MATERIAL SAFETY DATA SHEET CHEMICAL NAME; CLASS:

MATERIAL SAFETY DATA SHEET  CHEMICAL NAME; CLASS:
MATERIAL SAFETY
DATA SHEET
Prepared to U.S. OSHA, CMA, ANSI and Canadian WHMIS Standards
1. PRODUCT IDENTIFICATION
CHEMICAL NAME; CLASS:
NON-FLAMMABLE GAS MIXTURE
Containing the Following Component in a Nitrogen Balance Gas:
Hydrogen Cyanide: 0.0001- 0.02%
SYNONYMS: Not Applicable
CHEMICAL FAMILY NAME: Not Applicable
FORMULA: Not Applicable
Document Number: 50024 (Replaces ISC MSDS No.1810-2152, 1810-7490)
Note: The Material Safety Data Sheet is for this gas mixture supplied in cylinders with 33 cubic feet (935 liters) or less gas capacity (DOT - 39 cylinders). This MSDS has
been developed for various gas mixtures with the composition of components within the ranges listed in Section 2 (Composition and Information on Ingredients). Refer to
the product label for information on the actual composition of the product.
PRODUCT USE:
SUPPLIER/MANUFACTURER'S NAME:
ADDRESS:
EMERGENCY PHONE:
BUSINESS PHONE:
Calibration of Monitoring and Research Equipment
CALGAZ
821 Chesapeake Drive
Cambridge, MD 21613
CHEMTREC: 1-800-424-9300
1-410-228-6400
General MSDS Information: 1-713/868-0440
Fax on Demand: 1-800/231-1366
2. COMPOSITION and INFORMATION ON INGREDIENTS
CHEMICAL NAME
CAS #
mole %
EXPOSURE LIMITS IN AIR
ACGIH-TLV
Hydrogen Cyanide
Nitrogen
74-90-8
0.00010.020%
7727-37-9
Balance
OSHA
NIOSH
OTHER
TWA
ppm
STEL
ppm
PEL
ppm
STEL
ppm
IDLH
ppm
ppm
NE
4.7
(ceiling)
[skin]
10
(skin)
4.7
(skin)
50
NIOSH REL:
STEL = 4.7 (skin)
DFG MAKs:
TWA = 11.9 (skin)
PEAK = 5•MAK 30 min., average
value
There are no specific exposure limits for Nitrogen. Nitrogen is a simple asphyxiant (SA).
Oxygen levels should be maintained above 19.5%.
NE = Not Established.
See Section 16 for Definitions of Terms Used.
NOTE (1): ALL WHMIS required information is included in appropriate sections based on the ANSI Z400.1-1998 format. This gas mixture has been classified in
accordance with the hazard criteria of the CPR and the MSDS contains all the information required by the CPR.
3. HAZARD IDENTIFICATION
EMERGENCY OVERVIEW: This gas mixture is a colorless gas which is odorless. Hydrogen Cyanide (a component of this gas mixture) is an
extremely toxic gas; even brief over-exposures to relatively low doses may have significant health consequences. Acute low-level exposure can
cause symptoms such as cyanosis, headache, dizziness, unsteadiness of gait, a feeling of suffocation and nausea. Additionally, releases of
this gas mixture may produce oxygen-deficient atmospheres (especially in confined spaces or other poorly-ventilated environments); individuals
in such atmospheres may be asphyxiated.
SYMPTOMS OF OVER-EXPOSURE BY ROUTE OF EXPOSURE: The most significant route
HAZARDOUS MATERIAL IDENTIFICATION SYSTEM
of over-exposure for this gas mixture is by inhalation, as well as eye and skin absorption.
INHALATION: Due to the small size of an individual cylinder of this gas mixture, no unusual
(BLUE)
3
HEALTH HAZARD
health effects from over-exposure to the product are anticipated under routine circumstances of
use. The health hazards associated with this gas mixture are the potential for over-exposure to
Hydrogen Cyanide (a component of this gas mixture) and oxygen displacement if this gas
mixture is released in small, poorly-ventilated areas (i.e. enclosed or confined spaces).
0
FLAMMABILITY HAZARD (RED)
Hydrogen Cyanide is an extremely toxic gas. It is anticipated that, due to the low concentration
(1-200 ppm) of Hydrogen Cyanide and the fact this gas mixture is quickly dissipated, employees
will not be exposed to levels above those listed in Section 2 (Composition and Information on
(YELLOW )
PHYSICAL HAZARD
0
Ingredients). However, because Hydrogen Cyanide can produce significant health effects at
relatively low levels, individuals using this gas mixture must be aware of the symptoms of overexposure. Hydrogen Cyanide is a protoplasmic poison, combining in tissues with the enzymes
PROTECTIVE EQUIPMENT
associated with oxidation, thereby rendering oxygen unavailable to these tissues, and causing
death by chemical asphyxiation. Exposure to low concentrations of this gas can cause
EYES
HANDS
BODY
RESPIRATORY
headache, vertigo, irritation of the throat, difficulty breathing, reddening of eyes, salivation,
nausea and vomiting. Chronic, low level exposure to Hydrogen Cyanide over long periods of
See Section 8
time may lead to fatigue and weakness. Exposures to high concentrations of Hydrogen
Cyanide gas produces symptoms including tachypnea (causing increased intake of cyanide),
then dyspnea, weakness of arms and legs, paralysis, unconsciousness, convulsions and
For Routine Industrial Use and Handling Applications
respiratory arrest. Exposure to 150 ppm for one-half to one hour may endanger life. In cases
where the victim recovers, there is rarely any residual injury or disability. The action of Hydrogen Cyanide in cases of high concentration exposure
is extremely rapid. Specific effects, based on the concentration of Hydrogen Cyanide, are presented below:
CONCENTRATION OF HYDROGEN CYANIDE
OBSERVED EFFECT
2-5 ppm
Detectable odor threshold.
