TSQ Endura and TSQ Quantiva Preinstallation Requirements Guide

TSQ Endura and TSQ Quantiva Preinstallation Requirements Guide

TSQ Series

TSQ Endura and

TSQ Quantiva

Preinstallation Requirements Guide

80100-97015 Revision B July 2015

© 2015 Thermo Fisher Scientific Inc. All rights reserved.

Dionex, Optima, TSQ Endura, TSQ Quantiva, Thermo Scientific, UltiMate, and Xcalibur are registered trademarks of Thermo Fisher Scientific Inc. in the United States.

The following are registered trademarks in the United States and other countries: Microsoft and Windows are registered trademarks of Microsoft Corporation. Styrofoam is a registered trademark of Dow Chemical

Company. Teflon is a registered trademark of E.I. du Pont de Nemours & Co.

The following are registered trademarks in the United States and possibly other countries: Dranetz is a registered trademark of Dranetz Technologies, Inc. Matheson is a registered trademark of Matheson Tri-Gas,

Inc. Oerlikon Leybold Vacuum is a registered trademark of OC Oerlikon Corporation AG. SOGEVAC is a registered trademark of Oerlikon Leybold Vacuum. ShockWatch is a registered trademark of ShockWatch, Inc.

Swagelok is a registered trademark of the Crawford Fitting Co. Tygon is a registered trademark of the division of Saint-Gobain Performance Plastics Corporation.

All other trademarks are the property of Thermo Fisher Scientific Inc. and its subsidiaries.

Thermo Fisher Scientific Inc. provides this document to its customers with a product purchase to use in the product operation. This document is copyright protected and any reproduction of the whole or any part of this document is strictly prohibited, except with the written authorization of Thermo Fisher Scientific Inc.

The contents of this document are subject to change without notice. All technical information in this document is for reference purposes only. System configurations and specifications in this document supersede all previous information received by the purchaser.

This document is not part of any sales contract between Thermo Fisher Scientific Inc. and a purchaser. This document shall in no way govern or modify any Terms and Conditions of Sale, which Terms and Conditions of

Sale shall govern all conflicting information between the two documents.

Release history: Rev A, November 2013; Rev B, July 2015

For Research Use Only. Not for use in diagnostic procedures.

TSQ Endura and TSQ Quantiva Installation Request Form

Before completing this installation request form, read all of the TSQ Endura and TSQ Quantiva Preinstallation

Requirements Guide. For U.S. laboratory locations, send this completed and signed form to [email protected]

. For other countries or regions, go to www.thermoscientific.com/support , click Contact Us, click the email option, , and attach this form to your request to schedule the installation.

Laboratory setup

1. All laboratory remodeling is complete and complies with all relevant safety regulations.

2. The TSQ Endura or TSQ Quantiva is on site.

3. A principal operator will be on site during the installation/certification period.

4. Doorways, hallways, and so on are a minimum width of 94 cm (37 in.).

5. Laboratory lighting is adequate.

6. Air conditioning is adequate for temperature, humidity, and particulate matter control.

7. Relative humidity is 40–80%, noncondensing.

8. The work area is free from magnetic disruption and electrostatic discharge.

9. A step stool is on site.

10. A voice telephone line is installed near the system.

11. (Optional) The laboratory has Internet access.

12. Floor space is sufficient and flooring will support the load.

Power

13. Main power is installed and complies with local electrical codes.

14. Power is free from fluctuations due to slow changes in the average voltage or changes due to surges, sags, or transients.

 15. Power outlets are of the correct configuration for the power cords. See

page 18

.

Note NEMA type: ____________________

16. Voltage of power outlet has been measured.

Note measured voltage:

AC line-to-ground: __________________ V

AC neutral-to-ground: _______________ V

AC line-to-neutral: __________________ V

 17. Power outlets are available for testing and cleaning equipment.

Gas and exhaust

18. All required gases are on site, gas lines are installed, and appropriate gas regulators are available. For pressures, see

page 21

.

Note gas types and actual purity levels:

Gas: _____________ purity:_______________

Gas: _____________ purity:_______________

19. All gas lines are clean and have no leaks.

20. A suitable fume exhaust system is separate from the solvent waste and is within 2.4 m (8 ft) of the system. See

page 6

and page 25 .

System setup

21. Data system computer: (a) a new computer shows no changes to ANY settings and has no additional software, or (b) an existing computer meets the software system requirements. (a) __ (b) __

22. System setup provides for collecting solvent waste from the API source.

23. A new or recently cleaned HPLC system is available that produces pulse-free, continuous flow of 100–1000 μL/min.

24. Optima LC/MS-grade acetonitrile, formic acid, isopropyl alcohol, methanol, and water are available for testing the instrument’s performance.

25. Sufficient bench or table space is available for all of the equipment. Note the dimensions:

Width: _____________________________

Depth: _____________________________

Height: _____________________________

Does the bench (table) have wheels? Yes__ No__

26. Sufficient clearance is provided behind the bench

(or table). See page 5

.

27. The bench (or table) can support twice the load of the instrument (262 kg [576 lb]) and is free from vibration.

IMPORTANT Thermo Fisher Scientific reserves the right to invoice for the field service engineer’s time if the installation requirements are not met by the installation date.

CONTINUED ON THE NEXT PAGE

For customized installations

Does your contract contain any special acceptance specifications?

If YES, attach full details of the specifications.

Does the system require additional equipment?

If YES, attach full details of the additional equipment.

Yes

Yes

No

No

I certify that the preinstallation requirements for the TSQ Endura or TSQ Quantiva are complete and accurate.

Signature Date

Print name Telephone

Email address

Principal instrument operator:

Print name Telephone

Email address

Company Telephone

Address

Address

City State Country

Sales order number

Note This form is intended to cover the essential components of your TSQ Endura or TSQ Quantiva installation.

However, you must use the information in this guide and any additional information that your Thermo Fisher

Scientific field service engineer provides to ensure the proper setup of your system.

After receiving this form, the field service engineer contacts you to schedule the installation.

Regulatory Compliance

Thermo Fisher Scientific performs complete testing and evaluation of its products to ensure full compliance with applicable domestic and international regulations. When the system is delivered to you, it meets all pertinent electromagnetic compatibility (EMC) and safety standards as described in the next section or sections by product name.

Changes that you make to your system may void compliance with one or more of these EMC and safety standards.

Changes to your system include replacing a part or adding components, options, or peripherals not specifically authorized and qualified by Thermo Fisher Scientific. To ensure continued compliance with EMC and safety standards, replacement parts and additional components, options, and peripherals must be ordered from Thermo Fisher Scientific or one of its authorized representatives.

EMC Directive 2004/108/EC

EMC compliance has been evaluated by TÜV Rheinland of North America.

EN 55011: 2009, A1: 2010

EN 61000-3-2: 2006, A2: 2009

EN 61000-3-3: 2008

EN 61000-4-2: 2009

EN 61000-4-3: 2006, A2: 2010

EN 61000-4-4: 2004, A1: 2010

EN 61000-4-5: 2006

EN 61000-4-6: 2009

EN 61000-4-11: 2004

EN 61326-1: 2013

CISPR 11: 2009, A1: 2010

ICES-003 Issue 5: 2012

CFR 47, FCC Part 15, Subpart B, Class A: 2012

Low Voltage Safety Compliance

This device complies with Low Voltage Directive 2006/95/EC and harmonized standard EN/UL/CAN 61010-1.

FCC Compliance Statement

THIS DEVICE COMPLIES WITH PART 15 OF THE FCC RULES. OPERATION IS SUBJECT TO

THE FOLLOWING TWO CONDITIONS: (1) THIS DEVICE MAY NOT CAUSE HARMFUL

INTERFERENCE, AND (2) THIS DEVICE MUST ACCEPT ANY INTERFERENCE RECEIVED,

INCLUDING INTERFERENCE THAT MAY CAUSE UNDESIRED OPERATION.

