Orbitrap Fusion Series Preinstallation

Orbitrap Fusion Series Preinstallation
Orbitrap Fusion Series
Preinstallation Requirements Guide
80011-97001 Revision B
July 2015
© 2015 Thermo Fisher Scientific Inc. All rights reserved.
EASY-Max NG, EASY-nLC, Optima, and Orbitrap Fusion Lumos are trademarks, and Orbitrap,
Orbitrap Fusion, Thermo Scientific, Tribrid, and Xcalibur are registered trademarks of Thermo Fisher
Scientific Inc. in the United States.
The following are registered trademarks in the United States and other countries: Microsoft and Windows are
registered trademarks of Microsoft Corporation. Styrofoam is a registered trademark of Dow Chemical
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The following are registered trademarks in the United States and possibly other countries: Dranetz is a
registered trademark of Dranetz Technologies, Inc. Oerlikon Leybold Vacuum is a registered trademark of
OC Oerlikon Corporation AG. SOGEVAC is a registered trademark of Oerlikon Leybold Vacuum.
ShockWatch is a registered trademark of ShockWatch, Inc. Tygon is a registered trademark of the division of
Saint-Gobain Performance Plastics Corporation.
All other trademarks are the property of Thermo Fisher Scientific Inc. and its subsidiaries.
Thermo Fisher Scientific Inc. provides this document to its customers with a product purchase to use in the
product operation. This document is copyright protected and any reproduction of the whole or any part of this
document is strictly prohibited, except with the written authorization of Thermo Fisher Scientific Inc.
The contents of this document are subject to change without notice. All technical information in this
document is for reference purposes only. System configurations and specifications in this document supersede
all previous information received by the purchaser.
This document is not part of any sales contract between Thermo Fisher Scientific Inc. and a purchaser. This
document shall in no way govern or modify any Terms and Conditions of Sale, which Terms and Conditions of
Sale shall govern all conflicting information between the two documents.
Release history: Rev A, June 2015; Rev B, July 2015
For Research Use Only. Not for use in diagnostic procedures.
Orbitrap Fusion Series Installation Request Form
Before completing this installation request form, read all of the Orbitrap Fusion Series Preinstallation Requirements
Guide. For U.S. laboratory locations, send this completed and signed form to
[email protected] For other countries or regions, go to
www.thermoscientific.com/support, click Contact Us, click the email option,
, and attach this form to your
request to schedule the installation.
Laboratory setup
 1. All laboratory remodeling is complete and
complies with all relevant safety regulations.
 2. The instrument is on site.
 3. A principal operator will be on site during the
installation/certification period.
 4. Doorways, hallways, and so on are a minimum
width of 2 m (82 in.).
 5. Laboratory lighting is adequate.
 6. Air conditioning is adequate for temperature,
humidity, and particulate matter control.
 7. Relative humidity is 40–80%, noncondensing.
 8. The work area is free from magnetic disruption
and electrostatic discharge.
 9. A step stool is on site.
 10. A voice telephone line is installed near the system.
 11. (Optional) The laboratory has Internet access.
 12. Floor space is sufficient and flooring will support
the load.
Power
13. Main power is installed and complies with local
electrical codes.
 14. Power is free from fluctuations due to slow
changes in the average voltage or changes due to
surges, sags, or transients.
 15. Power outlets are of the correct configuration for
the power cords. See page 20.
Note NEMA type: ____________________
 16. Voltage of power outlet has been measured.
Note measured voltage:
AC line-to-ground: __________________ V
AC neutral-to-ground: _______________ V
AC line-to-neutral: __________________ V


17. Power outlets are available for testing and cleaning
equipment.
Gas and exhaust
 18. All required gases are on site, gas lines are
installed, and appropriate gas regulators are
available. For pressures, see page 23.
Note gas types and actual purity levels:
Gas: Helium purity:_______________
Gas: Nitrogen purity:_______________
Additional ultra-high-purity source for the
optional EASY-ETD source only:
Gas: Nitrogen purity:_______________
 19. All gas lines are clean and have no leaks.
 20. A suitable fume exhaust system is separate from
the solvent waste and is within 2.4 m (8 ft) of the
system. See page 6 and page 27.
System setup
 21. Data system computer: The new computer shows
no changes to ANY settings and has no additional
software.
 22. System setup provides for collecting solvent waste
from the API source.
 23. A new or recently cleaned HPLC system is
available that produces pulse-free, continuous flow
of 100–1000 μL/min.
 24. Optima LC/MS-grade acetonitrile, isopropyl
alcohol, methanol, and water are available for
testing the instrument’s performance.
 25. Sufficient clearance is provided behind the
instrument’s table. See page 5.
IMPORTANT Thermo Fisher Scientific reserves the right to invoice for the field service engineer’s time if the
installation requirements are not met by the installation date.
CONTINUED ON THE NEXT PAGE
For customized installations
Does your contract contain any special acceptance specifications?
If YES, attach full details of the specifications.

Yes
 No
Does the system require additional equipment?
If YES, attach full details of the additional equipment.

Yes
 No
I certify that the preinstallation requirements for the Orbitrap Fusion Series are complete and accurate.
Signature
Date
Print name
Telephone
Email address
Principal instrument operator:
Telephone
Print name
Email address
Company
Telephone
Address
Address
City
State
Country
Sales order number
Note This form is intended to cover the essential components of your Orbitrap Fusion Series installation. However,
you must use the information in this guide and any additional information that your Thermo Fisher Scientific field
service engineer provides to ensure the proper setup of your system. After receiving this form, the field service
engineer contacts you to schedule the installation.
Regulatory Compliance
Thermo Fisher Scientific performs complete testing and evaluation of its products to ensure full compliance with
applicable domestic and international regulations. When the system is delivered to you, it meets all pertinent
electromagnetic compatibility (EMC) and safety standards as described in the next section or sections by product name.
Changes that you make to your system may void compliance with one or more of these EMC and safety standards.
Changes to your system include replacing a part or adding components, options, or peripherals not specifically
authorized and qualified by Thermo Fisher Scientific. To ensure continued compliance with EMC and safety standards,
replacement parts and additional components, options, and peripherals must be ordered from Thermo Fisher Scientific
or one of its authorized representatives.
Regulatory compliance results for the following Thermo Scientific™ products:
•
•
Orbitrap Fusion Lumos
Orbitrap Fusion
Orbitrap Fusion Lumos
EMC Directive 2004/108/EC
EMC compliance has been evaluated by TÜV Rheinland of North America.
EN 55011: 2009, A1: 2010
EN 61000-4-6: 2009
EN 61000-3-2: 2006, A2: 2009
EN 61000-4-8: 2010
EN 61000-3-3: 2008
EN 61000-4-11: 2004
EN 61000-4-2: 2009
EN 61326-1: 2013
EN 61000-4-3: 2006, A2: 2010
CISPR 11: 2009, A1: 2010
EN 61000-4-4: 2004, A1: 2010
ICES-003 Issue 5: 2014
EN 61000-4-5: 2006
CFR 47, FCC Part 15, Subpart B, Class A: 2015
Low Voltage Safety Compliance
This device complies with Low Voltage Directive 2006/95/EC and harmonized standard EN 61010-1:2010
(3rd Edition).
Orbitrap Fusion
EMC Directive 2004/108/EC
EMC compliance has been evaluated by TÜV Rheinland of North America.
EN 55011: 2009, A1: 2010
EN 61000-4-6: 2009
EN 61000-3-2: 2006, A2: 2009
EN 61000-4-11: 2004
EN 61000-3-3: 2008
EN 61326-1: 2013
EN 61000-4-2: 2009
CISPR 11: 2009, A1: 2010
EN 61000-4-3: 2006, A2: 2010
ICES-003 Issue 5: 2012
EN 61000-4-4: 2004, A1: 2010
CFR 47, FCC Part 15, Subpart B, Class A: 2012
EN 61000-4-5: 2006
Low Voltage Safety Compliance
This device complies with Low Voltage Directive 2006/95/EC and harmonized standard EN 61010-1:2010
(3rd Edition).
