KMPi TFF System Instructions for Use

C/D/D/C MODE

KMPi

12.4.5. Concentration 1/Diafiltration 1/Diafiltration 2/Concentration 1 Mode

C/D/D/C Mode may be used to wash the solution with two different buffers.

Diafiltration Buffer Reservoir 1 Module Diafiltration Buffer Reservoir 1

Feed Reservoir

Permeate Reservoir

Diafiltration Pump 1 Feed Scale KMPi Pump Diafiltration Pump 2

(Permeate Pump)

Permeate Scale

NOTE:

In C/D/D/C Mode only, the Permeate Pump functions as Diafiltration Pump 2. For this functionality test, prepare two buffer reservoirs that both lead into the Feed Reservoir, and have one line go through the

Diafiltration Pump and the other line go through the Permeate Pump.

SW

Conc Factor 1

Diaf Volumes 1

Diaf Volumes 2

Conc Factor 2

10X

7

8

20X

Feed Wt After C1

Feed Wt After C2

20 kg

Perm Wt After C1

2 kg

Diaf Wt 1

Perm Wt After D1

Diaf Wt 2

Perm Wt After D2

1 kg

Feed Scale

18 kg

14 kg

30 kg

16 kg

46 kg

Permeate Scale

12.4.6. Constant Feed Concentration Mode

Set-up CFC mode exactly like C/D Mode

(see Section 12.4.5.)

47

KMPi TFF System • PRODUCT INFORMATION AND OPERATING INSTRUCTIONS

ORDERING INFORMATION

KMPi

13. Ordering Information

KMPi TFF System (KrosFlo

®

MiniKros

®

Pilot i)

Part Number Description

SYM3-U20 Complete

KMPi

System

SYM3-U10

KMPi

Pump Drive and Head Only

ACM3-IQOQ-PW IQ/OQ Paperwork

ACM3-IQOQ-SR IQ/OQ Sales Rep Service

System Components & Accessories

Part Number Description

ACPX-N-01N MiniKros Fittings Kit

ACPX-K-01N KrosFlo Fittings Kit

ACPX-KE-01N KrosFlo Essentials Fittings Kit

ACM3-H3S-01N 13 LPM Easy-Load Pump Head with mounting hardware

ACM3-PHP-01N 17 LPM High-Performance Pump Head with mounting hardware

ACPC-F17-01N KrosFlo Automatic Backpressure Valve for use with 3/16” to 5/8” OD Tubing,

110V (L/S #25, 17, 18, 15, 24, 35, 36 and IP # 26, 73)

ACPC-F82-01N KrosFlo Automatic Backpressure Valve for use with 1/4” to 1” OD Tubing, 110V

(L/S #73 and 82)

ACSC-60K-1212 Surface Acoustic Wave Auxiliary Scale, 60kg Capacity, Universal Voltage

ACSC-60K-1216 Surface Acoustic Wave Auxiliary Scale, 60kg Capacity, Universal Voltage

ACSC-200k-2023 Surface Acoustic Wave Auxiliary Scale, 200kg Capacity, Universal Voltage

ACSC-500K-3030 Surface Acoustic Wave Auxiliary Scale, 500kg Capacity, Universal Voltage

ACBT-4TC-01N Process Reservoir - Bottle, 4 L, 3/4” TC

ACBT-10TC-01N Process Reservoir - Carboy, 10 L, 3/4” TC

ACBT-20TC-01N Process Reservoir - Carboy, 20 L, 3/4” TC

ACBT-50TC-01N Process Reservoir - Carboy, 50 L, 3/4”

ACBT-1-D Process Reservoir - Disposable Bottle, 1 L, 2 1/8” HB and 2 1/4” HB

ACBT-2-D Process Reservoir - Disposable Bottle, 2 L, 2 1/8” HB and 2 1/4” HB

ACTU-P26-25N PharmaPure Tubing Size 26, 0.25” ID, 1/4” Hose Barb

ACTU-P73-25N PharmaPure Tubing Size 73, 0.375” ID, 3/8” Hose Barb

ACTU-P82-25N PharmaPure Tubing Size 82, 0.5” ID, 1/2” Hose Barb

NOTE:

Contact SpectrumLabs.com for assistance selecting the appropriate HF Module, Flowpath,

Reservoir Bottles and Customized Sterile Flowpaths (MBT's) for user’s application.

48

KMPi TFF System • PRODUCT INFORMATION AND OPERATING INSTRUCTIONS

CONTACT INFORMATION

Contact Information:

SpectrumLabs.com America

World-wide Headquarters

voice 310-885-4600 (world-wide) • 800-634-3300 (toll-free US and Canada)

fax 310-885-4666 (world-wide) • 800-445-7330 (toll-free US and Canada)

e-mail [email protected]

web www.spectrumlabs.com

SpectrumLabs.com Europe

European Headquarters

voice +31 (0) 76 5719 419

fax +31 (0) 76 5719 772

e-mail [email protected]

web www.spectrumlabs.eu

Southern Europe

e-mail [email protected]

web www.spectrumlabs.fr

Central Europe

e-mail [email protected]

web www.spectrumlabs.de

UK and Ireland

e-mail [email protected]

web www.spectrumlabs.co.uk

Scandinavia

e-mail [email protected]

web www.spectrumlabs.eu

SpectrumLabs.com China

voice (+86) 21 68810228

400-6284448 (toll-free Mainland China)

fax (+86) 21 60919246

e-mail [email protected]

web www.spectrumlabs.cn

SpectrumLabs.com Japan

voice +81-77-552-7820

fax +81-77-552-7826

e-mail [email protected]

web www.spectrumlabs.jp

Benelux

e-mail [email protected]

web www.spectrumlabs.eu

KMPi

49

KMPi TFF System • PRODUCT INFORMATION AND OPERATING INSTRUCTIONS

400-12355-000 Rev. 01 • 152010