18-36 ppm
Slight symptoms after several hours.
45-54 ppm
Tolerated for 0.5-1 hour without immediate or delayed effects.
110-135 ppm
Dangerous to life or fatal after 0.5-1 hour.
NON-FLAMMABLE GAS MIXTURE MSDS - 50024
PN 3485
EFFECTIVE DATE: JUNE 7, 2010
PAGE 1 OF 5
3. HAZARD IDENTIFICATION (Continued)
133 ppm
180 ppm
270 ppm
NOTE:
Fatal after 30 minutes.
Fatal after 10 minutes.
Immediately fatal.
This gas mixture contains 1-200 ppm Hydrogen Cyanide. Data pertinent to higher
concentrations of Hydrogen Cyanide are provided to give complete information on effects
observed in humans after over-exposures have occurred.
Additionally, under some circumstances, an oxygen-deficient environment may occur. Individuals breathing such an atmosphere may experience
symptoms which include headaches, ringing in ears, dizziness, drowsiness, unconsciousness, nausea, vomiting, and depression of all the senses.
The effects associated with various levels of oxygen are listed on the following page.
INHALATION (continued)::
CONCENTRATION OF OXYGEN
OBSERVED EFFECT
12-16% Oxygen:
Breathing and pulse rate increased, muscular coordination slightly disturbed.
10-14% Oxygen:
Emotional upset, abnormal fatigue, disturbed respiration.
6-10% Oxygen:
Nausea, vomiting, collapse, or loss of consciousness.
Below 6%:
Convulsive movements, possible respiratory collapse, and death.
CONTACT WITH THE EYES AND SKIN: Contact with the skin is not irritating, however, Hydrogen Cyanide (a component of this gas mixture) can
be absorbed through intact skin and may be absorbed though eyes. The symptoms of such absorption are the same as by inhalation. Contact of
the gas mixture with the eyes may be slightly irritating.
HEALTH EFFECTS OR RISKS FROM EXPOSURE: An Explanation in Lay Terms. Over-exposure to this gas mixture may cause the following
health effects:
ACUTE: Due to the small size of the individual cylinder of this gas mixture, no unusual health effects from exposure to the product are anticipated
under routine circumstances of use. Hydrogen Cyanide (a component of this gas mixture) is an extremely toxic gas; even brief over-exposures to
relatively low doses may have significant health consequences. Acute low-level exposure can cause symptoms such as cyanosis, headache,
dizziness, unsteadiness of gait, a feeling of suffocation and nausea. Contact with the eyes with Hydrogen Cyanide can cause irritation.
CHRONIC: There are a wide range of chronic symptoms that are thought to occur with chronic, low-level cyanide compound exposure. These
include persistent runny nose, weakness, dizziness, giddiness, headache, nausea, abdominal pain, vomiting, throat irritation, changes in the
perception of taste and smell, muscle cramps, weight loss, flushing of the face and enlargement of the thyroid gland. As these symptoms are not
exclusive to cyanide exposure, the symptoms of chronic cyanide toxicity are not conclusive. Some evidence exists that low-level, long-term
exposure to Hydrogen Cyanide on the eyes will result in damage to the nerves of the eyes. Chronic exposure to oxygen-deficient atmospheres
(below 18% oxygen in air) may affect the heart and nervous system.
TARGET ORGANS: ACUTE: Respiratory system, skin, eyes, enzymes associated with oxidation.
CHRONIC: Skin, respiratory system,
eyes, thyroid, heart, central nervous system.
4. FIRST-AID MEASURES
RESCUERS SHOULD NOT ATTEMPT TO RETRIEVE VICTIMS OF EXPOSURE TO THIS GAS MIXTURE WITHOUT ADEQUATE PERSONAL
PROTECTIVE EQUIPMENT. At a minimum, Self-Contained Breathing Apparatus must be worn. Victim(s) who experience any adverse effect
after over-exposure to this gas mixture must be taken for medical attention. Rescuers should be taken for medical attention if necessary. Take a
copy of the label and the MSDS to physician or other health professional with victim(s).
No unusual health effects are anticipated after exposure to this gas mixture, due to the small cylinder size. If any adverse symptom develops after
over-exposure to this gas mixture, remove victim(s) to fresh air as quickly as possible. Only trained personnel should administer supplemental
oxygen and/or cardio-pulmonary resuscitation if necessary.
A complete Cyanide Antidote Kit should be available near all areas of use. Personnel should be trained in the use of the kit to administer first-aid in
advance of medical assistance. The kit should contain at least the following:
• Two boxes (2 dozen) of amyl nitrite pearls.
• Two 50 mL sterile syringes.
• Two ampoules of sterile sodium nitrite solution (10 mL of a 3%
• Two sterile intravenous needles.
solution in each).
• One tourniquet.
• Two ampoules of sterile sodium thiosulfate solution (50 mL of a
• Twelve gauze pads.
25% solution of each).
• One bottle of 70% alcohol.
• Two 10 mL sterile syringes.
• One ampoule file.
Because of the special hazard of Cyanide compounds, special treatment procedures are administered to victims of exposure to Hydrogen Cyanide.
Personnel should be trained to administer initial first-aid treatment to victims of Hydrogen Cyanide poisoning prior to response from medical
professionals. If victim has difficulty breathing, is becoming confused and/or is losing consciousness, administer amyl nitrite. Crush one pearl of
amyl nitrite onto a cloth and hold to the victim’s nose 15 to 30 seconds of each minute. Use a new pearl every 5 minutes (0.3 mg size), or every 3
minutes (0.18 mg size). While amyl nitrite is being administered, if possible, monitor blood pressure. If blood pressure of the victim drops below
80/60, stop amyl nitrite treatment and obtain advice of professional medical personnel immediately. Administration of oxygen should only be done
by trained personnel. If cardiac arrest occurs, begin CPR, again by trained personnel. While waiting for response by professional medical
personnel, provide general supportive measures to victim such as keeping them warm and quiet. Take copy of label and MSDS to physician or
other health professional with victim(s). Physicians should refer below for specific recommendations to physicians.
