MSDS for Benzene

MSDS for Benzene
MATERIAL SAFETY DATA SHEET
Prepared to U.S. OSHA, CMA, ANSI and Canadian WHMIS Standards
1. PRODUCT IDENTIFICATION
CHEMICAL NAME; CLASS:
NON-FLAMMABLE GAS MIXTURE
Containing One or More of the Following Components in a Nitrogen
Balance Gas: Benzene, 0.0005-0.005%; Oxygen, 0-23.5%
SYNONYMS: Not Applicable
U.N. NUMBER: UN 1956
Document Number: 50059
CHEMICAL FAMILY NAME: Not Applicable
FORMULA: Not Applicable
U.N. DANGEROUS GOODS CLASS/SUBSIDIARY RISK: 2.2 (Non-Flammable Gas)
Note: The Material Safety Data Sheet is for this gas mixture supplied in both refillable and non-refillable cylinders with 33 cubic feet (935 liters) or less gas
capacity (DOT - 39 cylinders). This MSDS has been developed for various gas mixtures with the composition of components within the ranges listed in Section
3 (Composition and Information on Ingredients). Refer to the product label for information on the actual composition of the product.
PRODUCT USE:
U.S. SUPPLIER/MANUFACTURER'S NAME:
ADDRESS:
BUSINESS PHONE:
General MSDS Information:
Fax on Demand:
EMERGENCY PHONE:
Chemtrec: United States/Canada/Puerto Rico:
Chemtrec International:
Calibration of Monitoring and Research Equipment
CALGAZ
821 Chesapeake Drive
Cambridge, MD 21613
1-410-228-6400 (8 a.m. to 5 p.m. U.S. EST)
1-713-868-0440
1-800-231-1366
1-800-424-9300 [24-hours]
1-703-527-3887 [24-hours]
NOTE: ALL Canadian WHMIS required information is included in appropriate sections based on the ANSI Z400.1-2004 format. This product has been classified in
accordance with the hazard criteria of the CPR and the MSDS contains all the information required by the CPR.
2. HAZARD IDENTIFICATION
EMERGENCY OVERVIEW: Product Description: This is a colorless, odorless gas mixture. Health Hazards: Since the
possible level of Oxygen in this mixture may be either below or at the breathable level, releases of this gas mixture may
produce oxygen-deficient atmospheres (especially in confined spaces or other poorly-ventilated environments); individuals in
such atmospheres may be asphyxiated. This gas mixture may cause adverse health effects due to the presence of Benzene,.
Benzene, is a known human carcinogen and a possible human mutagen. Inhalation of vapors of Benzene can cause central
nervous system effects and serious, permanent damage to the blood system (even at relatively low concentrations). Rapidly
released gas can cause frostbite. Flammability Hazards: This gas is non-flammable and will not support combustion. A
moderate cylinder rupture hazard exists when this gas mixture, which is under pressure, is subject to heat or flames.
Reactivity Hazards: This gas mixture is not reactive. Environmental Hazards: Release of this gas mixture is not expected
to cause harm to the environment or to plants and animals, except for possible frost and freezing from rapid release of a
cylinder. Emergency Response Procedures: Emergency responders must wear the proper personal protective equipment
suitable for the situation to which they are responding. WARNING - If rescue personnel need to enter an area suspected of
having a low level of Oxygen, they should be equipped with Self-Contained Breathing Apparatus (SCBA).
3. COMPOSITION and INFORMATION ON INGREDIENTS
Chemical Name
Chemical Formula
CAS #
% Composition
Benzene
C6H6
71-43-2
0.0005-0.005%
Oxygen
O2
7782-44-7
0.0-23.0%
Nitrogen
N2
7727-37-9
Balance
4. FIRST-AID MEASURES
RESCUERS SHOULD NOT ATTEMPT TO RETRIEVE VICTIMS OF EXPOSURE TO THIS GAS MIXTURE WITHOUT
ADEQUATE PERSONAL PROTECTIVE EQUIPMENT. At a minimum, Self-Contained Breathing Apparatus must be worn.
No unusual health effects are anticipated after exposure to this gas mixture, due to the small cylinder size. If any adverse
symptom develops after over-exposure to this gas mixture, remove victim(s) to fresh air as quickly as possible. Only trained
personnel should administer supplemental oxygen and/or cardio-pulmonary resuscitation if necessary. Contaminated person(s)
who experience any adverse effect after over-exposure to this gas mixture must be taken for medical attention. Rescuers should
be taken for medical attention if necessary. Take a copy of the label and the MSDS to physician or other health professional with
victim(s).
MEDICAL CONDITIONS AGGRAVATED BY EXPOSURE: Acute or chronic respiratory conditions or central nervous system
disorders may be aggravated by over-exposure to this gas mixture. Due to the presence of Benzene, exposure to this gas mixture
may aggravate central nervous system and blood conditions.
RECOMMENDATIONS TO PHYSICIANS: Administer oxygen, if necessary; treat symptoms and eliminate exposure. Treat
symptoms and eliminate overexposure. Refer to the OSHA Benzene Standard (29 CFR 1910.1028; paragraph (i) and Appendix C)
for specific information on Medical Surveillance requirements (i.e. for the general physical exam, medical history, specific tests and
re-examination protocol).
5. FIRE-FIGHTING MEASURES
FLASH POINT: Not applicable.
AUTOIGNITION TEMPERATURE: Not applicable.
NFPA RATING
FLAMMABLE LIMITS (in air by volume, %):
F LAMM ABIL ITY
Upper (UEL): Not applicable.
Lower (LEL): Not applicable.
FIRE EXTINGUISHING MATERIALS: Non-flammable gas mixture. Use
0
extinguishing media appropriate for surrounding fire.
FIRE EXTINGUISHING MATERIALS NOT TO BE USED: None known.
