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PTWS 120S – USP/EP Tablet Dissolution Testing Instrument
PTWS 120S – USP/EP Tablet Dissolution Testing Instrument
The PTWS 120S is a 6 position, multiple drive, compact tablet dissolution testing instrument for solid dosage forms as described in USP chapter <711/724> and EP section<2.9.3/4> as well as the BP, DAB and Japanese Pharmacopeia section <15>. Its design for manual operation and ease of use.
User Interface
In keeping with our cutting edge design, a large color, touch screen allows control of the various mechanical features of the instrument such as the tool stirring speed, lift drive and heater. The instrument control is menu driven using a resistive touch screen and selection wheel technology. Visual signals on the display inform the user of the status of critical instrument parameters, e.g. bath target temperature not reached.
Access to the instrument can be password controlled if required. If certain operational parameters form a regular feature of the daily routine, then these can be incorporated into a test method for faster set up. These parameters can be tool speed, target bath
Pharma Test Apparatebau AG
Siemensstr. 5
63512 Hainburg/Germany
PTAG_30-41100_PTWS_120S_V1.2E.Docx Page 1 of 8
P: +49 6182 9532 600
F: +49 6182 9532 650 [email protected] www.pharma-test.com
PTWS 120S – USP/EP Tablet Dissolution Testing Instrument temperature, sampling time points and so on. The test method memory capacity is almost limitless.
As soon as the test is started, a screen saver can be activated with the most important information displayed in large script, like count-down timer so that this information remains visible even at time when the operator is not standing directly in front of the instrument.
Stirring Tools
The PTWS 120S uses the Pharma Test MonoShaft™ design. Tools consist of the main shaft plus interchangeable tool heads (adapters). The main shaft remains in place in the instrument regardless of the tool head being used. The clearance of each tool from the vessel base will always be correct once the main tool shaft has been installed and qualified with any one of the tool sets once. Each stirrer can be raised by hand into a convenient position for easy vessel removal or insertion.
PTWS 120S is capable to perform a staggered start for each of the six positions, which is essential in manual operation.
Vessel Centering System
The PTWS 120S features a rigid and precise three-point individual centering system for each dissolution vessel
(picture shows view from below). The vessels are held in position by three adjustable noses and are inserted into the instrument support framework. The access points for sampling as well as the openings for the tools are contained in an auxiliary, low evaporation, vessel cover.
Each USP Borosilicate glass vessel has a batch code on top of the flange for easy visibility and positioned placement inside the water bath cover.
Lift Mechanism
The upper drive is motorized and electronically controlled it offers eight programmable positions: an upper cleaning and instrument qualification position and lower working positions are programmable depending on the type of stirring tool used. The upper position offers ideal access to the stirring tools and vessels for a change of tools and cleaning steps between the dissolution tests. The motorized drive head lifting mechanism is positioned in a way so that the tool shafts are always kept parallel and at a 90° angle to the vessel walls when in the working position.
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Heating System
PTWS 120S – USP/EP Tablet Dissolution Testing Instrument
The heating system is contained in a separate stainless steel housing. The connections between the heater and the bath are made by "quick connect fittings" for easy connection and disconnection. Water is pumped through the system using a powerful, yet quiet, circulation pump. The pump itself is spring mounted (to limit vibration transmission) and the flow-through heater is protected from overloading (overheating in case of control electronics failure) via a thermal fuse as well as a thermo switch for added security. With service and maintenance in mind, access to the compact pump and heater section is easily achieved without having to move the main body of the instrument.
Vacuum-moulded Water Bath
The vacuum molded water bath can easily be removed from the support frame for cleaning purposes. The bath cover can also be easily unscrewed for cleaning. The water bath contains a water diffuser for faster heating and to ensure that heated water is evenly distributed throughout the whole bath. Optionally a double walled vacuum molded water bath is available which reduces the heat transfer to the outer environment to save internal heating and external cooling energy
Space Requirements
A key point in today’s crowded labs is the footprint of the PTWS 120S. The space saving design of the
PTWS 120S offers the user the choice between a 2x3 or a
3x2 configuration with a minimal space requirement of just 45cm by 65cm (width by depth). The display module can be mounted either of two positions on the drive head of the PTWS 120S instrument.