MEDICAL CONDITIONS AGGRAVATED BY EXPOSURE: Any respiratory disorder may be aggravated by over-exposure to gas mixtures
containing. Additionally, skin and eye conditions may be aggravated by Hydrogen Cyanide exposures.
RECOMMENDATIONS TO PHYSICIANS: Administer oxygen. Victims of exposure to Hydrogen Cyanide must be monitored closely. IN CASES
OF SEVERE HYDROGEN CYANIDE EXPOSURE: Administer amyl nitrate inhalations. If victim does not respond, inject, intravenously, 0.3 grams
sodium nitrite (10 mL of a 3% solution at a rate of 2.5-5.0 mL/minute), followed at once by 12.5 grams of sodium thiosulfate intravenously (50 mL of
a 25% solution injected at about the same rate as the sodium nitrite solution). The same needle and vein can be used for both injections. Watch
victim continuously for 24-48 hours. If symptoms recur or persist, repeat the sodium nitrite and sodium thiosulfate therapy at one-half the original
dose.
5. FIRE-FIGHTING MEASURES
FLASH POINT: Not applicable.
AUTOIGNITION TEMPERATURE: Not applicable.
FLAMMABLE LIMITS (in air by volume, %):
Lower (LEL): Not applicable.
Upper (UEL): Not applicable.
FIRE EXTINGUISHING MATERIALS: Non-flammable gas mixture. Use extinguishing
media appropriate for surrounding fire.
UNUSUAL FIRE AND EXPLOSION HAZARDS: Hydrogen Cyanide is toxic to humans
in relatively low concentrations, and in the concentrations present in this gas mixture,
poses a potential hazard to fire-fighters. This gas mixture is not flammable; however,
containers, when involved in fire, may rupture or burst in the heat of the fire.
Explosion Sensitivity to Mechanical Impact: Not sensitive.
Explosion Sensitivity to Static Discharge: Not sensitive.
SPECIAL FIRE-FIGHTING PROCEDURES: Structural firefighters must wear SelfContained Breathing Apparatus and full protective equipment.
NFPA RATING
FLAMMABILITY
0
HEALTH
0
3
REACTIVITY
OTHER
6. ACCIDENTAL RELEASE MEASURES
LEAK RESPONSE: Due to the small size and content of the cylinder, an accidental release of this gas mixture presents significantly less risk of
over-exposure to Hydrogen Cyanide, an oxygen-deficient environment, and other safety hazards than a similar release from a larger cylinder.
However, as with any chemical release, extreme caution must be used during emergency response procedures. In the event of a release in which
the atmosphere is unknown, and in which other chemicals are potentially involved, evacuate immediate area. Such releases should be responded
to by trained personnel using pre-planned procedures. Proper protective equipment should be used. In case of a leak, clear the affected area,
protect people, and respond with trained personnel. Allow the gas mixture to dissipate. If necessary, monitor the surrounding area (and the original
area of the release) for oxygen. A colorimetric tube is available for Hydrogen Cyanide. The level of Hydrogen Cyanide must be at acceptable
levels (less than 50% of the TLV; TLV = 4.7 ppm) and Oxygen levels must be above 19.5% before non-emergency personnel are allowed to reenter area.
If leaking incidentally from the cylinder, contact your supplier.
NON-FLAMMABLE GAS MIXTURE MSDS - 50024
PN 3485
EFFECTIVE DATE: JUNE 7, 2010
PAGE 2 OF 5
7. HANDLING and USE (Continued)
WORK PRACTICES AND HYGIENE PRACTICES: Be aware of any signs of dizziness or fatigue, especially if work is done in a poorly ventilated area; exposures to
harmful or fatal concentrations of this gas mixture could occur without any significant warning symptoms, due to Hydrogen Cyanide over-exposure and oxygen
deficiency. If necessary, areas in which this gas mixture is used should be monitored with very sensitive gas detection instruments. Detection of Hydrogen Cyanide
concentrations below 50% of the TLV level of 4.7 ppm should trigger immediate response and corrective action. Detection of higher levels should initiate an alarm
calling for evacuation of all personnel with the potential to be exposed. Do not attempt to repair, adjust, or in any other way modify cylinders containing this gas mixture.
If there is a malfunction or another type of operational problem, contact nearest distributor immediately.
STORAGE AND HANDLING PRACTICES: Cylinders should be firmly secured to prevent falling or being knocked-over. Cylinders must be protected from the
environment, and preferably kept at room temperature (approximately 21°C [70°F]). Cylinders should be stored in dry, well-ventilated areas, away from sources of heat,
ignition, and direct sunlight. Protect cylinders against physical damage.
Full and empty cylinders should be segregated. Use a first-in, first-out inventory system to prevent full containers from being stored for long periods of time. These
cylinders are not refillable. WARNING! Do not refill DOT 39 cylinders. To do so may cause personal injury or property damage.
SPECIAL PRECAUTIONS FOR HANDLING GAS CYLINDERS: WARNING! Compressed gases can present significant safety hazards. During cylinder use, use
equipment designed for these specific cylinders. Ensure all lines and equipment are rated for proper service pressure.
PROTECTIVE PRACTICES DURING MAINTENANCE OF CONTAMINATED EQUIPMENT: Follow practices indicated in Section 6 (Accidental Release Measures).
Make certain that application equipment is locked and tagged-out safely. Always use product in areas where adequate ventilation is provided.