0
HEAL TH
2
INSTABIL ITY
UNUSUAL FIRE AND EXPLOSION HAZARDS: This gas mixture is not
flammable; however, containers, when involved in fire, may rupture or burst in
the heat of the fire. Fire-fighters should be aware of the presence of Benzene in
this gas mixture, which can cause significant health effects.
Explosion Sensitivity to Mechanical Impact: Not sensitive.
OT HER
Explosion Sensitivity to Static Discharge: Not sensitive.
SPECIAL FIRE-FIGHTING PROCEDURES: Structural fire-fighters must wear
Self-Contained Breathing Apparatus and full protective equipment. If water is not available for cooling or protection of cylinder
exposures, evacuate the area.
NON-FLAMMABLE GAS MIXTURE MSDS - 50059
EFFECTIVE DATE: FEBRUARY 16, 2011
PAGE 1 OF 6
6. ACCIDENTAL RELEASE MEASURES
LEAK RESPONSE: Due to the small size and content of the cylinder, an accidental release of this gas mixture presents
significantly less risk of an oxygen deficient environment and other safety hazards than a similar release from a larger cylinder.
However, as with any chemical release, extreme caution must be used during emergency response procedures. In the event of a
release in which the atmosphere is unknown, and in which other chemicals are potentially involved, evacuate immediate area.
Such releases should be responded to by trained personnel using pre-planned procedures. Proper protective equipment should
be used. In case of a leak, clear the affected area, protect people, and respond with trained personnel. Allow the gas mixture to
dissipate. If necessary, monitor the surrounding area (and the original area of the release) for oxygen. Oxygen levels must be
above 19.5% before non-emergency personnel are allowed to re-enter area.
If leaking incidentally from the cylinder, contact your supplier.
7. HANDLING and USE
WORK PRACTICES AND HYGIENE PRACTICES: Be aware of any signs of dizziness or fatigue; exposures to fatal
concentrations of this gas mixture could occur without any significant warning symptoms, due to oxygen deficiency. Do not attempt
to repair, adjust, or in any other way modify the cylinders containing this gas mixture. If there is a malfunction or another type of
operational problem, contact nearest distributor immediately. Note: Refer to the OSHA Benzene Standard (29 CFR 1910.1028)
for specific requirements associated with the use of this product. The Action Level for Benzene is 0.5 ppm as an 8-hour, timeweighted average. In workplaces where employees are exposed above the Action Level, the OSHA requirements for monitoring,
establishment of regulated areas, methods of compliance, respiratory protection, emergency response protocol, medical
surveillance, training and record keeping must be followed.
STORAGE AND HANDLING PRACTICES: Entrances to regulated areas (as defined by the OSHA Benzene Standard) must be
posted with signs which read as follows:
DANGER
BENZENE
CANCER HAZARD
AUTHORIZED PERSONNEL ONLY
Cylinders should be firmly secured to prevent falling or being knocked-over. Cylinders must be protected from the environment,
and preferably kept at room temperature (approximately 21°C [70°F]). Cylinders should be stored in dry, well-ventilated areas,
away from sources of heat, ignition, and direct sunlight. Protect cylinders against physical damage. Full and empty cylinders
should be segregated. Use a first-in, first-out inventory system to prevent full containers from being stored for long periods of time.
These cylinders are not refillable. WARNING! Do not refill DOT 39 cylinders. To do so may cause personal injury or
property damage.
SPECIAL PRECAUTIONS FOR HANDLING GAS CYLINDERS: WARNING! Compressed gases can present significant safety
hazards. During cylinder use, use equipment designed for these specific cylinders. Ensure all lines and equipment is rated for
proper service pressure.
SPECIFIC USE(S): This product is for use in various industries. Follow all industry standards for use.
PROTECTIVE PRACTICES DURING MAINTENANCE OF CONTAMINATED EQUIPMENT: Follow practices indicated in Section
6 (Accidental Release Measures). Make certain that application equipment is locked and tagged-out safely. Always use product in
areas where adequate ventilation is provided.
8. EXPOSURE CONTROLS - PERSONAL PROTECTION
VENTILATION AND ENGINEERING CONTROLS: No special ventilation systems or engineering controls are needed under
normal circumstances of use. As with all chemicals, use this gas mixture in well-ventilated areas. If this gas mixture is used in a
poorly-ventilated area, install automatic monitoring equipment to detect the levels of components and oxygen.
EXPOSURE LIMITS:
CHEMICAL
NAME
Benzene
CAS #
EXPOSURE LIMITS IN AIR
ACGIH-TLVs
71-43-2
OSHA-PELs
NIOSH-RELs
NIOSH
TWA
ppm
STEL
ppm
TWA
ppm
STEL
ppm
TWA
ppm
STEL
ppm
IDLH
ppm
0.5
2.5
1*
5*
0.1
1
500
See 29 CFR 1910.1028
*See Table Z-2 for Exclusions in 29
CFR 1910.1028
OTHER
ppm
DFG MAK: Skin
DFG MAK Germ Cell Mutagen Category: 3A
Carcinogen: EPA-K, IARC-1, MAK-1,
NIOSH-Ca, NTP-K, OSHA-Ca, TLV-A1
Oxygen
7782-44-7
There are no specific exposure limits for Oxygen. Oxygen levels should be maintained above 19.5%.
Nitrogen
7727-37-9
There are no specific exposure limits for Nitrogen. Nitrogen is a simple asphyxiant (SA). Oxygen levels should be maintained above
19.5%.
NE = Not Established.
The following information on appropriate Personal Protective Equipment is provided to assist employers in complying with OSHA
regulations found in 29 CFR Subpart I (beginning at 1910.132) and equivalent standards of Canada (including CSA Standard Z94.402 and CSA Standard Z94.3-07.. Please reference applicable regulations and standards for relevant details.
RESPIRATORY PROTECTION: No special respiratory protection is required under normal circumstances of use. Maintain
component levels below 50% of the TLVs of components (see previous page) and oxygen levels above 19.5% in the workplace.