CAUTION Read and understand the various precautionary notes, signs, and symbols contained inside this manual pertaining to the safe use and operation of this product before using the device.

Notice on Lifting and Handling of

Thermo Scientific Instruments

For your safety, and in compliance with international regulations, the physical handling of this Thermo Fisher Scientific instrument requires a team effort to lift and/or move the instrument. This instrument is too heavy and/or bulky for one person alone to handle safely.

Notice on the Proper Use of

Thermo Scientific Instruments

In compliance with international regulations: This instrument must be used in the manner specified by Thermo Fisher

Scientific to ensure protections provided by the instrument are not impaired. Deviations from specified instructions on the proper use of the instrument include changes to the system and part replacement. Accordingly, order replacement parts from Thermo Fisher Scientific or one of its authorized representatives.

WEEE Directive

2012/19/EU

Thermo Fisher Scientific is registered with B2B Compliance ( B2Bcompliance.org.uk

) in the UK and with the

European Recycling Platform ( ERP-recycling.org

) in all other countries of the European Union and in Norway.

If this product is located in Europe and you want to participate in the Thermo Fisher Scientific Business-to-Business

(B2B) Recycling Program, send an email request to [email protected]

with the following information:

• WEEE product class

• Name of the manufacturer or distributor (where you purchased the product)

• Number of product pieces, and the estimated total weight and volume

• Pick-up address and contact person (include contact information)

• Appropriate pick-up time

• Declaration of decontamination, stating that all hazardous fluids or material have been removed from the product

For additional information about the Restriction on Hazardous Substances (RoHS) Directive for the European Union, search for RoHS on the Thermo Fisher Scientific European language websites.

IMPORTANT This recycling program is not for biological hazard products or for products that have been medically contaminated. You must treat these types of products as biohazard waste and dispose of them in accordance with your local regulations.

Directive DEEE

2012/19/EU

Thermo Fisher Scientific s'est associé avec une ou plusieurs sociétés de recyclage dans chaque état membre de l’Union

Européenne et ce produit devrait être collecté ou recyclé par celle(s)-ci. Pour davantage d'informations, rendez-vous sur la page www.thermoscientific.fr/rohs .

WEEE Direktive

2012/19/EU

Thermo Fisher Scientific hat Vereinbarungen mit Verwertungs-/Entsorgungsfirmen in allen EU-Mitgliedsstaaten getroffen, damit dieses Produkt durch diese Firmen wiederverwertet oder entsorgt werden kann. Weitere Informationen finden Sie unter www.thermoscientific.de/rohs .

C

Contents

Thermo Scientific

Preface . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . xi

Mass Spectrometer Models . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .xi

Related Documentation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . xii

Cautions and Special Notices . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .xiii

Contacting Us . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .xiv

Chapter 1 Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .1

Chapter 2 Site Preparation. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .3

Entrance . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3

Space and Load Requirements . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4

Workbench Requirements . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5

LC/MS System Layout . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6

Forepumps . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8

Telephone . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8

Chapter 3 Operating Environment. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .9

Summary of Environmental Requirements . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9

Humidity . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 10

Temperature . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 10

Particulate Matter . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11

Electrostatic Discharge . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11

Lighting. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 12

Vibration. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 12

Chapter 4 Line Power . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .13

Quality of Power . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 14

Power Monitoring Devices . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 14

Power Conditioning Devices . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 15

Uninterruptible Power Supply. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 15

Circuit Breakers. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 16

Earth Ground . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 16

Electrical Outlets . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 16

Power Supply Cords . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 18

Technical Assistance . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 19

TSQ Endura and TSQ Quantiva Preinstallation Requirements Guide

ix

Contents

Chapter 5 Gases and Solvents. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .21

Gases . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 21

Argon Supply . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 22

Nitrogen Supply . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 22

Solvent Recommendation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 23

Chapter 6 Waste and Exhaust . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .25

Exhaust System . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 25

Solvent Waste . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 26

Chapter 7 Instrument Shipments. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .27

Receiving Shipping Packages and Reporting Damage . . . . . . . . . . . . . . . . . . . . 27

Filing a Damage Claim Against the Carrier . . . . . . . . . . . . . . . . . . . . . . . . . . . . 28

Chapter 8 Installation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .29

Installation Kits . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 30

Customer-Supplied Hardware . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 31

Basic On-Site Training . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 32

Advanced Training Courses. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 32

Preventive Maintenance . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 32

Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .33

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TSQ Endura and TSQ Quantiva Preinstallation Requirements Guide Thermo Scientific

P

Preface

The TSQ Quantiva and TSQ Endura Preinstallation Requirements Guide provides information for planning and preparing your laboratory before delivery and installation of your Thermo

Scientific™ TSQ Endura™ or TSQ Quantiva™ mass spectrometer (MS). Read each section carefully to ensure that your lab is ready for the system.

Contents

Mass Spectrometer Models

Related Documentation

Cautions and Special Notices

Contacting Us

To suggest changes to the documentation or to the Help

Complete a brief survey about this document by clicking the button below.

Thank you in advance for your help.

Mass Spectrometer Models

This guide is intended for the following mass spectrometer models:

• TSQ Endura—Requires one forepump.

• TSQ Quantiva—Requires two forepumps.

Thermo Scientific TSQ Endura and TSQ Quantiva Preinstallation Requirements Guide

xi

Preface

Related Documentation

The TSQ Endura and TSQ Quantiva mass spectrometers include complete documentation.

In addition to this guide, you can also access the following documents as PDF files from the data system computer:

TSQ Endura and TSQ Quantiva Getting Connected Guide

TSQ Endura and TSQ Quantiva Getting Started Guide

TSQ Endura and TSQ Quantiva Hardware Manual

Ion Max NG and EASY-Max NG Ion Sources User Guide

Safety and Regulatory Guide

The TSQ Endura and TSQ Quantiva also ship with a printed copy of the Safety and

Regulatory Guide. This guide contains important safety information about Thermo

Scientific liquid chromatography (LC) and mass spectrometry (MS) systems. Make sure that all lab personnel have read and have access to this document.

To view the product manuals

From the Microsoft™ Windows™ taskbar, do the following:

• For a Thermo Scientific mass spectrometer, choose Start > All Programs > Thermo

Instruments > model x.x, and then open the applicable PDF file.

• For an LC instrument controlled by a Thermo Scientific application, choose Start >

All Programs > Thermo Instruments > Manuals > LC Devices and so on.

To download user documentation from the Thermo Scientific website

1. Go to www.thermoscientific.com

.

2. In the Search box, type the product name and press Enter.

3. In the left pane, select Documents & Videos, and then under Refine By Category, click

Operations and Maintenance.

4. (Optional) Narrow the search results or modify the display as applicable:

• For all related user manuals and quick references, click Operator Manuals.

• For installation and preinstallation requirements guides, click Installation

Instructions.

• For documents translated into a specific language, use the Refine By Language feature.

• Use the Sort By options or the Refine Your Search box (above the search results display).

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TSQ Endura and TSQ Quantiva Preinstallation Requirements Guide Thermo Scientific

Preface

5. Download the document as follows: a. Click the document title or click Download to open the file.

b. Save the file.

Cautions and Special Notices

Make sure you follow the cautions and special notices presented in this guide. Cautions and special notices appear in boxes; those concerning safety or possible system damage also have corresponding caution symbols.

This guide uses the following types of cautions and special notices.

CAUTION Highlights hazards to humans, property, or the environment. Each CAUTION notice is accompanied by an appropriate CAUTION symbol.

IMPORTANT Highlights information necessary to prevent damage to software, loss of data, or invalid test results; or might contain information that is critical for optimal performance of the system.

Note Highlights information of general interest.

Tip Highlights helpful information that can make a task easier.

The TSQ Endura and TSQ Quantiva Preinstallation Requirements Guide contains the

following caution-specific symbols ( Table 1

).