8. EXPOSURE CONTROLS - PERSONAL PROTECTION
VENTILATION AND ENGINEERING CONTROLS: No special ventilation systems or engineering controls are needed under normal
circumstances of use. As with all chemicals, use this gas mixture in well-ventilated areas. If this gas mixture is used in a poorly-ventilated area,
install automatic monitoring equipment to detect the levels of Hydrogen Cyanide and Oxygen.
RESPIRATORY PROTECTION: No special respiratory protection is required under normal circumstances of use. Maintain Hydrogen Cyanide
levels below 50% of the TLV (TLV = 4.7 ppm) and oxygen levels above 19.5% in the workplace. Use supplied air respiratory protection when
Hydrogen Cyanide levels exceed 50% of the TLV (TLV = 4.7 ppm), oxygen levels are below 19.5%, or during emergency response to a release of
this gas mixture. During an emergency situation, before entering the area, check the concentration of Hydrogen Cyanide and Oxygen. If
respiratory protection is needed, use only protection authorized in the U.S. Federal OSHA Standard (29 CFR 1910.134), applicable U.S. State
regulations, or the Canadian CSA Standard Z94.4-93 and applicable standards of Canadian Provinces. Oxygen levels below 19.16.33% are
considered IDLH by OSHA. In such atmospheres, use of a full-facepiece pressure/demand SCBA or a full facepiece, supplied air respirator with
auxiliary self-contained air supply is required under OSHA’s Respiratory Protection Standard (1910.134-1998). The following NIOSH respirator
recommendations are in place for the Hydrogen Cyanide component of this gas mixture.
HYDROGEN CYANIDE
CONCENTRATION
RESPIRATORY PROTECTION
Up to 47 ppm:
Any Supplied-Air Respirator (SAR)
Up to 50 ppm:
Any SAR operated in a continuous-flow mode, or any Self-Contained Breathing Apparatus (SCBA) with a full
facepiece, or any SAR with a full facepiece.
Emergency or Planned Entry into Unknown Concentrations or IDLH Conditions: Any SCBA that has a full facepiece and is operated in a
pressure-demand or other positive-pressure mode, or any SAR that has a full facepiece and is operated in a
pressure-demand or other positive-pressure mode in combination with an auxiliary SCBA operated in pressuredemand or other positive-pressure mode.
Escape:
Any air-purifying, full-facepiece respirator (gas mask) with a chin-style, front- or back-mounted organic vapor
canister, or any appropriate escape-type, SCBA.
EYE PROTECTION: Safety glasses. If necessary, refer to U.S. OSHA 29 CFR 1910.133 or appropriate Canadian Standards.
HAND PROTECTION: Wear leather gloves when handling cylinders. Chemically resistant gloves should be worn when using this gas mixture. If
necessary, refer to U.S. OSHA 29 CFR 1910.138 or appropriate Standards of Canada.
BODY PROTECTION: No special protection is needed under normal circumstances of use. If a hazard of injury to the feet exists due to falling
objects, rolling objects, where objects may pierce the soles of the feet or where employee’s feet may be exposed to electrical hazards, use foot
protection, as described in U.S. OSHA 29 CFR 1910.136.
9. PHYSICAL and CHEMICAL PROPERTIES
The following information is for Nitrogen, the main component of this gas mixture.
3
3
GAS DENSITY @ 32°F (0°C) and 1 atm: .072 lbs/ ft (1.153 kg/m )
FREEZING/MELTING POINT @ 10 psig: -345.8°F (-210°C)
BOILING POINT: -320.4°F (-195.8°C)
SPECIFIC GRAVITY (air = 1) @ 70°F (21.1°C): 0.906
pH: Not applicable.
SOLUBILITY IN WATER vol/vol @ 32°F (0°C) and 1 atm: 0.023
MOLECULAR WEIGHT: 28.01
EVAPORATION RATE (nBuAc = 1): Not applicable.
EXPANSION RATIO: Not applicable.
3
VAPOR PRESSURE @ 70°F (21.1°C) (psig): Not applicable.
SPECIFIC VOLUME (ft /lb): 13.8
COEFFICIENT WATER/OIL DISTRIBUTION: Not applicable.
The following information is for this gas mixture.
APPEARANCE, ODOR AND COLOR: This gas mixture is a colorless gas mixture which is odorless.
HOW TO DETECT THIS SUBSTANCE (warning properties): In terms of leak detection, fittings and joints can be painted with a soap solution to
detect leaks, which will be indicated by a bubble formation.
10. STABILITY and REACTIVITY
STABILITY: Normally stable in gaseous state. Pure Hydrogen Cyanide is very unstable as it is sensitive to heat, light and moisture; however, due to the low
concentration of this component in the gas mixture, this is not a potential hazard.
DECOMPOSITION PRODUCTS: When heated to combustion, Hydrogen Cyanide emits toxic fumes of carbon monoxide, carbon dioxide and nitrogen oxides. Nitrogen
does not decompose, per se, but can react with other compounds in the heat of a fire.
MATERIALS WITH WHICH SUBSTANCE IS INCOMPATIBLE: Titanium will burn in Nitrogen (the main component of this gas mixture). Lithium reacts slowly with
Nitrogen at ambient temperatures. Hydrogen Cyanide will attack some forms of plastics and rubber. Hydrogen Cyanide can react with many other compounds, but not
usually violently unless the other chemical is also highly reactive.
HAZARDOUS POLYMERIZATION: Will not occur. Hydrogen Cyanide may polymerize explosively; however, due to the low concentration of this component in the gas
mixture, this is not a potential hazard.
CONDITIONS TO AVOID: Contact with incompatible materials. Cylinders exposed to high temperatures or direct flame can rupture or burst.
