TSQ Endura and TSQ Quantiva Preinstallation Requirements Guide

TSQ Series
TSQ Endura and
TSQ Quantiva
Preinstallation Requirements Guide
80100-97015 Revision B
July 2015
© 2015 Thermo Fisher Scientific Inc. All rights reserved.
Dionex, Optima, TSQ Endura, TSQ Quantiva, Thermo Scientific, UltiMate, and Xcalibur are registered
trademarks of Thermo Fisher Scientific Inc. in the United States.
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The following are registered trademarks in the United States and possibly other countries: Dranetz is a
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All other trademarks are the property of Thermo Fisher Scientific Inc. and its subsidiaries.
Thermo Fisher Scientific Inc. provides this document to its customers with a product purchase to use in the
product operation. This document is copyright protected and any reproduction of the whole or any part of this
document is strictly prohibited, except with the written authorization of Thermo Fisher Scientific Inc.
The contents of this document are subject to change without notice. All technical information in this
document is for reference purposes only. System configurations and specifications in this document supersede
all previous information received by the purchaser.
This document is not part of any sales contract between Thermo Fisher Scientific Inc. and a purchaser. This
document shall in no way govern or modify any Terms and Conditions of Sale, which Terms and Conditions of
Sale shall govern all conflicting information between the two documents.
Release history: Rev A, November 2013; Rev B, July 2015
For Research Use Only. Not for use in diagnostic procedures.
TSQ Endura and TSQ Quantiva Installation Request Form
Before completing this installation request form, read all of the TSQ Endura and TSQ Quantiva Preinstallation
Requirements Guide. For U.S. laboratory locations, send this completed and signed form to
[email protected] For other countries or regions, go to
www.thermoscientific.com/support, click Contact Us, click the email option,
, and attach this form to your
request to schedule the installation.
Laboratory setup
 1. All laboratory remodeling is complete and
complies with all relevant safety regulations.
 2. The TSQ Endura or TSQ Quantiva is on site.
 3. A principal operator will be on site during the
installation/certification period.
 4. Doorways, hallways, and so on are a minimum
width of 94 cm (37 in.).
 5. Laboratory lighting is adequate.
 6. Air conditioning is adequate for temperature,
humidity, and particulate matter control.
 7. Relative humidity is 40–80%, noncondensing.
 8. The work area is free from magnetic disruption
and electrostatic discharge.
 9. A step stool is on site.
 10. A voice telephone line is installed near the system.
 11. (Optional) The laboratory has Internet access.
 12. Floor space is sufficient and flooring will support
the load.
Power
 13. Main power is installed and complies with local
electrical codes.
 14. Power is free from fluctuations due to slow
changes in the average voltage or changes due to
surges, sags, or transients.
 15. Power outlets are of the correct configuration for
the power cords. See page 18.
Note NEMA type: ____________________
 16. Voltage of power outlet has been measured.
Note measured voltage:
AC line-to-ground: __________________ V
AC neutral-to-ground: _______________ V
AC line-to-neutral: __________________ V
 17. Power outlets are available for testing and cleaning
equipment.
Gas and exhaust
18. All required gases are on site, gas lines are
installed, and appropriate gas regulators are
available. For pressures, see page 21.
Note gas types and actual purity levels:
Gas: _____________ purity:_______________
Gas: _____________ purity:_______________
 19. All gas lines are clean and have no leaks.
 20. A suitable fume exhaust system is separate from
the solvent waste and is within 2.4 m (8 ft) of the
system. See page 6 and page 25.

System setup
 21. Data system computer: (a) a new computer shows
no changes to ANY settings and has no additional
software, or (b) an existing computer meets the
software system requirements. (a) __ (b) __
 22. System setup provides for collecting solvent waste
from the API source.
 23. A new or recently cleaned HPLC system is
available that produces pulse-free, continuous flow
of 100–1000 μL/min.
 24. Optima LC/MS-grade acetonitrile, formic acid,
isopropyl alcohol, methanol, and water are
available for testing the instrument’s performance.
 25. Sufficient bench or table space is available for all
of the equipment. Note the dimensions:
Width: _____________________________
Depth: _____________________________
Height: _____________________________
Does the bench (table) have wheels? Yes__ No__
 26. Sufficient clearance is provided behind the bench
(or table). See page 5.
 27. The bench (or table) can support twice the load of
the instrument (262 kg [576 lb]) and is free from
vibration.
IMPORTANT Thermo Fisher Scientific reserves the right to invoice for the field service engineer’s time if the
installation requirements are not met by the installation date.
CONTINUED ON THE NEXT PAGE
For customized installations
Does your contract contain any special acceptance specifications?
If YES, attach full details of the specifications.

Yes
 No
Does the system require additional equipment?
If YES, attach full details of the additional equipment.

Yes
 No
I certify that the preinstallation requirements for the TSQ Endura or TSQ Quantiva are complete and
accurate.
Signature
Date
Print name
Telephone
Email address
Principal instrument operator:
Print name
Telephone
Email address
Company
Telephone
Address
Address
City
State
Country
Sales order number
Note This form is intended to cover the essential components of your TSQ Endura or TSQ Quantiva installation.
However, you must use the information in this guide and any additional information that your Thermo Fisher
Scientific field service engineer provides to ensure the proper setup of your system. After receiving this form, the
field service engineer contacts you to schedule the installation.
Regulatory Compliance
Thermo Fisher Scientific performs complete testing and evaluation of its products to ensure full compliance with
applicable domestic and international regulations. When the system is delivered to you, it meets all pertinent
electromagnetic compatibility (EMC) and safety standards as described in the next section or sections by product name.
Changes that you make to your system may void compliance with one or more of these EMC and safety standards.
Changes to your system include replacing a part or adding components, options, or peripherals not specifically
authorized and qualified by Thermo Fisher Scientific. To ensure continued compliance with EMC and safety standards,
replacement parts and additional components, options, and peripherals must be ordered from Thermo Fisher Scientific
or one of its authorized representatives.
EMC Directive 2004/108/EC
EMC compliance has been evaluated by TÜV Rheinland of North America.
EN 55011: 2009, A1: 2010
EN 61000-4-6: 2009
EN 61000-3-2: 2006, A2: 2009
EN 61000-4-11: 2004
EN 61000-3-3: 2008
EN 61326-1: 2013
EN 61000-4-2: 2009
CISPR 11: 2009, A1: 2010
EN 61000-4-3: 2006, A2: 2010
ICES-003 Issue 5: 2012
EN 61000-4-4: 2004, A1: 2010
CFR 47, FCC Part 15, Subpart B, Class A: 2012
EN 61000-4-5: 2006
Low Voltage Safety Compliance
This device complies with Low Voltage Directive 2006/95/EC and harmonized standard EN/UL/CAN 61010-1.
FCC Compliance Statement
THIS DEVICE COMPLIES WITH PART 15 OF THE FCC RULES. OPERATION IS SUBJECT TO
THE FOLLOWING TWO CONDITIONS: (1) THIS DEVICE MAY NOT CAUSE HARMFUL
INTERFERENCE, AND (2) THIS DEVICE MUST ACCEPT ANY INTERFERENCE RECEIVED,
INCLUDING INTERFERENCE THAT MAY CAUSE UNDESIRED OPERATION.
CAUTION Read and understand the various precautionary notes, signs, and symbols contained inside
this manual pertaining to the safe use and operation of this product before using the device.
Notice on Lifting and Handling of
Thermo Scientific Instruments
For your safety, and in compliance with international regulations, the physical handling of this Thermo Fisher Scientific
instrument requires a team effort to lift and/or move the instrument. This instrument is too heavy and/or bulky for one
person alone to handle safely.
Notice on the Proper Use of
Thermo Scientific Instruments
In compliance with international regulations: This instrument must be used in the manner specified by Thermo Fisher
Scientific to ensure protections provided by the instrument are not impaired. Deviations from specified instructions on
the proper use of the instrument include changes to the system and part replacement. Accordingly, order replacement
parts from Thermo Fisher Scientific or one of its authorized representatives.