FCC Compliance Statement
THIS DEVICE COMPLIES WITH PART 15 OF THE FCC RULES. OPERATION IS SUBJECT TO
THE FOLLOWING TWO CONDITIONS: (1) THIS DEVICE MAY NOT CAUSE HARMFUL
INTERFERENCE, AND (2) THIS DEVICE MUST ACCEPT ANY INTERFERENCE RECEIVED,
INCLUDING INTERFERENCE THAT MAY CAUSE UNDESIRED OPERATION.
CAUTION Read and understand the various precautionary notes, signs, and symbols contained inside
this manual pertaining to the safe use and operation of this product before using the device.
Notice on the Proper Use of
Thermo Scientific Instruments
In compliance with international regulations: This instrument must be used in the manner specified by Thermo Fisher
Scientific to ensure protections provided by the instrument are not impaired. Deviations from specified instructions on
the proper use of the instrument include changes to the system and part replacement. Accordingly, order replacement
parts from Thermo Fisher Scientific or one of its authorized representatives.
WEEE Directive
2012/19/EU
Thermo Fisher Scientific is registered with B2B Compliance (B2Bcompliance.org.uk) in the UK and with the
European Recycling Platform (ERP-recycling.org) in all other countries of the European Union and in Norway.
If this product is located in Europe and you want to participate in the Thermo Fisher Scientific Business-to-Business
(B2B) Recycling Program, send an email request to [email protected] with the following information:
• WEEE product class
• Name of the manufacturer or distributor (where you purchased the product)
• Number of product pieces, and the estimated total weight and volume
• Pick-up address and contact person (include contact information)
• Appropriate pick-up time
• Declaration of decontamination, stating that all hazardous fluids or material have been removed from the product
For additional information about the Restriction on Hazardous Substances (RoHS) Directive for the European Union,
search for RoHS on the Thermo Fisher Scientific European language websites.
IMPORTANT This recycling program is not for biological hazard products or for products that have been medically
contaminated. You must treat these types of products as biohazard waste and dispose of them in accordance with
your local regulations.
Directive DEEE
2012/19/EU
Thermo Fisher Scientific s'est associé avec une ou plusieurs sociétés de recyclage dans chaque état membre de l’Union
Européenne et ce produit devrait être collecté ou recyclé par celle(s)-ci. Pour davantage d'informations, rendez-vous sur
la page www.thermoscientific.fr/rohs.
WEEE Direktive
2012/19/EU
Thermo Fisher Scientific hat Vereinbarungen mit Verwertungs-/Entsorgungsfirmen in allen EU-Mitgliedsstaaten
getroffen, damit dieses Produkt durch diese Firmen wiederverwertet oder entsorgt werden kann. Weitere Informationen
finden Sie unter www.thermoscientific.de/rohs.
C
Contents
Preface . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . xi
Orbitrap Fusion Series Models . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .xi
Related Documentation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . xii
Cautions and Special Notices . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .xiii
Contacting Us . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .xiv
Thermo Scientific
Chapter 1
Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .1
Chapter 2
Site Preparation. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .3
Shipping Containers . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3
Space and Load Requirements . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4
Workbench Requirements . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5
LC and Data System Layouts . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6
Mass Spectrometer System Layout. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8
Forepumps . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9
Telephone . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9
Chapter 3
Operating Environment. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .11
Environmental Requirements . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11
Humidity . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 12
Temperature . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 12
Particulate Matter . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 13
Electrostatic Discharge . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 13
Lighting. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 14
Vibration. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 14
Chapter 4
Line Power . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .15
Quality of Power . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 16
Power Monitoring Devices . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 16
Power Conditioning Devices . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 17
Uninterruptible Power Supply. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 17
Circuit Breakers. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 18
Earth Ground . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 18
Electrical Outlets . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 18
Orbitrap Fusion Series Preinstallation Requirements Guide
ix
Contents
Power Supply Cords . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 20
Technical Assistance . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 21
Chapter 5
Gases and Solvents. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .23
Gases . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 23
Helium Supply . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 24
Nitrogen Supply . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 24
Solvent Recommendations . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 25
Chapter 6
Waste and Exhaust . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .27
Exhaust System . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 27
Solvent Waste . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 28
Chapter 7
Instrument Shipments. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .29
Receiving Shipping Packages and Reporting Damage . . . . . . . . . . . . . . . . . . . . 29
Filing a Damage Claim Against the Carrier . . . . . . . . . . . . . . . . . . . . . . . . . . . . 30
Chapter 8
Installation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .31
Installation Kits . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 32
Customer-Supplied Hardware . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 33
Basic On-Site Training . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 34
Advanced Training Courses. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 34
Preventive Maintenance . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 34
Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .35
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Orbitrap Fusion Series Preinstallation Requirements Guide
Thermo Scientific
P
Preface
The Orbitrap Fusion Series Preinstallation Requirements Guide provides information for
planning and preparing your laboratory before delivery and installation of your Thermo
Scientific Orbitrap Fusion™ Series Tribrid™ mass spectrometer (MS). Read each section
carefully to ensure that your lab is ready for the instrument.
Contents
• Orbitrap Fusion Series Models
• Related Documentation
• Cautions and Special Notices
• Contacting Us
 To suggest changes to the documentation or to the Help
Complete a brief survey about this document by clicking the button below.
Thank you in advance for your help.
Orbitrap Fusion Series Models
The Orbitrap Fusion Series documentation is intended for the following instrument models:
• Orbitrap Fusion—Requires one forepump.
• Orbitrap Fusion Lumos™—Requires two forepumps.
Thermo Scientific
Orbitrap Fusion Series Preinstallation Requirements Guide
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Preface
Related Documentation
The Orbitrap Fusion Series mass spectrometer includes complete documentation. In addition
to this guide, you can also access the following documents as PDF files from the data system
computer:
• Orbitrap Fusion Series Getting Connected Guide
• Orbitrap Fusion Series Getting Started Guide
• Orbitrap Fusion Series Hardware Manual
• Ion Max NG and EASY-Max NG Ion Sources User Guide
• EASY-ETD and EASY-IC Ion Sources User Guide (for instruments with the ETD or
Internal Calibration option)
• Safety and Regulatory Guide
The Orbitrap Fusion Series also ships with a printed copy of the Safety and Regulatory
Guide. This guide contains important safety information about Thermo Scientific liquid
chromatography (LC) and mass spectrometry (MS) systems. Make sure that all lab
personnel have read and have access to this document.
 To view the product manuals
From the Microsoft™ Windows™ taskbar, do the following:
• For a Thermo Scientific mass spectrometer, choose Start > All Programs > Thermo
Instruments > model x.x, and then open the applicable PDF file.
• For an LC instrument controlled by a Thermo application, choose Start > All
Programs > Thermo Instruments > Manuals > LC Devices and so on.
 To download user documentation from the Thermo Scientific website
1. Go to www.thermoscientific.com.
2. In the Search box, type the product name and press Enter.
3. In the left pane, select Documents & Videos, and then under Refine By Category, click
Operations and Maintenance.
4. (Optional) Narrow the search results or modify the display as applicable:
• For all related user manuals and quick references, click Operator Manuals.
• For installation and preinstallation requirements guides, click Installation
Instructions.
xii
Orbitrap Fusion Series Preinstallation Requirements Guide
Thermo Scientific
Preface
• For documents translated into a specific language, use the Refine By Language
feature.
• Use the Sort By options or the Refine Your Search box (above the search results
display).
5. Download the document as follows:
a. Click the document title or click Download to open the file.
b. Save the file.
Cautions and Special Notices
Make sure you follow the cautions and special notices presented in this guide. Cautions and
special notices appear in boxes; those concerning safety or possible system damage also have
corresponding caution symbols.
This guide uses the following types of cautions and special notices.
CAUTION Highlights hazards to humans, property, or the environment. Each CAUTION
notice is accompanied by an appropriate CAUTION symbol.
IMPORTANT Highlights information necessary to prevent damage to software, loss of
data, or invalid test results; or might contain information that is critical for optimal
performance of the system.