Use supplied air respiratory protection when component levels exceed 50% of the TLV, oxygen levels are below 19.5%, or during
emergency response to a release of this gas mixture. During an emergency situation, before entering the area, check the
concentration of components and Oxygen. If necessary, use only respiratory protection authorized in the U.S. Federal OSHA
Respiratory Protection Standard (29 CFR 1910.134), equivalent U.S. State standards and Canadian CSA Standard Z94.4-02,
the. Oxygen levels below 19.5% are considered IDLH by OSHA. In such atmospheres, use of a full-facepiece pressure/demand
SCBA or a full facepiece, supplied air respirator with auxiliary self-contained air supply is required under OSHA’s Respiratory
Protection Standard (1910.134-1998). The following are NIOSH Respiratory Protective Equipment Guidelines for the Benzene
component:
BENZENE
CONCENTRATION
RESPIRATORY PROTECTION
At Concentrations Above the NIOSH REL, or Where There is no REL, at Any Detectable Concentration: Any Self-Contained
Breathing Apparatus (SCBA) that has a full facepiece and is operated in a pressure-demand or
other positive-pressure mode, or any Supplied-Air Respirator (SAR) that has a full facepiece and
is operated in a pressure-demand or other positive-pressure mode in combination with an
auxiliary SCBA operated in pressure-demand or other positive-pressure mode.
Escape:
Any Air-Purifying, Full-Facepiece Respirator (gas mask) with a chin-style, front- or back-mounted
organic vapor canister, or any appropriate escape-type, SCBA.
EYE PROTECTION: Safety glasses. If necessary, refer to U.S. OSHA 29 CFR 1910.133 or the Canadian CSA Standard
Z94.3-07.
HAND PROTECTION: Wear leather gloves when handling cylinders. Chemically resistant gloves should be worn when using this
gas mixture. Use triple gloves for spill response. If necessary, refer to U.S. OSHA 29 CFR 1910.138 or appropriate Standards
of Canada.
BODY PROTECTION: No special protection is needed under normal circumstances of use. If necessary, refer to appropriate
Standards of Canada. If a hazard of injury to the feet exists due to falling objects, rolling objects, where objects may pierce the
soles of the feet or where employee’s feet may be exposed to electrical hazards, use foot protection, as described in U.S. OSHA
29 CFR 1910.136 and the Canadian CSA Standard Z195-02, Protective Footwear.
NON-FLAMMABLE GAS MIXTURE MSDS - 50059
EFFECTIVE DATE: FEBRUARY 16, 2011
PAGE 2 OF 6
9. PHYSICAL and CHEMICAL PROPERTIES
The following information is for Nitrogen, the main component of this gas mixture.
GAS DENSITY @ 0°C and 1 atm: .072 lb./ ft3 (1.153 kg/m3)
BOILING POINT: -320.4°F (-195.8°C)
FREEZING/MELTING POINT @ 10 psig -210°C (-345.8°F)
pH: Not applicable.
SPECIFIC GRAVITY (air = 1) @ 21.1°C: 0.906
MOLECULAR WEIGHT: 28.01
SOLUBILITY IN WATER vol/vol @ 0°C and 1 atm: 0.023
EXPANSION RATIO: Not applicable.
3
EVAPORATION RATE (nBuAc = 1): Not applicable.
SPECIFIC VOLUME (ft /lb): 13.8
ODOR THRESHOLD: Not applicable. Odorless.
VAPOR PRESSURE @ 21.1°C psig: Not applicable.
COEFFICIENT WATER/OIL DISTRIBUTION: Not applicable.
The following information is for this gas mixture.
APPEARANCE AND COLOR: This product is a colorless, odorless gas mixture.
HOW TO DETECT THIS SUBSTANCE (warning properties): There are no distinct warning properties associated with a
release of this gas mixture.
10. STABILITY and REACTIVITY
STABILITY: Normally stable in gaseous state under conditions of normal temperature and pressure.
DECOMPOSITION PRODUCTS: Combustion: The thermal decomposition products of Benzene (a component of this product)
include toxic fumes of carbon monoxide, carbon dioxide, irritating aldehydes and ketones. The other components of this gas
mixture do not decompose, per se, but can react with other compounds in the heat of a fire. Hydrolysis: None known.
MATERIALS WITH WHICH SUBSTANCE IS INCOMPATIBLE: Titanium will burn in Nitrogen (the main component of this
product). Lithium reacts slowly with Nitrogen at ambient temperatures. Benzene is incompatible with strong oxidizing materials and
strong acids, and may attack rubber and plastics.
HAZARDOUS POLYMERIZATION: Will not occur.
CONDITIONS TO AVOID: Contact with incompatible materials. Cylinders exposed to high temperatures or direct flame can
rupture or burst.
11. TOXICOLOGICAL INFORMATION
SYMPTOMS OF OVEREXPOSURE BY ROUTE OF EXPOSURE: The most significant route of overexposure for this gas mixture
is by inhalation.
INHALATION: Due to the small size of an individual cylinder of this product, no unusual health effects from overexposure to the
product are anticipated under routine circumstances of use. A possible health effect associated with inhalation of this gas mixture
is the potential for exposures to Benzene. Long-term exposures to Benzene at relatively low vapor concentrations can cause
blood system disorders. There are reports that exposure to low levels (10 ppm) over an extended period (24 weeks) of Benzene
vapors can damage the bone marrow and blood systems. This damage can result in the development of serious health disorders
(including anemia and leukemia). Adverse health effects on the immune system have also been reported. Refer to “Other health
Effects” in this section for further information. The specific effects associated with various levels of Benzene vapors are as follows:
EFFECTS OF OVER-EXPOSURES TO BENZENE:
OBSERVED EFFECT
CONCENTRATION
Brief (10 minute) up to 25 ppm:
No symptoms.
50-150 ppm:
Exhilaration, headache, tiredness, nose and throat irritation.
Long term:
Can cause chronic blood abnormalities (chronic exposures of 30-200 ppm). Low chronic
exposures (<1.4 ppm) have not produced any blood effects.