WEEE Directive
2012/19/EU
Thermo Fisher Scientific is registered with B2B Compliance (B2Bcompliance.org.uk) in the UK and with the
European Recycling Platform (ERP-recycling.org) in all other countries of the European Union and in Norway.
If this product is located in Europe and you want to participate in the Thermo Fisher Scientific Business-to-Business
(B2B) Recycling Program, send an email request to [email protected] with the following information:
• WEEE product class
• Name of the manufacturer or distributor (where you purchased the product)
• Number of product pieces, and the estimated total weight and volume
• Pick-up address and contact person (include contact information)
• Appropriate pick-up time
• Declaration of decontamination, stating that all hazardous fluids or material have been removed from the product
For additional information about the Restriction on Hazardous Substances (RoHS) Directive for the European Union,
search for RoHS on the Thermo Fisher Scientific European language websites.
IMPORTANT This recycling program is not for biological hazard products or for products that have been medically
contaminated. You must treat these types of products as biohazard waste and dispose of them in accordance with
your local regulations.
Directive DEEE
2012/19/EU
Thermo Fisher Scientific s'est associé avec une ou plusieurs sociétés de recyclage dans chaque état membre de l’Union
Européenne et ce produit devrait être collecté ou recyclé par celle(s)-ci. Pour davantage d'informations, rendez-vous sur
la page www.thermoscientific.fr/rohs.
WEEE Direktive
2012/19/EU
Thermo Fisher Scientific hat Vereinbarungen mit Verwertungs-/Entsorgungsfirmen in allen EU-Mitgliedsstaaten
getroffen, damit dieses Produkt durch diese Firmen wiederverwertet oder entsorgt werden kann. Weitere Informationen
finden Sie unter www.thermoscientific.de/rohs.
C
Contents
Preface . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . xi
Mass Spectrometer Models . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .xi
Related Documentation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . xii
Cautions and Special Notices . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .xiii
Contacting Us . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .xiv
Thermo Scientific
Chapter 1
Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .1
Chapter 2
Site Preparation. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .3
Entrance . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3
Space and Load Requirements . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4
Workbench Requirements . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5
LC/MS System Layout . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6
Forepumps . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8
Telephone . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8
Chapter 3
Operating Environment. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .9
Summary of Environmental Requirements . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9
Humidity . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 10
Temperature . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 10
Particulate Matter . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11
Electrostatic Discharge . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11
Lighting. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 12
Vibration. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 12
Chapter 4
Line Power . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .13
Quality of Power . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 14
Power Monitoring Devices . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 14
Power Conditioning Devices . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 15
Uninterruptible Power Supply. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 15
Circuit Breakers. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 16
Earth Ground . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 16
Electrical Outlets . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 16
Power Supply Cords . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 18
Technical Assistance . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 19
TSQ Endura and TSQ Quantiva Preinstallation Requirements Guide
ix
Contents
Chapter 5
Gases and Solvents. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .21
Gases . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 21
Argon Supply . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 22
Nitrogen Supply . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 22
Solvent Recommendation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 23
Chapter 6
Waste and Exhaust . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .25
Exhaust System . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 25
Solvent Waste . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 26
Chapter 7
Instrument Shipments. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .27
Receiving Shipping Packages and Reporting Damage . . . . . . . . . . . . . . . . . . . . 27
Filing a Damage Claim Against the Carrier . . . . . . . . . . . . . . . . . . . . . . . . . . . . 28
Chapter 8
Installation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .29
Installation Kits . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 30
Customer-Supplied Hardware . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 31
Basic On-Site Training . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 32
Advanced Training Courses. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 32
Preventive Maintenance . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 32
Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .33
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TSQ Endura and TSQ Quantiva Preinstallation Requirements Guide
Thermo Scientific
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Preface
The TSQ Quantiva and TSQ Endura Preinstallation Requirements Guide provides information
for planning and preparing your laboratory before delivery and installation of your Thermo
Scientific™ TSQ Endura™ or TSQ Quantiva™ mass spectrometer (MS). Read each section
carefully to ensure that your lab is ready for the system.
Contents
• Mass Spectrometer Models
• Related Documentation
• Cautions and Special Notices
• Contacting Us
 To suggest changes to the documentation or to the Help
Complete a brief survey about this document by clicking the button below.
Thank you in advance for your help.
Mass Spectrometer Models
This guide is intended for the following mass spectrometer models:
• TSQ Endura—Requires one forepump.
• TSQ Quantiva—Requires two forepumps.
Thermo Scientific
TSQ Endura and TSQ Quantiva Preinstallation Requirements Guide
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Preface
Related Documentation
The TSQ Endura and TSQ Quantiva mass spectrometers include complete documentation.
In addition to this guide, you can also access the following documents as PDF files from the
data system computer:
• TSQ Endura and TSQ Quantiva Getting Connected Guide
• TSQ Endura and TSQ Quantiva Getting Started Guide
• TSQ Endura and TSQ Quantiva Hardware Manual
• Ion Max NG and EASY-Max NG Ion Sources User Guide
• Safety and Regulatory Guide
The TSQ Endura and TSQ Quantiva also ship with a printed copy of the Safety and
Regulatory Guide. This guide contains important safety information about Thermo
Scientific liquid chromatography (LC) and mass spectrometry (MS) systems. Make sure
that all lab personnel have read and have access to this document.
 To view the product manuals
From the Microsoft™ Windows™ taskbar, do the following:
• For a Thermo Scientific mass spectrometer, choose Start > All Programs > Thermo
Instruments > model x.x, and then open the applicable PDF file.
• For an LC instrument controlled by a Thermo Scientific application, choose Start >
All Programs > Thermo Instruments > Manuals > LC Devices and so on.
 To download user documentation from the Thermo Scientific website
1. Go to www.thermoscientific.com.
2. In the Search box, type the product name and press Enter.
3. In the left pane, select Documents & Videos, and then under Refine By Category, click
Operations and Maintenance.
4. (Optional) Narrow the search results or modify the display as applicable:
• For all related user manuals and quick references, click Operator Manuals.
• For installation and preinstallation requirements guides, click Installation
Instructions.
• For documents translated into a specific language, use the Refine By Language
feature.
• Use the Sort By options or the Refine Your Search box (above the search results
display).
xii
TSQ Endura and TSQ Quantiva Preinstallation Requirements Guide
Thermo Scientific
Preface
5. Download the document as follows:
a. Click the document title or click Download to open the file.
b. Save the file.
Cautions and Special Notices
Make sure you follow the cautions and special notices presented in this guide. Cautions and
special notices appear in boxes; those concerning safety or possible system damage also have
corresponding caution symbols.
This guide uses the following types of cautions and special notices.
CAUTION Highlights hazards to humans, property, or the environment. Each CAUTION
notice is accompanied by an appropriate CAUTION symbol.
IMPORTANT Highlights information necessary to prevent damage to software, loss of
data, or invalid test results; or might contain information that is critical for optimal
performance of the system.
Note Highlights information of general interest.
Tip Highlights helpful information that can make a task easier.
The TSQ Endura and TSQ Quantiva Preinstallation Requirements Guide contains the
following caution-specific symbols (Table 1).
Table 1. Caution-specific symbols and their meaning (Sheet 1 of 2)
Symbol
Meaning
Chemical hazard: Wear gloves and other protective equipment, as
appropriate, when handling toxic, carcinogenic, mutagenic, corrosive,
or irritant chemicals. Use approved containers and proper procedures
to dispose of waste oil and when handling wetted parts of the
instrument.
Heavy object: Never lift or move the instrument by yourself; you can
suffer personal injury or damage the instrument.
Risk of electric shock: This instrument uses voltages that can cause
electric shock and/or personal injury. Before servicing, shut down the
instrument and disconnect it from line power. While operating the
instrument, keep covers on.
