UNICORN 7.1 Software Change Description

UNICORN

™

7.1

Software Change Description

1 Introduction

1 Introduction

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5

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This document describes the major implemented changes and improvements in UNICORN since UNICORN 6.2.

It contains the following sections:

Chapter Description

UNICORN 7.1 vs UNICORN 7.0.2

UNICORN 7.0.2 vs UNICORN 7.0.1

UNICORN 7.0.1 vs UNICORN 7.0




UNICORN 6.3.2 vs UNICORN 6.3.1


UNICORN 6.3 vs UNICORN 6.2

2 UNICORN 7.1 Software Change Description 29203965 AB

2 UNICORN 7.1 vs UNICORN 7.0.2


Operating systems and UNICORN database version

For information about compatibility between UNICORN versions and the supported operating systems and database versions see the UNICORN compatibility matrix at http://www.gelifesciences.com/UNICORNcompatibility.

Support for filtration applications

Two workflows are added to the Evaluation module to support results analysis from filtration applications, using the following algorithms:

• Any versus any algorithm provides the capability to plot any process parameters captured as curves from a filtration run. The algorithm can be used to graphically display data from any two curves generated during concentration, diafiltration or processing of cells.

• Normalized Water Flux (NWF) algorithm used to test membrane permeability. The test allows to automatically calculate the normalized water flux from a result file, and also to view results from multiple cycles in a single plot. This helps to ensure that the cleaning process is effective and to determine the lifetime of a filter.

Monitor run in Column Volume

(CV)

When the column volume is specified, the progress of a run in the System Control module can be monitored in CV both in the chromatogram, in Run Data and in the Run

Log.

UNICORN 7.1 Software Change Description 29203965 AB 3


Flow rate in CV/h (Column flow)

UNICORN 7.1 adds functionality which simplifies scaling of methods when using columns with different bed height, as well as functionality for easy comparison of results run on different systems. UNICORN 7.1 has a new flow unit in CV/h, which can be used in System

Control and when creating methods in the Method Editor. This flow is referred to as column flow and has a functionality similar to the existing linear flow (cm/h).

When using the column flow the residence time is kept even when scaling of methods using columns with different bed height.

Compare UV data generated with

UV cells of different path length

In the Evaluation module, it is possible to normalize the UV curves in a result to make them appear as if they were detected by a UV cell with 1 cm UV path length. This simplifies comparison of results generated using different systems.

Calculate amount and concentration for legacy systems

UNICORN 7.1 provides support to calculate amount and concentration for results from older systems, by allowing the user to manually enter the UV path length where this is not provided by the system.


3 UNICORN 7.0.2 vs UNICORN 7.0.1


Operating systems

The UNICORN 7.0.2 Client and Instrument Server is verified on the following operating system:

• Windows

®

7 Professional with SP1 installed, 32-bit and 64-bit

• Windows 10 Professional 64-bit

UNICORN database version

SQL Server

® gram.

Express 2014 SP1 is installed by default by UNICORN 7.0.2 installation pro-

Secure Windows Active

Directory

®

communication

UNICORN 7.0.2 offers secure Windows Active Directory communication for user authentication. Windows Active Directory must be configured for secure communication.

For more information see UNICORN Hardening Guide.

Secure database communication

UNICORN 7.0.2 offers secure database communication with an option to use trusted certificates.

For more information see UNICORN Hardening Guide.

Change database password

The default database passwords for UNICORN is changed targeting security issues.

UNICORN can now be configured to use a new database password.

It is possible to generate an encrypted password or to enter an already encrypted password. This is done by running the UNICORN Service Tool after UNICORN installation.

See UNICORN Service Tool User Manual for details on how to configure UNICORN to use the new database password.


6


Support for scouting on Frac-950

The possibility to set up scouting runs on specific fractionation parameters with Frac-

950.

Corrections and improvements

The following corrections and improvements are implemented in UNICORN 7.0.2:

• Possibility to include snapshots in time base in reports.

• Linear flow is now handled correct when saving text edited phases to phase library.

When such phase is added to another method using another column the same linear flow rate will be kept.

• Text wrapping is implemented in scouting header for long variable names.

• Possibility to define separate filters in System control for the Run log and the Run log curve.

• Correct calculation of Run summary when method contains watches.

• Possibility to change scouting for parameters set to OFF that have drop down lists, e.g. pump wash parameters.

• Corrected defect related to Curve export in Evaluation Classic when data reduction is selected.

• Corrected defect related to Curve export in Evaluation Classic when Normalize retention is selected.

• Import of methods and result from UNICORN 5 has improved with possibility to import the following:

Methods including messages with character “#”.