Additionally, releases of this product may produce oxygen-deficient atmospheres (especially in small confined spaces or other
poorly-ventilated environments); individuals in such atmospheres may be asphyxiated.
OTHER POTENTIAL HEALTH EFFECTS: The chief target organ affected by serious exposure to Benzene, a component of this
product, is the blood and bone marrow system. Chronic Benzene exposure eventually leads to pancytopenia (abnormal decrease
of all three formed elements of the blood; hemoglobin, disease-fighting leukocytes and blood-clotting thrombocytes), followed by
thrombocytopenia (problems with the blood-clotting properties of the blood) and anemia. These syndromes can lead to sudden,
overwhelming infections. After over-exposure to Benzene, bleeding from the nose, gums, or mucous membranes and
development of small bruises can occur. Benzene is a known human carcinogen and can produce forms of leukemia.
HEALTH EFFECTS OR RISKS FROM EXPOSURE: An Explanation in Lay Terms. Overexposure to this gas mixture may
cause the following health effects:
ACUTE: Due to the small size of the individual cylinder of this product, no unusual health effects from exposure to the product are
anticipated under routine circumstances of use. Inhalation of this product’s vapors can cause headaches, nausea, dizziness, and
drowsiness. Severe inhalation overexposures may be fatal, due to asphyxiation.
CHRONIC: Chronic exposure to the Benzene component of this product causes serious damage to the health by all routes of
exposure. Chronic oral and inhalation exposure causes severe effects on the blood system (e.g., damage to the bone marrow).
Effects can occur with an exposure level as low as 10 ppm for 24 weeks. Benzene also causes harmful changes to the immune
system, decreasing the production of mature B- and T- white blood cells. Benzene is a confirmed human carcinogen, which can
produce Hodgkin’s Disease, leukemia and lymphomas by inhalation. Benzene is a potential reproductive toxin.
TARGET ORGANS: Acute: Respiratory system, central nervous system. Chronic: Reproductive system, blood system, immune
system.
TOXICITY DATA: The main component of this gas mixture, Nitrogen has no toxicity data as it is inert. The Oxygen component
has data, but these data are only related to inhalation of Oxygen in a hyperbaric environment, which is not applicable to use of this
gas mixture. Although the Benzene component is in less than 1% concentration, human data, and LD50 (Oral-Rat), LD50 (OralMouse), LC50 (Inhalation-Rat) and LC50 (Inhalation-Mouse) are provided for additional information in the use and handling of this
gas mixture.
BENZENE:
LDLo (Oral-Man) 50 mg/kg
LDLo (Oral-Human) 0.7 mL/kg
LDLo (Oral-Man) 50 mg/kg
LDLo (Unreported-Man) 194 mg/kg
LDLo (Unreported-Man) 194 mg/kg
LCLo (Inhalation-Human) 2 pph/5 minutes
LCLo (Inhalation-Human) 65 mg/m3/5 years: Blood:
other changes
LCLo (Inhalation-Human) 2 pph/5 minute
LCLo (Inhalation-Human) 65 mg/m3/5 years: Blood:
Other changes
LCLo (Inhalation-Human) 2 pph/2 minutes
LCLo (Inhalation-Human) 5 mg/m3/5 hours
TCLo (Inhalation-Man) 150 ppm/1 years-intermittent:
Blood: other changes; Nutritional and Gross
Metabolic: body temperature increase
TCLo (Inhalation-Man) 150 ppm/1 years-intermittent:
Blood: other changes; Nutritional and Gross
Metabolic: body temperature increase
TCLo (Inhalation-Human) 100 ppm: Behavioral:
somnolence
(general
depressed
activity);
Gastrointestinal: nausea or vomiting; Skin and
Appendages: dermatitis, other (after systemic
exposure)
BENZENE (continued):
TCLo (Inhalation-Human) 100 ppm: Behavioral:
somnolence
(general
depressed
activity);
Gastrointestinal: nausea or vomiting; Skin and
Appendages: dermatitis, other (after systemic
exposure)
TCLo (Inhalation-Human) 50 mg/m3/2 hours:
Behavioral: changes in psychophysiological tests,
muscle weakness
TCLo (Inhalation-Human) 75 mg/m3/2 hours: Blood:
changes in other cell count (unspecified), changes in
leukocyte (WBC) count
TCLo (Inhalation-Human) 200 mg/m3/78 weeksintermittent: Tumorigenic: carcinogenic by RTECS
criteria; Blood: leukemia, thrombocytopenia
TCLo (Inhalation-Human) 10 ppm/8 hours/10 yearsintermittent: Tumorigenic: carcinogenic by RTECS
criteria; Blood: leukemia
TC (Inhalation-Man) 600 mg/m3/4 years-intermittent:
Tumorigenic: carcinogenic by RTECS criteria;
Blood: leukemia
TC (Inhalation-Man) 150 ppm/11 years-intermittent:
Tumorigenic: carcinogenic by RTECS criteria;
Blood: lymphoma, including Hodgkin's disease
TC (Inhalation-Human) 150 ppm/15M/8 yearsintermittent: Tumorigenic: carcinogenic by RTECS
criteria; Blood: leukemia
NON-FLAMMABLE GAS MIXTURE MSDS - 50059
BENZENE (continued):
TC (Inhalation-Human) 8 ppb/4 weeks-intermittent:
Tumorigenic: carcinogenic by RTECS criteria;
Blood: leukemia
TC (Inhalation-Human) 10 mg/m3/11 years-intermittent:
Tumorigenic: carcinogenic by RTECS criteria;
Blood: leukemia
Open Irritation Test (Skin-Rabbit) 15 mg/24 hours: Mild