Thermo Scientific
TSQ Endura and TSQ Quantiva Preinstallation Requirements Guide
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Preface
Table 1. Caution-specific symbols and their meaning (Sheet 2 of 2)
Symbol
Meaning
Risk of eye injury: Eye injury could occur from splattered chemicals or
airborne particles. Wear safety glasses when handling chemicals or
servicing the instrument.
Trip obstacle: Be aware of cords, hoses, or other objects located on the
floor.
Contacting Us
There are several ways to contact Thermo Fisher Scientific for the information you need. You
can use your smartphone to scan a QR code, which opens your email application or browser.
Contact us
xiv
Customer Service and Sales
Technical Support
(U.S.) 1 (800) 532-4752
(U.S.) 1 (800) 532-4752
(U.S.) 1 (561) 688-8731
(U.S.) 1 (561) 688-8736
us.customer-support.analyze
@thermofisher.com
us.techsupport.analyze
@thermofisher.com
TSQ Endura and TSQ Quantiva Preinstallation Requirements Guide
Thermo Scientific
Preface
Contact us
Customer Service and Sales
Technical Support
 To find global contact information or customize your request
1. Go to www.thermoscientific.com.
2. Click Contact Us, select the Using/Servicing a Product option, and then
type the product name.
3. Use the phone number, email address, or online form.
 To find product support, knowledge bases, and resources
Go to www.thermoscientific.com/support.
 To find product information
Go to www.thermoscientific.com/lc-ms.
Note To provide feedback for this document:
• Send an email message to Technical Publications ([email protected]).
• Complete a survey at www.surveymonkey.com/s/PQM6P62.
Thermo Scientific
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TSQ Endura and TSQ Quantiva Preinstallation Requirements Guide
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1
Introduction
For the Thermo Scientific TSQ Endura and TSQ Quantiva system, you are responsible for
providing a suitable location, a carefully controlled operating environment, a source of power
of acceptable quality, correct gases and solvent supplies, and proper waste and exhaust
systems.
CAUTION Operating a system or maintaining it outside the power and operating
environment specifications described in this guide might cause failures of many types. The
repair of such failures is specifically excluded from the Thermo Fisher Scientific standard
warranty and service contract coverage.
Note
• For preinstallation support and additional information, contact your local Thermo
Fisher Scientific office.
• Unless otherwise noted, the information in this guide applies to both models.
Thermo Scientific
TSQ Endura and TSQ Quantiva Preinstallation Requirements Guide
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2
Introduction
TSQ Endura and TSQ Quantiva Preinstallation Requirements Guide
Thermo Scientific
2
Site Preparation
You are responsible for providing an acceptable installation site for the TSQ Endura or
TSQ Quantiva system before the Thermo Fisher Scientific service engineer arrives. Make sure
your laboratory meets these requirements:
• When transporting the equipment to the designated site, you have a wide turning radius
through entrances, hallways, elevators, and so on. Remember to consider the width of the
device transporting the shipping container to the lab.
• The lab has a designated location for the system modules.
• The laboratory has large, strong workbenches to support the weights of the mass
spectrometer, LC instrument, and data system module.
Contents
• Entrance
• Space and Load Requirements
• Forepumps
• Telephone
Entrance
The entrance to your facility and the width of all hallways, elevators, and so on must be a
minimum of 95 cm (37 in.). However, allow additional room for maneuvering the system
around corners, into elevators, or through doorways.
The system ships in multiple containers. The main shipping container measures 104 cm l,
95 cm w, and 135 cm h (41 in. l, 37 in. w, and 53 in. h) and, including its contents, weighs
approximately 187 kg (410 lb). Use this information to determine how to transport and
remove its contents.
Note If the lab entrance cannot accommodate a 95 cm (37 in.) container, remove the
modules from the container before moving them into the room. If you remove the
instrument from its shipping container before it is delivered to the lab site, ensure that all
the container contents remain with the instrument.
Thermo Scientific
TSQ Endura and TSQ Quantiva Preinstallation Requirements Guide
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2
Site Preparation
Space and Load Requirements
Other equipment in your order have their own smaller shipping containers and do not require
special consideration. These modules—such as the forepumps, data system computer,
monitor, and other options—ship in separate containers. The chemicals kit typically arrives
earlier than the other parts of your order.
Space and Load Requirements
Table 2 lists the dimensions and weights for the data system and mass spectrometer system
modules. Use this information to ensure that all workbenches are large enough and strong
enough to support the modules.
Table 2. Space and load requirements for the system modules
Width (w)
cm (in.)
Height (h)
cm (in.)
Depth (d)
cm (in.)
Weight
kg (lb)
(Optional) Thermo Scientific
Dionex™ UltiMate™ 3000a
41 (16)
97 (38)
46 (18)
62 (138)
TSQ Quantiva or TSQ Endura
mass spectrometerb
76 (30)
70 (28)
80 (32)
131 (288)
32 (12.6)
26.4 (10.4)
48 (19)
52 (115)
17.5 (7)
36 (14.2)
41.7 (16.4)
9.4 (21)
Monitor
64 (25.3)
54 (21)
c
20 (8)
7 (15.8)
Ethernet switch
15.4 (6.1)
2.9 (1.14)
11 (4.5)
0.17 (0.4)
45 (18)
32 (12.4)
41 (16)
16 (35)
Modules
LC/MS system
Forepump (each)
Data system
Computer, mini-tower
(Optional) Laser printer
4
a
Approximate. The actual value depends on your equipment.
b
Includes the divert/inject valve
c
Fully extended
TSQ Endura and TSQ Quantiva Preinstallation Requirements Guide
Thermo Scientific
2 Site Preparation
Space and Load Requirements
This section discusses the following:
• Workbench Requirements
• LC/MS System Layout
Workbench Requirements
Table 3 lists the recommended minimum surface dimensions and load capacities for each
workbench that you must provide. Thermo Fisher Scientific recommends that workbenches
have a load capacity of at least twice the combined weight of all expected devices.
CAUTION Heavy object. Never lift or move the mass spectrometer by yourself; you can
suffer personal injury or damage the instrument.
Table 3. Minimum workbench surface dimensions and load capacities
Equipment
Surface
Load capacity
–
–
Mass spectrometer
81.3 × 86.4 cm (32 × 34 in.)
261.3 kg (576 lb)
Data system
122 × 91.4 cm (48 × 36 in.)
65.3 kg (144 lb)
LC
a
systema
Refer to the product manual for information about the LC system’s workbench.
Follow these clearance guidelines for the workbenches:
• Place the data system and MS workbenches adjacent to each other to prevent strain on
the interconnecting Ethernet communications cables.
CAUTION Safety and EMC regulations require the use of Category 5e shielded
Ethernet communications cables, maximum 3 m (10 ft) long.
• For all systems, allow for a minimum vertical clearance of 92 cm (36 in.) between the top
of the system and any shelves above it.
• For the MS system, allow for these minimum horizontal clearance for proper air
circulation and for the installed gas lines and tubing:
Thermo Scientific
–
25 cm (10 in.) behind the instrument
–
46 cm (18 in.) on the right side of the instrument
TSQ Endura and TSQ Quantiva Preinstallation Requirements Guide
5
2
Site Preparation
Space and Load Requirements
Figure 1 shows the top view (footprint) for the system workbenches.
Figure 1.
Top view and recommended placement of the workbenches (tables)
Laboratory wall
Minimum 25 cm (10 in.) horizontal clearance
LC system
Mass spectrometer
Data system
LC/MS System Layout
Figure 2 shows the recommended layout for the data system, LC instrument, and mass
spectrometer. Not all connections are shown; for connection information, refer to the
TSQ Endura and TSQ Quantiva Getting Connected Guide and the LC product manual.
CAUTION For information about the LC drainage systems, refer to the LC instrument
manual.