Methods containing blocks with more than one End_block instruction.

Results that contains a date and time with indication of summer or standard time.

Results that contain signed questions.

UNICORN 7.1 Software Change Description 29203965 AB

4 UNICORN 7.0.1 vs UNICORN 7.0



The UNICORN 7.0.1 Client and Instrument Server is verified on the following operating system:

• Windows 7 Professional with SP1 installed, 32-bit and 64-bit

SQL Server

®

The UNICORN database is verified for:

• SQL Server 2008 R2, 32-bit and 64-bit, running on Windows

®

7 Professional with

SP1 installed, 32-bit and 64-bit

• SQL Server 2012 with SP2 installed, 64-bit, running on Windows Server

®

2012 R2

• SQL Server 2014, 64-bit, running on Windows Server 2012 R2

Compatible systems

Compatibility with the ÄKTA™ ready system is implemented in UNICORN 7.0.1.

E-mail notifications

The functionality of sending e-mail notifications from UNICORN 7.0.1 is improved. It is now possible to send e-mail notifications about an event (alarm, warning, or error) that has been issued on the system, to the following persons:

• User who started the run

• User who currently has control of the system

• Optional e-mail receiver (type the appropriate e-mail address in the input field)

The users must define their e-mail addresses in the user profile to be able to receive the e-mail notifications.

Follow the instructions to enable notifications for alarms, warnings and errors.



Step

1

Action

In the System Control module, on the System menu, click Notification Set-

tings.

Result: The Notification Settings dialog box opens.

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2 Select one or more of the available check boxes:

• User that started the run

• User in control of the system

• Enter optional email addresses. Type in one or more e-mail addresses in the empty text field. Separate multiple addresses with a semicolon.

Select for which occurrences notifications should be sent in the Notification

on check boxes.

Click Test Notification E-mail to test if the e-mail settings are correct.

Click OK.

Folder access rights

The user access rights in UNICORN 7.0.1 are specified as follows:

• All users who have access to a folder can read and write to the folder.

• All users who have access to a folder can rename items in the folder.



• To overwrite an item or to delete an item, the user must have the appropriate access rights specified. The administrator must select the check box Delete/Move files &

folders to give the user these rights.

The user access rights described above are valid for both the user's home folder and for shared folders.

The access category Delete/copy/move files & folders has been renamed to Delete/Move

files & folders to reflect the changes in folder access rights.

New upgrade procedure from

UNICORN 6.0 or 6.1

You must have the UNICORN 6.0 or UNICORN 6.1 installation disks to uninstall these older versions of UNICORN.

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Step

1

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Action

Backup the database as described in UNICORN Administration and Technical

Manual.

Insert the UNICORN 6.0 or UNICORN 6.1 installation DVD in your DVD drive.

Result: The UNICORN Installation wizard opens with a welcome dialog box.

Tip:

If the DVD drive is not set up to allow automatic start, browse the DVD contents and double-click the file Setup.exe

in the UNICORN folder to initiate the installation.

Click Remove Installation and proceed to uninstall the old UNICORN version.

Install the newer UNICORN version as described in UNICORN Administration

and Technical Manual, but do not define a system or import any column lists, report formats or recipes since the backup performed in Step 1 will be restored later on.

Install the workstation e-license on the instrument server computer as described in UNICORN Administration and Technical Manual.

Uninstall the oldest version of OPC Core Components from the Windows

Uninstall or change a program dialog box and repair the latest version.

To open the Uninstall or change a program dialog box:

• In Control Panel, in the Programs group, click Uninstall a program.



Step

7

8

Action

Restore the database backup as described in UNICORN Administration and

Technical Manual.

Note:

The default backup location has changed since the old UNICORN version so the old database backup might have to be moved into the new backup location. Run a manual backup as described in the to create this location.

Upgrade the database as described in UNICORN Administration and Technical

Manual.



• Various memory and performance defects have been corrected.

• Adjustable timeout has been implemented.




In this chapter

Section

5.1 Operating Systems

5.2 New Evaluation module

5.3 Optional Evaluation Classic module

5.4 OPC certification

5.5 Corrections and improvements

See page

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5.1

Operating Systems

UNICORN 7.0 is verified for the following operating systems:

• Windows 7 (Professional with SP1 installed, 32-bit and 64-bit)

The SQL database is verified for:

• Windows Server 2008 R2

5.2

New Evaluation module

UNICORN 7.0.2 includes a default Evaluation module that provides a simplified user interface optimized for most commonly used workflows like quick evaluation, compare results and work with peaks and fractions.

General

• New user interface with instant visual feedback that supports common workflows such as:

Quick evaluation.

