Thermo Scientific TSQ Quantiva Triple-Stage Quadrupole Mass Spectrometer

Thermo Scientific TSQ Quantiva Triple-Stage Quadrupole Mass Spectrometer
Extreme quantitative performance
with unprecedented ease
• Extreme quantitative performance through Thermo
Scientific™ Active Ion Management (AIM™) technology
•Attogram sensitivity
•Ultrafast selected-reaction monitoring enables
quantification of more compounds in less time
•Robustness and reliability that is unprecedented in a
research-grade triple quadrupole mass spectrometer
•Close integration with application-specific software
ensures maximum productivity
•Simple method development and easy operation
The Thermo Scientific™ TSQ Quantiva™
triple-stage quadrupole mass spectrometer
exceeds the most stringent analytical
requirements. With AIM technology, the TSQ
Quantiva MS achieves unrivaled LODs and
LOQs and provides unsurpassed ultra-low-level
quantitation of complex and difficult-to-run
samples. This extreme analytical performance
doesn’t come at the cost of complexity or
lack of durability; breakthrough software
and hardware make operation far easier and
more reliable than in previous-generation
triple quadrupoles. Close integration with
application-specific software ensures
maximum productivity. The TSQ Quantiva
MS helps users spend more time thinking
about their analyses and less time worrying
about instrument setup and operation.
RFQ Product Specif ications
Thermo Scientific TSQ Quantiva
Triple-Stage Quadrupole
Mass Spectrometer
Hardware Features
Thermo Scientific™ Ion Max NG™
API Source
• Automatic connection of all gases and
voltages on installation simplifies operation
and improves reliability
• Automatic source recognition simplifies
use and data logging
• Sweep gas reduces chemical noise
• Enhanced exhaust port efficiently removes
solvent vapor, improving uptime and
reducing chemical noise
• Flexible X, Y, and Z positioning for all
ionization probes maximizes performance
• Optimal 60 degree spray angle
• Interchangeable HESI and APCI
ionization probes
• Dual-mode HESI and APCI capability
High-Capacity Transfer Tube
The high-capacity transfer tube (HCTT)
allows more ions into the vacuum system
for improved sensitivity while still providing
great desolvation.
Active Ion Management Ion Optics
AIM technology maximizes ion transmission,
eliminates major sources of noise, and
precisely isolates analytes to achieve
extreme quantitative performance.
Electrodynamic Ion Funnel
The electrodynamic ion funnel (EDIF)
efficiently captures ions as they leave the
transfer tube. Its broad transmission curve
reduces ion losses, increasing sensitivity.
The EDIF also reduces in-source fragmentation.
Ion Beam Guide
The ion beam guide, with its neutral blocker,
stops neutrals and high-velocity clusters,
keeping the ion optics cleaner, reducing
noise, and increasing sensitivity.
HyperQuad Quadrupole Mass Filter
(Q1 and Q3)
Thermo Scientific™ HyperQuad™ quadrupole
mass filters with 6 mm field radius and
asymmetric RF drive increase ion transmission
and sensitivity. Resolution up to 0.2 FWHM
enables better selected-reaction monitoring.
Active Collision Cell (Q2)
The high-pressure argon-filled collision cell
produces efficient fragmentation for high
sensitivity. An axial DC field speeds ion
transits, yielding up to 500 SRMs/s with
zero cross talk.
Figure 1. TSQ Quantiva ion optics
• Dual-mode discrete-dynode detector
increases sensitivity by operating in
pulse-counting mode when ion flux is low
and analog mode when ion flux is high
• Six orders of dynamic range provide
high-confidence quantitation
Vacuum System
• Four-stage differentially pumped vacuum
• Advanced triple-inlet turbomolecular pump
integrated with the vacuum manifold
• Dual rotary vacuum pump configuration
Integrated Divert Valve and Syringe Pump
Fully automated data system control of the
divert valve enables switching the solvent
front, gradient end point, or any portion of
the HPLC run to waste.