6
TSQ Endura and TSQ Quantiva Preinstallation Requirements Guide
Thermo Scientific
2 Site Preparation
Space and Load Requirements
Figure 2.
Workbenches for the optional UltiMate 3000 LC system (left), mass spectrometer (center), and data system
41 cm
(16 in)
76 cm
(30 in)
UltiMate 3000 LC system
TSQ Quantiva (shown) or
TSQ Endura mass spectrometer
85 cm
(34 in)
Data system
97 cm
(38 in)
Solvent waste container
Electrical outlets for the
LC system (120 or 230 Vac)
External vent for the solvent trap (waste)
External vent for the forepump exhaust
Thermo Scientific
Forepumps
Electrical outlets for the
data system (120 or 230 Vac)
Separate 230 Vac electrical outlets
for the instrument and forepumps
(circuits A, B, and C)
TSQ Endura and TSQ Quantiva Preinstallation Requirements Guide
7
2
Site Preparation
Forepumps
Forepumps
The TSQ Endura system uses one forepump, whereas the TSQ Quantiva system uses two.
Depending on available space, you have two options for the placement of the forepumps and
for connecting the vacuum hose from the mass spectrometer to the forepumps.
• If the workbench has space underneath, place the forepumps under the workbench
immediately behind the mass spectrometer. Either run the vacuum hose behind the
workbench or make a 6.4 cm (2.5 in.) diameter hole through the bench for the vacuum
hose. Allow for room to run the power cords from the forepumps through the hole.
• If the workbench has no space under it, place the forepumps at the end of the workbench.
CAUTION Trip hazard. Whenever possible, provide space under the workbench for the
forepumps. If placed in front of the mass spectrometer, the forepumps become a trip
hazard.
CAUTION
• Do not place the forepump on a shelf or other surface connected to the workbench.
Vibration from the pump can affect system performance.
• The exhaust hose tubing acts as a trap for exhaust fumes that would otherwise
recondense in the forepump oil.
–
To maintain forepump integrity, route the exhaust tubing from the exhaust port
down to the floor, not from the forepump vertically toward the ceiling.
–
Run the exhaust hose at floor level for a minimum of 2 m (79 in.) before it
reaches the external exhaust system.
Telephone
Make sure all of the laboratory staff have access to a telephone (landline or mobile) in the lab
near the system so that, if necessary, you can operate the mass spectrometer while speaking
with Thermo Fisher Scientific Technical Support. For a landline connection, make sure that
the telephone jack is within 1.8 m (6 ft) of the mass spectrometer.
8
TSQ Endura and TSQ Quantiva Preinstallation Requirements Guide
Thermo Scientific
3
Operating Environment
For proper operation of the system, you are responsible for providing the operating
environment described in this chapter. Attention to the operating environment ensures
continued high performance of your Thermo Scientific LC/MS system. Any expenditures for
air conditioning are more than offset by good sample throughput and reduced repair costs.
Contents
• Summary of Environmental Requirements
• Humidity
• Temperature
• Particulate Matter
• Electrostatic Discharge
• Lighting
• Vibration
Summary of Environmental Requirements
Table 4 lists the environmental requirements for the designated laboratory.
Table 4. Summary of environmental requirements (Sheet 1 of 2)
Parameter
Specification
Humidity
40–80%, noncondensing
Temperature
• Standard performance: 15–27 °C (59–81 °F)
• Optimum performance: 18–21 °C (65–70 °F)
• Ambient temperature: Fluctuations of less than
1 °C or 2 °F over a one-hour period
Particulate Matter
Thermo Scientific
Does not exceed 3 500 000 particles per cubic meter
(100 000 particles per cubic foot).
TSQ Endura and TSQ Quantiva Preinstallation Requirements Guide
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3
Operating Environment
Humidity
Table 4. Summary of environmental requirements (Sheet 2 of 2)
Parameter
Specification
Electrostatic Discharge (ESD)
Follow the stated precautions to help prevent ESD.
Lighting
• Operating: Typical laboratory lighting
• Cleaning: Use a small, high-intensity lamp
Vibration
Choose a lab location that is vibration-free.
Humidity
Maintain the relative humidity in the designated lab at 40–80 percent, without condensation.
Operating a Thermo Scientific mass spectrometer in an environment with very low humidity
can cause the accumulation and discharge of static electricity that can shorten the life of the
electronic components. Operating the mass spectrometer in an environment with high
humidity can cause condensation, oxidation, and short electronic circuits. It can also cause the
accumulation of dust that can block filters on cooling fans.
To ensure that the lab is always within the required temperature and humidity specifications,
Thermo Fisher Scientific recommends that you install a temperature and humidity monitor in
the lab.
Temperature
For precision instruments, such as a Thermo Scientific mass spectrometer, maintain the lab
temperature at 15–27 °C (59–81 °F). For optimum performance, maintain the lab
temperature at 18–21 °C (65–70 °F). Temperature control is vital to acquiring accurate mass
measurements. Therefore, make sure that during any one-hour period, ambient temperature
fluctuations are less than 1 °C or 2 °F.
IMPORTANT
• All electronic components generate heat while operating. This heat must dissipate to
the surrounding air for the components to continue to operate reliably.
• Do not locate the instrument under an air duct, near windows, or near heating and
cooling sources. As the lab temperature increases, the LC/MS system reliability
decreases.
There must be good air flow around the system, and the air conditioning system must
maintain a constant temperature in the immediate vicinity of the instrument. Table 5 lists the
approximate heat output (power) for the system. For the heat output of your specific LC
devices and the data system components, refer to the instrument manuals.
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TSQ Endura and TSQ Quantiva Preinstallation Requirements Guide
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3
Operating Environment
Particulate Matter
Table 5. Maximum heat output
Heat output
(W)
Heat output
(Btu/h)
Liquid chromatograph (LC)a
1060
3690
TSQ Endura or TSQ Quantiva mass spectrometer
1550
5396
Forepump (each)
1500
5220
Data system modules (mini-tower computer, monitor,
and optional laser printer)
889
3033
Total—TSQ Endura system (one forepump)
4999
17 339
Total—TSQ Quantiva system (two forepumps)
6499
22 559
Module
a
Approximate values for the UltiMate 3000. The actual values depend on your installed equipment.
Particulate Matter
Make sure that the air in the lab is free from excessive dust, smoke, or other particulate matter
in excess of 5 μm—that is, fewer than 3 500 000 particles per cubic meter (100 000 particles
per cubic foot).
Dust can clog the air filters, causing a reduction in air flow around electronic components.
Dust on electronic components can act as an insulating blanket, which reduces the transfer of
heat from the components to the surrounding air.
Electrostatic Discharge
Electrostatic discharge (ESD) can damage the electronic components of the TSQ Endura or
TSQ Quantiva mass spectrometer.
Most Thermo Scientific instruments are designed to withstand ESD up to 4 kV (air
discharge) and 4 kV (contact discharge) with all panels in place. However, removing the
panels and handling the printed circuit boards (PCBs) without proper precautions might
damage the electrical components or cause them to fail prematurely.
Because of ESD, Thermo Fisher Scientific recommends the following precautions, especially
when operating the system at the lower end of the relative humidity specification:
• Use a static-dissipating floor covering (such as tile or conductive linoleum) in the lab.
• Use laboratory chairs covered with natural fibers or other static-dissipating material.
• Wear a laboratory coat and clothing made of natural fiber or other static-dissipating
material when operating the instrument.
• Keep Styrofoam™ cups or packing materials away from the instrument.
Thermo Scientific
TSQ Endura and TSQ Quantiva Preinstallation Requirements Guide
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3
Operating Environment
Lighting
Lighting
Good lighting makes any work area more enjoyable. Thermo Fisher Scientific recommends
that you use a small, high-intensity lamp when cleaning the mass spectrometer components.
Vibration
Select a lab location that is free from vibration—floors at ground level usually have less
vibration. When selecting the location, be aware of adjacent rooms with equipment that could
transmit vibrations through the floor to the mass spectrometer workbench.