Note Highlights information of general interest.
Tip Highlights helpful information that can make a task easier.
The Orbitrap Fusion Series Preinstallation Requirements Guide contains the following
caution-specific symbols (Table 1).
Thermo Scientific
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Preface
Table 1. Caution-specific symbols and their meaning
Symbol
Meaning
Chemical hazard: Wear gloves and other protective equipment, as
appropriate, when handling toxic, carcinogenic, mutagenic, corrosive,
or irritant chemicals. Use approved containers and proper procedures
to dispose of waste oil and when handling wetted parts of the
instrument.
Heavy object: The Orbitrap Fusion Series MS, excluding its
workbench, weighs over 227 kg (500 lb). Never try to detach and
move the instrument from its workbench; you can suffer personal
injury or damage the instrument.
Risk of electric shock: This instrument uses voltages that can cause
electric shock and/or personal injury. Before servicing, shut down the
instrument and disconnect it from line power. While operating the
instrument, keep covers on.
Risk of eye injury: Eye injury could occur from splattered chemicals or
airborne particles. Wear safety glasses when handling chemicals or
servicing the instrument.
Trip obstacle: Be aware of cords, hoses, or other objects located on the
floor.
Contacting Us
There are several ways to contact Thermo Fisher Scientific for the information you need. You
can use your smartphone to scan a QR code, which opens your email application or browser.
Contact us
xiv
Customer Service and Sales
Technical Support
(U.S.) 1 (800) 532-4752
(U.S.) 1 (800) 532-4752
(U.S.) 1 (561) 688-8731
(U.S.) 1 (561) 688-8736
us.customer-support.analyze
@thermofisher.com
us.techsupport.analyze
@thermofisher.com
Orbitrap Fusion Series Preinstallation Requirements Guide
Thermo Scientific
Preface
Contact us
Customer Service and Sales
Technical Support
 To find global contact information or customize your request
1. Go to www.thermoscientific.com.
2. Click Contact Us, select the Using/Servicing a Product option, and then
type the product name.
3. Use the phone number, email address, or online form.
 To find product support, knowledge bases, and resources
Go to www.thermoscientific.com/support.
 To find product information
Go to www.thermoscientific.com/lc-ms.
Note To provide feedback for this document:
• Send an email message to Technical Publications ([email protected]).
• Complete a survey at www.surveymonkey.com/s/PQM6P62.
Thermo Scientific
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Preface
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Orbitrap Fusion Series Preinstallation Requirements Guide
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1
Introduction
Before the Thermo Fisher Scientific field service engineer arrives to install the Thermo
Scientific Orbitrap Fusion Series Tribrid mass spectrometer, you must provide a suitable
location, a carefully controlled operating environment, a source of power of acceptable
quality, correct gases and solvent supplies, and proper waste and exhaust systems.
CAUTION Operating an instrument or maintaining it outside the power and operating
environment specifications described in this guide might cause failures of many types. The
repair of such failures is specifically excluded from the Thermo Fisher Scientific standard
warranty and service contract coverage.
Note
• For preinstallation support and additional information, contact your local Thermo
Fisher Scientific office.
• Unless otherwise noted, the information in this guide applies to all Orbitrap Fusion
Series models.
Thermo Scientific
Orbitrap Fusion Series Preinstallation Requirements Guide
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2
Introduction
Orbitrap Fusion Series Preinstallation Requirements Guide
Thermo Scientific
2
Site Preparation
You are responsible for providing an acceptable installation site for the Orbitrap Fusion Series
system before the Thermo Fisher Scientific service engineer arrives. Make sure your laboratory
meets these requirements:
• When transporting the equipment to the designated site, you have a wide turning radius
through entrances, hallways, elevators, and so on. Remember to consider the width of the
device transporting the shipping container to the lab.
• The lab has a designated location for the MS and data system modules.
Contents
• Shipping Containers
• Space and Load Requirements
• Forepumps
• Telephone
Shipping Containers
Your system ships in multiple containers. Table 2 lists the overall dimensions and weights of
the shipping containers that are too large to carry by hand. Use this information to determine
how to transport the containers and remove their contents. Other equipment in your order
have their own smaller shipping containers and do not require special consideration. The
chemicals kit typically arrives earlier than the other parts of your order.
See “Installation Kits” on page 32 for the kit part numbers.
Note Transport the container with the mass spectrometer assembly (container #1) to the
lab and do not open it until the service engineer is on site.
Thermo Scientific
Orbitrap Fusion Series Preinstallation Requirements Guide
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2
Site Preparation
Space and Load Requirements
Table 2. Shipping container dimensions and weightsa
Container
Size
Weight
Content
1
175 × 119 × 160 cm (l × w × h)
(69 × 47 × 63 in.) (l × w × h)
493 kg
(1087 lb)
Mass spectrometer assembly
2
109 × 76 × 125 cm (l × w × h)
(43 × 30 × 49 in.) (l × w × h)
68 kg
(150 lb)
Syringe pump, divert/inject
valve, and data system
components
3
79 × 51 × 51 cm (l × w × h)
(31 × 20 × 20 in.) (l × w × h)
66 kg
(145 lb)
Forepumpb
a
The height and weight measurements include the shipping pallets.
b
The Orbitrap Fusion Lumos system comes with two forepumps in two shipping containers.
Space and Load Requirements
Table 3 lists the dimensions and weights for the LC, MS, and data system modules. Use this
information to ensure that all workbenches are large enough and strong enough to support
the modules.
Table 3. Space and load requirementsa for the system modules
Width (w)
cm (in.)
Height (h)
cm (in.)
Depth (d)
cm (in.)
Weight
kg (lb)
(Optional) Thermo Scientific
EASY-nLC™ 1000b
36 (14.2)
45 (17.7)
38 (15.1)
35 (77.2)
Orbitrap Fusion Series mass
spectrometerc
127 (50)
70.31 (27.7)
76.7 (30)
245 (540)
Forepump (each)
32 (12.6)
26.4 (10.4)
48 (19)
52 (115)
Computer, mini-tower
17.5 (7)
36 (14.2)
41.7 (16.4)
9.4 (21)
Monitor
64 (25.3)
54 (21)d
20 (8)
7 (15.8)
Ethernet switch
15.4 (6.1)
2.9 (1.14)
11 (4.3)
0.17 (0.4)
45 (18)
32 (12.4)
41 (16)
16 (35)
Modules
LC/MS system
Data system
(Optional) Laser printer
4
a
Approximate values
b
These values exclude the solvent bottles and tubing.
c
These values exclude the workbench, API source, syringe pump, and divert/inject valve.
d
Fully extended
Orbitrap Fusion Series Preinstallation Requirements Guide
Thermo Scientific
2 Site Preparation
Space and Load Requirements
This section discusses the following:
• Workbench Requirements
• LC and Data System Layouts
• Mass Spectrometer System Layout
Workbench Requirements
Table 4 lists the recommended minimum surface dimensions and load capacities for each
workbench. Thermo Fisher Scientific recommends that workbenches have a load capacity of
at least twice the combined weight of all expected devices. The workbench that ships with the
mass spectrometer meets this requirement. You must provide the workbenches for the data
system modules and the LC system.
CAUTION Heavy object. The Orbitrap Fusion Series MS, excluding its workbench,
weighs over 227 kg (500 lb). Never try to detach and move the instrument from its
workbench; you can suffer personal injury or damage the instrument. For additional
information, contact your local Thermo Fisher Scientific service engineer.
Table 4. Minimum workbench surface dimensions and load capacities
Equipment
Surface
Load capacity
LC systema
–
–
132 × 78.8 cm (52 × 31 in.)
508 kg (1120 lb)
122 × 91.4 cm (48 × 36 in.)
65.3 (144 lb)
Mass
spectrometerb
Data system
a
Refer to the product manual for information about the LC system’s workbench.
b
Measurements are for the provided workbench, which has a height of approximately 74 cm (29 in.).
Follow these clearance guidelines for the workbenches:
• Place the data system and MS workbenches adjacent to each other to prevent strain on
the interconnecting Ethernet communications cables.
