacturer.

The lifetimes given in the above table are average lifetimes


combiline

List of Consumeables

Article no.: description

Calibration- and Rinsing solutions

for combiline BGA

3-4.100

40 6 10 20

40 6 10 30

WASH 1 (Rinsing solution for BGA)

BGA 1 (Calibration solution for BGA / low)

BGA 2 (Calibration solution for BGA / high) packing/unit

6x330 ml

12x130 ml

12x130 ml

for combiline BGA+E

40 6 10 10

40 6 10 40

40 6 10 50

40 6 10 45

40 6 10 55

WASH 2 (Rinsing solution for BGA plus E)

BGA 3 (Calibration solution BGA plus E/low)

BGA 4 (Calibration solution BGA plus E/high)

CAL 3 (Calibration solution for BGA plus E/low)

CAL 4 (Calibration solution for BGA plus E/high) for COMBILINE meta

40 6 10 11

40 6 10 40

40 6 10 50

40 6 10 45

40 6 10 56

WASH 2+M Rinsing solution

BGA 3 Calibration solution BGA plus E/low

BGA 4 Calibration solution BGA plus E/high

CAL 3 Calibration solution for BGA plus E/low

CAL 4+M Calibration solution for BGA plus E/high

for combiline ISE

3-4.110

3-4.400

3-4.500

WASH 2 (Rinsing solution for ISE)

CAL 3 (Calibration solution for ISE/low)

CAL 4 (Calibration solution for ISE/high)

6x250 ml

12x130 ml

12x130 ml

12x150 ml

12x150 ml

8x250 ml

12x130 ml

12x130 ml

12x150 ml

12x150 ml

6x330 ml

6x330 ml

6x330 ml

Special Solutions

50 6 10 80

50 6 10 84

50 6 10 88

Protein remover

Electrode cleaner

Activating solution for pH-sensor

Quality Controls

Control Solutions for BGA

50 6 20 10

50 6 20 20

50 6 20 30

Level I BGA (acidosis)

Level II BGA (normal)

Level III BGA (alkalosis)

1 x 100 ml

50 ml

20 ml

30 ampoules

30 ampoules

30 ampoules

Control Solutions for BGA plus E

50 6 20 40

50 6 20 50

50 6 20 60

50 6 20 70

Level I BGA+E (acidosis)

Level II BGA+E (normal)

Level III BGA+E (alkalosis)

Level IV (high pO

2

)

Control Solutions for BGA plus E+Li+

50 6 20 45

50 6 20 55

50 6 20 65

Level I EGL (acidosis)

Level II EGL (normal)

Level III EGL (alkalosis)

30 ampoules

30 ampoules

30 ampoules

30 ampoules

30 ampoules

30 ampoules

30 ampoules

Sampling Systems

Capillaries

50 6 30 08

50 6 30 10

50 6 30 12

50 6 30 14

50 6 30 16

50 6 30 30

50 6 30 35

50 6 30 40 hep. capillaries 8 cm/lg hep. capillaries 10 cm/lg hep. capillaries 12 cm/lg hep. capillaries 14 cm/lg for instruments with Hb sensor

250 pcs.

250 pcs.

250 pcs.

250 pcs.

hep. capillaries 16 cm/lg for instr. with meta and Hb sensor 250 pcs.

metal stirrers for capillaries 250 pcs.

magnet for stirrer end-caps for capillaries 500 pcs.

combiline




Aspiration Pipes

3-7.200

50 6 30 55 pipe for control solution, activating solution etc.

ampoule holder for aspiration pipe

Printer Paper

50 6 50 00

Cleaning Paste

50 1 10 41 printer paper cleaning paste (silicon carbide) packing/unit

10 pcs.