Because of the natural vibration of the forepump during operation, install the forepump on
the floor under the mass spectrometer.
12
TSQ Endura and TSQ Quantiva Preinstallation Requirements Guide
Thermo Scientific
4
Line Power
You are responsible for providing a power source of acceptable quality to operate the system.
The quality of line power (ac mains power system) delivered to the TSQ Endura or
TSQ Quantiva system can affect its performance and longevity. To ensure that the system
performs optimally and is not damaged by line power fluctuations, verify that the lab’s
electrical supply complies with all power quality requirements.
CAUTION To support compliance and safety requirements, all devices connected between
the power source and the mass spectrometer must be certified by recognized organizations
for your country or territory (for example, UL, CSA, SEMKO, VDE, or TÜV).
Such devices include the power supply cords, electrical outlets, circuit breakers,
uninterruptible power supplies (UPSs), and so on.
Contents
• Quality of Power
• Power Monitoring Devices
• Power Conditioning Devices
• Uninterruptible Power Supply
• Circuit Breakers
• Earth Ground
• Electrical Outlets
• Power Supply Cords
• Technical Assistance
Thermo Scientific
TSQ Endura and TSQ Quantiva Preinstallation Requirements Guide
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4
Line Power
Quality of Power
Quality of Power
Establishing the quality of power supplied to the LC/MS system is very important for these
reasons:
• Constant high line voltage, impulses, or surges in voltage can cause overheating and
component failures.
• Constant low line voltage or sags in voltage can cause the system to function erratically or
not at all.
• Transients—even a few microseconds in duration—can cause electronic devices to
degrade or fail catastrophically, shortening the lifetime of the system.
Before the service engineer arrives to install your system, make sure the line voltage is stable
and within the recommended specifications. The line voltage must be free of fluctuations due
to slow changes in the average sags, surges, transients, or voltage. For the mass spectrometer’s
electrical ratings, see Table 7 on page 17.
Table 6 lists the definitions for the three most common voltage disturbances.
Table 6. Common voltage disturbances
Voltage disturbance
Definition
Slow average
A gradual, long-term change in average root mean square
(RMS) voltage level, with typical durations greater than 2 s
Sags and surges
Sudden changes in average RMS voltage level, with typical
durations between 50 ms and 2 s
Transients or impulses
A brief voltage spike of up to several thousand volts, with
typical durations up to 50 μs
Power Monitoring Devices
Several devices are available to monitor the quality of the line power. These devices provide a
continuous record of line performance by analyzing and printing out data for the three most
common voltage disturbances (see Table 6).
In the first two cases, the time interval recording indicates the duration and the amplitude of
the disturbance. A power line disturbance analyzer detects and records most types of line
power problems. The Dranetz™ system1 is an example of a suitable analyzer. In some
countries, you can rent power line analyzers from electrical equipment suppliers.
1
14
Thermo Fisher Scientific does not endorse any power monitoring company, nor does it endorse products other
than its own. Companies and products listed in this guide are given as examples only.
TSQ Endura and TSQ Quantiva Preinstallation Requirements Guide
Thermo Scientific
4 Line Power
Power Conditioning Devices
Monitor the power line 24 hours a day for seven consecutive days. If inspection of the
printout indicates disturbances, stop the test and take corrective action. Monitor the power
again as previously described.
Power Conditioning Devices
You can correct a line voltage problem by using various line voltage conditioning devices. If
the power regulation is good but the power line disturbance analyzer shows transient voltages,
an isolation/noise-suppression transformer can resolve the problem. For both transient and
regulation problems, consider the use of power conditioners to control these problems. See
the CAUTION statement on page 13.
CAUTION Any conditioning devices installed with the system must be able to handle the
potentially high currents that are drawn during the initial startup of the system. For
example, during startup, the forepump or forepumps can draw a high inrush current.
Because the TSQ Endura and TSQ Quantiva mass spectrometers require the use of one or
two forepumps, the system draws an inrush current. The maximum inrush (start) current
for one forepump (Oerlikon Leybold Vacuum™, model SOGEVAC™ SV 65 BI) is 12 A.
The average duration of the forepump’s inrush current is less than 1 s. Therefore, this
initial energy demand from the ac power line is very low.
Thermo Scientific systems are protected from overcurrents with time-delay fuses and
active switches. For more information, contact your Thermo Fisher Scientific service
engineer.
When the line voltage is free from voltage sags, surges, and impulses but is more than
10 percent outside of the voltage specifications, a buck/boost transformer can lower (buck
10 percent) or raise (boost 10 percent) the line voltage as appropriate for the rated voltage.
Order the Buck/Boost Transformer Kit (P/N OPTON-01460) from Thermo Fisher Scientific
San Jose. Each buck/boost transformer is encased in a metal housing approximately
13  13  26 cm (5  5  10 in.) and ships with a 2 m (6.5 ft) power supply cable. Have a
certified electrician install the transformer, using the installation instructions that are
included. Then, install the TSQ Endura or TSQ Quantiva system.
CAUTION Systems installed in areas with 208 Vac power can experience voltage sags
during high use periods that might place the line voltage below the operating parameters
discussed in this section. In this case, protect the system by using a buck/boost
transformer to ensure that power stays within the specified parameters.
Uninterruptible Power Supply
If your local area is susceptible to corrupted power or power disruptions, install an
uninterruptible power supply (UPS) in the lab. See the Caution on page 13.
Thermo Scientific
TSQ Endura and TSQ Quantiva Preinstallation Requirements Guide
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4
Line Power
Circuit Breakers
Circuit Breakers
Make sure that each circuit breaker is suitably rated so that the equipment connected to the
electrical outlets does not lose power by triggering a current overload condition. For added
protection, install a surge protector at the input to the circuit breaker panel.
Earth Ground
Make sure that the earth ground connections in the lab are hardwired to the same ground
used for the main circuit breaker panel. Multiple external ground points can cause noise
current to flow through the ground loop that is formed.
Electrical Outlets
Installing a complete TSQ Endura or TSQ Quantiva system can require extensive electrical
resources for connecting all of the equipment. Plan the power system properly, with a
sufficient number of grounded, electrical outlets that are suitably rated. In addition, Thermo
Fisher Scientific recommends having several additional outlets close to the work area for
testing and cleaning equipment, such as an oscilloscope and a sonicator.
CAUTION To avoid an electric shock, always have a certified electrician install any new
wall receptacles.
Table 7 lists the electrical ratings (labels) and required number of outlets for the modules in a
typical lab setup. For the LC modules, refer to the manufacturer's manuals. To prevent
overloading the outlets, select outlets with a load rating that is suitable for the expected total
current draw per outlet.
IMPORTANT
• Thermo Fisher Scientific recommends that you connect the mass spectrometer and
each forepump to separate electrical outlets that have their own dedicated
single-phase, circuit breakers rated 230 Vac, 15 A for North America and 230 Vac,
16 A for other countries and territories. For example, the TSQ Quantiva system
requires three separate, dedicated electrical outlets (one for the instrument and two
for the forepumps). See also Figure 2.
• In North America, the LC/MS system requires both 120 and 230 Vac single-phase
electrical outlets.
16
TSQ Endura and TSQ Quantiva Preinstallation Requirements Guide
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4 Line Power
Electrical Outlets
Table 7. Electrical ratings and required outlets per module
Voltage
(Vac)
Current
(A)
Required
outlets
TSQ Endura or TSQ Quantiva mass
spectrometera
230
5
1
Forepump (SV 65 BI)b
230
8
1 or 2
Thermo Scientific divert/inject valve
110–220
1.5
1
Thermo Scientific syringe pump
110/220
0.2/0.1
1
Computer, mini-tower
100–240
5.4
1
Monitor
100–240
1.5
1
Ethernet switch
100–240
Less than 1
1
110
–or–
220
8.6
–or–
4.2
1
High-intensity lamp
(for instrument maintenance)
–
–
1
Laboratory stereoscope
(for inspecting fused-silica parts)
–
–
1
Module
MS system
Data system
(Optional) Laser printer
Optional devicesc
Total number of electrical outletsd:
a
Manufacturer-tested within ±10% of the electrical rating
b
The values are for one forepump.
c
Refer to the equipment manual for the electrical ratings.
d
Remember to add the number of outlets required for your LC system.