CAUTION Safety and EMC regulations require the use of Category 5e shielded
Ethernet communications cables, maximum 3 m (10 ft) long.
• For all systems, allow for a minimum vertical clearance of 92 cm (36 in.) between the top
of the system and any shelves above it.
• For the MS system, allow for these minimum horizontal clearances for proper air
circulation and for the installed gas lines and tubing:
Thermo Scientific
–
25 cm (10 in.) behind the instrument
–
46 cm (18 in.) on the right side of instrument
Orbitrap Fusion Series Preinstallation Requirements Guide
5
2
Site Preparation
Space and Load Requirements
Figure 1 shows the top view (footprint) for the system workbenches.
Figure 1.
Top view and recommended placement of the workbenches (tables)
Laboratory wall
Minimum 25 cm (10 in.)
horizontal clearance
Data system
LC system
Mass spectrometer
Minimum 46 cm
(18 in.) horizontal
clearance
LC and Data System Layouts
Figure 2 shows an optional layout for the data system and LC system. Not all connections are
shown; for connection information, refer to the Orbitrap Fusion Series Getting Connected
Guide and the LC product manual.
CAUTION For information about the LC drainage systems, refer to the LC instrument
manual.
6
Orbitrap Fusion Series Preinstallation Requirements Guide
Thermo Scientific
2 Site Preparation
Space and Load Requirements
Figure 2.
Workbenches for the data system (left) and an optional EASY-nLC 1000 LC instrument (right)
122 cm (48 in.)
Data system
computer
Monitor
Printer
(optional)
EASY-nLC 1000
instrument
Ethernet switch
120 Vac electrical outlets
(for North America)
Thermo Scientific
(Not all connections are shown.)
Orbitrap Fusion Series Preinstallation Requirements Guide
7
2
Site Preparation
Space and Load Requirements
Mass Spectrometer System Layout
Figure 3 shows an example of the recommended layout for the Orbitrap Fusion Lumos MS
(two-forepump system). The layout for the Orbitrap Fusion MS is the same, except it has one
forepump. Not all connections are shown; for connection information, refer to the
Orbitrap Fusion Series Getting Connected Guide.
Figure 3.
Workbench for the Orbitrap Fusion Lumos MS
132 cm (52 in.)
Solvent waste
container
External vent for the
forepump exhaust
External vent for the
solvent trap (waste)
8
Orbitrap Fusion Series Preinstallation Requirements Guide
Forepumps
Separate 230 Vac electrical
outlets for the instrument and
forepumps (circuits A, B, and C)
(Not all connections are shown.)
Thermo Scientific
2
Site Preparation
Forepumps
Forepumps
The Orbitrap Fusion system uses one forepump, whereas the Orbitrap Fusion Lumos system
uses two. For information about connecting the forepumps, refer to the Orbitrap Fusion Series
Getting Connected Guide and the installation instructions provided with the forepump.
CAUTION Trip hazard. Whenever possible, provide space under the workbench for the
forepumps. If placed in front of the mass spectrometer, the forepumps become a trip
hazard.
CAUTION
• Do not place the forepump on a shelf or other surface connected to the workbench.
Vibration from the pump can affect instrument performance.
• The exhaust hose tubing acts as a trap for exhaust fumes that would otherwise
recondense in the forepump oil.
–
To maintain forepump integrity, route the exhaust tubing from the exhaust port
down to the floor, not from the forepump vertically toward the ceiling.
–
Run the exhaust hose at floor level for a minimum of 2 m (79 in.) before it
reaches the external exhaust system.
Telephone
Make sure that laboratory staff has access to a telephone (landline or mobile) near the mass
spectrometer. For a landline connection, install the telephone jack close enough so that you
can operate the instrument while speaking with Thermo Fisher Scientific Technical Support.
Thermo Scientific
Orbitrap Fusion Series Preinstallation Requirements Guide
9
2
Site Preparation
Telephone
10
Orbitrap Fusion Series Preinstallation Requirements Guide
Thermo Scientific
3
Operating Environment
For proper operation of the Orbitrap Fusion Series MS, you are responsible for providing the
operating environment described in this chapter. Attention to the operating environment
ensures continued high performance of the Thermo Scientific instrument. Any expenditures
for air conditioning are more than offset by good sample throughput and reduced repair costs.
Contents
• Environmental Requirements
• Humidity
• Temperature
• Particulate Matter
• Electrostatic Discharge
• Lighting
• Vibration
Environmental Requirements
Table 5 lists the environmental requirements for the designated laboratory.
Table 5. Environmental requirements (Sheet 1 of 2)
Parameter
Specification
Humidity
40–80%, noncondensing
Temperature
• Standard performance: 15–27 °C (59–81 °F)
• Optimum performance: 18–21 °C (65–70 °F)
• Ambient temperature: Fluctuations of less than
1 °C or 2 °F over a one-hour period
Particulate Matter
Thermo Scientific
Does not exceed 3 500 000 particles per cubic meter
(100 000 particles per cubic foot).
Orbitrap Fusion Series Preinstallation Requirements Guide
11
3
Operating Environment
Humidity
Table 5. Environmental requirements (Sheet 2 of 2)
Parameter
Specification
Electrostatic Discharge (ESD)
Follow the stated precautions to help prevent ESD.
Lighting
• Operating: Use typical laboratory lighting.
• Cleaning: Use a small, high-intensity lamp.
Vibration
Choose a lab location that is vibration-free.
Humidity
Maintain the relative humidity in the designated lab at 40–80 percent, without condensation.
Operating a Thermo Scientific mass spectrometer in an environment with very low humidity
can cause the accumulation and discharge of static electricity that can shorten the life of the
electronic components. Operating the MS in an environment with high humidity can cause
condensation, oxidation, and short electronic circuits. It can also cause the accumulation of
dust that can block filters on the cooling fans.
You can ensure that the lab is always within the required temperature and humidity
specifications by installing a temperature and humidity monitor in the lab.
Temperature
For precision instruments, such as the Orbitrap Fusion Series MS, maintain the lab
temperature at 15–27 °C (59–81 °F). For optimum performance, maintain the lab
temperature at 18–21 °C (65–70 °F). Temperature control is vital to acquiring accurate mass
measurements. Therefore, make sure that during any one-hour period, ambient temperature
fluctuations are less than 1 °C or 2 °F.
IMPORTANT
• All electronic components generate heat while operating. This heat must dissipate to
the surrounding air for the components to continue to operate reliably.
• Do not locate the mass spectrometer under an air duct, near windows, or near heating
and cooling sources. As the lab temperature increases, instrument reliability decreases.
Ensure that there is good air flow around the system and that the air conditioning system
maintains a constant temperature in the immediate vicinity of the instrument. Table 6 lists
the approximate heat output (power) for the system modules. For the heat output of your
specific LC devices and the data system components, refer to the instrument manuals.
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3
Operating Environment
Particulate Matter
Table 6. Maximum heat output
Heat output
(W)
Heat output
(BTU/h)
Liquid chromatograph (LC)a
125
427
Mass spectrometer
2300
7848
Forepump (each)
1500
5118
Data system modules (mini-tower computer, monitor,
and optional laser printer)
889
3033
Total—Orbitrap Fusion system (one forepump)
4814
16 426
Total—Orbitrap Fusion Lumos system (two forepumps)
6314
21 544
Module
a
Approximate values for the EASY-nLC 1000. The actual values depend on your installed equipment.
Particulate Matter
Make sure that the air in the lab is free from excessive dust, smoke, or other particulate matter
in excess of 5 μm—that is, fewer than 3 500 000 particles per cubic meter (100 000 particles
per cubic foot).
Dust can clog the air filters, causing a reduction in air flow around the electronic components.
Dust on electronic components can act as an insulating blanket, which reduces the transfer of
heat from the components to the surrounding air.
Electrostatic Discharge
Electrostatic discharge (ESD) can damage the electronic components of the Orbitrap Fusion
Series mass spectrometer.