Optional Ion Sources
• Thermo Scientific™ EASY-Max NG™ ion
source provides high performance with
minimal adjustments
• Thermo Scientific™ EASY-Spray NG™ ion
source is designed for maximum
nanoelectrospray performance with no
need for adjustments
• T hermo Scientific™ Nanospray Flex NG™
ion source is designed for ultimate
nanoelectrospray performance with
complete flexibility of column selection
Active collision cell
with axial DC fields
HyperQuad quadrupole
mass filter
Ion beam guide with
neutral blocker
mass filter
Ion Max NG ion source
Electrodynamic ion funnel (EDIF)
transfer tube (HCTT)
Software Features
Performance Specifications
Installation Requirements
Data System
• High-performance PC with Intel®
• High-resolution LCD color monitor
• Microsoft® Windows® 7 operating
system (64 bit)
• Microsoft Office 2010 software
• Three 230 Vac ±10%, 50/60 Hz at 16 A
• Four 120 Vac +6–10%, 50/60 Hz at 20 A
or four 230 Vac ±10%, 50/60 Hz at 13 A
• Earth ground hardwired to main panel
• Free from voltage variations above or
below the recommended operating range
Standard MS Software
• Thermo Scientific™ Xcalibur™ processing
and instrument control software
• Tune editor for system calibration,
diagnostics, and manual data acquisition
• Method editor with comprehensive
application-specific template library and
drag-and-drop user interface to facilitate
method development
• Automated optimization of all instrument
parameters, including gas pressures and
collision energy, within an experiment
• Direct control of multiple vendors’ LC
systems and autosampler configurations
through Xcalibur software
• Foundation of shared, state-of-the-art
software makes it easier to transfer methods
between next-generation instruments
Scan Functions
• Highly sensitive full-scan MS in Q1 or Q3
• Selected-ion monitoring (SIM) in Q1 or Q3
• Selected-reaction monitoring (SRM) with
up to 30,000 SRMs definable and up to
500 SRMs/s
• High-resolution (0.2 Da) selected-reaction
• Product ion scanning
• Precursor ion scanning
• Neutral-loss scanning
• Reverse energy ramp MS/MS spectra
(RER) gives information-rich MS/MS
spectra for solid compound identification
• Polarity switching capabilities
Optional Application-Specific Software
• Thermo Scientific™ LCQUAN™ quantitation
software supports 21 CFR Part 11
• Thermo Scientific™ TraceFinder™ software
simplifies method development and routine
analysis in food safety, environmental,
clinical research, and forensic toxicology
• Thermo Scientific™ Pinpoint™ software
automates peptide quantitation
• Thermo Scientific™ Mass Frontier™
spectral interpretation and classification
software for the identification of unknowns
Positive Electrospray (HESI) at
Resolution 0.2 Da FWHM
A 2 µL injection of a 500 fg/µL reserpine
solution on a Thermo Scientific™ Hypersil
GOLD™ aQ 20 x 2.1 mm 1.9 µm particle
packed column at a flow rate of 300 µL/min
30:70:0.02 water/methanol/formic acid will
produce a minimum signal-to-noise ratio of
100,000:1 for the transition of the
protonated molecule at m/z 609.3 to the
fragment ion at m/z 195.1 when operated in
selected-reaction monitoring (SRM) mode
with Q1 and Q3 resolution set to 0.2 and
0.7 Da FWHM respectively.
Mass Range
m/z 10-1850
Q1 and Q3 adjustable to 0.2 Da peak width
(FWHM) across the entire mass range
Scan Rate
15,000 amu/second at a resolution of 2 FWHM
500 SRMs/second (for any resolution from
0.2 through 2.0 FWHM)
Mass Stability
Mass assignment will be within ±0.05 Da
over a 24 hour period. The laboratory room
temperature must be maintained between
18–27 °C (65–81 °F). The room
temperature may not change by more than
5 °C (9 °F) during this period.
• Collision gas: 99.995% pure Argon
ollision gas supply pressure: 135 ± 70 kPa
(20 ± 10 psig)
• S heath/aux/sweep gas: 99% pure Nitrogen
• Sheath/aux/sweep gas supply pressure:
690 ± 140 kPa (100 ± 20 psig)
• Maximum sheath gas consumption:
≈20 L/min
• Functional temperature range: 15–27 °C
(59–81 °F)
• Optimal temperature range: 18–21 °C
(65–70 °F)
• Heat output: 1550 W (5400 Btu/h)
• Total system heat output: 4420 W
(15,380 Btu/h)
• Particulate matter: <3,500,000 particles
per cubic meter of air (<100,000 particles
of >5 µm diameter per cubic foot of air)
• Relative humidity: 20% to 80%, without
• Floors must be free of vibration
• TSQ Quantiva MS1: 680 × 760 × 840 mm
(h, w, d – 27 × 30 × 33 in)
erlikon® SV 65 forepump: 270 × 320 ×
489 mm (h, w, d – 10 × 13 × 19 in)
• TSQ Quantiva MS: 125 kg (275 lb)
• Oerlikon® SV 65 forepump: 52 kg (115 lb)
1. Includes the divert/inject valve
RFQ Product Specif ications
For Research Use Only. Not for use in diagnostic procedures.
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