10+ (one-forepump system)
11+ (two-forepump system)
IMPORTANT After planning the location of the workbenches (see Chapter 2), consider
the following before installing the electrical outlets:
• Each module’s location and whether each requires a 120 or 230 Vac outlet (see
Table 7)
• The minimum number of outlets needed for a given voltage and adding the number
of outlets needed for any additional lab equipment (see Table 7)
• The length of the power supply cords (see Power Supply Cords)
Thermo Scientific
TSQ Endura and TSQ Quantiva Preinstallation Requirements Guide
17
4
Line Power
Power Supply Cords
Power Supply Cords
Your order includes the power supply cords for the TSQ Endura or TSQ Quantiva mass
spectrometer, one or two forepumps, and peripheral components. The mass spectrometer and
forepump use the same power plugs and receptacles. The power supply cords for the mass
spectrometer and forepump are 2.5 m (8 ft) long. The power supply cords for the data system
components are 1.8 m (6 ft) long.
Figure 3 shows an example of the NEMA 6-15 plug and receptacle configuration (rated
250 Vac, 15 A) for use in North America and other locations that use the same configuration.
Figure 3.
NEMA 6-15 plug (left) and receptacle (right) for North America (example)
Figure 4 shows the international power supply cord and receptacle (rated 250 Vac, 16 A) with
a CEE (3-pole) configuration for use in locations outside of North America.
Figure 4.
MS power supply cord and receptacle for outside of North America (provided)
The peripheral components (syringe pump, divert/inject valve, data system computer,
monitor, and Ethernet switch) ship with detachable power supply cords that are appropriate
for your country or territory. The power supply cords for the data system components are
1.8 m (6 ft) long. The power supply cord for the optional laser printer has either a NEMA
5-15P plug or a European CEE 7/7 (Schuko) plug, which is rated 16 A, 220 Vac.
18
TSQ Endura and TSQ Quantiva Preinstallation Requirements Guide
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4 Line Power
Technical Assistance
Technical Assistance
Occasionally, you might encounter line power sources with unacceptable quality that
adversely affect the operation of the LC/MS system. You are responsible for correcting any
line power problems. Contact Thermo Fisher Scientific for assistance in monitoring the line
voltage in your lab and in selecting a line conditioner.
Specifying power conditioning equipment is a complex task that is best handled by a company
or consultant specializing in that field. Contact Thermo Fisher Scientific for assistance in
locating a power consultant in your area.
Thermo Scientific
TSQ Endura and TSQ Quantiva Preinstallation Requirements Guide
19
4
Line Power
Technical Assistance
20
TSQ Endura and TSQ Quantiva Preinstallation Requirements Guide
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5
Gases and Solvents
You are responsible for providing the correct gas, solvent, and regulators to operate the
TSQ Endura or TSQ Quantiva system. The mass spectrometer requires ultra-high-purity
(UHP) argon gas, high-purity (HP) nitrogen gas, and solvents. The Thermo Fisher Scientific
service engineer might also require certain solvents for the installation verification of your
system.
The gas connections are located on the left side of the instrument. For information about
connecting the gas lines, refer to the TSQ Endura and TSQ Quantiva Getting Connected
Guide.
.
Contents
• Gases
• Solvent Recommendation
Gases
The instrument can use large amounts of gas during daily operations. Make sure that the gases
are delivered with the necessary pressure and purity as listed in Table 8.
Table 8. Summary of the required gases for the mass spectrometer
a
Required gas
pressure
Typical daily
consumptiona
Function
UHP (99.995%)—Has less than
1.0 ppm each of water, oxygen,
and total hydrocarbons.
135 ±70 kPa
(20 ±10 psi)
17 L (0.6 ft3)
Collision gas
HP (99%)
690 ±140 kPa
(100 ±20 psi)
11 500–26 700 L Venting gas; API source
auxiliary gas, sheath gas, and
(406–943 ft3)
sweep gas
Type
Recommended purity
Argon
Nitrogen
Approximate value when operating 24 hours and 7 days a week
Thermo Scientific
TSQ Endura and TSQ Quantiva Preinstallation Requirements Guide
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5
Gases and Solvents
Gases
CAUTION
• Contaminants introduced during the installation of house lines used for gas delivery
can cause damage to the mass spectrometer. Make sure that all gas lines used with the
instrument have been cleaned of all particulates and oils. You are responsible for any
damage to the instrument caused by contaminants introduced from your gas delivery
system.
• Because particulate filters can be a source of contamination, Thermo Fisher Scientific
does not recommend their use.
Argon Supply
To dispense UHP argon from a tank (such as one containing 245 ft3 of argon), use a
Matheson™ 3120 Series1 regulator (or equivalent tank and regulator). Particulate filters are
not recommended because they can be a source of contamination. Use either stainless steel
tubing or the provided copper tubing for the argon gas line, and make sure that it is free of oil
and preferably flame dried. Terminate the argon gas supply lines with 1/8 in., female,
Swagelok™-type connectors.
Note After you start using the mass spectrometer, do not shut off the argon gas.
Optimum performance requires a continuous flow of argon.
Nitrogen Supply
You must provide a regulator for the nitrogen gas supply that you can adjust over the specified
pressure range. Thermo Fisher Scientific recommends one of the following sources for the HP
nitrogen supply:
• A large, sealed, thermally insulated cylinder containing liquid nitrogen from which the
nitrogen gas is boiled off. Because the 35 psi (240 kPa) and 80 psi (550 kPa) models do
not provide sufficient gas pressure, Thermo Fisher Scientific recommends a 230 psi
(1590 kPa) model. A typical 240 L cylinder yields 143 850 L (5080 ft3) of gas. Replace
the cylinder approximately once every month.
• A nitrogen generator that can generate up to 5560 L (200 ft3) per day at 99% purity with
100 psi (689 kPa) at the side panel. Maximum consumption of nitrogen gas is 21 L/min
(40 ft3/h). Nitrogen generators require an air compressor. Because some models of air
compressors are quite noisy, be careful to select a quiet compressor. A generator is a
continuous source, with no replacement required.
1
22
For more information, visit www.mathesongas.com. Thermo Fisher Scientific does not endorse any products
other than its own. Companies and products listed in this guide are given as examples only.
TSQ Endura and TSQ Quantiva Preinstallation Requirements Guide
Thermo Scientific
5 Gases and Solvents
Solvent Recommendation
Note Liquid nitrogen conversion factors:
• 1.0 lb of liquid nitrogen = 0.5612 L
• 1.0 kg of liquid nitrogen = 1.237 L
Terminate the nitrogen gas supply line with a quick-connect connector. Because particulate
filters can be a source of contamination, Thermo Fisher Scientific does not recommend their
use.
CAUTION When you turn on the system, the initial nitrogen surge might exceed the
capacity of the nitrogen generator. This sudden surge causes a flow rate drop that can
trigger a low nitrogen warning from the mass spectrometer. If low nitrogen warnings
happen frequently, call your Thermo Fisher Scientific service engineer.
Solvent Recommendation
As specified in Table 9, use only LC/MS-grade solvents and reagents for operating and
maintaining the TSQ Endura or TSQ Quantiva system. Installation of the instrument
requires LC/MS-grade methanol and water. Installation of some systems might also require
solvent modifiers.
CAUTION Avoid exposure to potentially harmful materials.