Most Thermo Scientific instruments are designed to withstand ESD up to 4 kV (air
discharge) and 4 kV (contact discharge) with all panels in place. However, removing the
panels and handling the printed circuit boards (PCBs) without proper precautions might
damage the electrical components or cause them to fail prematurely.
Because of ESD, take the following precautions, especially when operating the system at the
lower end of the relative humidity specification:
• Use a static-dissipating floor covering (such as tile or conductive linoleum) in the lab.
• Use laboratory chairs covered with natural fibers or other static-dissipating material.
• Wear a laboratory coat and clothing made of natural fiber or other static-dissipating
material when operating the instrument.
• Keep Styrofoam™ cups or packing materials away from the instrument.
Thermo Scientific
Orbitrap Fusion Series Preinstallation Requirements Guide
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3
Operating Environment
Lighting
Lighting
Good lighting makes any work area more enjoyable. When you clean the mass spectrometer
components, use a small, high-intensity lamp.
Vibration
Select a lab location that is free from vibration—floors at ground level usually have less
vibration. When selecting the location, be aware of adjacent rooms with equipment that can
transmit vibrations through the floor to the mass spectrometer workbench.
Because of the natural vibration of the forepump during operation, install the forepump on
the floor beneath the mass spectrometer.
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4
Line Power
You are responsible for providing a power source of acceptable quality to operate the
Orbitrap Fusion Series MS. The quality of line power (ac mains power system) delivered to
the mass spectrometer can affect its performance and longevity. To ensure that the instrument
performs optimally and is not damaged by line power fluctuations, verify that the lab’s
electrical supply complies with all power quality requirements.
CAUTION To support compliance and safety requirements, all devices connected between
the power source and the mass spectrometer must be certified by recognized organizations
for your country or territory (for example, UL, CSA, SEMKO, VDE, or TÜV).
Such devices include the power supply cords, electrical outlets, circuit breakers,
uninterruptible power supplies (UPSs), and so on.
Contents
• Quality of Power
• Power Monitoring Devices
• Power Conditioning Devices
• Uninterruptible Power Supply
• Circuit Breakers
• Earth Ground
• Electrical Outlets
• Power Supply Cords
• Technical Assistance
Thermo Scientific
Orbitrap Fusion Series Preinstallation Requirements Guide
15
4
Line Power
Quality of Power
Quality of Power
Establishing the quality of power supplied to the LC/MS system is very important for these
reasons:
• Constant high line voltage, impulses, or surges in voltage can cause overheating and
component failures.
• Constant low line voltage or sags in voltage can cause the equipment to function
erratically or not at all.
• Transients—even a few microseconds in duration—can cause electronic devices to
degrade or fail catastrophically, shortening the lifetime of the equipment.
Before the service engineer arrives to install your system, make sure the line voltage is stable
and within the recommended specifications. The line voltage must be free of fluctuations due
to slow changes in the average sags, surges, transients, or voltage. For the mass spectrometer’s
electrical ratings, see Table 8 on page 19.
Table 7 lists the definitions for the three most common voltage disturbances.
Table 7. Common voltage disturbances
Voltage disturbance
Definition
Slow average
A gradual, long-term change in the average root mean square
(RMS) voltage level, with typical durations greater than 2 s
Sags and surges
Sudden changes in the average RMS voltage level, with typical
durations between 50 ms and 2 s
Transients or impulses
A brief voltage spike of up to several thousand volts, with
typical durations up to 50 μs
Power Monitoring Devices
Several devices are available to monitor the quality of the line power. These devices provide a
continuous record of line performance by analyzing and printing out data for the three most
common voltage disturbances (see Table 7).
In the first two cases, the time interval recording indicates the duration and the amplitude of
the disturbance. A power line disturbance analyzer detects and records most types of line
power problems. The Dranetz™ system1 is an example of a suitable analyzer. In some
countries, you can rent power line analyzers from electrical equipment suppliers.
1
16
Thermo Fisher Scientific does not endorse any power monitoring company, nor does it endorse products other
than its own. Companies and products listed in this guide are given as examples only.
Orbitrap Fusion Series Preinstallation Requirements Guide
Thermo Scientific
4 Line Power
Power Conditioning Devices
Monitor the power line 24 hours a day for seven consecutive days. If inspection of the
printout indicates disturbances, stop the test and take corrective action. Monitor the power
again as previously described.
Power Conditioning Devices
You can correct a line voltage problem by using various line voltage conditioning devices. If
the power regulation is good but the power line disturbance analyzer shows transient voltages,
an isolation/noise-suppression transformer can resolve the problem. For both transient and
regulation problems, consider the use of power conditioners to control these problems. For
regulatory information, see the CAUTION statement on page 15.
CAUTION Any conditioning device installed with the mass spectrometer must be able to
handle the potentially high currents that are drawn during the initial startup of the
system. For example, during startup, the forepump or forepumps can draw a high inrush
current.
Because the mass spectrometer requires the use of one or two forepumps, it draws an
inrush current. The maximum system inrush (start) current for one forepump (Oerlikon
Leybold Vacuum™, model SOGEVAC™ SV 65 BI) is 12 A. The average duration of the
inrush current is less than 1 s. Therefore, this initial energy demand from the ac power
line is very low.
Thermo Scientific mass spectrometers are protected from overcurrents with time-delay
fuses and active switches. For more information, contact your service engineer.
When the line voltage is free from voltage sags, surges, and impulses but is more than
10 percent outside of the voltage specifications, a buck/boost transformer can lower (buck
10 percent) or raise (boost 10 percent) the line voltage as appropriate for the rated voltage.
Order the Buck/Boost Transformer Kit (P/N OPTON-01460) from Thermo Fisher Scientific
San Jose. Each buck/boost transformer is encased in a metal housing approximately
13 × 13 × 26 cm (5 × 5 × 10 in.) and ships with a 2 m (6.5 ft) power supply cord. Have a
certified electrician install the transformer, using the installation instructions that are
included. Then, install the Orbitrap Fusion Series system.
CAUTION Instruments installed in areas with 208 Vac power can experience voltage sags
during high use periods that might place the line voltage below the operating parameters
discussed in this section. In this case, protect the instrument by using a buck/boost
transformer to ensure that power stays within the specified parameters.
Uninterruptible Power Supply
If your local area is susceptible to corrupted power or power disruptions, install an
uninterruptible power supply (UPS) in the lab. See the Caution on page 15.
Thermo Scientific
Orbitrap Fusion Series Preinstallation Requirements Guide
17
4
Line Power
Circuit Breakers
Circuit Breakers
Make sure that each circuit breaker is suitably rated so that the equipment connected to the
electrical outlets does not lose power by triggering a current overload condition. For added
protection, install a surge protector at the input to the circuit breaker panel.
Earth Ground
Make sure that the earth ground connections in the lab are hardwired to the same ground
used for the main circuit breaker panel. Multiple external ground points can cause noise
current to flow through the ground loop that is formed.
Electrical Outlets
Installing a complete Orbitrap Fusion Series system can require extensive electrical resources
for connecting all of the equipment. Plan the power system with a sufficient number of
grounded, electrical outlets that are suitably rated. In addition, for testing and cleaning
equipment, such as an oscilloscope and a sonicator, have several additional outlets close to the
work area.
CAUTION To avoid an electric shock, always have a certified electrician install any new
wall receptacles.
Table 8 lists the electrical ratings (labels) and required number of outlets for the system
modules in a typical lab setup. For the LC modules, refer to the manufacturer's manuals. To
prevent overloading the outlets, select outlets with a load rating that is suitable for the
expected total current draw per outlet.
IMPORTANT
• Thermo Fisher Scientific recommends that you connect the mass spectrometer and
each forepump to separate electrical outlets that have their own dedicated
single-phase, circuit breakers rated 230 Vac, 15 A for North America and 230 Vac,
16 A for other countries and territories. For example, the Orbitrap Fusion Lumos
installation requires three separate, dedicated electrical outlets (one for the instrument
and two for the forepumps). See also Figure 3.
• In North America, the LC/MS system requires both 120 and 230 Vac single-phase
electrical outlets.
