ITC 4000 Whole Blood CO-Oximeter Operator's and Service Manual
The AVOXimeter 4000 is intended for professional use in settings in which rapid, accurate measurements are needed of the total hemoglobin concentration and the relative concentrations of oxy-, carboxy-, and methemoglobin. Direct analyte values are obtained in 10 seconds. In addition, oxygen content (O2Ct) is automatically calculated and available on the printout and data output.
The AVOXimeter 4000 is a light-weight, portable instrument that is calibrated at the factory prior to shipment. Optical technology (patent pending) and disposable cuvettes enable the AVOXimeter 4000 to make its measurements six to ten times faster than standard co-oximeters and eliminate the extensive care associated with their use.
No sample preparation is required. Analysis is quickly accomplished by injecting the whole blood sample into a disposable cuvette and inserting the cuvette into the instrument. The AVOXimeter 4000 then illuminates the sample with multiple wavelengths, records the optical absorbance of the sample at each wavelength, and computes the results. In 10 seconds, the total hemoglobin concentration and the relative concentrations of oxy-, carboxy- and methemoglobin are shown in appropriate units on the liquid-crystal display on the front panel.
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U.S. Patent No. 5,430,542, 6,262,798 and 6,519,025 and Euro/UK Patent 0663070
Operator's and Service Manual
Operator's and Service Manual
Table of Contents
Topic Page
General Precautions 3
Introduction to the AVOXimeter 4000 4
System Components 5
Getting Started 7
Keypad Overview 8
Installation and Operation 9
Software Features 10
Sample Collection and Preparation 1
Sample Analysis 13
Sample Printouts 15
Settings 16
Computer key Settings 16
Main Menu key Settings 3
Calibration and Quality Control 8
Optical QC Filters 8
Liquid QC 30
Proficiency Testing 31
Maintenance 3
Theory of Measurement 35
Troubleshooting 37
Specifications 42
Appendix A: Printer Information 43
Appendix B: Menu Flowcharts 44
Appendix C: ASTM Output 51
Warranty and Service 55
Appendix D: Circuit Diagrams 56
Index 61
R ev 9.06
3
1. Do not allow untrained or an unauthorized personnel to use this instru-
ment.
. This instrument will give accurate readings only if the cuvettes are at
room temperaure and the temperature probe is near the cuvettes.
3. Do not attempt to use this instrument outside the recommended tempera-
ture range: 15°C - 30°C (59°F - 86°F). Do not place this instrument in air
currents or thermally unstable surroundings. Do not warm the cuvettes in
your hand.
4. Do not allow blood, water, or other liquids to enter the instrument itself.
5. Cuvettes are not sterile. Blood exposed to the cuvette should not be
returned to the patient.
6. Do not re-use the cuvettes; discard after each use.
7. Always keep cuvettes in sealed bag with desiccant.
8. When filling cuvette, do not use excessive pressure or cause the vent
patch to bulge outward. Do not insert a cuvette if the vent patch pro-
trudes; discard it.
9. Do not leave a cuvette in the oximeter. Remove the cuvette as soon as
the sample has been analyzed.
10. For proper calibration, use only the hemoglobin controls recommended in
this manual. Controls from other sources yield erroneous results.
11. Use this instrument only with the AC adapter (battery charger) supplied
by ITC.
12. Do not use this instrument in the presence of flammable agents or anes-
thetics.
13. Operator should take appropriate precautions when handling potentially
infectious blood samples.
General
Precautions
2
!
1. Do not allow untrained or an unauthorized personnel to use this instru-
ment.
. This instrument will give accurate readings only if the cuvettes are at
room temperaure and the temperature probe is near the cuvettes.
3. Do not attempt to use this instrument outside the recommended tempera-
ture range: 15°C - 30°C (59°F - 86°F). Do not place this instrument in air
currents or thermally unstable surroundings. Do not warm the cuvettes in
your hand.
4. Do not allow blood, water, or other liquids to enter the instrument itself.
5. Cuvettes are not sterile. Blood exposed to the cuvette should not be
returned to the patient.
6. Do not re-use the cuvettes; discard after each use.
7. Always keep cuvettes in sealed bag with desiccant.
8. When filling cuvette, do not use excessive pressure or cause the vent
patch to bulge outward. Do not insert a cuvette if the vent patch pro-
trudes; discard it.
9. Do not leave a cuvette in the oximeter. Remove the cuvette as soon as
the sample has been analyzed.
10. For proper calibration, use only the hemoglobin controls recommended in
this manual. Controls from other sources yield erroneous results.
11. Use this instrument only with the AC adapter (battery charger) supplied
by ITC.
12. Do not use this instrument in the presence of flammable agents or anes-
thetics.