By law, producers and suppliers of chemical compounds are required to provide their
customers with the most current health and safety information in the form of Material
Safety Data Sheets (MSDSs) or Safety Data Sheets (SDSs). The MSDSs and SDSs must
be freely available to lab personnel to examine at any time. These data sheets describe the
chemicals and summarize information on the hazard and toxicity of specific chemical
compounds. They also provide information on the proper handling of compounds, first
aid for accidental exposure, and procedures to remedy spills or leaks.
Read the MSDS or SDS for each chemical you use. Store and handle all chemicals in
accordance with standard safety procedures. Always wear protective gloves and safety
glasses when you use solvents or corrosives. Also, contain waste streams, use proper
ventilation, and dispose of all laboratory reagents according to the directions in the MSDS
or SDS.
Thermo Scientific
TSQ Endura and TSQ Quantiva Preinstallation Requirements Guide
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5
Gases and Solvents
Solvent Recommendation
Table 9. Recommended solutions
a
Solvent
Grade
Sizea
Part number
Acetonitrile
Optima™ LC/MS
Amber glass, 4 L
A955-4
Formic acid (modifier)
Optima LC/MS
Ampule, 10 × 1 mL
A117-10X1AMP
Methanol
Optima LC/MS
Amber glass, 4 L
A456-4
Water
Optima LC/MS
Amber glass, 4 L
W6-4
Size for the stated part number
IMPORTANT
• Some solvent impurities are transparent to a UV-Vis detector. Therefore, some
HPLC-grade solvents might contain contaminants that interfere with the
performance of the mass spectrometer. To operate the mass spectrometer, choose
HPLC solvents with minimum contamination.
• Do not filter solvents. Filtering solvents can introduce contamination.
Note Visit www.fishersci.com for a wide variety of solvents and consumables for purchase.
24
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6
Waste and Exhaust
You are responsible for providing the proper waste and exhaust systems that are required to
operate the TSQ Endura or TSQ Quantiva system.The waste and exhaust arrangements can
affect the proper performance of the system. You must vent vacuum and solvent wastes
separately, and collect and dispose of wastes properly.
For information about setting up the exhaust and waste systems, refer to the TSQ Endura and
TSQ Quantiva Getting Connected Guide.
Contents
• Exhaust System
• Solvent Waste
Exhaust System
To properly operate one or both forepumps, Thermo Fisher Scientific strongly recommends
connecting the forepump to an efficient fume exhaust system. The forepump eventually
exhausts much of what is introduced into the mass spectrometer, including the small amount
of oil vapor that a mechanical pump can emit.
Note Most API applications contribute to solvents accumulating in the forepump.
Although Thermo Fisher Scientific recommends that you periodically open the ballast
valve (on the side of the pump) to purge the accumulated solvents, opening the valve
might allow a large volume of volatile solvent waste to enter the fume exhaust system.
Choose an exhaust system that can accommodate the periodic purging of these solvents.
The frequency of the purging depends on the throughput of the system.
The forepump requires one 15 mm (0.6 in.) OD exhaust port. The exhaust system for the
forepump must be able to accommodate an initial inrush flow rate of 3 L/min (6.4 ft3/hr) and
a continuous flow rate of 1 L/min (2 ft3/hr). The exhaust tubing from the forepump to the
exhaust system is 0.5 in. ID, 3/4 in. OD, and 3 m (10 ft) long.
Thermo Scientific
TSQ Endura and TSQ Quantiva Preinstallation Requirements Guide
25
6
Waste and Exhaust
Solvent Waste
IMPORTANT The port for the lab exhaust system must be close enough to the forepump
or forepumps so that the exhaust hose is at floor level for a minimum of 2 m (78.7 in.).
This hose acts as a trap for exhaust fumes that would otherwise recondense in the
forepump oil.
Equip your lab with at least two fume exhaust systems:
• The analyzer optics become contaminated if the drain/waste tubing and the exhaust
tubing from the forepump connect to the same fume exhaust system. Route the exhaust
tubing from the forepump to a dedicated fume exhaust system.
CAUTION Do NOT run the forepump exhaust lines vertically near the forepump.
Solvents and oils can condense in the line and flow back into the pump, causing
pump damage, and diminished pump capability.
• Do not vent the Tygon™ drain tube (or any vent tubing connected to the waste container)
to the same fume exhaust system that connects to the forepump. Vent the waste container
to a dedicated fume exhaust system. The exhaust system for the API source must
accommodate a flow rate of up to 30 L/min (64 ft3/h).
Solvent Waste
The mass spectrometer comes with parts to collect the solvent waste from the API source.
Because the API source can accommodate high flow rates, you must use a method of
collecting the waste solvent that avoids pressure buildup in the source. The solvent
drain/waste exhaust port is located on the left side of the instrument.
IMPORTANT The solvent waste tubing that connects from the waste container to the
exhaust system is 1 in. ID, 1-3/8 in. OD. Make sure that your lab exhaust system can
accommodate this tubing without using reducing connectors along the solvent waste path.
Use these guidelines for the API source drain:
• Use the Tygon tubing provided with the solvent waste container to connect the solvent
waste container to the lab’s fume exhaust system.
• To prevent solvent waste from backing up into the mass spectrometer, make sure that all
Tygon tubing is above the level of liquid in the waste container as follows:
–
From the mass spectrometer to the solvent waste container
–
From the solvent waste container to the exhaust system
For additional information, refer to the TSQ Endura and TSQ Quantiva Getting Connected
Guide.
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7
Instrument Shipments
Electronic equipment carriers that specialize in the handling and transport of delicate
machinery ship the TSQ Endura or TSQ Quantiva mass spectrometer to your site. When the
instrument arrives, move it to a protected indoor location. If you have questions about
moving your instrument, contact your local office for Thermo Scientific San Jose products
(see “Contacting Us” on page xiv).
CAUTION Heavy object. Never lift or move the instrument by yourself; you can suffer
personal injury or damage the instrument.
On the occasion when shipments arrive that appear damaged, take these immediate actions.
Contents
• Receiving Shipping Packages and Reporting Damage
• Filing a Damage Claim Against the Carrier
Receiving Shipping Packages and Reporting Damage
Upon delivery, visually inspect for any damage to the shipment packages.
 To visually inspect for damage
Carefully inspect for obvious damage or evidence of rough handling.
If the instrument shipping container, ShockWatch™, or other indicators show visible
evidence of damage or mishandling, do NOT open the container.
Follow the next procedure, and then call your Thermo Fisher Scientific sales representative for
further instructions.
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7
Instrument Shipments
Filing a Damage Claim Against the Carrier
 To record damages on the receiving documents
1. Read the information in Filing a Damage Claim Against the Carrier to determine which
parties might be responsible for filing a claim against the carrier.
2. On all copies of the receiving documents, note any apparent external damage and briefly
describe the extent of the damage.
3. Have the driver sign or initial next to your comments to signify agreement with your
observations.
4. Report the list of damages to your Thermo Fisher Scientific representative.
IMPORTANT Freight insurance requires that you note obvious damage on the
receiving documents. Thermo Fisher Scientific does not accept liability for damage if
materials are received with obvious damage AND the damage is not recorded on the
receiving documents.
Filing a Damage Claim Against the Carrier
If the instrument is damaged in transit, the shipment method determines the party who
assumes the risk of damage and files a claim against the carrier—Thermo Fisher Scientific or
the purchaser. To determine the shipment method for instruments shipped from the San Jose,
CA site, check the sales agreement or the sales quote.
Table 10 lists the party who files the damage claim against the carrier for instruments
damaged in transit based on the shipment method.
Table 10. Shipment methods for delivery from the San Jose, CA site to domestic and international
destinations
Destination
Shipment method
Domestic
(United States)
Destination or Origin—Thermo Fisher
Scientific pays the carrier.