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Thermo Scientific
4 Line Power
Electrical Outlets
Table 8. Electrical ratings and required outlets per system module
Voltage
(Vac)
Current
(A)
Required
outlets
Orbitrap Fusion Series mass spectrometera
230
10
1
Forepump (SV 65 BI)b
230
8
1 or 2
Thermo Scientific divert/inject valve
110–220
1.5
1
Thermo Scientific syringe pump
110/220
0.2/0.1
1
Computer, mini-tower
100–240
5.4
1
Monitor
100–240
1.5
1
Ethernet switch
100–240
<1
1
110
–or–
220
8.6
–or–
4.2
1
High-intensity lamp
(for instrument maintenance)
–
–
1
Laboratory stereoscope
(for inspecting fused-silica parts)
–
–
1
Module
MS system
Data system
(Optional) Laser printer
Optional devicesc
Total number of electrical outletsd:
10+ (one-forepump system)
11+ (two-forepump system)
a
Manufacturer-tested within ±10% of the electrical rating
b
The values are for one forepump.
c
Refer to the equipment manual for the electrical ratings.
d
Remember to add the number of outlets required for your LC system.
IMPORTANT After planning the location of the workbenches (see Chapter 2), consider
the following before installing the electrical outlets:
• Each module’s location and whether each requires a 120 or 230 Vac outlet (See
Table 8.)
• The minimum number of outlets needed for a given voltage, including extra outlets
for additional lab equipment (See Table 8.)
• The length of the power supply cords (See Power Supply Cords.)
Thermo Scientific
Orbitrap Fusion Series Preinstallation Requirements Guide
19
4
Line Power
Power Supply Cords
Power Supply Cords
Your order includes the power supply cords for the Orbitrap Fusion Series mass spectrometer,
one or two forepumps, and peripheral components. The mass spectrometer and forepump use
the same power plugs and receptacles. The length of the power supply cords for the mass
spectrometer and forepumps is 2.5 m (8 ft).
Figure 4 shows an example of the NEMA 6-15 plug and receptacle configuration (rated
250 Vac, 15 A) for use in North America and other locations that use the same configuration.
Figure 4.
NEMA 6-15 plug (left) and receptacle (right) for North America (example)
Figure 5 shows the international power supply cord and receptacle (rated 250 Vac, 16 A) with
a CEE (3-pole) configuration for use in locations outside of North America.
Figure 5.
MS power supply cord and receptacle for outside of North America (provided)
The peripheral components (syringe pump, divert/inject valve, data system computer,
monitor, and Ethernet switch) ship with detachable power supply cords that are appropriate
for your country or territory. The length of the power supply cords for the data system
components is 1.8 m (6 ft). The power supply cord for the optional laser printer has either a
NEMA 5-15 plug or a European CEE 7/7 (Schuko) plug, which is rated 16 A, 220 Vac.
20
Orbitrap Fusion Series Preinstallation Requirements Guide
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4 Line Power
Technical Assistance
Technical Assistance
Occasionally, you might encounter line power sources with unacceptable quality that
adversely affect the operation of the Orbitrap Fusion Series system. You are responsible for
correcting any line power problems. Contact Thermo Fisher Scientific for assistance in
monitoring the line voltage in your lab and in selecting a line conditioner.
Specifying power conditioning equipment is a complex task that is best handled by a company
or consultant specializing in that field. Contact Thermo Fisher Scientific for assistance in
locating a power consultant in your area.
Thermo Scientific
Orbitrap Fusion Series Preinstallation Requirements Guide
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4
Line Power
Technical Assistance
22
Orbitrap Fusion Series Preinstallation Requirements Guide
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5
Gases and Solvents
You are responsible for providing the correct gas, solvent, and regulators to operate the
Orbitrap Fusion Series MS. The mass spectrometer requires ultra-high-purity (UHP) helium
gas, high-purity (HP) nitrogen gas, and UHP nitrogen gas, and solvents. The service engineer
might also require certain solvents for the installation verification of your system.
The gas connections are located on the back of the instrument. For information about
connecting the gas lines, refer to the Orbitrap Fusion Series Getting Connected Guide.
Contents
• Gases
• Solvent Recommendations
Gases
The instrument can use large amounts of gas during daily operations. Make sure that the gases
are delivered with the necessary pressure and purity as listed in Table 9.
Table 9. Required gases for the Orbitrap Fusion Series MS
a
Required gas
pressure
Typical daily
consumptiona
Function
UHP (99.999%)—Has less than
1.0 ppm each of water, oxygen,
and total hydrocarbons.
275 ±70 kPa
(40 ±10 psi)
9.22 L
(0.325 ft3)
Linear ion trap damping gas
and collision gas
HP (99%)
690 ±140 kPa
(100 ±20 psi)
11 500–26 700 L API source auxiliary gas,
(406–943 ft3)
sheath gas, and sweep gas
UHP (99.999%)—Has less than
3.0 ppm each of water, oxygen,
and total hydrocarbons.
345 ±70 kPa
(50 ±10 psi)
46 L (1.62 ft3)
Type
Recommended purity
Helium
Nitrogen
Venting gas, ion routing
multipole (IRM) collision
gas, and make-up gas and
reagent carrier gas for the IC
and ETD configurations
Approximate value when operating 24 hours and 7 days a week
Thermo Scientific
Orbitrap Fusion Series Preinstallation Requirements Guide
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5
Gases and Solvents
Gases
CAUTION
• Contaminants introduced during the installation of house lines used for gas delivery
can cause damage to the mass spectrometer. Make sure that all gas lines used with the
mass spectrometer have been cleaned of all particulates and oils. You are responsible
for any damage to the instrument caused by contaminants introduced from your gas
delivery system.
• Avoid using particulate filters, as they can be a source of contamination.
• You must use either copper (provided) or stainless steel for the UHP gas lines.
Helium Supply
To dispense the UHP helium from a tank (such as one containing 245 ft3 of helium), use a
suitable regulator. Use either stainless steel tubing or the provided copper tubing for the
helium gas line, and make sure that it is free of oil and preferably flame dried.
Note
• After you start using the mass spectrometer, do not shut off the helium gas. Optimum
performance requires a continuous flow of helium.
• If you intend to use helium for sparging your LC solvents, you must have a second
tank and regulator.
Nitrogen Supply
You must provide a regulator for the nitrogen gas supply that you can adjust over the specified
pressure range. Use the following sources for the HP nitrogen supply:
• A large, sealed, thermally insulated cylinder containing liquid nitrogen from which the
nitrogen gas is boiled off. The selected Dewar flask must be able to provide the required
gas flows and a head pressure of 690 ±140 kPa (100 ±20 psi) going to the mass
spectrometer.
• A nitrogen generator that can generate up to 21 L/min (44.5 ft3/h) of HP nitrogen with a
head pressure of 690 ±140 kPa (100 ±20 psi).
CAUTION When you turn on the Orbitrap Fusion Series MS, the initial nitrogen surge
might exceed the capacity of the nitrogen generator. This sudden surge causes a flow rate
drop that can trigger a low nitrogen warning from the instrument. If low nitrogen
warnings happen frequently, call your Thermo Fisher Scientific service engineer.
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5 Gases and Solvents
Solvent Recommendations
Solvent Recommendations
As specified in Table 10, use only LC/MS-grade solvents and reagents for operating and
maintaining the Orbitrap Fusion Series MS. Installation of the instrument requires
LC/MS-grade methanol and water. Installation of some instruments might also require
solvent modifiers.
CAUTION Avoid exposure to potentially harmful materials.
By law, producers and suppliers of chemical compounds are required to provide their
customers with the most current health and safety information in the form of Material
Safety Data Sheets (MSDSs) or Safety Data Sheets (SDSs). The MSDSs and SDSs must
be freely available to lab personnel to examine at any time. These data sheets describe the
chemicals and summarize information on the hazard and toxicity of specific chemical
compounds. They also provide information on the proper handling of compounds, first
aid for accidental exposure, and procedures to remedy spills or leaks.