Table 1. Caution-specific symbols and their meaning (Sheet 1 of 2)

Symbol Meaning

Chemical hazard: Wear gloves and other protective equipment, as appropriate, when handling toxic, carcinogenic, mutagenic, corrosive, or irritant chemicals. Use approved containers and proper procedures to dispose of waste oil and when handling wetted parts of the instrument.

Heavy object: Never lift or move the instrument by yourself; you can suffer personal injury or damage the instrument.

Risk of electric shock: This instrument uses voltages that can cause electric shock and/or personal injury. Before servicing, shut down the instrument and disconnect it from line power. While operating the instrument, keep covers on.

Thermo Scientific TSQ Endura and TSQ Quantiva Preinstallation Requirements Guide

xiii

Preface

Table 1. Caution-specific symbols and their meaning (Sheet 2 of 2)

Symbol Meaning

Risk of eye injury: Eye injury could occur from splattered chemicals or airborne particles. Wear safety glasses when handling chemicals or servicing the instrument.

Trip obstacle: Be aware of cords, hoses, or other objects located on the floor.

Contacting Us

There are several ways to contact Thermo Fisher Scientific for the information you need. You can use your smartphone to scan a QR code, which opens your email application or browser.

Contact us Customer Service and Sales Technical Support

(U.S.) 1 (800) 532-4752 (U.S.) 1 (800) 532-4752

(U.S.) 1 (561) 688-8731 us.customer-support.analyze

@thermofisher.com

(U.S.) 1 (561) 688-8736 us.techsupport.analyze

@thermofisher.com

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TSQ Endura and TSQ Quantiva Preinstallation Requirements Guide Thermo Scientific

Preface

Contact us Customer Service and Sales Technical Support

To find global contact information or customize your request

1. Go to www.thermoscientific.com

.

2. Click Contact Us, select the Using/Servicing a Product option, and then type the product name.

3. Use the phone number, email address, or online form.

To find product support, knowledge bases, and resources

Go to www.thermoscientific.com/support .

To find product information

Go to www.thermoscientific.com/lc-ms .

Note To provide feedback for this document:

• Send an email message to Technical Publications ( [email protected]

).

• Complete a survey at www.surveymonkey.com/s/PQM6P62 .

Thermo Scientific TSQ Endura and TSQ Quantiva Preinstallation Requirements Guide

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Preface xvi

TSQ Endura and TSQ Quantiva Preinstallation Requirements Guide Thermo Scientific

1

Introduction

For the Thermo Scientific TSQ Endura and TSQ Quantiva system, you are responsible for providing a suitable location, a carefully controlled operating environment, a source of power of acceptable quality, correct gases and solvent supplies, and proper waste and exhaust systems.

CAUTION Operating a system or maintaining it outside the power and operating environment specifications described in this guide might cause failures of many types. The repair of such failures is specifically excluded from the Thermo Fisher Scientific standard warranty and service contract coverage.

Note

• For preinstallation support and additional information, contact your local Thermo

Fisher Scientific office.

• Unless otherwise noted, the information in this guide applies to both models.

Thermo Scientific TSQ Endura and TSQ Quantiva Preinstallation Requirements Guide

1

1

Introduction

2

TSQ Endura and TSQ Quantiva Preinstallation Requirements Guide Thermo Scientific

2

Site Preparation

You are responsible for providing an acceptable installation site for the TSQ Endura or

TSQ Quantiva system before the Thermo Fisher Scientific service engineer arrives. Make sure your laboratory meets these requirements:

• When transporting the equipment to the designated site, you have a wide turning radius through entrances, hallways, elevators, and so on. Remember to consider the width of the device transporting the shipping container to the lab.

• The lab has a designated location for the system modules.

• The laboratory has large, strong workbenches to support the weights of the mass spectrometer, LC instrument, and data system module.

Contents

Entrance

Space and Load Requirements

Forepumps

Telephone

Entrance

The entrance to your facility and the width of all hallways, elevators, and so on must be a minimum of 95 cm (37 in.). However, allow additional room for maneuvering the system around corners, into elevators, or through doorways.

The system ships in multiple containers. The main shipping container measures 104 cm l,

95 cm w, and 135 cm h (41 in. l, 37 in. w, and 53 in. h) and, including its contents, weighs approximately 187 kg (410 lb). Use this information to determine how to transport and remove its contents.

Note If the lab entrance cannot accommodate a 95 cm (37 in.) container, remove the modules from the container before moving them into the room. If you remove the instrument from its shipping container before it is delivered to the lab site, ensure that all the container contents remain with the instrument.

Thermo Scientific TSQ Endura and TSQ Quantiva Preinstallation Requirements Guide

3

2

Site Preparation

Space and Load Requirements

Other equipment in your order have their own smaller shipping containers and do not require special consideration. These modules—such as the forepumps, data system computer, monitor, and other options—ship in separate containers. The chemicals kit typically arrives earlier than the other parts of your order.

Space and Load Requirements

Table 2 lists the dimensions and weights for the data system and mass spectrometer system

modules. Use this information to ensure that all workbenches are large enough and strong enough to support the modules.

Table 2. Space and load requirements for the system modules

Modules

Width (w) cm (in.)

Height (h) cm (in.)

Depth (d) cm (in.)

Weight kg (lb)

LC/MS system

(Optional) Thermo Scientific

Dionex™ UltiMate™ 3000 a

TSQ Quantiva or TSQ Endura mass spectrometer b

41 (16)

76 (30)

97 (38)

70 (28)

46 (18)

80 (32)

62 (138)

131 (288)

Forepump (each)

Data system

Computer, mini-tower

32 (12.6) 26.4 (10.4) 48 (19) 52 (115)

Monitor

Ethernet switch

17.5 (7)

15.4 (6.1)

(Optional) Laser printer 45 (18) a c

Approximate. The actual value depends on your equipment.

b

Includes the divert/inject valve

Fully extended

36 (14.2) 41.7 (16.4) 9.4 (21)

64 (25.3) 54 (21) c

2.9 (1.14)

32 (12.4)

20 (8)

11 (4.5)

41 (16)

7 (15.8)

0.17 (0.4)

16 (35)

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TSQ Endura and TSQ Quantiva Preinstallation Requirements Guide Thermo Scientific

2

Site Preparation

Space and Load Requirements

This section discusses the following:

Workbench Requirements

LC/MS System Layout

Workbench Requirements

Table 3 lists the recommended minimum surface dimensions and load capacities for each

workbench that you must provide. Thermo Fisher Scientific recommends that workbenches have a load capacity of at least twice the combined weight of all expected devices.

CAUTION

Heavy object.

Never lift or move the mass spectrometer by yourself; you can suffer personal injury or damage the instrument.

Table 3. Minimum workbench surface dimensions and load capacities

Equipment

LC system a

Surface

Load capacity

Mass spectrometer 81.3 × 86.4 cm (32 × 34 in.) 261.3 kg (576 lb)

Data system 122 × 91.4 cm (48 × 36 in.) 65.3 kg (144 lb) a

Refer to the product manual for information about the LC system’s workbench.

Follow these clearance guidelines for the workbenches:

• Place the data system and MS workbenches adjacent to each other to prevent strain on the interconnecting Ethernet communications cables.

CAUTION Safety and EMC regulations require the use of Category 5e shielded

Ethernet communications cables, maximum 3 m (10 ft) long.

• For all systems, allow for a minimum vertical clearance of 92 cm (36 in.) between the top of the system and any shelves above it.

• For the MS system, allow for these minimum horizontal clearance for proper air circulation and for the installed gas lines and tubing:

– 25 cm (10 in.) behind the instrument

– 46 cm (18 in.) on the right side of the instrument

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2

Site Preparation

Space and Load Requirements

Figure 1

shows the top view (footprint) for the system workbenches.

Figure 1.