13. Operator should take appropriate precautions when handling potentially
infectious blood samples.
General
Precautions
2
!
4
The AVOXimeter 4000 is intended for professional use in settings in which rapid, ac-
curate measurements are needed of the total hemoglobin concentration and the rela-
tive concentrations of oxy-, carboxy-, and methemoglobin. Direct analyte values are
obtained in 10 seconds. In addition, oxygen content (OCt) is automatically calculated
and available on the printout and data output.
The AVOXimeter 4000 is a light-weight, portable instrument that is calibrated at the
factory prior to shipment. Optical technology (patent pending) and disposable cuvettes
enable the AVOXimeter 4000 to make its measurements six to ten times faster than
standard co-oximeters and eliminate the extensive care associated with their use.
No sample preparation is required. Analysis is quickly accomplished by injecting the
whole blood sample into a disposable cuvette and inserting the cuvette into the instru-
ment. The AVOXimeter 4000 then illuminates the sample with multiple wavelengths,
records the optical absorbance of the sample at each wavelength, and computes the
results. In 10 seconds, the total hemoglobin concentration and the relative concentra-
tions of oxy-, carboxy- and methemoglobin are shown in appropriate units on the liquid-
crystal display on the front panel.
The total hemoglobin concentration measured by the AVOXimeter 4000 includes oxy-,
deoxy-, met- and carboxyhemoglobin:
tHb = [OHb] + [HHb]+ [MetHb] + [COHb]
Accordingly, the percentage of oxyhemoglobin reported by the AVOXimeter 4000 is
The fractions of carboxy- and methemoglobin are defined in a similar manner.
In the U.S., the AVOXimeter is classified as "moderately complex" under the CLIA
test categorization.
[OHb] +[HHb]+ [MetHb] + [COHb]
[OHb] x 100
%OHb =
Introduction
NOTE
The AVOXimeter 4000 is intended for professional use in settings in which rapid, ac-
curate measurements are needed of the total hemoglobin concentration and the rela-
tive concentrations of oxy-, carboxy-, and methemoglobin. Direct analyte values are
obtained in 10 seconds. In addition, oxygen content (OCt) is automatically calculated
and available on the printout and data output.
The AVOXimeter 4000 is a light-weight, portable instrument that is calibrated at the
factory prior to shipment. Optical technology (patent pending) and disposable cuvettes
enable the AVOXimeter 4000 to make its measurements six to ten times faster than
standard co-oximeters and eliminate the extensive care associated with their use.
No sample preparation is required. Analysis is quickly accomplished by injecting the
whole blood sample into a disposable cuvette and inserting the cuvette into the instru-
ment. The AVOXimeter 4000 then illuminates the sample with multiple wavelengths,
records the optical absorbance of the sample at each wavelength, and computes the
results. In 10 seconds, the total hemoglobin concentration and the relative concentra-
tions of oxy-, carboxy- and methemoglobin are shown in appropriate units on the liquid-
crystal display on the front panel.
The total hemoglobin concentration measured by the AVOXimeter 4000 includes oxy-,
deoxy-, met- and carboxyhemoglobin:
tHb = [OHb] + [HHb]+ [MetHb] + [COHb]
Accordingly, the percentage of oxyhemoglobin reported by the AVOXimeter 4000 is
The fractions of carboxy- and methemoglobin are defined in a similar manner.
In the U.S., the AVOXimeter is classified as "moderately complex" under the CLIA
test categorization.
[OHb] +[HHb]+ [MetHb] + [COHb]
[OHb] x 100
%OHb =
Introduction
NOTE
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Key Features
- Rapid, accurate hemoglobin measurements
- Direct analyte values in 10 seconds
- Optical technology
- Disposable cuvettes
- Lightweight, portable
- No sample preparation required
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Frequently Answers and Questions
What is the purpose of the AVOXimeter 4000?
The AVOXimeter 4000 is designed for professional use in settings where rapid and accurate measurements of total hemoglobin concentration and relative concentrations of oxy-, carboxy-, and methemoglobin are needed.
How fast does the AVOXimeter 4000 produce results?
The AVOXimeter 4000 provides direct analyte values in just 10 seconds.
What is the advantage of using disposable cuvettes with the AVOXimeter 4000?
Disposable cuvettes eliminate the extensive care and maintenance associated with traditional co-oximeters, allowing for faster and more efficient measurements.
Does the AVOXimeter 4000 require any sample preparation?
No, the AVOXimeter 4000 does not require any sample preparation. Simply inject the whole blood sample into a disposable cuvette and insert it into the instrument.
What kind of samples can be analyzed with the AVOXimeter 4000?
The AVOXimeter 4000 can analyze whole blood samples collected in sodium or lithium heparinized plastic syringes.
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