Read the MSDS or SDS for each chemical you use. Store and handle all chemicals in
accordance with standard safety procedures. Always wear protective gloves and safety
glasses when you use solvents or corrosives. Also, contain waste streams, use proper
ventilation, and dispose of all laboratory reagents according to the directions in the MSDS
or SDS.
Table 10. Recommended solutions
Grade
Sizea
Part number
2-Propanol
Optima™ LC/MS
Amber glass, 4 L
A461-4
Acetonitrile
Optima LC/MS
Amber glass, 4 L
A955-4
Methanol
Optima LC/MS
Amber glass, 4 L
A456-4
Water
Optima LC/MS
Amber glass, 4 L
W6-4
0.1% Formic acid in acetonitrile
Optima LC/MS
Amber glass, 4 L
LS120-4
0.1% Formic acid in water
Optima LC/MS
Amber glass, 4 L
LS118-4
Acetic acid (modifier)
Optima LC/MS
Ampule, 10 × 1 mL
A113-10X1AMP
Ammonium acetate
Optima LC/MS
Amber glass, 50 g
A114-50
Ammonium formate
Optima LC/MS
Amber glass, 50 g
A115-50
Formic acid (modifier)
Optima LC/MS
Ampule, 10 × 1 mL
A117-10X1AMP
Product
Solvents
Blends
Additives
a
Size for the stated part number
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25
5
Gases and Solvents
Solvent Recommendations
IMPORTANT
• Some solvent impurities are transparent to a UV-Vis detector. Therefore, some
HPLC-grade solvents might contain contaminants that interfere with the
performance of the instrument. To operate the mass spectrometer, choose HPLC
solvents with minimum contamination.
• Do not filter solvents. Filtering solvents can introduce contamination.
Note Visit www.fishersci.com for a wide variety of solvents and consumables for purchase.
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Orbitrap Fusion Series Preinstallation Requirements Guide
Thermo Scientific
6
Waste and Exhaust
You are responsible for providing the proper waste and exhaust systems that are required to
operate the Orbitrap Fusion Series MS. The waste and exhaust arrangements can affect the
proper performance of the instrument. You must vent vacuum and solvent wastes separately,
and collect and dispose of wastes properly.
For information about setting up the exhaust and waste systems, refer to the Orbitrap Fusion
Series Getting Connected Guide.
Contents
• Exhaust System
• Solvent Waste
Exhaust System
To properly operate one or both forepumps, Thermo Fisher Scientific strongly recommends
connecting the forepump to an efficient fume exhaust system. The forepump eventually
exhausts much of what is introduced into the mass spectrometer, including the small amount
of oil vapor that a mechanical pump can emit.
Note Most API applications contribute to solvents accumulating in the forepump.
Although Thermo Fisher Scientific recommends that you periodically open the ballast
valve (on the side of the pump) to purge the accumulated solvents, opening the valve
might allow a large volume of volatile solvent waste to enter the fume exhaust system.
Choose an exhaust system that can accommodate the periodic purging of these solvents.
The frequency of the purging depends on the throughput of the instrument.
The forepump requires one 15 mm (0.6 in.) OD exhaust port. The exhaust system for the
forepump must be able to accommodate an initial inrush flow rate of 3 L/min (6.4 ft3/hr) and
a continuous flow rate of 1 L/min (2 ft3/hr). The exhaust tubing from the forepump to the
exhaust system is 0.5 in. ID, 3/4 in. OD, and 3 m (10 ft) long.
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Orbitrap Fusion Series Preinstallation Requirements Guide
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6
Waste and Exhaust
Solvent Waste
IMPORTANT The port for the lab exhaust system must be close enough to the forepump
or forepumps so that the exhaust hose is at floor level for a minimum of 2 m (78.7 in.).
This hose acts as a trap for exhaust fumes that would otherwise recondense in the
forepump oil.
Equip your lab with at least two fume exhaust systems:
• The analyzer optics become contaminated if the drain/waste tubing and the exhaust
tubing from the forepump connect to the same fume exhaust system. Route the exhaust
tubing from the forepump to a dedicated fume exhaust system.
CAUTION Do NOT run the forepump exhaust lines vertically near the forepump.
Solvents and oils can condense in the line and flow back into the pump, causing
pump damage and diminished pump capability.
• Do not vent the Tygon™ drain tube (or any vent tubing connected to the waste container)
to the same fume exhaust system that connects to the forepump. Vent the waste container
to a dedicated fume exhaust system. The exhaust system for the API source must
accommodate a flow rate of up to 30 L/min (64 ft3/h).
Solvent Waste
The mass spectrometer comes with parts to collect the solvent waste from the API source.
Because the API source can accommodate high flow rates, you must use a method of
collecting the waste solvent that avoids pressure buildup in the source. The solvent
drain/waste exhaust port is located on the back of the instrument.
IMPORTANT The solvent waste tubing that connects from the waste container to the
exhaust system is 1 in. ID, 1-3/8 in. OD. Make sure that your lab exhaust system can
accommodate this tubing without using reducing connectors along the solvent waste path.
Use these guidelines for the API source drain:
• Use the Tygon tubing provided with the solvent waste container to connect the solvent
waste container to the lab’s fume exhaust system.
• To prevent solvent waste from backing up into the mass spectrometer, make sure that all
Tygon tubing is above the level of liquid in the waste container as follows:
–
From the mass spectrometer to the solvent waste container
–
From the solvent waste container to the exhaust system
For additional information, refer to the Orbitrap Fusion Series Getting Connected Guide.
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Orbitrap Fusion Series Preinstallation Requirements Guide
Thermo Scientific
7
Instrument Shipments
Electronic equipment carriers that specialize in the handling and transport of delicate
machinery ship the Orbitrap Fusion Series MS to your site. When the instrument arrives,
move it to a protected indoor location. If you have questions about moving your instrument,
contact your local office for Thermo Scientific San Jose products (see ““Contacting Us” on
page xiv).
On the occasion when shipments arrive that appear damaged, take these immediate actions.
Contents
• Receiving Shipping Packages and Reporting Damage
• Filing a Damage Claim Against the Carrier
Receiving Shipping Packages and Reporting Damage
Upon delivery, visually inspect for any damage to the shipment packages.
 To visually inspect for damage
Carefully inspect for obvious damage or evidence of rough handling.
If the instrument shipping container, ShockWatch™, or other indicators show visible
evidence of damage or mishandling, do NOT open the container.
Follow the next procedure, and then call your Thermo Fisher Scientific sales representative for
further instructions.
 To record damages on the receiving documents
1. Read the information in Filing a Damage Claim Against the Carrier to determine which
parties might be responsible for filing a claim against the carrier.
2. On all copies of the receiving documents, note any apparent external damage and briefly
describe the extent of the damage.
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7
Instrument Shipments
Filing a Damage Claim Against the Carrier
3. Have the driver sign or initial next to your comments to signify agreement with your
observations.
4. Report the list of damages to your Thermo Fisher Scientific representative.
IMPORTANT Freight insurance requires that you note obvious damage on the
receiving documents. Thermo Fisher Scientific does not accept liability for damage if
materials are received with obvious damage AND the damage is not recorded on the
receiving documents.
Filing a Damage Claim Against the Carrier
If the instrument is damaged in transit, the shipment method determines the party who
assumes the risk of damage and files a claim against the carrier—Thermo Fisher Scientific or
the purchaser. To determine the shipment method for instruments shipped from the San Jose,
CA site, check the sales agreement or the sales quote.
Table 11 lists the party who files the damage claim against the carrier for instruments
damaged in transit based on the shipment method.
Table 11. Shipment methods for delivery from the San Jose, CA site to domestic and international
destinations
Destination
Shipment method
Domestic
(United States)
Destination or Origin—Thermo Fisher
Scientific pays the carrier.
Party responsible for filing a
damage claim
Thermo Fisher Scientific
Origin—The purchaser pays the carrier. Purchaser
International
30
Carriage Paid To (CPT) named
destinationa
Purchaser
Carriage and Insurance Paid (CIP) to
named destinationb
Thermo Fisher Scientific
a
Unless specified differently, Thermo Fisher Scientific uses this shipment method for international shipments.
b
Under special circumstances, Thermo Fisher Scientific uses this shipment method for international shipments.