Top view and recommended placement of the workbenches (tables)

Laboratory wall

Minimum 25 cm (10 in.) horizontal clearance

LC system Mass spectrometer Data system

LC/MS System Layout

Figure 2

shows the recommended layout for the data system, LC instrument, and mass spectrometer. Not all connections are shown; for connection information, refer to the

TSQ Endura and TSQ Quantiva Getting Connected Guide and the LC product manual.

CAUTION For information about the LC drainage systems, refer to the LC instrument manual.

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TSQ Endura and TSQ Quantiva Preinstallation Requirements Guide Thermo Scientific

2

Site Preparation

Space and Load Requirements

Figure 2.

Workbenches for the optional UltiMate 3000 LC system (left), mass spectrometer (center), and data system

41 cm

(16 in)

76 cm

(30 in)

UltiMate 3000 LC system

TSQ Quantiva (shown) or

TSQ Endura mass spectrometer

85 cm

(34 in)

Data system

97 cm

(38 in)

Solvent waste container

Electrical outlets for the

LC system (120 or 230 Vac)

External vent for the solvent trap (waste)

External vent for the forepump exhaust

Forepumps

Electrical outlets for the data system (120 or 230 Vac)

Separate 230 Vac electrical outlets for the instrument and forepumps

(circuits A, B, and C)

Thermo Scientific TSQ Endura and TSQ Quantiva Preinstallation Requirements Guide

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Site Preparation

Forepumps

Forepumps

The TSQ Endura system uses one forepump, whereas the TSQ Quantiva system uses two.

Depending on available space, you have two options for the placement of the forepumps and for connecting the vacuum hose from the mass spectrometer to the forepumps.

• If the workbench has space underneath, place the forepumps under the workbench immediately behind the mass spectrometer. Either run the vacuum hose behind the workbench or make a 6.4 cm (2.5 in.) diameter hole through the bench for the vacuum hose. Allow for room to run the power cords from the forepumps through the hole.

• If the workbench has no space under it, place the forepumps at the end of the workbench.

CAUTION Trip hazard. Whenever possible, provide space under the workbench for the forepumps. If placed in front of the mass spectrometer, the forepumps become a trip hazard.

CAUTION

• Do not place the forepump on a shelf or other surface connected to the workbench.

Vibration from the pump can affect system performance.

• The exhaust hose tubing acts as a trap for exhaust fumes that would otherwise recondense in the forepump oil.

– To maintain forepump integrity, route the exhaust tubing from the exhaust port down to the floor, not from the forepump vertically toward the ceiling.

– Run the exhaust hose at floor level for a minimum of 2 m (79 in.) before it reaches the external exhaust system.

Telephone

Make sure all of the laboratory staff have access to a telephone (landline or mobile) in the lab near the system so that, if necessary, you can operate the mass spectrometer while speaking with Thermo Fisher Scientific Technical Support. For a landline connection, make sure that the telephone jack is within 1.8 m (6 ft) of the mass spectrometer.

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TSQ Endura and TSQ Quantiva Preinstallation Requirements Guide Thermo Scientific

3

Operating Environment

For proper operation of the system, you are responsible for providing the operating environment described in this chapter. Attention to the operating environment ensures continued high performance of your Thermo Scientific LC/MS system. Any expenditures for air conditioning are more than offset by good sample throughput and reduced repair costs.

Contents

Summary of Environmental Requirements

Humidity

Temperature

Particulate Matter

Electrostatic Discharge

Lighting

Vibration

Summary of Environmental Requirements

Table 4 lists the environmental requirements for the designated laboratory.

Table 4. Summary of environmental requirements (Sheet 1 of 2)

Parameter

Humidity

Temperature

Specification

40–80%, noncondensing

• Standard performance: 15–27 °C (59–81 °F)

Particulate Matter

• Optimum performance: 18–21 °C (65–70 °F)

• Ambient temperature: Fluctuations of less than

1 °C or 2 °F over a one-hour period

Does not exceed 3 500 000 particles per cubic meter

(100 000 particles per cubic foot).

Thermo Scientific TSQ Endura and TSQ Quantiva Preinstallation Requirements Guide

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3

Operating Environment

Humidity

Table 4. Summary of environmental requirements (Sheet 2 of 2)

Parameter

Electrostatic Discharge

(ESD)

Lighting

Vibration

Specification

Follow the stated precautions to help prevent ESD.

• Operating: Typical laboratory lighting

• Cleaning: Use a small, high-intensity lamp

Choose a lab location that is vibration-free.

Humidity

Maintain the relative humidity in the designated lab at 40–80 percent, without condensation.

Operating a Thermo Scientific mass spectrometer in an environment with very low humidity can cause the accumulation and discharge of static electricity that can shorten the life of the electronic components. Operating the mass spectrometer in an environment with high humidity can cause condensation, oxidation, and short electronic circuits. It can also cause the accumulation of dust that can block filters on cooling fans.

To ensure that the lab is always within the required temperature and humidity specifications,

Thermo Fisher Scientific recommends that you install a temperature and humidity monitor in the lab.

Temperature

For precision instruments, such as a Thermo Scientific mass spectrometer, maintain the lab temperature at 15–27 °C (59–81 °F). For optimum performance, maintain the lab temperature at 18–21 °C (65–70 °F). Temperature control is vital to acquiring accurate mass measurements. Therefore, make sure that during any one-hour period, ambient temperature fluctuations are less than 1 °C or 2 °F.

IMPORTANT

• All electronic components generate heat while operating. This heat must dissipate to the surrounding air for the components to continue to operate reliably.

• Do not locate the instrument under an air duct, near windows, or near heating and cooling sources. As the lab temperature increases, the LC/MS system reliability decreases.

There must be good air flow around the system, and the air conditioning system must maintain a constant temperature in the immediate vicinity of the instrument.

Table 5 lists the

approximate heat output (power) for the system. For the heat output of your specific LC devices and the data system components, refer to the instrument manuals.

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TSQ Endura and TSQ Quantiva Preinstallation Requirements Guide Thermo Scientific

3

Operating Environment

Particulate Matter

Table 5. Maximum heat output

Module

Liquid chromatograph (LC) a

TSQ Endura or TSQ Quantiva mass spectrometer

Forepump (each)

Data system modules (mini-tower computer, monitor, and optional laser printer)

Heat output

(W)

1060

1550

1500

889

Heat output

(Btu/h)

3690

5396

5220

3033

Total—TSQ Endura system (one forepump)

4999 17 339

Total—TSQ Quantiva system (two forepumps)

6499 22 559

a

Approximate values for the UltiMate 3000. The actual values depend on your installed equipment.

Particulate Matter

Make sure that the air in the lab is free from excessive dust, smoke, or other particulate matter in excess of 5 μm—that is, fewer than 3 500 000 particles per cubic meter (100 000 particles per cubic foot).

Dust can clog the air filters, causing a reduction in air flow around electronic components.

Dust on electronic components can act as an insulating blanket, which reduces the transfer of heat from the components to the surrounding air.

Electrostatic Discharge

Electrostatic discharge (ESD) can damage the electronic components of the TSQ Endura or

TSQ Quantiva mass spectrometer.

Most Thermo Scientific instruments are designed to withstand ESD up to 4 kV (air discharge) and 4 kV (contact discharge) with all panels in place. However, removing the panels and handling the printed circuit boards (PCBs) without proper precautions might damage the electrical components or cause them to fail prematurely.

Because of ESD, Thermo Fisher Scientific recommends the following precautions, especially when operating the system at the lower end of the relative humidity specification:

• Use a static-dissipating floor covering (such as tile or conductive linoleum) in the lab.

• Use laboratory chairs covered with natural fibers or other static-dissipating material.

• Wear a laboratory coat and clothing made of natural fiber or other static-dissipating material when operating the instrument.

• Keep Styrofoam™ cups or packing materials away from the instrument.

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3

Operating Environment

Lighting

Lighting

Good lighting makes any work area more enjoyable. Thermo Fisher Scientific recommends that you use a small, high-intensity lamp when cleaning the mass spectrometer components.