Compare results.

Work with peaks and fractions.

• Undo in several steps.



5.2 New Evaluation module

Peak area calculation

• Calculate amount and concentration in peaks.

• Align peaks to fractions.

• Integration window with improved baseline.

• Auto integration/Single click integration.

Results

• New result browser with quick filter and sorting options.

• Result preview in result browser.

Chart

• Right y-axis in chart.

• Display method information in chart:

Scouting variables.

Phases.

• Shift offset in both x and y direction.

• Zoom miniature displayed.

• Panning in zoomed chart.

• Change curve layout from context menu.

• Improved copy of chart.

• Easy curve selection.

Compare

• Compare in column volume unit.

• Compare results in overlay or tile view.

• Sort results on scouting variables to see trending.



5.3 Optional Evaluation Classic module

5.3

Optional Evaluation Classic module

The previous evaluation module has changed name to Evaluation Classic. To perform operations like DoE that are not included in the default Evaluation module, users can easily switch to Evaluation Classic. This is an optional module that requires an additional license.

5.4

OPC certification

UNICORN OPC server Data Access 2.05a and Data Access 3.0 have been certified by

OPC Foundation.

5.5

Corrections and improvements

The following corrections and improvements are implemented in UNICORN 7.0:

• Corrections of the LDAP functionality.

• Raw data status is now kept when performing Save as and Import result.

• Corrected Import curve from file function.

• Improved algorithm for display of data in volume base. Previously the curve could be jagged at low flow rates.

• Improved options for configuring archiving of results in enterprise solutions.




UNICORN Service Tool

The new application UNICORN Service Tool is used to troubleshoot and set parameters in an existing UNICORN installation. It can also be used to make sure that the operating system environment is properly set up prior to installing UNICORN.

DoE sweet spot plot

The new DoE evaluation function sweet spot plot graphically displays the range where two or more selected response criteria are satisfied.

Database connection status

A database connection status field is added to the status bar of the System Control module.

OPC certification

UNICORN OPC server Data Access 2.05a and Data Access 3.0 are certified by

OPC Foundation.





• Improved error handling when database connection is lost.

• Corrected peak detection algorithm. It is now possible to detect signal levels lower than the signal level at the start of detection.

• Corrected BufferPro recipe creation. It is now possible to select an Acid/Base when only one buffer substance is selected.

• Improvement of DoE re-randomize of experimental plan. If possible, system setup is kept when changing DoE response or factor settings.

• It is now possible to export methods or results to UNC path

(\\server\share\folder path).

• It is now possible to install a database when security policies forced passwords to be longer than 8 characters.


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Note: The SQL database is also verified for:

• Windows Server 2008 R2


Compatibility with the ÄKTA purifier system and the ÄKTA explorer system is implemented in UNICORN 6.4.

UNICORN extension framework

In UNICORN 6.4 it is possible to extend UNICORN with software packages for specific purposes, that is, extensions.

UNICORN extensions can be loaded into all UNICORN applications.

UNICORN database compatibility

After upgrading the UNICORN database to the database version that is delivered together with UNICORN 6.4 (database version 1.6.7), it is still possible to connect UNICORN 6.3.2

clients to the upgraded database.

Note: Future database versions will allow for minor upgrades of the database where the old clients does not have to be upgraded.




The following corrections and improvements are implemented in UNICORN 6.4:

• Major performance improvements of creating and editing large methods.

• Corrections in the Maintenance Manager dialog for UNIFLUX systems.

• Unable to view X-axis in CV in the Method Editor module.

• Improvements of the handling of the CompactFlash (CF) memory card of CU-960.

• The Maintenance Manager dialog support for ÄKTA explorer and ÄKTA purifier.

• Correction of the import of UNICORN 5 strategies.

• Correction of issues in the Method Wizard for ÄKTA explorer and ÄKTA purifier that occurred when using sample pump.

• CU-960 communication issues have been solved. Changes in the CU-950/960 software have been introduced to avoid short disconnects between the CU-950/960 and the UNICORN PC. This occurs mostly when starting a method or manual run after the system has been idle for several hours.

Note: It is recommended that the CF memory card is removed if System set-

tings:Generic:Data recovery:OFF is selected in the System Control module.


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UNICORN 6.3.2 is verified for the following operating systems:

• Windows XP (Professional with SP3 installed, 32-bit)



Compatibility with the ÄKTA pure system and the ReadyToProcess WAVE™ 25 bioreactor system is implemented in UNICORN 6.3.2.

Import and export of DoE results, method queues and folders

In UNICORN 6.3.2 it is possible to import and export Design of Experiments results, method queues and folders to and from a specified target system from the Method Ed-

itor module and the Evaluation module.