Orbitrap Fusion Series Preinstallation Requirements Guide
Thermo Scientific
8
Installation
Complete all preparations described in the previous chapters before the Thermo Fisher
Scientific service engineer installs the Orbitrap Fusion Series MS.
IMPORTANT If the instrument shipping container, ShockWatch, or other indicators show
any evidence of damage or mishandling during shipment, do NOT open the container.
Call your Thermo Fisher Scientific representative for instructions on what to do. If the
instrument arrives safely, proceed with the following instructions.
After you have completed the laboratory site preparation and received the Orbitrap Fusion
Series MS, send the completed and signed “Orbitrap Fusion Series Installation Request Form”
on page iii to your local office for Thermo Fisher Scientific San Jose products. After receiving
this form, the service engineer contacts you to schedule the installation.
CAUTION Heavy object. The Orbitrap Fusion Series MS, excluding its workbench,
weighs over 227 kg (500 lb). Never try to detach and move the instrument from its
workbench; you can suffer personal injury or damage the instrument. For additional
information, contact the service engineer.
Contents
• Installation Kits
• Customer-Supplied Hardware
• Basic On-Site Training
• Advanced Training Courses
• Preventive Maintenance
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Orbitrap Fusion Series Preinstallation Requirements Guide
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8
Installation
Installation Kits
Installation Kits
The Orbitrap Fusion Series MS includes the following kits (Table 12).
Table 12. Kits provided with the Orbitrap Fusion Series mass spectrometer
Kit name
Description
Preinstallation Kit
(North American or
International, as applicable)
Contains this guide and the Orbitrap Fusion Series
Chemicals Kit. The International Preinstallation Kit
also includes three 230 Vac CEE (3-pole) wall
receptacles.
Chemicals Kit
(P/N 80000-62049)
Contains the chemicals for demonstrating the
instrument performance specifications.
Calibration Kit
(P/N 80000-62078)
Contains a syringe and the installation components,
such as fittings and tubing.
MS Setup Kit
(P/N 80100-62003)
Contains the components to connect the mass
spectrometer to the forepump or forepumps, the gas
supplies, the Ethernet switch, and the waste container.
Performance Specification Kit
(P/N 80100-62008)
Contains the plumbing hardware for demonstrating the
instrument performance specifications.
Single Mechanical Pump Kit
(P/N 80100-62004)
–or–
Dual Mechanical Pumps Kit
(P/N 80011-62006)
Contains the forepump (single pump kit) or forepumps
(dual pumps kit), relay control cable, and installation
components, such as the exhaust waste tubing.
Depending on your purchase order, you might have other kits with your shipment.
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Orbitrap Fusion Series Preinstallation Requirements Guide
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8 Installation
Customer-Supplied Hardware
Customer-Supplied Hardware
Thermo Fisher Scientific does not provide all parts, materials, or tools that are required for
installation. To complete the installation, you must provide these additional parts (Table 13).
Table 13. Customer-supplied hardware for installation
Item
Description
Communications cable
Connects from the Ready Out and Injection Hold pins
(peripheral control connector) on the mass spectrometer
to a device not controlled by one of the Thermo
Scientific mass spectrometer applications, such as the
Xcalibur™ data system.
Refer to the Orbitrap Fusion Series Getting Connected
Guide.
Gas line fitting, helium
Connects the 1/8 in. ID copper or stainless steel tubing
to the helium gas supply.
Refer to the Orbitrap Fusion Series Getting Connected
Guide.
Gas line fitting, nitrogen
Connects the 1/8 in. OD Teflon™ PFA tubing to the
nitrogen gas supply.
Refer to the Orbitrap Fusion Series Getting Connected
Guide.
LC system
LC system, solvents
IMPORTANT If your LC system is manufactured by
another company, you must verify that it is suitable
for use with the Orbitrap Fusion Series MS. The
output (start) signal from the external device must be
Normally Hi (+5 Vdc) and momentarily go to Low. If
you cannot configure the external device to go from
Normally Hi to Low momentarily, you cannot use it
with the Orbitrap Fusion Series MS.
Used by the service engineer to calibrate the system
during the initial setup.
For details, refer to the appropriate manual.
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Orbitrap Fusion Series Preinstallation Requirements Guide
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8
Installation
Basic On-Site Training
Basic On-Site Training
When your new Orbitrap Fusion Series system is on site and ready for installation, the service
engineer unpacks and installs it.
During the installation, the service engineer demonstrates the following:
• Basics of the instrument operation and routine maintenance
• Marketing specifications that are in effect when you purchased the instrument
Tip To receive maximum benefit from this on-site training opportunity, plan for the
system operators to be available during the entire installation process.
Do not use the new system for sample analysis until the installation is complete and you have
signed the Acceptance Form.
Advanced Training Courses
Thermo Fisher Scientific provides introductory and advanced training courses in analytical
techniques, in addition to specialized operation and maintenance courses for Thermo
Scientific products.
Thermo Fisher Scientific recommends that the key user receive advanced training for
operating and maintaining the Orbitrap Fusion Series MS after using it for several months.
After this training is complete, the key user can conduct in-house training for other staff
members, certifying them to operate the system.
Preventive Maintenance
You are responsible for the routine and preventive maintenance of the Orbitrap Fusion Series
MS.
Regular preventive maintenance is essential. It increases the life of the system, maximizes the
uptime of the system, and provides optimum system performance. You can find maintenance
procedures in the following manuals:
• Orbitrap Fusion Series Hardware Manual
• Ion Max NG and EASY-Max NG Ion Sources User Guide
• Manuals shipped with other devices for your system
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Orbitrap Fusion Series Preinstallation Requirements Guide
Thermo Scientific
I
Index
A
air conditioning system 12
API source, drain guidelines 28
B
buck/boost transformer 17
C
circuit breakers 18
communications cables, Ethernet 5
compliance
FCC vi
regulatory v
contacting us xiv
contaminants, gas 24
D
damage indicator, packaging 31
data system
number of outlets 19
recommended layout 7
dimensions
shipping containers 4
system modules 4
directive, WEEE vii
documentation
accessing xii
additional xii
downloading xii
Ethernet, communications cables 5
exhaust system 27
F
FCC compliance vi
forepumps 9, 17, 27
G
gases 23
generator, nitrogen gas 24
ground
See earth ground connections
H
hardware, supplied by customer 33
heat output, maximum 13
helium gas supply 24
I
installation kits 32
Installation Request Form iii
instrument shipments, reporting damage 29
isolation/noise-suppression transformer 17
K
kits
Buck/Boost Transformer 17
installation 32
E
L
earth ground connections 18
electrical outlets 18
electromagnetic compatibility v
EMC compliance v
environmental requirements 11
lab environment, requirements 11
line power 15
load capacity
air conditioning 13
workbenches 5
Thermo Scientific
Orbitrap Fusion Series Preinstallation Requirements Guide
35
Index: M
M
U
maintenance, preventive 34
mass spectrometers
recommended layout 8
system, number of outlets 19
uninterruptible power supply (UPS) 17
UV-Vis detector 26
V
nitrogen gas
generator 24
regulator 24
supply 24
venting
forepumps 27
solvent waste container 28
voltage
single phase for MS 18
transient, description 16
P
W
power
conditioning devices 17
monitoring devices 16
quality of 16
power supply cords 20
warranty, limitations 1
waste and exhaust 27
WEEE directive vii
workbench requirements 5
N
R
regulatory compliance v
S
safety and special notices xiii
safety standards v
service contract, exclusions 1
shipment, damage indicator 31
shipping containers 4
site preparation 3
solvent waste
contaminants, instrument damage 26
description 28
solvents, recommendations 25
surge protector 18
system damage, gas contaminants 24
system layouts 7–8
T
technical assistance 21
telephone 9
temperature and humidity monitor 12
training 34
transformer
buck/boost 17
isolation/noise-suppression 17
transient voltages 16
36
Orbitrap Fusion Series Preinstallation Requirements Guide
Thermo Scientific
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