Open Irritation Test (Skin-Rat) 60 µL/8 hours: Mild
Standard Draize Test (Skin-Rabbit) 20 mg/24 hours:
Moderate
Standard Draize Test (Eye-Rabbit) 88 mg: Moderate
Standard Draize Test (Eye-Rabbit) 2 mg/24 hours:
Severe
LC50 (Inhalation-Rat) 10,000 ppm/7 hours
LC50 (Inhalation-Mouse) 9980 ppm: Behavioral: general
anesthetic, muscle weakness; Lungs, Thorax, or
Respiration: dyspnea
LD50 (Oral-Rat) 930 mg/kg: Behavioral: tremor;
Behavioral: convulsions or effect on seizure
threshold
LD50 (Oral-Rat) 1 mL/kg
LD50 (Oral-Rat) 1800 mg/kg
LD50 (Oral-Rat) 6400 mg/kg: Peripheral Nerve and
Sensation: recording from peripheral motor nerve;
Blood: changes in other cell count (unspecified),
changes in leukocyte (WBC) count
LD50 (Oral-Mouse) 4700 mg/kg
EFFECTIVE DATE: FEBRUARY 16, 2011
PAGE 3 OF 6
11. TOXICOLOGICAL INFORMATION (Continued)
CARCINOGENIC POTENTIAL OF COMPONENTS: The components of this product are listed by agencies tracking
the carcinogenic potential of chemical compounds as follows:
BENZENE: ACGIH-TLV-A1 (Confirmed human Carcinogen); EPA-K (Known Human Carcinogen); IARC-1 (Carcinogenic to Humans); MAK-1 (Substances that Cause Cancer
in Man and Can Be Assumed to Make a Significant Contribution to Cancer Risk); NIOSH-Ca (Potential Occupational Carcinogen with No Further Categorization); NTP-K
(Known to Be a Human Carcinogen); OSHA-Ca (Carcinogen Defined with No Further Categorization)
The remaining components of this product are not found on the following lists: U.S. EPA, U.S. NTP, U.S. OSHA, U.S. NIOSH,
GERMAN MAK, IARC, or ACGIH and therefore are neither considered to be nor suspected to be cancer-causing agents by
these agencies.
IRRITANCY OF PRODUCT: This gas mixture is not expected to be irritating to humans.
SENSITIZATION TO THE PRODUCT: The components of this gas mixture are not known to cause human skin or respiratory
sensitization.
REPRODUCTIVE TOXICITY INFORMATION: Listed below is information concerning the effects of the components this gas
mixture on the human reproductive system.
Mutagenicity: The trace Benzene component has been found to be mutagenic in studies of human tissues. Despite many
limitations, virtually all studies have found positive evidence of mutagenic effects in exposed workers, usually at exposure
levels that also produced changes to the blood system. Reports have included chromosomal aberrations in peripheral
lymphocytes, clastogenic (DNA) effects as well as damaged chromosomes in hematopoietic (blood-forming) cells.
Embryotoxicity: This gas mixture is not expected to cause embryotoxic effects in humans.
Teratogenicity: This gas mixture is not expected to cause teratogenic effects in humans due to the small cylinder size and small
total amount of all components. Teratogenic data are available from clinical studies involving test animals exposed to relatively
high doses of Benzene (a component of this product). Fetotoxic effects (i.e., reduced birth weight and/or minor skeletal
variations) were observed at exposures above 50 ppm.
Reproductive Toxicity: This gas mixture is not expected to cause adverse reproductive effects in humans. Data on reproductive
effects are available from clinical studies involving test animals exposed to relatively high doses to the following component of
this product: Benzene. These data were obtained at doses which caused toxic effects on other organs.
A mutagen is a chemical which causes permanent changes to genetic material (DNA) such that the changes will propagate through
generation lines. An embryotoxin is a chemical which causes damage to a developing embryo (i.e. within the first eight weeks of
pregnancy in humans), but the damage does not propagate across generational lines. A teratogen is a chemical which causes
damage to a developing fetus, but the damage does not propagate across generational lines. A reproductive toxin is any substance
which interferes in any way with the reproductive process.
ACGIH BIOLOGICAL EXPOSURE INDICES (BEIs): Currently, the following ACGIH Biological Exposure Indices (BEIs) are
applicable for the Benzene component of this gas mixture.
CHEMICAL:
DETERMINANT
SAMPLING TIME
Benzene
• S-Phenylmercapturic Acid in Urine
• t,t-Muconic Acid in Urine
BEI
• End of Shift
• End of Shift
• 25 µg/g Creatinine
• 500 µg/g Creatinine
12. ECOLOGICAL INFORMATION
ENVIRONMENTAL STABILITY: The gas will be dissipated rapidly in well-ventilated areas.
EFFECT OF MATERIAL ON PLANTS or ANIMALS: Any adverse effect on plants would be related to oxygen-deficient
environments or frost from rapidly expanding gases, unless exposure occurs in a confined space or potential toxicity of exposure to
Benzene. The following information is available on the potential plant toxicity of Benzene:
BENZENE:
Benzene is lethal to plants at high concentrations (GT 15600 ppm in air) and short (30 minutes) exposure times. In all species studied recovery was complete upon
removal from exposure to sub-lethal concentrations.