Vibration

Select a lab location that is free from vibration—floors at ground level usually have less vibration. When selecting the location, be aware of adjacent rooms with equipment that could transmit vibrations through the floor to the mass spectrometer workbench.

Because of the natural vibration of the forepump during operation, install the forepump on the floor under the mass spectrometer.

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TSQ Endura and TSQ Quantiva Preinstallation Requirements Guide Thermo Scientific

4

Line Power

You are responsible for providing a power source of acceptable quality to operate the system.

The quality of line power (ac mains power system) delivered to the TSQ Endura or

TSQ Quantiva system can affect its performance and longevity. To ensure that the system performs optimally and is not damaged by line power fluctuations, verify that the lab’s electrical supply complies with all power quality requirements.

CAUTION To support compliance and safety requirements, all devices connected between the power source and the mass spectrometer must be certified by recognized organizations for your country or territory (for example, UL, CSA, SEMKO, VDE, or TÜV).

Such devices include the power supply cords, electrical outlets, circuit breakers, uninterruptible power supplies (UPSs), and so on.

Contents

Quality of Power

Power Monitoring Devices

Power Conditioning Devices

Uninterruptible Power Supply

Circuit Breakers

Earth Ground

Electrical Outlets

Power Supply Cords

Technical Assistance

Thermo Scientific TSQ Endura and TSQ Quantiva Preinstallation Requirements Guide

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4

Line Power

Quality of Power

Quality of Power

Establishing the quality of power supplied to the LC/MS system is very important for these reasons:

• Constant high line voltage, impulses, or surges in voltage can cause overheating and component failures.

• Constant low line voltage or sags in voltage can cause the system to function erratically or not at all.

• Transients—even a few microseconds in duration—can cause electronic devices to degrade or fail catastrophically, shortening the lifetime of the system.

Before the service engineer arrives to install your system, make sure the line voltage is stable and within the recommended specifications. The line voltage must be free of fluctuations due to slow changes in the average sags, surges, transients, or voltage. For the mass spectrometer’s

electrical ratings, see Table 7 on page 17 .

Table 6 lists the definitions for the three most common voltage disturbances.

Table 6. Common voltage disturbances

Voltage disturbance

Slow average

Sags and surges

Transients or impulses

Definition

A gradual, long-term change in average root mean square

(RMS) voltage level, with typical durations greater than 2 s

Sudden changes in average RMS voltage level, with typical durations between 50 ms and 2 s

A brief voltage spike of up to several thousand volts, with typical durations up to 50 μs

Power Monitoring Devices

Several devices are available to monitor the quality of the line power. These devices provide a continuous record of line performance by analyzing and printing out data for the three most

common voltage disturbances (see Table 6 ).

In the first two cases, the time interval recording indicates the duration and the amplitude of the disturbance. A power line disturbance analyzer detects and records most types of line power problems. The Dranetz™ system

1

is an example of a suitable analyzer. In some countries, you can rent power line analyzers from electrical equipment suppliers.

14

1

Thermo Fisher Scientific does not endorse any power monitoring company, nor does it endorse products other than its own. Companies and products listed in this guide are given as examples only.

TSQ Endura and TSQ Quantiva Preinstallation Requirements Guide Thermo Scientific

4

Line Power

Power Conditioning Devices

Monitor the power line 24 hours a day for seven consecutive days. If inspection of the printout indicates disturbances, stop the test and take corrective action. Monitor the power again as previously described.

Power Conditioning Devices

You can correct a line voltage problem by using various line voltage conditioning devices. If the power regulation is good but the power line disturbance analyzer shows transient voltages, an isolation/noise-suppression transformer can resolve the problem. For both transient and regulation problems, consider the use of power conditioners to control these problems. See

the CAUTION statement on page 13 .

CAUTION Any conditioning devices installed with the system must be able to handle the potentially high currents that are drawn during the initial startup of the system. For example, during startup, the forepump or forepumps can draw a high inrush current.

Because the TSQ Endura and TSQ Quantiva mass spectrometers require the use of one or two forepumps, the system draws an inrush current. The maximum inrush (start) current for one forepump (Oerlikon Leybold Vacuum™, model SOGEVAC™ SV 65 BI) is 12 A.

The average duration of the forepump’s inrush current is less than 1 s. Therefore, this initial energy demand from the ac power line is very low.

Thermo Scientific systems are protected from overcurrents with time-delay fuses and active switches. For more information, contact your Thermo Fisher Scientific service engineer.

When the line voltage is free from voltage sags, surges, and impulses but is more than

10 percent outside of the voltage specifications, a buck/boost transformer can lower (buck

10 percent) or raise (boost 10 percent) the line voltage as appropriate for the rated voltage.

Order the Buck/Boost Transformer Kit (P/N OPTON-01460) from Thermo Fisher Scientific

San Jose. Each buck/boost transformer is encased in a metal housing approximately

13  13  26 cm (5  5  10 in.) and ships with a 2 m (6.5 ft) power supply cable. Have a certified electrician install the transformer, using the installation instructions that are included. Then, install the TSQ Endura or TSQ Quantiva system.

CAUTION Systems installed in areas with 208 Vac power can experience voltage sags during high use periods that might place the line voltage below the operating parameters discussed in this section. In this case, protect the system by using a buck/boost transformer to ensure that power stays within the specified parameters.

Uninterruptible Power Supply

If your local area is susceptible to corrupted power or power disruptions, install an

uninterruptible power supply (UPS) in the lab. See the Caution on page 13 .

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4

Line Power

Circuit Breakers

Circuit Breakers

Make sure that each circuit breaker is suitably rated so that the equipment connected to the electrical outlets does not lose power by triggering a current overload condition. For added protection, install a surge protector at the input to the circuit breaker panel.

Earth Ground

Make sure that the earth ground connections in the lab are hardwired to the same ground used for the main circuit breaker panel. Multiple external ground points can cause noise current to flow through the ground loop that is formed.

Electrical Outlets

Installing a complete TSQ Endura or TSQ Quantiva system can require extensive electrical resources for connecting all of the equipment. Plan the power system properly, with a sufficient number of grounded, electrical outlets that are suitably rated. In addition, Thermo

Fisher Scientific recommends having several additional outlets close to the work area for testing and cleaning equipment, such as an oscilloscope and a sonicator.

CAUTION To avoid an electric shock, always have a certified electrician install any new wall receptacles.

Table 7 lists the electrical ratings (labels) and required number of outlets for the modules in a

typical lab setup. For the LC modules, refer to the manufacturer's manuals. To prevent overloading the outlets, select outlets with a load rating that is suitable for the expected total current draw per outlet.

IMPORTANT

• Thermo Fisher Scientific recommends that you connect the mass spectrometer and each forepump to separate electrical outlets that have their own dedicated single-phase, circuit breakers rated 230 Vac, 15 A for North America and 230 Vac,

16 A for other countries and territories. For example, the TSQ Quantiva system requires three separate, dedicated electrical outlets (one for the instrument and two

for the forepumps). See also Figure 2 .

• In North America, the LC/MS system requires both 120 and 230 Vac single-phase electrical outlets.

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TSQ Endura and TSQ Quantiva Preinstallation Requirements Guide Thermo Scientific

Thermo Scientific

4

Line Power

Electrical Outlets

Table 7. Electrical ratings and required outlets per module

Module

Voltage

(Vac)

Current

(A)

Required outlets

MS system

TSQ Endura or TSQ Quantiva mass spectrometer a

Forepump (SV 65 BI) b

Thermo Scientific divert/inject valve

Thermo Scientific syringe pump

Data system

230

230

110–220

110/220

5

8

1.5

0.2/0.1

1

1 or 2

1

1

Computer, mini-tower

Monitor

Ethernet switch

(Optional) Laser printer

100–240

100–240

100–240

110

–or–

220

5.4

1.5

Less than 1

8.6

–or–

4.2

1

1

1

1

Optional devices c

High-intensity lamp

(for instrument maintenance)

– – 1

Laboratory stereoscope

(for inspecting fused-silica parts)

– – 1

Total number of electrical outlets d

: 10+

11+ (two-forepump system)

a c

Manufacturer-tested within ±10% of the electrical rating b

The values are for one forepump.