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Advantages
PTWS 120S – USP/EP Tablet Dissolution Testing Instrument
Some of the highlights the PTWS 120S offers are:
6 stirring positions, individually electronically regulated high precision drive system for each one of the 6 stirrers.
Grouping of stirrers, like 2 groups of 3, or 3 groups of 2 running at the same speed
Modular design to minimize bench space requirements
3-point individual vessel centering system
Borosilicate glass vessels including extra low evaporation vessel covers
Individual vessel batch code at the top of the vessel flange for easy identification
Excellent access to all vessels
Motorized Drive Head lifting mechanism including head position programming facility
Screen saver functionality and count-down timer offers most important information at a glance (stirrer speed, bath temperature, time to next sampling interval, elapsed time, media temperature etc.)
Wake up functionality to start heating at a pre-programmed time
Ultra-fast heating system due to newly designed heat exchanger, saves up to 1/3 rd of the heating up time compared to most other models
MonoShaft™ system to avoid re-adjustment of immersion depth
Staggered stirrer start feature for convenient manual sampling
Water diffuser inside the vacuum moulded water bath for even temperature distribution and fast temperature equilibration
Spring loaded pump assembly to eliminate vibration transfer
Extraordinary safety features for pump and heating system, flow control, digital temperature control, thermo switch, thermo fuse
Auto stirrer stop when drive lift is moved
Excellent stirrer shaft verticality inside the vessels due to central position of lift columns, drive head assembly and rigid anodized aluminum framework
Easy removal of the water bath from of the frame work for cleaning and maintenance work
Energy saving double walled bath option, less heat transfer into the lab environment, less power consumption during instrument operation
DQ/QC, IQ and OQ documents included free of charge
The main features of the PTWS 120S are:
Fully USP <711/724> and EP <2.9.3/4> compliant
6 individually motorized stirred positions
Centrally located motorized lift drive to raise and lower the drive head
Individually coded Borosilicate vessels
File up a nearly unlimited number of different test descriptions (methods)
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PTWS 120S – USP/EP Tablet Dissolution Testing Instrument
CAN Bus technology offering instrument suitability check prior to start of a test run
Staggered start capability
Vessel low evaporation sealing covers
Removable water bath for easy cleaning
Drainage tap to empty the bath
Method management and CFR compliant user administration
User Access control, password expiry control
Optical and acoustic signals to inform about sampling intervals,
Timer count down function
Traffic Light optical information on display shows the instrument status by different colors (green = ready to use, yellow = preparing to use, red = error encountered)
OQ, PQ interval warning with programmable interval
USB port for remote control of the PTWS 120S
RS-232 port to connect a serial PT-RP80 report printer, printing date/time, sampling time information, selected sampling position, used stirring tools, media temperature, operator name etc.
I/O port for remote control of external instruments in automated applications, like DSR-M,
Pumps and PTFC-2/8
Standard Scope of Supply
The PTWS 120S comes ready to use with the following standard scope of supply:
One set of stainless steel paddles
One set of batch coded 1000ml Borosilicate glass vessels
One set of depth adjustment balls
One bottle of ALGEX water preservative
Comprehensive documentation folder including:
User manual
DQ/QC instrument compliance test certificate
IQ documentation
OQ documentation
Instrument logbook
Compliance certificates for vessels and stirring tools
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PTWS 120S – USP/EP Tablet Dissolution Testing Instrument
Options
In addition to the standard scope of supply Pharma Test offers a broad range of accessories and options including:
Direct control of peripheral instruments via I/O port such as PTFC-2/8 fraction collector or
DSR-M Sampling Robot
Eco saving double walled vacuum molded water bath
2 liter vessel version (can also be used with 1 liter vessels)
250 ml Mini Vessel set incl. mini paddle stirrers
Amber colored vessels for UV sensitive test materials
Full range of MonoShaft™ stirring tools available
Full range of certified validation tools available
PT-RP80 serial report printer
PT-RP80 Report Printer
Use the PT-RP80 serial report printer to print out the runtime report of the PTWS 120S.