Party responsible for filing a
damage claim
Thermo Fisher Scientific
Origin—The purchaser pays the carrier. Purchaser
International
28
Carriage Paid To (CPT) named
destinationa
Purchaser
Carriage and Insurance Paid (CIP) to
named destinationb
Thermo Fisher Scientific
a
Unless specified differently, Thermo Fisher Scientific uses this shipment method for international shipments.
b
Under special circumstances, Thermo Fisher Scientific uses this shipment method for international shipments.
TSQ Endura and TSQ Quantiva Preinstallation Requirements Guide
Thermo Scientific
8
Installation
Complete all preparations described in the previous chapters before your Thermo Fisher
Scientific service engineer installs the TSQ Endura or TSQ Quantiva system.
IMPORTANT If the instrument shipping container, ShockWatch, or other indicators show
any evidence of damage or mishandling during shipment, do NOT open the container.
Call your Thermo Fisher Scientific representative for instructions on what to do. If the
instrument arrives safely, proceed with the following instructions.
After you have completed the laboratory site preparation and received the TSQ Endura or
TSQ Quantiva system, send the completed and signed “TSQ Endura and TSQ Quantiva
Installation Request Form” on page iii to your local office for Thermo Fisher Scientific San
Jose products. After receiving this form, the service engineer contacts you to schedule the
installation.
CAUTION Heavy object. Never lift or move the instrument by yourself; you can suffer
personal injury or damage the instrument.
Contents
• Installation Kits
• Customer-Supplied Hardware
• Basic On-Site Training
• Advanced Training Courses
• Preventive Maintenance
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8
Installation
Installation Kits
Installation Kits
The TSQ Endura and TSQ Quantiva mass spectrometers include the following kits
(Table 11).
Table 11. Kits provided with the mass spectrometer
Kit name
Description
Preinstallation Kit
(North American or
International, as applicable)
Contains this guide and the Chemicals Kit. The
International Preinstallation Kit also includes three
230 Vac CEE (3-pole) wall receptacles.
Chemicals Kit
(P/N 80100-62006)
Contains the chemicals for demonstrating the system
performance specifications.
Calibration Kit
(P/N 80000-62013)
Contains a syringe and the installation components, such
as fittings and tubing.
MS Setup Kit
(P/N 80100-62003)
Contains the components to connect the mass
spectrometer to the forepump or forepumps, the gas
supplies, the Ethernet switch, and the waste container.
Performance Specification Kit
(P/N 80100-62008)
Contains the plumbing hardware for demonstrating the
system performance specifications.
Single Mechanical Pump Kit
(P/N 80100-62004)
–or–
Dual Mechanical Pump Kit
(P/N 80100-62013)
Contains the forepump (single pump kit) or forepumps
(dual pump kit), relay control cable, and installation
components, such as the exhaust waste tubing.
Depending on your system configuration, you might have other kits with your shipment.
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8 Installation
Customer-Supplied Hardware
Customer-Supplied Hardware
Thermo Fisher Scientific does not provide all parts, materials, or tools that are required for
installation. To complete the installation, you must provide these additional parts (Table 12).
Table 12. Customer-supplied hardware for installation
Item
Description
Communications cable
Connects from the Ready Out and Injection Hold pins
(peripheral control connector) on the mass spectrometer
to a device not controlled by one of the Thermo
Scientific mass spectrometer applications, such as the
Thermo Xcalibur™ data system.
Refer to the TSQ Endura and TSQ Quantiva Getting
Connected Guide.
Gas line fitting, argon
Connects the 1/8 in. ID copper or stainless steel tubing
to the argon gas supply.
Refer to the TSQ Endura and TSQ Quantiva Getting
Connected Guide.
Gas line fitting, nitrogen
Connects the 1/4 in. OD Teflon™ PFA tubing to the
nitrogen gas supply.
Refer to the TSQ Endura and TSQ Quantiva Getting
Connected Guide.
LC system
LC system, solvents
IMPORTANT If your LC system is manufactured by
another company, you must verify that it is suitable
for use with the TSQ Endura or TSQ Quantiva mass
spectrometer. The output (start) signal from the
external device must be Normally Hi (+5 Vdc) and
momentarily go to Low. If you cannot configure the
external device to go from Normally Hi to Low
momentarily, you cannot use it with the mass
spectrometer.
Used by the service engineer to calibrate the system
during the initial setup.
For details, refer to the appropriate manual.
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8
Installation
Basic On-Site Training
Basic On-Site Training
When your new TSQ Endura or TSQ Quantiva system is on site and ready for installation,
the Thermo Fisher Scientific service engineer unpacks and installs it.
During the installation, the service engineer demonstrates the following:
• Basics of the instrument operation and routine maintenance
• Marketing specifications that are in effect when you purchased the system
Tip To receive maximum benefit from this on-site training opportunity, plan for the
system operators to be available during the entire installation process.
Do not use the new system for sample analysis until the installation is complete and you have
signed the Acceptance Form.
Advanced Training Courses
Thermo Fisher Scientific provides introductory and advanced training courses in analytical
techniques, in addition to specialized operation and maintenance courses for Thermo
Scientific products.
Thermo Fisher Scientific recommends that the key user receive advanced training for
operating and maintaining the TSQ Endura or TSQ Quantiva system after using it for several
months. After this training from Thermo Fisher Scientific, the key user can conduct in-house
training for other staff members, certifying them to operate the system.
Preventive Maintenance
You are responsible for the routine and preventive maintenance of the TSQ Endura or
TSQ Quantiva system.
Regular preventive maintenance is essential. It increases the life of the system, maximizes the
uptime of the system, and provides optimum system performance. You can find maintenance
procedures in the following manuals:
• TSQ Endura and TSQ Quantiva Hardware Manual
• Ion Max NG and EASY-Max NG Ion Sources User Guide
• Manuals shipped with other devices for your system
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I
Index
A
air conditioning system 10
API source, drain guidelines 26
argon gas supply 22
B
buck/boost transformer 15
C
circuit breakers 16
communications cables, Ethernet 5
compliance
FCC v
regulatory v
contacting us xiv
contaminants, gas 22
environmental requirements 9
Ethernet, communications cables 5
exhaust system 25
F
FCC compliance v
forepumps 8, 15, 25
G
gases 21
generator, nitrogen gas 22
ground
See earth ground connections
H
hardware, supplied by customer 31
heat output, maximum 11
D
damage indicator, packaging 29
data system
number of outlets 17
recommended layout 7
dimensions
shipping container 3
system modules 4
directive, WEEE vii
documentation
downloading xii
E
earth ground connections 16
electrical outlets 16
electromagnetic compatibility v
EMC compliance v
entrance requirements 3
Thermo Scientific
I
installation kits 30
Installation Request Form iii
instrument shipments, reporting damage 27
isolation/noise-suppression transformer 15
K
kits
Buck/Boost Transformer 15
installation 30
L
lab environment, requirements 9
line power 13
liquid nitrogen, conversion factors 23
TSQ Endura and TSQ Quantiva Preinstallation Requirements Guide
33
Index: M
load capacity
air conditioning 11
workbenches 5
transformer
buck/boost 15
isolation/noise-suppression 15
transient voltages 14
M
maintenance, preventive 32
mass spectrometers
recommended layout 7
system, number of outlets 17
U
uninterruptible power supply (UPS) 15
UV-Vis detector 24
V
N
nitrogen gas
generator 22
regulator 22
supply 22
venting
forepump 25
solvent waste container 26
voltage
single phase for MS 16
transient, description 14
P
power
conditioning devices 15
monitoring devices 14
quality of 14
power supply cords 18
W
warranty, limitations 1
waste and exhaust 25
WEEE directive vii
workbench requirements 5
R
regulatory compliance v
reliability, effect of temperature on system 10
S
safety and special notices xiii
safety standards v
service contract, exclusions 1
shipment, damage indicator 29
shipping container 3
site preparation 3
solvent waste
contaminants, instrument damage 24
description 26
solvents, recommendations 24
space requirements 6
surge protector 16
T
technical assistance 19
telephone 8
temperature and humidity monitor 10
training 32
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