11. TOXICOLOGICAL INFORMATION
TOXICITY DATA: The following toxicology data are available for the components of this gas mixture:
HYDROGEN CYANIDE:
TCLo (Inhalation-Man) 500 mg/m3/3 minutescontinuous: Sense Organs and Special
Senses (Eye): mydriasis (pupillary dilation);
Behavioral: coma; Lungs, Thorax, or
Respiration: respiratory depression
LCLo (Inhalation-Human) 120 mg/m3/1hour
LCLo (Inhalation-Human) 200 mg/m3/10
minutes: Behavioral: general anesthetic;
Lungs, Thorax, or Respiration: dyspnea;
Gastrointestinal: nausea or vomiting
LCLo (Inhalation-Man) 400 mg/m3/2 minutes
LDLo (Oral-Human) 570 µg/kg
LDLo (Subcutaneous-Human) 1 mg/kg
LDLo (Unreported-Man) 1471 µg/kg
TDLo (Intravenous-Man) 55 µg/kg: Lungs,
Thorax, or Respiration: respiratory stimulation
LC50 (Inhalation-Rat) 160 ppm/30 minutes
LC50 (Inhalation-Mouse) 323 ppm/5 minutes
LDLo (Subcutaneous-Frog) 60 mg/kg
LDLo (Subcutaneous-Pigeon) 2150 µg/kg
LDLo (Oral-Rabbit) 4 mg/kg
LDLo (Oral-Dog) 4 mg/kg
LDLo (Oral-Pig) 2 mg/kg
LDLo (Oral-Pigeon) 14 mg/kg
NON-FLAMMABLE GAS MIXTURE MSDS - 50024
PN 3485
LC50 (Inhalation-Rabbit) 208 mg/m3/35 minutes:
Brain and Coverings: other degenerative
changes; Cardiac: other changes; Blood:
other changes
HYDROGEN CYANIDE (continued):
LD50 (Intravenous-Rat) 810 µg/kg
LD50 (Oral-Mouse) 3700 µg/kg
LD50 (Intraperitoneal-Mouse) 2990 µg/kg
LD50 (Intraperitoneal-Rabbit) 1570 µg/kg
LD50 (Intravenous-Mouse) 990 µg/kg
LD50 (Intravenous-Dog) 1340 µg/kg
LD50 (Intravenous-Cat) 810 µg/kg
LD50 (Intravenous-Rabbit) 660 µg/kg
LD50 (Intravenous-Guinea Pig) 1430 µg/kg
LD50
(Intravenous-Mammal-domestic)
660
µg/kg
LD50 (Intramuscular-Mouse) 2700 µg/kg
LD50 (Intramuscular-Rabbit) 486 µg/kg
LD50 (Intravenous-Monkey) 1300 µg/kg
LD50 (Subcutaneous-Rabbit) 2500 µg/kg
LD50 (Ocular-Rabbit) 1040 µg/kg: Sense
Organs and Special Senses (Eye): effect, not
otherwise specified; Behavioral: ataxia;
Lungs, Thorax, or Respiration: respiratory
stimulation
LCLo (Inhalation-Mammal-species unspecified)
200 ppm/5 minutes
LCLo (Inhalation-Mammal-species unspecified)
36 ppm/2 hours
HYDROGEN CYANIDE (continued):
LDLo (Subcutaneous-Mouse) 3 mg/kg
LDLo (Subcutaneous-Dog) 1700 µg/kg
LDLo (Subcutaneous-Cat) 1100 µg/kg
LDLo (Subcutaneous-Guinea Pig) 100 µg/kg
LDLo (Oral-Duck) 3280 µg/kg
LDLo (Intramuscular-Pigeon) 1500 µg/kg
LDLo (Oral-Bird-Domestic) 600 µg/kg
LDLo (Oral-Bird-wild bird species) 7500 µg/kg
LDLo (Subcutaneous-Bird-wild bird species)
100 µg/kg
LDLo (Subcutaneous-Bird-domestic) 100 µg/kg
NITROGEN: There are no specific toxicology
data for Nitrogen. Nitrogen is a simple
asphyxiant, which acts to displace oxygen in
the environment.
EFFECTIVE DATE: JUNE 7, 2010
PAGE 3 OF 5
11. TOXICOLOGICAL INFORMATION (Continued)
SUSPECTED CANCER AGENT: The components of this gas mixture are not found on the following lists: FEDERAL OSHA Z LIST, NTP,
CAL/OSHA, and IARC; therefore, they are not considered to be, nor suspected to be, cancer-causing agents by these agencies.
IRRITANCY OF PRODUCT: Hydrogen Cyanide (a component of this gas mixture) may be irritating to contaminated eyes.
SENSITIZATION TO THE PRODUCT: The components of this gas mixture are not known to cause sensitization in humans.
REPRODUCTIVE TOXICITY INFORMATION: Listed below is information concerning the effects of this gas mixture and its components on the
human reproductive system.
Mutagenicity: No mutagenicity effects have been described for this gas mixture.
Embryotoxcity: No embryotoxic effects have been described for this gas mixture.
Teratogenicity: No teratogenicity effects have been described for this gas mixture.
Reproductive Toxicity: No reproductive toxicity effects have been described for gas mixture.
A mutagen is a chemical which causes permanent changes to genetic material (DNA) such that the changes will propagate through generation
lines. An embryotoxin is a chemical which causes damage to a developing embryo (i.e. within the first eight weeks of pregnancy in humans), but
the damage does not propagate across generational lines. A teratogen is a chemical which causes damage to a developing fetus, but the damage
does not propagate across generational lines. A reproductive toxin is any substance which interferes in any way with the reproductive process.
BIOLOGICAL EXPOSURE INDICES (BEIs): Currently, Biological Exposure Indices (BEIs) are not applicable for the components of this gas
mixture.
12. ECOLOGICAL INFORMATION
ENVIRONMENTAL STABILITY: The gas will be dissipated rapidly in well-ventilated areas. The following environmental data are applicable to the
components of this gas mixture.