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Example Runtime Report
PTWS 120S – USP/EP Tablet Dissolution Testing Instrument
RUN TIME REPORT
================
PHARMA TEST PTWS120S
S/N: 19018
V: 1.00
PRINT DATE/TIME:
02.02.2015 12:31:48
USER NAME: ADMIN
PRODUCT NAME: PRODUCT1
METHOD NAME: METHOD1
BATCH: 1
BATH TEMP NOM.: 37.0
BATH TEMP ACT.: 36.9
LIFT: USP 1
VOLUME: 900ml
DURATION: 0:10
SPEED Pos.1: 50
SPEED Pos.2: 50
SPEED Pos.3: 50
SPEED Pos.4: 100
SPEED Pos.5: 100
SPEED Pos.6: 100
I.-COUNT1: 1
I.-DELAY1: 0:01
I.-COUNT2: 1
I.-DELAY2: 0:02
I.-COUNT3: 0
I.-DELAY3: 0:00
TEST STATUS: NO ERRORS
START: 02.02.2015 12:21:08
END: 02.02.2015 12:31:08
INT.1:
02.02.2015 12:22:08
BATH TEMP ACT.: 36.8
INT.2:
02.02.2015 12:24:08
BATH TEMP ACT.: 36.9
OPERATOR
NAME
...............................
SIGNATURE
...............................
Type of the instrument (PTWS 120S)
Serial number of the instrument
Firmware version installed on the instrument
Date and time of this print out
Name of the user currently logged in
Name of the product used for this test
Name of the method used for this test
Batch number entered at the start of this test
Nominal bath temperature from the method for this test
Actual bath temperature at time of the print out
Name of the lift position from the method for this test
Media volume from the method for this test
Total duration time setting for the method for this test
Nominal speed settings from the method for this test
(different speed settings for each station are possible)
First interval count
First interval delay
Second interval count
Second interval delay
Third interval count
Third interval delay
Current status of the test, if test is still running it will be
“IN PROGRESS”
Start date and time of the test
End date and time of the test (if already finished)
Occurrence of first interval
Date and time of first interval
Actual bath temperature when first interval occurred
Occurrence of second interval
Date and time of second interval
Actual bath temperature when first interval occurred
If no intervals have yet occurred it will be “NO INT”
Space to write down name of the operator
Space for the operator’s signature
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PTWS 120S – USP/EP Tablet Dissolution Testing Instrument
Technical Data (Standard 1 Liter Version)
Parameter
Display
Data Entry
Acoustic Signal
Timer
Specification
6", 320x240 pixel color LCD, illuminated
Resistive touch screen, functional touch keys
Programmable acoustic signal for operator information
Programmable sampling times, wake-up and sleeping mode, operation time information and timer count-down mode
Stirrer Position 8 programmable stirrer immersion positions (paddle over disk, transdermal cylinder etc.)
Testing Method Programming Unlimited number of different test descriptions can be stored on SD card
User Access Control
OQ, PQ control
Printer
Number of Stirred Vessels
Standard Vessels
Vessel Covers
Individual Speed Control
Speed Accuracy
Stirrer Shaft Wobble
System Tools
Multiple level access control, password expiry date control, CFR compliant
Programmable time periods to remind on QO or PQ testing
External PT-RP80 report printer using long-life printer paper
6 (3 by 2 or 2 by 3 arrangement)
1 liter USP/EP Borosilicate glass vessel, each individually coded
Ultra low evaporation design (< 0.7% within 24h)
25 - 250 RPM for each stirrer
±2% of set speed, typically < 1%
Better than 0.2 mm total run out
Heating System
MonoShaft™ stirrer design, USP/EP apparatus 1, 2, 5, 6 tool adapter, cream cell, transdermal patch tools, each tool and vessel individually coded
Pump for water circulation and 1500W heater for fast heating up
(230/240V units only)
Heater Range
Heater Accuracy
Heat Up Process
Water Circulation
Vibration Elimination
Calibration
25 - 45°C
± 0.2°C inside the water bath
Energy saving, programmable “wake up” heater function and “sleep mode”
Water circulated from external heating system through special diffuser inside the water bath
External heating system, spring loaded pump assembly
Bench Space Requirement
Certification
CE / EMC Certification
Validation
Built-in calibration procedures for speed, temperature control, OQ/PQ interval programmable including alarm indicator
45 x 65 cm (2 by 4) or 65 x 45 cm (4 by 2)
All components certified to USP / EP requirements
All CE / EMC Certification provided
All IQ & OQ documents included
We reserve the right to make technical changes without any prior notice.
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