Plant growth and rooting is stimulated by aqueous solutions of low benzene concentrations (0.01-0.10 saturated). Aqueous solutions containing high concentrations
(0.10-0.15% Benzene) inhibit growth and interfere with metabolism and cell division
EFFECT OF CHEMICAL ON AQUATIC LIFE: Due to the presence of Benzene in this mixture, release near an aquatic
environment may cause harm. The following toxicological data are available for Benzene:
BENZENE:
LC50 (Palaemonetes pugio grass shrimp) 96 hours = 27 ppm/Conditions of bioassay
not specified
LC50 (Cancer magister crab larvae) stage 1, 96 hours = 108 ppm/Conditions of
bioassay not specified
LC50 (Crangon franciscorum shrimp) 96 hours = 20 mg/L/Conditions of bioassay not
specified
LC50 (Morone saxatilis bass) 96 hours = 5.8 to 11 mg/L/Conditions of bioassay not
specified
LC50 (Poecilia reticulata guppy) 14 days = 63 mg/L/Conditions of bioassay not
specified
LC50 (Salmo trutta brown trout yearlings) 1 hour = 12 mg/L (static bioassay)
LC50 (Ambystoma mexicanum Mexican axolotl) (3-4 wk after hatching) 48 hours =
370 mg/L/Conditions of bioassay not specified
LC50 (Clawed toad 3-4 wk after hatching) 48 hours = 190 mg/L/Conditions of
bioassay not specified
LC50 (Carassius auratus goldfish) 24 hours = 46 mg/L/Conditions of bioassay not
specified
LC50 (Lepomis macrochirus bluegill sunfish) 24-48 hours = 20 mg/L/Conditions of
bioassay not specified
BENZENE (continued):
LC50 (Brine shrimp) 24-48 hours = 66-21 mg/L/Conditions of bioassay not specified
LC50 (Pimephales promelas fathead minnow) 24-96 hours = 35 to 33 mg/L (soft
water) /Conditions of bioassay not specified
LC50 (Pimephales promelas fathead minnow) 24-96 hours = 24 to 32 mg/L (hard
water) /Conditions of bioassay not specified
LC50 (Bluegill) 24-96 hours = 22 mg/L (soft water) /Conditions of bioassay not
specified
LC50 (Carassius auratus goldfish) 24-96 hours = 34.4 mg/L (soft water) /Conditions of
bioassay not specified
TLm (Lebistes reticulata guppy) 24-96 hours = 36 mg/L (soft water) /Conditions of
bioassay not specified
LC50 (Gambusia affinis mosquito fish) 24-96 hours = 395 mg/L/Conditions of bioassay
not specified
LC100 (Tetrahymena pyriformis ciliate) 24 hours = 12.8 mmole/L/Conditions of
bioassay not specified
LD100 (Lepomis macrochirus bluegill sunfish) 24 hours = 34 mg/L/Conditions of
bioassay not specified
LD100 (Lepomis macrochirus bluegill sunfish) 2 hours = 60 mg/L/Conditions of
bioassay not specified
MOBILITY: Nitrogen and Oxygen do not present a hazard of mobility. For Benzene, an experimentally derived log Koc of 1.93
(Koc = 85) was obtained via reverse phase HPLC (High Performance Liquid Chromatography) with a cyanopropyl column and
a mobile phase of water. According to a classification scheme, this estimated Koc value suggests that Benzene is expected to
have high mobility in soil. The sorption equilibrium for Benzene in a soil/water mixture (ratio soil/water 0.12 kg/L) took 72 hours.
The Koc for Benzene has also been experimentally determined to be 79.
PERSISTENCE AND BIODEGRADABILITY: Persistence: Nitrogen and Oxygen are natural elements and present no hazard of
persistence. If released to air, a vapor pressure of 94.8 mm Hg at 25°C indicates Benzene will exist solely as a vapor in the
ambient atmosphere. Vapor-phase Benzene will be degraded in the atmosphere by reaction with photochemically-produced
hydroxyl radicals; the half-life for this reaction in air is estimated to be 13 days. Vapor-phase Benzene is also degraded by
ozone radicals and nitrate found in the atmosphere but at such low rates as to not be important. Since Benzene is very water
soluble, it may be removed from the atmosphere by rain. If released to soil, Benzene is expected to have high mobility based
upon a Koc of 85. Volatilization from moist soil surfaces is expected to be an important fate process based upon a Henry's
Law constant of 5.56X10-3 atm-cu m/mole. Benzene may volatilize from dry soil surfaces based upon its vapor pressure.
Benzene is expected to biodegrade in soils based on a biodegradation study in a base-rich para-brownish soil where 20 ppm
Benzene was 24% degraded in 1 week, 44% in 5 weeks, and 47% in 10 weeks. If released into water, Benzene is not
expected to adsorb to sediment and suspended solids in water based upon the Koc. Volatilization from water surfaces is
expected to be an important fate process based upon this compound's Henry's Law constant. Estimated volatilization half-lives
for a model river and model lake are 1 hr and 3.5 days, respectively. Biodegradation of Benzene in water is expected based
on an experiment using an enriched aerobic bacterial culture in which Benzene began to degrade 12 hrs after incubation in an
aqueous (soil-free) solution with 50% of Benzene degrading after 60 hrs and almost complete degradation within 90 hrs. In
aqueous solution, Benzene will react with hydroxyl radical (OH radical average concentration = 1.0X10-17 molec/cu cm) at a
reaction rate of 7.8X10+9 L/mol sec which results in an estimated half-life of 103 days. Hydrolysis is not expected to occur due
to the lack of hydrolyzable functional groups.
NON-FLAMMABLE GAS MIXTURE MSDS - 50059
EFFECTIVE DATE: FEBRUARY 16, 2011
PAGE 4 OF 6
12. ECOLOGICAL INFORMATION (Continued)
POTENTIAL TO BIOACCUMULATE: The Nitrogen and Oxygen components of this gas mixture will not bioaccumulate.
Benzene has a BCF ranging from 1.1-20. According to a classification scheme, this BCF suggests the potential for
bioconcentration in aquatic organisms is low. The uptake and elimination rate constants for Benzene in fathead minnows were
studied. Fathead minnows were found to have an average uptake rate of 7 L/kg/hr with an average elimination rate of 0.384/hr
which corresponds to a BCF of 19. In a study of BCF values for various aquatic species, Benzene was found to have a BCF
value of 3.5 in eels, 4.4 in pacific herring, and 4.3 in goldfish.
OZONE-DEPLETION POTENTIAL: Components are not Class I or Class II ozone depleting chemicals (40 CFR Part 82). A
photochemical model was used to quantify the sensitivity of the tropospheric oxidants Ozone (O3) and Hydroxide Ion (OH-) to
changes in Methane (CH4), Carbon Monoxide (CO), and Nitric Oxide (NO) emissions and to perturbations in climate and
stratospheric chemistry. In most cases, increased CH4 and CO emissions will suppress OH- (negative coefficients) in
increased O3 (positive coefficients) except in areas where NO and O3 influenced by pollution are sufficient to increased OH-. In
most regions, NO, CO, and CH4 emission increase will suppress OH- and increase O3, but these trends may be opposed by
stratospheric O3 depletion and climate change.