Refer to the equipment manual for the electrical ratings. d

Remember to add the number of outlets required for your LC system.

IMPORTANT After planning the location of the workbenches (see

Chapter 2

), consider the following before installing the electrical outlets:

• Each module’s location and whether each requires a 120 or 230 Vac outlet (see

Table 7 )

• The minimum number of outlets needed for a given voltage and adding the number of outlets needed for any additional lab equipment (see

Table 7

)

• The length of the power supply cords (see

Power Supply Cords

)

TSQ Endura and TSQ Quantiva Preinstallation Requirements Guide

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4

Line Power

Power Supply Cords

Power Supply Cords

Your order includes the power supply cords for the TSQ Endura or TSQ Quantiva mass spectrometer, one or two forepumps, and peripheral components. The mass spectrometer and forepump use the same power plugs and receptacles. The power supply cords for the mass spectrometer and forepump are 2.5 m (8 ft) long. The power supply cords for the data system components are 1.8 m (6 ft) long.

Figure 3

shows an example of the NEMA 6-15 plug and receptacle configuration (rated

250 Vac, 15 A) for use in North America and other locations that use the same configuration.

Figure 3.

NEMA 6-15 plug (left) and receptacle (right) for North America (example)

Figure 4

shows the international power supply cord and receptacle (rated 250 Vac, 16 A) with a CEE (3-pole) configuration for use in locations outside of North America.

Figure 4.

MS power supply cord and receptacle for outside of North America (provided)

The peripheral components (syringe pump, divert/inject valve, data system computer, monitor, and Ethernet switch) ship with detachable power supply cords that are appropriate for your country or territory. The power supply cords for the data system components are

1.8 m (6 ft) long. The power supply cord for the optional laser printer has either a NEMA

5-15P plug or a European CEE 7/7 (Schuko) plug, which is rated 16 A, 220 Vac.

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TSQ Endura and TSQ Quantiva Preinstallation Requirements Guide Thermo Scientific

4

Line Power

Technical Assistance

Technical Assistance

Occasionally, you might encounter line power sources with unacceptable quality that adversely affect the operation of the LC/MS system. You are responsible for correcting any line power problems. Contact Thermo Fisher Scientific for assistance in monitoring the line voltage in your lab and in selecting a line conditioner.

Specifying power conditioning equipment is a complex task that is best handled by a company or consultant specializing in that field. Contact Thermo Fisher Scientific for assistance in locating a power consultant in your area.

Thermo Scientific TSQ Endura and TSQ Quantiva Preinstallation Requirements Guide

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4

Line Power

Technical Assistance

20

TSQ Endura and TSQ Quantiva Preinstallation Requirements Guide Thermo Scientific

5

Gases and Solvents

You are responsible for providing the correct gas, solvent, and regulators to operate the

TSQ Endura or TSQ Quantiva system. The mass spectrometer requires ultra-high-purity

(UHP) argon gas, high-purity (HP) nitrogen gas, and solvents. The Thermo Fisher Scientific service engineer might also require certain solvents for the installation verification of your system.

.

The gas connections are located on the left side of the instrument. For information about connecting the gas lines, refer to the TSQ Endura and TSQ Quantiva Getting Connected

Guide.

Contents

Gases

Solvent Recommendation

Gases

The instrument can use large amounts of gas during daily operations. Make sure that the gases

are delivered with the necessary pressure and purity as listed in Table 8

.

Table 8. Summary of the required gases for the mass spectrometer

Type

Argon

Recommended purity

UHP (99.995%)—Has less than

1.0 ppm each of water, oxygen, and total hydrocarbons.

Nitrogen HP (99%)

Required gas pressure

135 ±70 kPa

(20 ±10 psi)

690 ±140 kPa

(100 ±20 psi)

Typical daily consumption a

17 L (0.6 ft

3

)

11 500–26 700 L

(406–943 ft

3

)

Function

Collision gas

Venting gas; API source auxiliary gas, sheath gas, and sweep gas a

Approximate value when operating 24 hours and 7 days a week

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5

Gases and Solvents

Gases

CAUTION

• Contaminants introduced during the installation of house lines used for gas delivery can cause damage to the mass spectrometer. Make sure that all gas lines used with the instrument have been cleaned of all particulates and oils. You are responsible for any damage to the instrument caused by contaminants introduced from your gas delivery system.

• Because particulate filters can be a source of contamination, Thermo Fisher Scientific does not recommend their use.

Argon Supply

To dispense UHP argon from a tank (such as one containing 245 ft

3

Matheson™ 3120 Series

1

of argon), use a

regulator (or equivalent tank and regulator). Particulate filters are not recommended because they can be a source of contamination. Use either stainless steel tubing or the provided copper tubing for the argon gas line, and make sure that it is free of oil and preferably flame dried. Terminate the argon gas supply lines with 1/8 in., female,

Swagelok™-type connectors.

Note After you start using the mass spectrometer, do not shut off the argon gas.

Optimum performance requires a continuous flow of argon.

Nitrogen Supply

You must provide a regulator for the nitrogen gas supply that you can adjust over the specified pressure range. Thermo Fisher Scientific recommends one of the following sources for the HP nitrogen supply:

• A large, sealed, thermally insulated cylinder containing liquid nitrogen from which the nitrogen gas is boiled off. Because the 35 psi (240 kPa) and 80 psi (550 kPa) models do not provide sufficient gas pressure, Thermo Fisher Scientific recommends a 230 psi

(1590 kPa) model. A typical 240 L cylinder yields 143 850 L (5080 ft

3

) of gas. Replace the cylinder approximately once every month.

• A nitrogen generator that can generate up to 5560 L (200 ft

3

) per day at 99% purity with

100 psi (689 kPa) at the side panel. Maximum consumption of nitrogen gas is 21 L/min

(40 ft

3

/h). Nitrogen generators require an air compressor. Because some models of air compressors are quite noisy, be careful to select a quiet compressor. A generator is a continuous source, with no replacement required.

22

1

For more information, visit www.mathesongas.com

. Thermo Fisher Scientific does not endorse any products other than its own. Companies and products listed in this guide are given as examples only.

TSQ Endura and TSQ Quantiva Preinstallation Requirements Guide Thermo Scientific

5

Gases and Solvents

Solvent Recommendation

Note Liquid nitrogen conversion factors:

• 1.0 lb of liquid nitrogen = 0.5612 L

• 1.0 kg of liquid nitrogen = 1.237 L

Terminate the nitrogen gas supply line with a quick-connect connector. Because particulate filters can be a source of contamination, Thermo Fisher Scientific does not recommend their use.

CAUTION When you turn on the system, the initial nitrogen surge might exceed the capacity of the nitrogen generator. This sudden surge causes a flow rate drop that can trigger a low nitrogen warning from the mass spectrometer. If low nitrogen warnings happen frequently, call your Thermo Fisher Scientific service engineer.

Solvent Recommendation

As specified in

Table 9 , use only LC/MS-grade solvents and reagents for operating and

maintaining the TSQ Endura or TSQ Quantiva system. Installation of the instrument requires LC/MS-grade methanol and water. Installation of some systems might also require solvent modifiers.

CAUTION Avoid exposure to potentially harmful materials.

By law, producers and suppliers of chemical compounds are required to provide their customers with the most current health and safety information in the form of Material

Safety Data Sheets (MSDSs) or Safety Data Sheets (SDSs). The MSDSs and SDSs must be freely available to lab personnel to examine at any time. These data sheets describe the chemicals and summarize information on the hazard and toxicity of specific chemical compounds. They also provide information on the proper handling of compounds, first aid for accidental exposure, and procedures to remedy spills or leaks.