HYDROGEN CYANIDE:
Terrestrial Fate: By analogy to the fate of cyanides in water, it is predicted that the fate in soil would be pH dependent. Cyanide may occur in the
form of hydrogen cyanide, alkali metal salts, or immobile metallo-cyanide complexes. At soil surfaces with pH < 9.2, it is expected that
volatilization of Hydrogen Cyanide would be an important loss mechanism for cyanides. In subsurface soil, cyanide present at low concentrations
would probably biodegrade. In soil with pH < 9.2, Hydrogen Cyanide is expected to be highly mobile, and in cases where cyanide levels are toxic
to microorganisms (i.e., landfills, spills), this compound may leach into groundwater.
Atmospheric Fate: The reaction of Hydrogen Cyanide with photochemically generated hydroxyl radicals proceeds fairly slowly. Based on a reaction
rate constant of 3x10-14 cu m/(molecules-sec) at 25°C, and assuming an ambient hydroxyl radical concentration of 8x10+5 molecules/cu m, the
half-life for the reaction of hydrogen cyanide vapor with hydroxyl radicals in the atmosphere has been approximately 334 days. Hydrogen Cyanide
is expected to be resistant to direct photolysis. The relatively slow rate of degradation of Hydrogen Cyanide suggests that this compound has the
potential to be transported over long distances before being removed by physical or chemical processes. Since hydrogen cyanide is miscible in
water, it appears that wet deposition may be an important fate process. Metal cyanide particles are expected to be removed from air by both wet
and dry deposition.
Aquatic Fate: Hydrogen cyanide is not expected to adsorb to suspended solids and sediment in water. Volatilization from water surfaces is
expected based upon a Henry's Law constant of 1.33X10-4 atm-cu m/mole. Using this Henry's Law constant and an estimation method,
volatilization half-lives for a model river and model lake are 3 hours and 3 days, respectively. According to a classification scheme(4), an
estimated BCF of 3, from its log Kow of -0.25 and a regression-derived equation, suggests the potential for bioconcentration in aquatic organisms
is low. Hydrogen Cyanide can be biodegraded by acclimated microbial cultures and sludges, but is usually toxic at high concentrations to unacclimated microbial systems.
Bioconcentration: Cyanide compounds are not accumulated or stored in any mammalian species that have been studied. An estimated BCF of 3
was calculated for Hydrogen Cyanide, using a log Kow of -0.25 and a regression-derived equation. According to a classification scheme, this BCF
suggests the potential for bioconcentration in aquatic organisms is low.
NITROGEN: Water Solubility = 2.4 volumes Nitrogen/100 volumes water at 0°C. 1.6 volumes Nitrogen/100 volumes water at 20°C.
EFFECT OF MATERIAL ON PLANTS or ANIMALS: Due to the presence of Hydrogen Cyanide, this gas mixture may be harmful to over-exposed
plant or animal life.
EFFECT OF CHEMICAL ON AQUATIC LIFE: The Hydrogen Cyanide component of this gas mixture is soluble in water and highly toxic; therefore,
this gas mixture may be harmful or fatal to aquatic life in contaminated bodies of water. The following are aquatic toxicity data for the Hydrogen
Cyanide component of this gas mixture:
HYDROGEN CYANIDE:
LTC (Asellus communis) 10-12 days = 1.90 mg/L
LTC (Gammarus pseudolimnaeus) 10-12 days =
0.07 mg/L
Toxic (trout) 0.10 to 0.15 mg/L
IC50 (Daphnia) 48 hours = 1.8 mg/L
LC50 (Asellus communis) 96 hours = 2.29 mg/L
LC50 (Gammarus pseudolimnaeus) 96 hours = 0.17
mg/L
LC50 (pinperch) 24 hours = 0.069 mg/L
LC50 (sunfish)
24 hours = 0.18 mg/L
LC50 (pinperch in seawater) 24 hours = 0.05 mg/L
LTC,F (bluegill, eggs) 96 hours = 535-693 mg/L
LC50,F (bluegill swim-up fry) 96 hours = 232-365
mg/L
LC50,F (bluegill juvenile) 96 hours = 75-125 mg/L
LC50,F (Perca flavescens yellow perch eggs) 96
hours = > 276-> 389 mg/L
LC50,F (Perca flavescens yellow perch swim-up fry)
96 hours = 295-> 395 mg/L
LC50,F (Perca flavescens yellow perch juvenile) 96
hours =76-108 mg/L
LC50,F (brook trout, eggs) 96 hours = > 212-> 242
mg/L
LC50,F (brook trout, sac fry) 96 hours = 108-518
mg/L
HYDROGEN CYANIDE (continued):
LC50,F (brook trout, swim-up fry) 96 hours = 56-106
mg/L
LC50,F (brook trout, juvenile) 96 hours = 53-143
mg/L
LC50,F (Pimephales promelas fathead minnow,
eggs) 96 hours = 121-352 mg/L
LC50,F (Pimephales promelas fathead minnow,
juvenile) 96 hours = 82-137 mg/L
LC50,F (Pimephales promelas fathead minnow,
juvenile wild stock) 96 hours = 157–191 mg/L
LC50 (Goniobasis livescens snail) 48 hours =
760,000 µg/L/Conditions of bioassay not
specified
LC50 (Lymnaea emarginata snail) 48 hours = 3,300
µg/L/Conditions of bioassay not specified
LC50 (Lymnaea sp, snail, embryo) 96 hours =
51,900 µg/L
LC50 (Physa integra snail) 48 hours = 1,350
µg/L/Conditions of bioassay not specified
LC50 (Stemonema rubrum mayfly) 48 hours = 500
µg/L/Conditions of bioassay not specified
LC50 (Hyfropsyche sp caddis fly) 48 hours = 2,000
µg/L/Conditions of bioassay not specified
HYDROGEN CYANIDE (continued):
LC50 (Salmo gairdneri rainbow trout) 48 hours = 68
µg/L/Conditions of bioassay not specified
LC50 (Pimephales promelas fathead minnow) 48
hours = 240 µg/L/Conditions of bioassay not
specified
LC50 (Pimephales promelas fathead minnow,
juvenile) 5 days = 20 µg/L/Conditions of
bioassay not specified
LC50 (Pimephales promelas fathead minnow,
juvenile) 96 hours = 123 µg/L/Conditions of
bioassay not specified
LC50 (Lepomis macrochirus bluegill, juvenile) 48
hours = 134 µg/L/Conditions of bioassay not
specified
LC50 (Lepomis macrochirus bluegill, juvenile) 72
hours = 154 µg/L/Conditions of bioassay not
specified
LC50 (Lepomis macrochirus bluegill) 48 hours =
160 µg/L/Conditions of bioassay not specified
LC50, (Perca flavescens yellow perch, embryo) 96
hours = 281 µg/L, Conditions of bioassay not
specified
13. DISPOSAL CONSIDERATIONS
PREPARING WASTES FOR DISPOSAL PREPARING WASTES FOR DISPOSAL: Waste disposal must be in accordance with appropriate
Federal, State, and local regulations. Cylinders with undesired residual product may be safely vented outdoors with the proper regulator. For
further information, refer to Section 16 (Other Information).