ENVIRONMENTAL EXPOSURE CONTROLS: Controls should be engineered to prevent release to the environment,
including procedures to prevent spills, atmospheric release and release to waterways.
13. DISPOSAL CONSIDERATIONS
PREPARING WASTES FOR DISPOSAL PREPARING WASTES FOR DISPOSAL: Waste disposal must be in accordance with
appropriate Federal, State, and local regulations. Cylinders with undesired residual product may be safely vented outdoors with
the proper regulator. For further information, refer to Section 16 (Other Information).
14. TRANSPORTATION INFORMATION
U.S. DEPARTMENT OF TRANSPORTATION REGULATIONS: This gas mixture is classified as dangerous goods, per U.S. DOT
regulations, under 49 CFR 172.101.
PROPER SHIPPING NAME:
Compressed gases, n.o.s. (Nitrogen, Oxygen)
HAZARD CLASS NUMBER and DESCRIPTION:
2.2 (Non-Flammable Gas)
UN IDENTIFICATION NUMBER:
UN 1956
PACKING GROUP:
Not applicable.
DOT LABEL(S) REQUIRED:
Class 2.2 (Non-Flammable Gas)
NORTH AMERICAN EMERGENCY RESPONSE GUIDEBOOK NUMBER (2008): 126
MARINE POLLUTANT: The components of this gas mixture are not classified by the DOT as Marine Pollutants (as defined by
49 CFR 172.101, Appendix B).
SPECIAL SHIPPING INFORMATION: Cylinders should be transported in a secure position, in a well-ventilated vehicle. The
transportation of compressed gas cylinders in automobiles or in closed-body vehicles can present serious safety hazards. If
transporting these cylinders in vehicles, ensure these cylinders are not exposed to extremely high temperatures (as may occur
in an enclosed vehicle on a hot day). Additionally, the vehicle should be well-ventilated during transportation.
Note: DOT 39 Cylinders ship in a strong outer carton (outer package). Pertinent shipping information goes on the outside of the
outer package. DOT 39 Cylinders do not have transportation information on the cylinder itself.
TRANSPORT CANADA TRANSPORTATION OF DANGEROUS GOODS REGULATIONS: This gas is classified as Dangerous
Goods, per regulations of Transport Canada.
PROPER SHIPPING NAME:
Compressed gases, n.o.s. (Nitrogen, Oxygen)
HAZARD CLASS NUMBER and DESCRIPTION:
2.2 (Non-Flammable Gas)
UN IDENTIFICATION NUMBER:
UN 1956
PACKING GROUP:
Not Applicable
HAZARD LABEL:
Class 2.2 (Non-Flammable Gas)
SPECIAL PROVISIONS:
None
EXPLOSIVE LIMIT AND LIMITED QUANTITY INDEX: 0.12
ERAP INDEX:
None
PASSENGER CARRYING SHIP INDEX:
None
PASSENGER CARRYING ROAD VEHICLE OR PASSENGER CARRYING RAILWAY VEHICLE INDEX: 75
NORTH AMERICAN EMERGENCY RESPONSE GUIDEBOOK NUMBER (2008): 126
NOTE: Shipment of compressed gas cylinders via Public Passenger Road Vehicle is a violation of Canadian law (Transport
Canada Transportation of Dangerous Goods Act, 1992).
INTERNATIONAL AIR TRANSPORT ASSOCIATION SHIPPING INFORMATION (IATA): This gas mixture is classified as
Dangerous Goods, per the International Air Transport Association.
UN IDENTIFICATION NUMBER:
UN 1956
PROPER SHIPPING NAME:
Compressed gases, n.o.s. (Nitrogen, Oxygen)
HAZARD CLASS NUMBER and DESCRIPTION:
2.2 (Non-Flammable Gas)
HAZARD LABEL(S) REQUIRED:
Class 2.2 (Non-Flammable Gas)
PACKING GROUP:
None
PASSENGER & CARGO AIRCRAFT LIMITED QUANTITY PACKING INSTRUCTION: None
PASSENGER & CARGO AIRCRAFT LIMITED QUANTITY MAXIUMUM NET QUANTITY/PKG: None
PASSENGER & CARGO AIRCRAFT PACKING INSTRUCTION: 200
PASSENGER & CARGO AIRCRAFT MAXIUMUM NET QUANTITY/PKG: 75 kg
CARGO AIRCRAFT ONLY PACKING INSTRUCTION: 200
CARGO AIRCRAFT ONLY MAXIUMUM NET QUANTITY/PKG: 150 kg
SPECIAL PROVISIONS: None
ERG CODE: 2L
15. REGULATORY INFORMATION
ADDITIONAL U.S. REGULATIONS:
U.S. SARA REPORTING REQUIREMENTS: Benzene is subject to the reporting requirements of Sections 302, 304 and 313 of
Title III of the Superfund Amendments and Reauthorization Act, as follows:
CHEMICAL NAME
Benzene
SARA 302
(40 CFR 355, Appendix A)
SARA 304
(40 CFR Table 302.4)
SARA 313
(40 CFR 372.65)
No
No
Yes
U.S. SARA 302 EXTREMELY HAZARDOUS THRESHOLD PLANNING QUANTITY (TPQ): Not applicable.
U.S. SARA 304 EXTREMELY HAZARDOUS REPORTABLE QUANTITY (RQ): Not applicable.
U.S. CERCLA REPORTABLE QUANTITY (RQ): Benzene = 10 lb (4.54 kg)
U.S. TSCA INVENTORY STATUS: The components of this gas mixture are listed on the TSCA Inventory.