Read the MSDS or SDS for each chemical you use. Store and handle all chemicals in accordance with standard safety procedures. Always wear protective gloves and safety glasses when you use solvents or corrosives. Also, contain waste streams, use proper ventilation, and dispose of all laboratory reagents according to the directions in the MSDS or SDS.

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5

Gases and Solvents

Solvent Recommendation

Table 9. Recommended solutions

Solvent

Acetonitrile

Formic acid (modifier)

Grade

Methanol

Water a

Size for the stated part number

Optima LC/MS

Optima LC/MS

Size a

Optima™ LC/MS Amber glass, 4 L

Optima LC/MS Ampule, 10

×

1 mL

A955-4

A117-10X1AMP

Amber glass, 4 L

Amber glass, 4 L

Part number

A456-4

W6-4

IMPORTANT

• Some solvent impurities are transparent to a UV-Vis detector. Therefore, some

HPLC-grade solvents might contain contaminants that interfere with the performance of the mass spectrometer. To operate the mass spectrometer, choose

HPLC solvents with minimum contamination.

• Do not filter solvents. Filtering solvents can introduce contamination.

Note Visit www.fishersci.com for a wide variety of solvents and consumables for purchase.

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TSQ Endura and TSQ Quantiva Preinstallation Requirements Guide Thermo Scientific

6

Waste and Exhaust

You are responsible for providing the proper waste and exhaust systems that are required to operate the TSQ Endura or TSQ Quantiva system.The waste and exhaust arrangements can affect the proper performance of the system. You must vent vacuum and solvent wastes separately, and collect and dispose of wastes properly.

For information about setting up the exhaust and waste systems, refer to the TSQ Endura and

TSQ Quantiva Getting Connected Guide.

Contents

Exhaust System

Solvent Waste

Exhaust System

To properly operate one or both forepumps, Thermo Fisher Scientific strongly recommends connecting the forepump to an efficient fume exhaust system. The forepump eventually exhausts much of what is introduced into the mass spectrometer, including the small amount of oil vapor that a mechanical pump can emit.

Note Most API applications contribute to solvents accumulating in the forepump.

Although Thermo Fisher Scientific recommends that you periodically open the ballast valve (on the side of the pump) to purge the accumulated solvents, opening the valve might allow a large volume of volatile solvent waste to enter the fume exhaust system.

Choose an exhaust system that can accommodate the periodic purging of these solvents.

The frequency of the purging depends on the throughput of the system.

The forepump requires one 15 mm (0.6 in.) OD exhaust port. The exhaust system for the forepump must be able to accommodate an initial inrush flow rate of 3 L/min (6.4 ft

3

/hr) and a continuous flow rate of 1 L/min (2 ft

3

/hr). The exhaust tubing from the forepump to the exhaust system is 0.5 in. ID, 3/4 in. OD, and 3 m (10 ft) long.

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6

Waste and Exhaust

Solvent Waste

IMPORTANT The port for the lab exhaust system must be close enough to the forepump or forepumps so that the exhaust hose is at floor level for a minimum of 2 m (78.7 in.).

This hose acts as a trap for exhaust fumes that would otherwise recondense in the forepump oil.

Equip your lab with at least two fume exhaust systems:

• The analyzer optics become contaminated if the drain/waste tubing and the exhaust tubing from the forepump connect to the same fume exhaust system. Route the exhaust tubing from the forepump to a dedicated fume exhaust system.

CAUTION Do NOT run the forepump exhaust lines vertically near the forepump.

Solvents and oils can condense in the line and flow back into the pump, causing pump damage, and diminished pump capability.

• Do not vent the Tygon™ drain tube (or any vent tubing connected to the waste container) to the same fume exhaust system that connects to the forepump. Vent the waste container to a dedicated fume exhaust system. The exhaust system for the API source must accommodate a flow rate of up to 30 L/min (64 ft

3

/h).

Solvent Waste

The mass spectrometer comes with parts to collect the solvent waste from the API source.

Because the API source can accommodate high flow rates, you must use a method of collecting the waste solvent that avoids pressure buildup in the source. The solvent drain/waste exhaust port is located on the left side of the instrument.

IMPORTANT The solvent waste tubing that connects from the waste container to the exhaust system is 1 in. ID, 1-3/8 in. OD. Make sure that your lab exhaust system can accommodate this tubing without using reducing connectors along the solvent waste path.

Use these guidelines for the API source drain:

• Use the Tygon tubing provided with the solvent waste container to connect the solvent waste container to the lab’s fume exhaust system.

• To prevent solvent waste from backing up into the mass spectrometer, make sure that all

Tygon tubing is above the level of liquid in the waste container as follows:

– From the mass spectrometer to the solvent waste container

– From the solvent waste container to the exhaust system

For additional information, refer to the TSQ Endura and TSQ Quantiva Getting Connected

Guide.

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TSQ Endura and TSQ Quantiva Preinstallation Requirements Guide Thermo Scientific

7

Instrument Shipments

Electronic equipment carriers that specialize in the handling and transport of delicate machinery ship the TSQ Endura or TSQ Quantiva mass spectrometer to your site. When the instrument arrives, move it to a protected indoor location. If you have questions about moving your instrument, contact your local office for Thermo Scientific San Jose products

(see

“Contacting Us” on page xiv ).

CAUTION

Heavy object.

Never lift or move the instrument by yourself; you can suffer personal injury or damage the instrument.

On the occasion when shipments arrive that appear damaged, take these immediate actions.

Contents

Receiving Shipping Packages and Reporting Damage

Filing a Damage Claim Against the Carrier

Receiving Shipping Packages and Reporting Damage

Upon delivery, visually inspect for any damage to the shipment packages.

To visually inspect for damage

Carefully inspect for obvious damage or evidence of rough handling.

If the instrument shipping container, ShockWatch™, or other indicators show visible evidence of damage or mishandling, do NOT open the container.

Follow the next procedure, and then call your Thermo Fisher Scientific sales representative for further instructions.

Thermo Scientific TSQ Endura and TSQ Quantiva Preinstallation Requirements Guide

27

7

Instrument Shipments

Filing a Damage Claim Against the Carrier

To record damages on the receiving documents

1. Read the information in Filing a Damage Claim Against the Carrier to determine which

parties might be responsible for filing a claim against the carrier.

2. On all copies of the receiving documents, note any apparent external damage and briefly describe the extent of the damage.

3. Have the driver sign or initial next to your comments to signify agreement with your observations.

4. Report the list of damages to your Thermo Fisher Scientific representative.

IMPORTANT Freight insurance requires that you note obvious damage on the receiving documents. Thermo Fisher Scientific does not accept liability for damage if materials are received with obvious damage AND the damage is not recorded on the receiving documents.

Filing a Damage Claim Against the Carrier

If the instrument is damaged in transit, the shipment method determines the party who assumes the risk of damage and files a claim against the carrier—Thermo Fisher Scientific or the purchaser. To determine the shipment method for instruments shipped from the San Jose,

CA site, check the sales agreement or the sales quote.

Table 10

lists the party who files the damage claim against the carrier for instruments damaged in transit based on the shipment method.

Table 10. Shipment methods for delivery from the San Jose, CA site to domestic and international destinations

Destination Shipment method

Party responsible for filing a damage claim

Thermo Fisher Scientific Domestic

(United States)

Destination or Origin—Thermo Fisher

Scientific pays the carrier.

International

Origin—The purchaser pays the carrier. Purchaser

Carriage Paid To (CPT) named destination a

Purchaser

Carriage and Insurance Paid (CIP) to named destination b

Thermo Fisher Scientific a

Unless specified differently, Thermo Fisher Scientific uses this shipment method for international shipments.

b

Under special circumstances, Thermo Fisher Scientific uses this shipment method for international shipments.

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TSQ Endura and TSQ Quantiva Preinstallation Requirements Guide Thermo Scientific

8

Installation

Complete all preparations described in the previous chapters before your Thermo Fisher

Scientific service engineer installs the TSQ Endura or TSQ Quantiva system.