14. TRANSPORTATION INFORMATION
THIS GAS MIXTURE IS HAZARDOUS AS DEFINED BY 49 CFR 172.101 BY THE U.S. DEPARTMENT OF TRANSPORTATION.
PROPER SHIPPING NAME:
Compressed gases, n.o.s. (Hydrogen Cyanide, Nitrogen)
HAZARD CLASS NUMBER and DESCRIPTION: 2.2 (Non-Flammable Gas)
UN IDENTIFICATION NUMBER:
UN 1956
PACKING GROUP:
Not applicable.
DOT LABEL(S) REQUIRED:
Non-Flammable Gas
NORTH AMERICAN EMERGENCY RESPONSE GUIDEBOOK NUMBER (2000): 126
MARINE POLLUTANT: The components of this gas mixture are not classified by the DOT as Marine Pollutants (as defined by 49 CFR 172.101,
Appendix B).
SPECIAL SHIPPING INFORMATION: Cylinders should be transported in a secure position, in a well-ventilated vehicle. The transportation of
compressed gas cylinders in automobiles or in closed-body vehicles can present serious safety hazards. If transporting these cylinders in
vehicles, ensure these cylinders are not exposed to extremely high temperatures (as may occur in an enclosed vehicle on a hot day).
Additionally, the vehicle should be well-ventilated during transportation.
Note: DOT 39 Cylinders ship in a strong outer carton (overpack). Pertinent shipping information goes on the outside of the overpack. DOT 39
Cylinders do not have transportation information on the cylinder itself.
TRANSPORT CANADA TRANSPORTATION OF DANGEROUS GOODS REGULATIONS: This gas is considered as Dangerous Goods, per
regulations of Transport Canada.
PROPER SHIPPING NAME:
Compressed gases, n.o.s. (Hydrogen Cyanide, Nitrogen)
NON-FLAMMABLE GAS MIXTURE MSDS - 50024
PN 3485
EFFECTIVE DATE: JUNE 7, 2010
PAGE 4 OF 5
14. TRANSPORTATION INFORMATION (Continued)
HAZARD CLASS NUMBER and DESCRIPTION:
2.2 (Non-Flammable Gas)
UN IDENTIFICATION NUMBER:
UN 1956
PACKING GROUP:
Not Applicable
HAZARD LABEL:
Class 2.2 (Non-Flammable Gas)
SPECIAL PROVISIONS:
None
EXPLOSIVE LIMIT AND LIMITED QUANTITY INDEX:
0.12
ERAP INDEX:
None
PASSENGER CARRYING SHIP INDEX:
None
PASSENGER CARRYING ROAD VEHICLE OR PASSENGER CARRYING RAILWAY VEHICLE INDEX: 75
NORTH AMERICAN EMERGENCY RESPONSE GUIDEBOOK NUMBER (2000): 121
NOTE: Shipment of compressed gas cylinders via Public Passenger Road Vehicle is a violation of Canadian law (Transport Canada
Transportation of Dangerous Goods Act, 1992).
15. REGULATORY INFORMATION
ADDITIONAL U.S. REGULATIONS:
U.S. SARA REPORTING REQUIREMENTS: This gas mixture is subject to the reporting requirements of Sections 302, 304, and 313 of Title III of
the Superfund Amendments and Reauthorization Act, as follows:
CHEMICAL NAME
SARA 302
(40 CFR 355, Appendix A)
SARA 304
(40 CFR Table 302.4)
SARA 313
(40 CFR 372.65)
YES
YES
YES
Hydrogen Cyanide
U.S. SARA SECTION 302 EXTREMELY HAZARDOUS SUBSTANCE THRESHOLD PLANNING QUANTITY: Hydrogen Cyanide = 100 lb (45.4
kg)
U.S. SARA SECTION 304 EXTREMELY HAZARDOUS SUBSTANCE REPORTABLE QUANTITY: Hydrogen Cyanide = 10 lb (4.54 kg)
U.S. TSCA INVENTORY STATUS: The components of this gas mixture are listed on the TSCA Inventory.
U.S. CERCLA REPORTABLE QUANTITY (RQ): Hydrogen Cyanide = 10 lb (4.54 kg)
OTHER U.S. FEDERAL REGULATIONS:
• Hydrogen Cyanide is subject to the requirements of CFR 29 1910.1000 (under the 1989 PELs). Hydrogen Cyanide is listed on Table Z.1.
• Hydrogen Cyanide is subject to the reporting requirements of Section 112(r) of the Clean Air Act. The Threshold Quantity for this gas is 2,500
lb (1135 kg).