U.S. EPA CLEAN WATER ACT SECTIONS 301, 307, AND 311: Benzene is a toxic pollutant designated pursuant to section
307(a)(1) of the Federal Water Pollution Control Act and is subject to effluent limitations. Benzene is designated as a
hazardous substance under section 311(b)(2)(A) of the Federal Water Pollution Control Act and further regulated by the Clean
Water Act Amendments of 1977 and 1978. These regulations apply to discharges of this substance. This designation includes
any isomers and hydrates, as well as any solutions and mixtures containing this substance.
NON-FLAMMABLE GAS MIXTURE MSDS - 50059
EFFECTIVE DATE: FEBRUARY 16, 2011
PAGE 5 OF 6
15. REGULATORY INFORMATION (Continued)
ADDITIONAL U.S. REGULATIONS (continued):
U.S. EPA LIST OF REGULATED TOXIC SUBSTANCES AND THRESHOLD QUANTITIES FOR ACCIDENTAL RELEASE
PREVENTION- Table 1 to §68.130: Not applicable.
U.S. EPA REGULATED SUBSTANCES, PER 40 CFR, PART 68, OF THE RISK MANAGEMENT FOR CHEMICAL RELEASES:
Benzene is listed under this regulation in Table 3 as a Regulated Substance (Flammable Substances), in quantities of 10,000 lb.
(4,553 kg) or greater, and so this mixture will not be affected by the regulation.
CLEAN AIR ACT SECTION 112(r)- Table 3 to §68.130: Benzene is listed as a hazardous air pollutant (HAP) generally known
or suspected to cause serious health problems. The Clean Air Act, as amended in 1990, directs EPA to set standards requiring
major sources to sharply reduce routine emissions of toxic pollutants. EPA is required to establish and phase in specific
performance based standards for all air emission sources that emit one or more of the listed pollutants. Benzene is included on
this list.
OTHER U.S. FEDERAL REGULATIONS:
• This gas mixture does not contain any Class I or Class II ozone depleting chemicals (40 CFR part 82).
• Benzene is subject to the requirements of CFR 29 1910.1000. Benzene is listed on Table Z.2.
• Benzene is subject to the requirements of CFR 29 1910.1028, the OSHA Benzene Standard. The Action Level for Benzene is
0.5 ppm as an 8-hour, time-weighted average under this regulation.
CALIFORNIA SAFE DRINKING WATER AND TOXIC ENFORCEMENT ACT (PROPOSITION 65): The Benzene component of
this gas mixture is on the California Proposition 65 lists. WARNING! This product contains a chemical known to the State of
California to cause birth defects or other reproductive harm.
ADDITIONAL CANADIAN REGULATIONS:
CANADIAN DSL/NDSL INVENTORY STATUS: The components of this gas mixture are listed on the DSL Inventory.
CANADIAN DSL/NDSL INVENTORY STATUS: The components of this product are on the Canadian DSL Inventory.
OTHER CANADIAN REGULATIONS: Not applicable.
CANADIAN ENVIRONMENTAL PROTECTION ACT (CEPA) PRIORITIES SUBSTANCES LISTS: The Benzene component of
this gas mixture is on the first Priority Substances List (PSL1) of the CEPA.
CANADIAN WHMIS CLASSIFICATION: This gas mixture is categorized as a Controlled Product, Hazard Classes A and D2A, as
per the Controlled Product Regulations.
GREENHOUSE GASES KYOTO PROTOCOL: Not applicable.
CANADIAN WHMIS SYMBOLS:
16. OTHER INFORMATION
INFORMATION ABOUT DOT-39 NRC (Non-Refillable Cylinder) PRODUCTS
DOT 39 cylinders ship as hazardous materials when full. Once the cylinders are relieved of pressure (empty) they are not considered
hazardous material or waste. Residual gas in this type of cylinder is not an issue because toxic gas mixtures are prohibited. Calibration gas
mixtures typically packaged in these cylinders are Non-flammable n.o.s., UN 1956. A small percentage of calibration gases packaged in DOT
39 cylinders are flammable or oxidizing gas mixtures.
For disposal of used DOT-39 cylinders, it is acceptable to place them in a landfill if local laws permit. Their disposal is no different than that
employed with other DOT containers such as spray paint cans, household aerosols, or disposable cylinders of propane (for camping, torch
etc.). When feasible, we recommended recycling for scrap metal content. Calgaz will do this for any customer that wishes to return cylinders
to us prepaid. All that is required is a phone call to make arrangements so we may anticipate arrival. Scrapping cylinders involves some
preparation before the metal dealer may accept them. We perform this operation as a service to valued customers who want to participate.
MIXTURES: When two or more gases or liquefied gases are mixed, their hazardous properties may combine to create additional, unexpected
hazards. Obtain and evaluate the safety information for each component before you produce the mixture. Consult an Industrial Hygienist or
other trained person when you make your safety evaluation of the end product. Remember, gases and liquids have properties which can
cause serious injury or death.
Further information about the handling of compressed gases can be found in the following pamphlets published by: Compressed Gas
th
Association Inc. (CGA), 421 Walney Road, 5 Floor, Chantilly, VA 20151. Telephone: (703) 788-2700, Fax: (703) 961-1831.
P-1 “Safe Handling of Compressed Gases in Containers”
AV-1 “Safe Handling and Storage of Compressed Gases”
“Handbook of Compressed Gases”
This Material Safety Data Sheet is offered pursuant to OSHA’s Hazard Communication Standard, 29 CFR, 1910.1200. Other government regulations must be
reviewed for applicability to this gas mixture. To the best of Calgas’ knowledge, the information contained herein is reliable and accurate as of this date;
however, accuracy, suitability or completeness are not guaranteed and no warranties of any type, either express or implied, are provided. The information
contained herein relates only to this specific product. If this gas mixture is combined with other materials, all component properties must be considered. Data
may be changed from time to time. Be sure to consult the latest edition.
NON-FLAMMABLE GAS MIXTURE MSDS - 50059
EFFECTIVE DATE: FEBRUARY 16, 2011
PAGE 6 OF 6
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