1 pc.

pack.=2 rolls

Accessories for Maintenance

40 6 40 00 service-set complete for COMBILINE without Metabolites consisting of:

40 6 40 10

40 6 40 15

40 6 40 20

40 6 40 25 set tubings for roller-pump (reagents) tubing for magnetic valve VE1 tubing for magnetic valve VE2 tubing for magnetic valve ABS

40 6 40 01 consisting of:

40 6 40 11

40 6 40 15

40 6 40 20

40 6 40 25 service-set complete for COMBILINE with Metabolites set tubings for roller-pump (reagents) tubing for magnetic valve VE1 tubing for magnetic valve VE2 tubing for magnetic valve ABS sample port insert (red) 1-8.106

Sensors pO

2

-Sensor

50 1 10 00

50 1 10 10

50 1 10 15

50 1 10 20

50 1 10 21

50 1 10 25

50 1 10 30

50 1 10 35

50 1 10 50 pO pO pO

2

2 gasket for Sensor-unit (8.0 x 1.0)

2

-Sensor complete

-Sensor-unit with membrane shell

-Sensor-casing with screw-cap screw cap for Sensor-casing gasket for Sensor-casing (1.8 x 1.0) pO pO

2

2

-membrane shells

-fill solution polishing kit for pO2 sensors

2 pcs.

1 pc.

1 pc.

1 pc.

2 pcs.

1 pc.

1 pc.

1 pc.

1 pc.

pack.= 5 pcs.

bot.=20 ml pCO

2

-Sensor

50 1 20 00

50 1 20 10

50 1 10 15

50 1 20 20

50 1 10 21

50 1 10 25

50 1 20 30

50 1 20 35 pH-Sensor

50 1 30 00

50 1 30 10

50 1 30 20

50 1 10 21

50 1 10 25 pCO pCO

2

2

-Sensor complete

-Sensor-unit with membrane shell gasket for Sensor-unit (8.0 x 1.0) pCO2-Sensor-casing screw cap for Sensor-casing gasket for Sensor-casing (1.8 x 1.0) pCO pCO

2

2

-membrane shells

-fillsolution pH-Sensor complete pH-Sensor-unit pH-Sensor-casing screw cap for Sensor-casing gasket for Sensor-casing (1.8 x 1.0) pack.=5 pcs.

bot.=20 ml


combiline



Hb-Sensor

50 2 10 01 Hb-Sensor Type II complete

K + -Sensor

50 3 10 00

50 3 10 10

50 3 10 20

50 1 10 25

50 3 10 30

50 3 10 35

Na + -Sensor

50 3 20 00

50 3 20 10

50 3 20 15

50 3 20 20

50 1 10 25

50 3 20 35

Ca ++ -Sensor

50 3 30 00

50 3 30 10

50 3 30 20

50 1 10 25

50 3 30 30

50 3 30 35

Cl -Sensor

50 3 40 00

50 3 40 10

50 3 40 20

50 1 10 25

50 3 40 30

50 3 40 35

K + -Sensor complete

K + -conducting system

K + -Sensor casing gasket for Sensor-casing 1.8 x 1.0)

K + -membrane shell with membrane

K + -fillsolution (organic tenside, buffer substances)

Na + -Sensor complete

Na + -conducting system gasket for conducting system (3.2 x 1.8)

Na + -Sensor-casing gasket for Sensor-casing 1.8 x 1.0)

Na + -fillsolution

Ca ++ -Sensor complete

Ca ++ -conducting system

Ca ++ -Sensor casing gasket for Sensor-casing 1.8 x 1.0)

Ca ++ -membrane shell with membrane

Ca ++ - fillsolution

Cl -Sensor complete

Cl - conducting system

Cl -Sensor casing gasket for Sensor-casing 1.8 x 1.0)

Cl -membrane shell with membrane

Cl -fillsolution

Li + -Sensor

50 3 50 00

50 3 50 10

50 3 50 20

50 1 10 25

50 3 50 30

50 3 50 35

Li + -Sensor complete

Li + -conducting system

Li + -Sensor casing gasket for Sensor-casing 1.8 x 1.0)

Li + -membrane shell with membrane

Li + -fillsolution

Reference-Sensor

40 5 10 00

50 5 10 10

50 3 20 15

50 5 10 20

50 1 10 25

40 5 10 50

50 5 10 30

50 5 10 35 reference-sensor complete reference-conducting system gasket for conducting system (3.2 x 1.8) reference-Sensor casing gasket for Sensor-casing 1.8 x 1.0) reservoir for reference-Sensor casing ref.-membrane shell with membrane reference-fillsolution packing/unit bot.=20 ml btl.= bottle bot.= 20 ml bot.=20 ml bot.=20 ml bot.=20 ml bot.=50 ml

combiline


List of Spare Parts

Article no.:

System casing

60 7 10 00

60 7 10 10 description

system casing, complete

front cover complete, painted, with print

Sensor fixing device / Thermostate

50 7 20 00

40 7 10 30

50 7 20 10

40 7 10 20

40 7 10 25

50 7 20 20

50 7 20 21

50 7 20 05

50 7 20 90 sensor fixing device, complete device for specimen input closing mechanism sample Light Barrier COMBILINE capillary for sample light barrier board for thermostate illumination, (LED) panel for thermostate illumination (LED), complete temperature safety switch temperature regulation sensor NTC (for Thermostat or Meta block)

Sensor fixing device for Metabolites

50 7 20 60

50 7 20 70

50 7 20 75

50 7 20 80

50 7 20 85

50 7 20 95 thermostate block, for Metabolite sensors, complete fixing screw, white, for GLU-Sensor fixing screw, black, for LAC-Sensor holding device for GLU-Sensor holding device for LAC-Sensor peltier-element for Meta-block

Calibration-bag adapter

40 7 10 35

G 40.1

40 7 10 40

G 41.3

G 40.4

G 40.5

40 7 10 36

Peristaltic pump

50 7 40 00

50 7 40 10

50 7 40 20

50 7 40 30

50 7 40 40

50 7 40 50

Reagent-wall

50 7 40 60

50 7 40 61

50 7 40 62

50 7 40 70

40 7 40 70

40 7 10 50

40 7 10 55 bag-adapter COMBILINE, complete consisting of: metal-casing slide-bar holder COMBILINE slide-bar COMBI 1 set spring for slide-bar 1 set cannula 1set

Suspension for Calibration-Bags peristaltic pump, complete micromotor with gear 97.3:1 bush for bearing bearing roller device for peristaltic pump clutch tube connector, black tube connector, white, reagent-wall tube connector, white, bottle compartment holder for roller pump tubing, reagents (low) holder for roller pump tubing WASH (high) intermediate vessel holder for intermediate vessel


combiline



Bottles for COMBILINE BGA+E

Rm 100.24

Rm 100.30

Rm 100.31

R 100.21

60 8 20 80 waste-bottle 250ml, empty suction tube for reagent bottle WASH (250ml) suction tube for reagent bottle CAL3/4(+M) (150ml) screw cap for reagent- WASH- or waste-bottle (150 / 250ml) waste bottle device, complete

Bottles for COMBILINE BGA and COMBILINE ISE

Rm 100.23

Rm 100.21

R 100.20

60 8 20 70 waste-bottle 330ml (empty) suction tube for reagent bottle WASH / CAL (330ml) screw cap for CAL- WASH or waste-bottle (330ml) waste bottle device, complete for 330ml bottle

Sample port

Rm 20.80

R 20.81 (1-8.105)

R 20.83 (1-8.106)

G 20.51

G 20.52

G 20.53

Wiring

SEm 100.21

SEm 200.21

SEm 300.21

SEm 400.21

SEm 500.21

SEm 600.21

SEm 700.21

SEm 800.21

SEm 900.22

Valves

F 200.25

F 200.28

50 8 30 20

40 8 20 11

40 8 20 16

40 8 20 21

40 8 20 25 sample port device, complete with insert consisting of: sample port insert with integr. Steel canula (white) sample port insert (red) sample port holder sample port cover sample port support sensor-cable pO2 sensor-cable pCO2 sensor-cable pH sensor-cable Na+ sensor-cable K+ sensor-cable Ca++ sensor-cable Li+ sensor-cable Clsensor-cable reference tube valve (normally open) sample port valve PV (normally open) liquid Valve SMC liquid-valve block SMC complete for COMBILINE BGA+E liquid-valve block SMC complete for COMBILINE BGA liquid-valve block SMC complete for COMBILINE ISE multilayer valve carrier SMC

combiline



Article no.:

Electronic boards

(ESW- ANALOG)

60 8 10 10

60 8 10 11

60 8 10 15

60 8 10 20

60 8 10 25

60 8 10 26

60 8 10 30

60 8 10 35

60 8 11 10

60 8 11 11

60 8 11 15

60 8 11 20

60 8 11 25

60 8 11 26

60 8 11 30

60 8 11 35

60 8 10 40

60 8 10 45

60 8 10 50

60 8 10 55

40 8 10 60

60 8 10 70

60 8 10 80

60 8 10 90

40 8 20 00

E 210.5

60 8 20 40 description analog-board for pO2 -pCO2-pH-baro.pressure, temperature analog-board for pO2 -pCO2-pH-baro-pressure-temperature-Hb analog-board for BGA, BP, K-temperature analog-board for BGA, BP, K-Na-temperature analog-board for BGA, BP, K-Na-Ca-temperature analog-board for BGA, BP, K-Na-Cl-temperature analog-board for BGA, BP, K-Na-Ca-Cl-temperature analog-board for BGA, BP, K-Na-Ca-Cl-Li-temperature analog-board for pO2 -pCO2-pH-Meta-baro.pressure, temperature analog-board for pO2 -pCO2-pH-Meta-baro-pressure-temperature-Hb analog-board for BGA, Meta, BP, K-temperature analog-board for BGA, Meta, BP, K-Na-temperature analog-board for BGA, Meta, BP, K-Na-Ca-temperature analog-board for BGA, Meta, BP, K-Na-Cl-temperature analog-board for BGA, Meta, BP, K-Na-Ca-Cl-temperature analog-board for BGA, Meta, BP, K-Na-Ca-Cl-Li-temperature analog-board for K-Na-temperature analog-board for K-Na-Ca-temperature analog-board for K-Na-Ca-Cl-temperature analog-board for K-Na-Ca-Cl-Li-temperature air pressure sensor 1240-015A-3N

CPU board (Z80 ADC) power supply board for valves, motors and temperature regulation (CL TEMP NETZ) switching power supply PM110 45-2A for +5V, -12V, +12V, +24V compl.

board for filling level control (CL FÜLLSTAND) displayadapter (ECODISP) interface RS232 for data output, incl. SD-Card Reader

Various electronical and electrical devices

50 8 20 65

50 8 20 70

50 8 20 71

F 100.4.2

60 8 20 50

60 8 20 90

F 10.5.1

60 8 20 60

F 10.19

temperature measuring sensor keyboard, complete keyboard adapter CL TASTATUR

LCD Display 240x128 dpi

LCD Converter thermal printer GBT-4352 heating resistor for thermostate heating device fan for power supply 24V, 1W suction pump


combiline

combiline


ESCHWEILER

automatic analysing systems

Eschweiler GmbH & Co. KG z

Holzkoppelweg 35 z

D - 24118 Kiel phone: ..49-(0)431-546580 e-mail: [email protected] fax: ..49-(0)431-549423 homepage: www.eschweiler-kiel.de

Declaration of EC-Conformity

as defined by EC In-Vitro Diagnostica (IVD) directive 98/79/EG

Eschweiler GmbH & Co. KG

Holzkoppelweg 35 / D-24118 Kiel / Germany declares that the product

Description: blood gas-/ electrolyte- and metabolite - analysers

Model:

ESCHWEILER combi line

to which this declaration relates is in accordance with the provisions of the following directives

Applied harmonised standards:

EN 61010-1 Safety requirements for electrical equipment for measurement, control, and laboratory use:

EN 61010-2-08/A1

EN 61010-2-101

Emission:

EN 55011 A2

EN 61000-3-2

EN 61000-3-3

Immunity:

EN 61326-1

Safety requirements for electrical equipment for measurement, control, and laboratory use:

Safety requirements for electrical equipment for measurement, control, and laboratory use:

Industrial, scientific and medical radio-frequency equipment – Emission: Class B

Harmonic current emissions

Voltage fluctuation and flicker

Electrical equipment for measurement, control and laboratory use – EMC requirements:

EN 61000-4-2

EN 61000-4-3 +A1

EN 61000-4-4

EN 61000-4-5

EN 61000-4-6

EN 61000-4-11

Electrostatic discharge immunity test

Radiated, radio-frequency electromagnetic field – immunity test

Electrical fast transient/burst immunity test

Surge immunity tests

Immunity to conducted disturbances, induced by radio frequency fields

Voltage dips, short interruptions and voltage variations immunity test

ESCHWEILER GmbH & Co. KG

Kiel, 01.04.2010

..................................... i.A Dr. H.-J. Heupke

(QCM)

EC declaration combilineV2 IVD engl/01012010

ESCHWEILER

GmbH & Co. KG

Holzkoppelweg 35

D-24118 Kiel

Telefon: 0431 / 546580 Deutsche Bank AG, Kiel Commerzbank, Kiel Postbank

Telefax: 0431 / 549423 [email protected] www.eschweiler-kiel.de

Kto.-Nr. 0324 426

(BLZ 210 700 20)

SWIFT: DEUTDEHH 210

IBAN: DE46 2107 0020 0032 4426 00

Kto.-Nr. 7224488

(BLZ 210 400 10)

SWIFT: COBADEFFXXX

IBAN: DE66 2104 0010 0722 4488 00

Hamburg 24676 - 204

(BLZ 200 100 20)

PBNKDEFF

IBAN: DE56 2001 0020 0024 6762 04

Gerichtsstand / Place of Jurisdiction: Kiel USt.-ID Nr.: DE 188048227

Handelsregister Kiel HRA 3736 KI Kompl.: Eschweiler Verwaltungs GmbH Kiel HRB 4610 KI Geschäftsführer: Horst H. Kock


combiline

ESCHWEILER Combi Blood Gas Electrolyte Analyser Service Manual

Assistant Bot

combi

Blood-Gas-Electrolyte-Analyser

Service Manual

! 1 Hazards and Precautions

! 2 Maintenance and Hygiene

! 3 First-Aid Measures

! 4 Repairs

POWER UP COMBILINE

STAND BY

OPERATION

SERVICE - TEST

STANDARD DATA

Opened front cover

Opened Front

Opened Rear Wall

Opened Rearwall, inside

combiline BGA

combiline ISE

combiline BGA+E

combiline meta

Determination of Valves

Type: PM110-45-2A

Power Supply für Pumps, Valves and Heating

Voltage Supply for Pumps and Valves

Voltage Supply for Pumps and Valves

Adjustment of the operating voltage for Roller pump RP

Circuit Diagram Temperature-Regulation

Temperature-Regulation

Metabolite Temperature Regulation, Circuit Diagram

Layout

Circuit-Diagram for Sensor Amplifiers

Adjustment of polarization voltage

Adjustment of O

zero point

Circuit-Diagram for BP, TEMP, Sample-Light-Barrier, Hb

Adjustment and Testing of the Barometric Pressure indication

Adjustment of thermostate-temperature indication-circuit

Adjustment of the Sample Light-Barrier

Capillary exchange in Sample Light-Barrier LB

Measure method

Activation of Hb-Sensor type II

Layout

Circuitdiagram 1/3

Circuitdiagram 2/3

Circuitdiagram 3/3

Specification

Serial interface with SD-Card Reader RS-232 SD INT 1.4

Layout

Circuit Diagram

Interface Cable

Description:

Layout

Circuit Diagram

Specification

Keyboard Adaptor CL-TASTATUR

Specification

Circuit-Diagram and Layout

Pin configuration for Printer GPT-4352-60

Voltage supply plug:

Pin 5:CTS (output)

Interface (TTL/ 4,5V Pegel ):

Pin 1:GND

Pin 2:TXD (input)

Pin 3:RXD (output)

Pin 4:RTS (input)

Pin 5:CTS (output)

Delay-circuit, Layout and Circuit-Diagram

ESCHWEILER

Ref.

pO

pCO

pH

Na

ISE

Lebensdauer von Sensoren / Lifetime of sensors

ESCHWEILER

automatic analysing systems

Declaration of EC-Conformity