IMPORTANT If the instrument shipping container, ShockWatch, or other indicators show any evidence of damage or mishandling during shipment, do NOT open the container.

Call your Thermo Fisher Scientific representative for instructions on what to do. If the instrument arrives safely, proceed with the following instructions.

After you have completed the laboratory site preparation and received the TSQ Endura or

TSQ Quantiva system, send the completed and signed

“TSQ Endura and TSQ Quantiva

Installation Request Form” on page iii

to your local office for Thermo Fisher Scientific San

Jose products. After receiving this form, the service engineer contacts you to schedule the installation.

CAUTION

Heavy object.

Never lift or move the instrument by yourself; you can suffer personal injury or damage the instrument.

Contents

Installation Kits

Customer-Supplied Hardware

Basic On-Site Training

Advanced Training Courses

Preventive Maintenance

Thermo Scientific TSQ Endura and TSQ Quantiva Preinstallation Requirements Guide

29

8

Installation

Installation Kits

Installation Kits

The TSQ Endura and TSQ Quantiva mass spectrometers include the following kits

( Table 11

).

Table 11. Kits provided with the mass spectrometer

Kit name

Preinstallation Kit

(North American or

International, as applicable)

Chemicals Kit

(P/N 80100-62006)

Calibration Kit

(P/N 80000-62013)

MS Setup Kit

(P/N 80100-62003)

Performance Specification Kit

(P/N 80100-62008)

Single Mechanical Pump Kit

(P/N 80100-62004)

–or–

Dual Mechanical Pump Kit

(P/N 80100-62013)

Description

Contains this guide and the Chemicals Kit. The

International Preinstallation Kit also includes three

230 Vac CEE (3-pole) wall receptacles.

Contains the chemicals for demonstrating the system performance specifications.

Contains a syringe and the installation components, such as fittings and tubing.

Contains the components to connect the mass spectrometer to the forepump or forepumps, the gas supplies, the Ethernet switch, and the waste container.

Contains the plumbing hardware for demonstrating the system performance specifications.

Contains the forepump (single pump kit) or forepumps

(dual pump kit), relay control cable, and installation components, such as the exhaust waste tubing.

Depending on your system configuration, you might have other kits with your shipment.

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TSQ Endura and TSQ Quantiva Preinstallation Requirements Guide Thermo Scientific

8

Installation

Customer-Supplied Hardware

Customer-Supplied Hardware

Thermo Fisher Scientific does not provide all parts, materials, or tools that are required for

installation. To complete the installation, you must provide these additional parts ( Table 12 ).

Table 12. Customer-supplied hardware for installation

Item

Communications cable

Description

Connects from the Ready Out and Injection Hold pins

(peripheral control connector) on the mass spectrometer to a device not controlled by one of the Thermo

Scientific mass spectrometer applications, such as the

Thermo Xcalibur™ data system.

Gas line fitting, argon

Gas line fitting, nitrogen

LC system

LC system, solvents

Refer to the TSQ Endura and TSQ Quantiva Getting

Connected Guide.

Connects the 1/8 in. ID copper or stainless steel tubing to the argon gas supply.

Refer to the TSQ Endura and TSQ Quantiva Getting

Connected Guide.

Connects the 1/4 in. OD Teflon™ PFA tubing to the nitrogen gas supply.

Refer to the TSQ Endura and TSQ Quantiva Getting

Connected Guide.

IMPORTANT If your LC system is manufactured by another company, you must verify that it is suitable for use with the TSQ Endura or TSQ Quantiva mass spectrometer. The output (start) signal from the external device must be Normally Hi (+5 Vdc) and momentarily go to Low. If you cannot configure the external device to go from Normally Hi to Low momentarily, you cannot use it with the mass spectrometer.

Used by the service engineer to calibrate the system during the initial setup.

For details, refer to the appropriate manual.

Thermo Scientific TSQ Endura and TSQ Quantiva Preinstallation Requirements Guide

31

8

Installation

Basic On-Site Training

Basic On-Site Training

When your new TSQ Endura or TSQ Quantiva system is on site and ready for installation, the Thermo Fisher Scientific service engineer unpacks and installs it.

During the installation, the service engineer demonstrates the following:

• Basics of the instrument operation and routine maintenance

• Marketing specifications that are in effect when you purchased the system

Tip To receive maximum benefit from this on-site training opportunity, plan for the system operators to be available during the entire installation process.

Do not use the new system for sample analysis until the installation is complete and you have signed the Acceptance Form.

Advanced Training Courses

Thermo Fisher Scientific provides introductory and advanced training courses in analytical techniques, in addition to specialized operation and maintenance courses for Thermo

Scientific products.

Thermo Fisher Scientific recommends that the key user receive advanced training for operating and maintaining the TSQ Endura or TSQ Quantiva system after using it for several months. After this training from Thermo Fisher Scientific, the key user can conduct in-house training for other staff members, certifying them to operate the system.

Preventive Maintenance

You are responsible for the routine and preventive maintenance of the TSQ Endura or

TSQ Quantiva system.

Regular preventive maintenance is essential. It increases the life of the system, maximizes the uptime of the system, and provides optimum system performance. You can find maintenance procedures in the following manuals:

TSQ Endura and TSQ Quantiva Hardware Manual

Ion Max NG and EASY-Max NG Ion Sources User Guide

• Manuals shipped with other devices for your system

32

TSQ Endura and TSQ Quantiva Preinstallation Requirements Guide Thermo Scientific

I

Index

A

air conditioning system

10

API source, drain guidelines

26

argon gas supply

22

B

buck/boost transformer

15

C

circuit breakers

16

communications cables, Ethernet

5

compliance

FCC

v

regulatory

v

contacting us

xiv

contaminants, gas

22

D

damage indicator, packaging

29

data system number of outlets

17

recommended layout

7

dimensions shipping container

3

system modules

4

directive, WEEE

vii

documentation downloading

xii

E

earth ground connections

16

electrical outlets

16

electromagnetic compatibility

v

EMC compliance

v

entrance requirements

3

Thermo Scientific environmental requirements

9

Ethernet, communications cables

5

exhaust system

25

F

FCC compliance

v

forepumps

8 ,

15 ,

25

G

gases

21

generator, nitrogen gas

22

ground

See earth ground connections

H

hardware, supplied by customer

31

heat output, maximum

11

I

installation kits

30

Installation Request Form

iii

instrument shipments, reporting damage

27

isolation/noise-suppression transformer

15

K

kits

Buck/Boost Transformer

15

installation

30

L

lab environment, requirements

9

line power

13

liquid nitrogen, conversion factors

23

TSQ Endura and TSQ Quantiva Preinstallation Requirements Guide 33

Index: M load capacity air conditioning

11

workbenches

5

M

maintenance, preventive

32

mass spectrometers recommended layout

7

system, number of outlets

17

N

nitrogen gas generator

22

regulator

22

supply

22

P

power conditioning devices

15

monitoring devices

14

quality of

14

power supply cords

18

R

regulatory compliance

v

reliability, effect of temperature on system

10

S

safety and special notices

xiii

safety standards

v

service contract, exclusions

1

shipment, damage indicator

29

shipping container

3

site preparation

3

solvent waste contaminants, instrument damage

24

description

26

solvents, recommendations

24

space requirements

6

surge protector

16

T

technical assistance

19

telephone

8

temperature and humidity monitor

10

training

32

34

TSQ Endura and TSQ Quantiva Preinstallation Requirements Guide transformer buck/boost

15

isolation/noise-suppression

15

transient voltages

14

U

uninterruptible power supply (UPS)

15

UV-Vis detector

24

V

venting forepump

25

solvent waste container

26

voltage single phase for MS

16

transient, description

14

W

warranty, limitations

1

waste and exhaust

25

WEEE directive

vii

workbench requirements

5

Thermo Scientific

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