Support for cell cultivation

UNICORN 6.3.2 has support for control, supervision and evaluation of cell cultivation runs.



• Correction of the issue that it was not possible to access text methods in some results.

• Improvements of connection between UNICORN and UNICORN Instrument Server.





UNICORN 6.3.1 is verified for the following operating systems:



Corrections


• Retrieval of results from older UNICORN versions is supported.

• Pressure regulation functions when working from the Process picture.

• Shorter waiting time for starting a method queue.

• Method notes are saved in a method or result file.

• ÄKTA avant sample application phase works.


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10 UNICORN 6.3 vs UNICORN 6.2






Compatible system

Compatibility with the ÄKTA pure system is implemented in UNICORN 6.3.

Client and instrument server installation

For UNICORN 6.3 the client and the instrument server installations are no longer separated.

License handling

UNICORN 6.3 features a new solution for license handling. There are different types of e-licenses. A node locked license can be used on one workstation only and a floating license can be used on any workstation in a network, however only on one workstation at the time. Design of Experiments and Column handling require separate e-licenses.

Power-save

In UNICORN 6.3, it is possible to enable power-save for a connected ÄKTA pure system.

A time can be set for how long the instrument is in state Ready before power-save mode is entered.



E-mail notifications

UNICORN 6.3 features the possibility to make notification settings. If an alarm, a warning or an error occurs during a run, it is possible to get a notification sent to a specified e-mail address.

Column type filtration

It is possible to filtrate the column type list based on Technique, Diameter, Access label and/or Search criteria.

Process picture

UNICORN 6.3 has a new improved process picture applicable for ÄKTA pure, with the possibility to execute instructions directly from the process picture.

Performance test method layout

The layout of the performance test methods has been improved in UNICORN 6.3.

Adapt methods

UNICORN 6.3 features a new solution to automatically adapt a method when opening or saving it after change of active components for an ÄKTA pure system.


A number of corrections and improvements are implemented in UNICORN 6.3, including the following:

• Improved stability in the connection between the UNICORN Client and the ÄKTA system.

• Improved resource management and memory usage.

• Simplified installation and uninstallation of UNICORN.


For local office contact information, visit www.gelifesciences.com/contact

GE Healthcare Bio-Sciences AB

Björkgatan 30

751 84 Uppsala

Sweden www.gelifesciences.com/unicorn

GE, GE monogram, ÄKTA, ReadyToProcess WAVE and UNICORN are trademarks of General Electric Company.

Active Directory, SQL Server, Windows and Windows Server are registered trademarks of Microsoft Corporation.

All other third party trademarks are the property of their respective owner.

Any use of UNICORN is subject to GE Healthcare Standard Software End-User

License Agreement for Life Sciences Software Products. A copy of this Standard

Software End-User License Agreement is available on request.

UNICORN 6 and 7 © 2009-2016 General Electric Company

© 2016 General Electric Company

First published Apr. 2016

All goods and services are sold subject to the terms and conditions of sale of the company within GE Healthcare which supplies them. A copy of these terms and conditions is available on request. Contact your local GE Healthcare representative for the most current information.

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29203965 AB 04/2016 a424

UNICORN 7.1 Software Change Description

™

Software Change Description

Operating systems and UNICORN database version

Support for filtration applications

Monitor run in Column Volume

(CV)

Flow rate in CV/h (Column flow)

Compare UV data generated with

UV cells of different path length

Calculate amount and concentration for legacy systems

Operating systems

UNICORN database version

Secure Windows Active

Directory

communication

Secure database communication

Change database password

Support for scouting on Frac-950

Corrections and improvements

Operating systems

SQL Server

Compatible systems

E-mail notifications

Folder access rights

New upgrade procedure from

UNICORN 6.0 or 6.1

Corrections and improvements

In this chapter

5.1

Operating Systems

5.2

New Evaluation module

General

Peak area calculation

Results

Chart

Compare

5.3

Optional Evaluation Classic module

5.4

OPC certification

5.5

Corrections and improvements

UNICORN Service Tool

DoE sweet spot plot

Database connection status

OPC certification

Corrections and improvements

Operating systems

Compatible systems

UNICORN extension framework

UNICORN database compatibility

Corrections and improvements

Operating systems

Compatible systems

Import and export of DoE results, method queues and folders

Support for cell cultivation

Corrections and improvements

Operating systems

Corrections

Operating systems

Compatible system

Client and instrument server installation

License handling

Power-save

E-mail notifications

Column type filtration

Process picture

Performance test method layout

Adapt methods

Corrections and improvements

Related manuals