•
Depending on specific operations involving the use of Hydrogen Cyanide, the regulations of the Process Safety Management of Highly
Hazardous Chemicals may be applicable (29 CFR 1910.119). Hydrogen Cyanide is listed in Appendix A of this regulation. The threshold
quantity for Hydrogen Cyanide under this regulation is 1,000 pounds.; therefore, the requirements of this regulation are not applicable to one
cylinder of this gas mixture.
• This gas mixture does not contain any Class I or Class II ozone depleting chemicals (40 CFR Part 82).
• Nitrogen is not listed as a Regulated Substance, per 40 CFR, Part 68, of the Risk Management for Chemical Releases. Hydrogen Cyanide is
listed under Table 1 as a Regulated Toxic Substance; the threshold quantity for Hydrogen Cyanide under this regulation is 2,500 pounds.
U.S. STATE REGULATORY INFORMATION: The components of this gas mixture are covered under the following specific State regulations:
Alaska - Designated Toxic and Hazardous
Substances: Hydrogen Cyanide.
California - Permissible Exposure Limits for
Chemical Contaminants: Nitrogen, Hydrogen
Cyanide.
Florida - Substance List: Oxygen, Hydrogen
Cyanide.
Illinois - Toxic Substance List:
Hydrogen
Cyanide.
Kansas - Section 302/313 List: No.
Massachusetts - Substance List:
Oxygen,
Hydrogen Cyanide.
Michigan - Critical Materials Register: No.
Minnesota - List of Hazardous Substances:
Hydrogen Cyanide.
Missouri
Employer
Information/Toxic
Substance List: Hydrogen Cyanide.
New Jersey - Right to Know Hazardous
Substance List: Oxygen, Nitrogen, Hydrogen
Cyanide.
North Dakota - List of Hazardous Chemicals,
Reportable Quantities: No.
Pennsylvania - Hazardous Substance List:
Oxygen, Nitrogen, Hydrogen Cyanide.
Rhode Island - Hazardous Substance List:
Oxygen, Nitrogen, Hydrogen Cyanide.
Texas - Hazardous Substance List: Hydrogen
Cyanide.
West Virginia - Hazardous Substance List:
Hydrogen Cyanide.
Wisconsin - Toxic and Hazardous Substances:
Hydrogen Cyanide.
CALIFORNIA SAFE DRINKING WATER AND TOXIC ENFORCEMENT ACT (PROPOSITION 65): No component of this gas mixture is on the
California Proposition 65 lists.
ADDITIONAL CANADIAN REGULATIONS:
CANADIAN DSL/NDSL INVENTORY STATUS: The components of this gas mixture are listed on the DSL Inventory.
CANADIAN ENVIRONMENTAL PROTECTION ACT (CEPA) PRIORITIES SUBSTANCES LISTS: The components of this gas mixture are not on
the CEPA Priorities Substances Lists.
CANADIAN WHMIS CLASSIFICATION: This gas mixture is categorized as a Controlled Product, Hazard Classes A and D2B, as per the
Controlled Product Regulations.
16. OTHER INFORMATION
INFORMATION ABOUT DOT-39 NRC (Non-Refillable Cylinder) PRODUCTS
DOT 39 cylinders ship as hazardous materials when full. Once the cylinders are relieved of pressure (empty) they are not considered
hazardous material or waste. Residual gas in this type of cylinder is not an issue because toxic gas mixtures are prohibited. Calibration gas
mixtures typically packaged in these cylinders are Nonflammable n.o.s., UN 1956. A small percentage of calibration gases packaged in DOT
39 cylinders are flammable or oxidizing gas mixtures.
For disposal of used DOT-39 cylinders, it is acceptable to place them in a landfill if local laws permit. Their disposal is no different than that
employed with other DOT containers such as spray paint cans, household aerosols, or disposable cylinders of propane (for camping, torch
etc.). When feasible, we recommended recycling for scrap metal content. CALGAZ will do this for any customer that wishes to return
cylinders to us prepaid. All that is required is a phone call to make arrangements so we may anticipate arrival. Scrapping cylinders involves
some preparation before the metal dealer may accept them. We perform this operation as a service to valued customers who want to
participate.
MIXTURES: When two or more gases or liquefied gases are mixed, their hazardous properties may combine to create additional, unexpected
hazards. Obtain and evaluate the safety information for each component before you produce the mixture. Consult an Industrial Hygienist or other
trained person when you make your safety evaluation of the end product. Remember, gases and liquids have properties which can cause serious
injury or death. Further information about the handling of compressed gases can be found in the following pamphlets published by: Compressed Gas
Association Inc. (CGA), 1725 Jefferson Davis Highway, Suite 1004, Arlington, VA 22202-4102. Telephone: (703) 412-0900.
P-1
“Safe Handling of Compressed Gases in Containers”
AV-1
“Safe Handling and Storage of Compressed Gases”
“Handbook of Compressed Gases”
PREPARED BY:
CHEMICAL SAFETY ASSOCIATES, Inc.
PO Box 3519, La Mesa, CA 91944-3519
619/670-0609
Fax on Demand:
1-800/231-1366
This Material Safety Data Sheet is offered pursuant to OSHA’s Hazard Communication Standard, 29 CFR, 1910.1200. Other government regulations must be reviewed for
applicability to this gas mixture. To the best of CALGAZ knowledge, the information contained herein is reliable and accurate as of this date; however, accuracy, suitability or
completeness are not guaranteed and no warranties of any type, either express or implied, are provided. The information contained herein relates only to this specific product.
If this gas mixture is combined with other materials, all component properties must be considered. Data may be changed from time to time. Be sure to consult the latest
edition.
NON-FLAMMABLE GAS MIXTURE MSDS - 50024
PN 3485
EFFECTIVE DATE: JUNE 7, 2010
PAGE 5 OF 5
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